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Spegra Tablet is an antiretroviral drug used in the treatment of HIV-1 infection. This combination medicine works by blocking the activity of HIV integrase and reverse transcriptase enzymes, which are necessary for the virus to multiply. Common side effects include dizziness, headache, diarrhoea, nausea, vomiting, rashes, trouble sleeping, and feeling weak.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

DOLUTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Spegra Tablet

Spegra Tablet is a prescription tablet used to treat Human Immunodeficiency Virus type 1 (HIV-1) infection in adults and children who meet specific weight requirements. This medicine helps lower the amount of the virus in your blood and protects your immune system from damage. It is prescribed as a complete treatment regimen, meaning you generally do not need to take other HIV medicines with it.

To get the best results, you must take Spegra Tablet consistently every day at the same time to prevent the virus from adapting and becoming resistant. This tablet can be taken with or without food, making it easy to fit into your daily schedule. Alongside your treatment, making healthy lifestyle choices like eating a balanced diet, sleeping well, and reducing stress can help support your immune system.

Many people taking this medicine experience only mild side effects, such as trouble sleeping, tiredness, or headaches. However, you must seek medical attention immediately if you notice serious symptoms like a severe skin rash, yellowing of your skin or eyes, or unusual muscle pain. Your healthcare team can help you manage these side effects safely.

Tell your doctor about your complete medical history before starting Spegra Tablet , especially if you have liver conditions like Hepatitis B, or kidney problems. Do not take this medicine if you are currently taking dofetilide, as combining these medicines can cause severe heart rhythm issues. Your doctor will determine if this medicine is safe for your specific health needs.

This medicine can interact with other products, such as antacids or iron supplements, which block your body from properly absorbing the active ingredients. It is also important to talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as they will help you decide on the safest treatment plan.

Uses of Spegra Tablet

Spegra Tablet may be used to help manage the following conditions:

  • HIV-1 Infection: Spegra Tablet is used as a complete daily regimen to treat Human Immunodeficiency Virus type 1 (HIV-1) by reducing the amount of virus in the body and supporting immune system recovery.

Key Benefits

Taking Spegra Tablet offers key benefits to help manage your health effectively:

  • Simplified daily routine: By combining multiple therapies into one single daily tablet, Spegra Tablet reduces your daily pill burden and makes it much easier to stay consistent with your treatment schedule.
  • Immune system recovery: By keeping the virus under control, this medicine allows your immune system's helper cells (CD4 cells) to recover and grow stronger, which helps protect your body from other infections.
  • Maintained long-term health: Keeping your viral load low reduces the long-term damage HIV can cause to your body, helping you maintain your physical health and day-to-day energy.

Directions for Use

  • Spegra Tablet can be taken with or without food, or as advised by a doctor.
  • Generally, Spegra Tablet is taken once daily, or as prescribed by your doctor.
  • Swallow Spegra Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Spegra Tablet Works

Spegra Tablet works by blocking the machinery that the HIV virus needs to copy itself in your body. It contains three distinct active ingredients that attack the virus at different stages of its life cycle. Dolutegravir is an integrase inhibitor. It works by blocking a viral enzyme called integrase, which prevents the virus from inserting its genetic material into your healthy immune cells. Emtricitabine and Tenofovir Alafenamide are nucleoside reverse transcriptase inhibitors (NRTIs). They act as faulty building blocks. When the virus tries to use these blocks to copy its genetic code, the copying process is cut short, preventing the virus from multiplying. Together, these three ingredients work to lower the amount of virus in your body to very low levels.
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Alcohol

Unsafe

It is not recommended to consume alcohol with Spegra Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe if the benefits are found to outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while on treatment with Spegra Tablet .

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Driving

Caution

Spegra Tablet may cause dizziness and tiredness. Do not drive if you experience any side effects after using Spegra Tablet .

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Liver

Caution

Exercise caution before using Spegra Tablet in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Spegra Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Spegra Tablet is not recommended for use in children under 12 years of age. Please consult your doctor in case of any concerns.

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Heart

Caution

Spegra Tablet should be used with caution in patients with cardiovascular disease. Please inform your doctor if you have any pre-existing heart problems before using Spegra Tablet .

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Geriatrics

Caution

Spegra Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform a healthcare professional before use.

What if I have taken an overdose of Spegra Tablet

If you take too much of this medicine, seek emergency medical care.

Diet & Lifestyle Advise

  • Limit alcohol intake: Alcohol can strain your liver. Since both HIV and certain medications can affect liver health, it is best to drink in moderation or avoid alcohol completely.
  • Eat nutrient-rich foods: Focus on a diet high in lean proteins, whole grains, fruits, and vegetables to help support your immune system and combat potential metabolic shifts.
  • Stay hydrated: Drinking plenty of water throughout the day helps your kidneys process and clear medications safely.
  • Practice food safety: Since HIV affects your immune system, always cook meats fully, wash raw produce thoroughly, and avoid unpasteurised dairy to prevent foodborne infections.
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How Soon It Starts Working

The time required for Spegra Tablet to start to work: The time required for Spegra Tablet to show its action is unknown.

The time for which the effects of Spegra Tablet last: The duration of action for Spegra Tablet is clinically unknown.

What if you forget to take Spegra Tablet

If you miss a dose of Spegra Tablet , take it as soon as you remember, unless your next scheduled dose is due soon. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Spegra Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original container to protect them from moisture and light.

Drug Warnings

  • Take It Consistently: Take Spegra Tablet at the same time every day to help keep HIV under control and reduce the risk of the virus becoming resistant to treatment.
  • Do Not Stop Without Medical Advice: Continue taking this medicine unless your doctor tells you to stop, even if you feel well.
  • Separate from Certain Medicines and Supplements: Antacids or supplements containing calcium, iron, magnesium, or aluminium can affect how dolutegravir is absorbed. Follow your doctor's or pharmacist's advice on when to take these products.
  • Attend Regular Check-ups: Keep all scheduled appointments so your doctor can monitor your viral load, immune health, kidney function, liver function, and overall response to treatment.
  • Practice Safer Sex: Continue to use condoms and follow your doctor's advice to help reduce the risk of transmitting HIV to others.
  • Do Not Share Your Medicine: Spegra Tablet has been prescribed specifically for you. Do not share it with anyone else, even if they have similar symptoms or the same condition.

verifiedApollotooltip
  • Dofetilide: Taking Spegra Tablet with this heart rhythm medicine can increase dofetilide levels in your blood, which may lead to serious heart complications.
  • Antacids and mineral supplements: Products containing aluminium, magnesium, calcium, or iron can bind to dolutegravir and significantly reduce how much medicine your body absorbs.
  • Rifampin: This tuberculosis medicine can lower the levels of Spegra Tablet in your body, making the treatment less effective.
  • Certain anti-seizure medicines (like carbamazepine, phenytoin, or phenobarbital): These can decrease the effectiveness of Spegra Tablet by speeding up its clearance from your body.

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verifiedApollotooltip
  • Food: Spegra Tablet can be taken with or without food. No clinically significant food interactions are known when it is taken as directed. 

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Spegra Tablet is used for the treatment of HIV-1 infection (human immunodeficiency virus type 1) in adults and children above 12 years weighing at least 40 kg.
Spegra Tablet contains Dolutegravir, Emtricitabine, and Tenofovir alafenamide. These medicines work together to block the activity of HIV integrase and reverse transcriptase enzymes that the virus needs to multiply, thereby reducing the amount of virus in the body and helping to treat HIV infection.
It is not known if Spegra Tablet is safe for patients who have HIV-1 and hepatitis-B infections. Please consult your doctor for any concerns.
Spegra Tablet might cause lactic acidosis (excess of lactic acid in the blood). Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, or deep, rapid breathing.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Avoid nursing while receiving Spegra Tablet therapy. Avoid alcohol consumption. It is critical to engage in safe sex to avoid transferring HIV to your partner.
Before taking the Spegra Tablet , let your doctor know about all your medical conditions, sensitivities, and all the medications you are using. And inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Your doctor will determine the duration of Spegra Tablet based on your medical condition and response to treatment.
The recommended dosage of Spegra Tablet is one tablet taken orally once daily. However, dosage may vary depending on various factors, including medical condition and treatment response.
Dolutegravir, Emtricitabine and Tenofovir Alafenamide are the key active ingredients present in Spegra Tablet .
Spegra Tablet is not recommended for use in children under 12 years of age. Please consult your doctor in case of any concerns.
Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.
No, you should not stop taking Spegra Tablet even if your viral load becomes undetectable. An undetectable viral load means the medicine is working well to keep the virus suppressed, but stopping the medicine will allow the virus to start multiplying again. Talk to your doctor before making any changes to your therapy.
If you vomit within 1 hour of taking your dose, take another tablet. If you vomit more than 1 hour after taking it, do not take an extra dose; just wait and take your next dose at your regularly scheduled time. Talk to your doctor or pharmacist if you experience frequent vomiting.
While moderate alcohol consumption does not directly stop Spegra Tablet from working, both alcohol and this medicine can strain your liver. It is best to limit your alcohol intake to protect your liver health. Talk to your doctor about what is safe for you.
No, Spegra Tablet does not cure HIV infection. It is a long-term treatment that manages the virus, reduces the amount of virus in your body, and helps protect your immune system so you can live a healthy life. Talk to your doctor to understand how to manage your long-term health.
Yes, but you must space them out. Antacids containing aluminum, magnesium, or calcium can prevent your body from absorbing Spegra Tablet properly. Take your antacid at least 2 hours before or 6 hours after taking your medication. Talk to your doctor or pharmacist for specific timing advice.
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the benefits and risks of Spegra Tablet with your doctor. They will help you weigh the options to ensure both your health and your baby's health are protected. Talk to your doctor for personalised advice.
Some clinical studies have shown that people taking modern HIV regimens, including components found in Spegra Tablet , may experience weight gain. This is often a sign of returning to good health as the infection is controlled. Talk to your doctor if you have concerns about weight changes.
If you develop a skin rash, pay close attention to other symptoms. If the rash is mild, monitor it, but if it is severe, spreads quickly, or is accompanied by a fever, blisters, or trouble breathing, seek emergency medical care immediately, as this could be a serious allergic reaction. Talk to your doctor right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.9313 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Dolutegravir + Emtricitabine + Tenofovir Alafenamide Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Pmc3312400 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. DrugBank Online. Db09299 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  6. Dolutegravir, emtricitabine and tenofovir alafenamide [FDA Label]. 2018. [Accessed on 16 Apr. 2021]Check here
  7. Dolutegravir, emtricitabine and tenofovir alafenamide [Prescribing Information]. 2023. [Accessed on 22 Aug. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - SPE0220
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