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compositionComposition:DASATINIB-100MG
prescription
Prescription Medicine
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Spnib 100 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DASATINIB-100MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Spnib 100 Tablet

Spnib 100 Tablet is an oral prescription medication used to treat specific types of blood cancers, including chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). It is prescribed to slow down or stop the growth of abnormal cancer cells in the bone marrow. This medication helps manage these complex blood conditions in both adults and, in some cases, children.

For the best results, you must take Spnib 100 Tablet consistently at the same time every day. You can take this tablet with or without food, but you should stick to the same routine daily. Making healthy lifestyle choices, such as eating a well-balanced diet and drinking plenty of fluids, can help support your body during this treatment.

While taking Spnib 100 Tablet , you may experience some common side effects, which are usually manageable. However, you must contact your doctor immediately if you experience serious symptoms, such as sudden shortness of breath, unexplained swelling, or unusual bleeding. Regular medical follow-ups and blood tests are required to ensure the medication is working safely.

Do not take this if you are allergic to any of its ingredients. Before starting Spnib 100 Tablet , tell your doctor if you have a history of heart disease, liver damage, low potassium or magnesium levels in your blood, or a personal or family history of long QT syndrome. Pregnant women must not take this medication, as it can cause harm to an unborn baby.

Spnib 100 Tablet can interact with several common medications, including stomach-acid reducers and certain antibiotics, which can prevent it from working properly. You should avoid drinking alcohol while taking this medicine as it may increase the risk of side effects, and talk to your doctor if you smoke. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, consult your doctor to discuss the risks and benefits of this treatment.

Uses of Spnib 100 Tablet

Spnib 100 Tablet is used to treat specific types of blood cancers. The detailed uses of Spnib 100 Tablet are as follows:

  • Chronic Myeloid Leukaemia (CML): Spnib 100 Tablet helps by targeting and blocking abnormal proteins that send signals to cancer cells to multiply, helping to control the overproduction of abnormal white blood cells.
  • Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia (Ph+ ALL): Spnib 100 Tablet stops the rapid growth of abnormal leukaemia cells, allowing the bone marrow to produce healthier, normally functioning blood cells.
     

Key Benefits

Spnib 100 Tablet provides targeted action directly against the proteins causing cancer cell growth, which offers several practical benefits for patients:

  • Disease Control: It helps slow down or halt the progression of leukaemia, allowing many patients to achieve and maintain remission.
  • Symptom Relief: By reducing the number of abnormal white blood cells, it helps relieve common leukaemia symptoms like severe fatigue, night sweats, and bone pain, allowing you to feel stronger and more active.
  • Oral Convenience: Because it is taken as a simple daily tablet, it allows you to manage your treatment at home without requiring frequent, lengthy hospital stays for intravenous therapies.
Side effects of Spnib 100 Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.

Directions for Use

  • Spnib 100 Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.
  • It is usually taken once a day, or as prescribed by your doctor.
  • Swallow Spnib 100 Tablet as a whole with water.
  • Do not crush, chew or break Spnib 100 Tablet .

How Spnib 100 Tablet Works

Spnib 100 Tablet contains dasatinib, which belongs to a class of medications called tyrosine kinase inhibitors. In certain leukaemias, an abnormal gene creates a protein that signals white blood cells to grow out of control. This medication works by specifically binding to and blocking these abnormal proteins. By cutting off these growth signals, Spnib 100 Tablet stops the leukaemia cells from multiplying and surviving, which helps your bone marrow regain its normal balance of healthy blood cells.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Spnib 100 Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Spnib 100 Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Spnib 100 Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Spnib 100 Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Spnib 100 Tablet . Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Spnib 100 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Spnib 100 Tablet or until you become alert.

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Liver

Caution

Use Spnib 100 Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Spnib 100 Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Spnib 100 Tablet is safe for use in children above one year of age if prescribed by the doctor.

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Heart

Caution

Spnib 100 Tablet may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Spnib 100 Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Spnib 100 Tablet to geriatric patients. Your doctor will prescribe Spnib 100 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Spnib 100 Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking Spnib 100 Tablet , as it can dangerously increase the levels of the medicine in your body.
  • Manage infection risk: Wash your hands frequently and avoid close contact with people who have active infections, as this medicine can temporarily lower your white blood cell count.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out waste products as tumour cells break down.
  • Track your weight: Weigh yourself regularly and report any sudden, unexplained weight gain to your doctor, as this can be an early sign of fluid retention.
health query

Have a query?

How Soon It Starts Working

The time required for Spnib 100 Tablet to start to work: Spnib 100 Tablet ideally shows its action within few hours after administration. The time for which the effects of Spnib 100 Tablet last: The effect of Spnib 100 Tablet lasts for 24 hours.

What if you forget to take Spnib 100 Tablet

If you miss a dose, skip the missed dose and take your next dose at your regularly scheduled time. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store Spnib 100 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Never crush or break Spnib 100 Tablet tablets. If a tablet is broken, pregnant women must avoid handling it, as the active drug can be absorbed through the skin and harm an unborn baby.
  • Always carry a list of all your current medicines, vitamins, and herbal supplements, and show it to any doctor or dentist before receiving new treatments.
  • Check your body daily for any unusual bruising, red spots on your skin, or dark stools, and report these to your doctor immediately.
  • Make sure to attend all scheduled laboratory appointments so your doctor can check your blood counts and monitor your liver and heart health.

 

Drug-Drug Interactions

verifiedApollotooltip
  • Acid-reducers: Medicines like proton pump inhibitors (e.g., omeprazole) and H2 blockers can significantly lower the absorption of Spnib 100 Tablet , making it less effective.
  • Blood thinners: Taking this medicine with anticoagulants (like warfarin) or antiplatelet drugs (like aspirin) can increase your risk of severe bleeding.
  • CYP3A4 inhibitors and inducers: Certain antibiotics, antifungals, and anti-seizure medicines can change how quickly your liver breaks down Spnib 100 Tablet , causing levels to become dangerously high or too low.
DasatinibMesoridazine
Critical
DasatinibHalofantrine
Critical

Drug-Drug Interactions

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DasatinibMesoridazine
Critical
How does the drug interact with Spnib 100 Tablet:
Using Mesoridazine together with Spnib 100 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Spnib 100 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibHalofantrine
Critical
How does the drug interact with Spnib 100 Tablet:
Using Halofantrine together with Spnib 100 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 100 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
DasatinibPimozide
Critical
How does the drug interact with Spnib 100 Tablet:
Using Pimozide together with Spnib 100 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 100 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibDronedarone
Critical
How does the drug interact with Spnib 100 Tablet:
Using dronedarone together with Spnib 100 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 100 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibKetorolac
Severe
How does the drug interact with Spnib 100 Tablet:
Taking Spnib 100 Tablet together with ketorolac may increase the risk of bleeding.

How to manage the interaction:
Although taking Ketorolac and Spnib 100 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience bruising, dizziness, red or black, tarry stools, severe headache, and weakness, you should consult a doctor. Do not stop using any medications without talking to a doctor.
DasatinibAnistreplase
Severe
How does the drug interact with Spnib 100 Tablet:
Using Spnib 100 Tablet together with Anistreplase may increase the risk of bleeding.

How to manage the interaction:
Taking Spnib 100 Tablet with Anistreplase together can result in an interaction, but it can be taken if a doctor has advised it. If you notice dizziness;; red or black, tarry stools; severe headache; and weakness contact a doctor. Do not discontinue any medications without consulting a doctor.
DasatinibAtazanavir
Severe
How does the drug interact with Spnib 100 Tablet:
Coadministration of Spnib 100 Tablet with Atazanavir may significantly increase the blood levels of Spnib 100 Tablet.

How to manage the interaction:
Taking Spnib 100 Tablet with Atazanavir together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - like dizziness, fainting, or shortness of breath - call a doctor right away. Do not stop using any medications without a doctor's advice.
DasatinibVemurafenib
Severe
How does the drug interact with Spnib 100 Tablet:
Using vemurafenib together with Spnib 100 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Spnib 100 Tablet and Vemurafenib together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
DasatinibBaricitinib
Severe
How does the drug interact with Spnib 100 Tablet:
Using baricitinib together with Spnib 100 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Spnib 100 Tablet, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DasatinibClozapine
Severe
How does the drug interact with Spnib 100 Tablet:
Coadministration of Clozapine together with Spnib 100 Tablet can cause irregular heart rhythm.

How to manage the interaction:
Although taking Clozapine and Spnib 100 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you experience fever, sore throat, muscle aches, difficulty breathing, pain, dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit: Consuming grapefruit or its juice can block the enzymes that break down Spnib 100 Tablet , leading to a high buildup of the medicine in your blood and increasing the risk of serious side effects.
DASATINIB-100MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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DASATINIB-100MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice can significantly increase the blood levels and effects of Spnib 100 Tablet. Avoid consumption of Grapefruit juice with Spnib 100 Tablet. However, contact a doctor if you experience dizziness, shortness of breath, heart palpitations, pain, or burning during urination.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Spnib 100 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Spnib 100 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Spnib 100 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Spnib 100 Tablet as antacids may alter the absorption of this medicine.
Yes, you can take Spnib 100 Tablet either with or without food. However, try to be consistent with how you take it each day to help keep drug levels steady in your body. Talk to your doctor if you have questions.
Contact your healthcare team immediately. A fever can be a sign of a serious infection, which requires prompt medical evaluation since this medicine can lower your white blood cell count. Talk to your doctor right away.
No, you must avoid grapefruit and grapefruit juice entirely while taking this medication. Grapefruit can dramatically increase the drug levels in your body, leading to severe side effects. Talk to your doctor if you have dietary concerns.
No, you must not crush, cut, or chew the tablets. They must be swallowed whole. If you have difficulty swallowing pills, talk to your doctor or pharmacist for alternative guidance.
Some patients may experience thinning of the hair or mild hair loss while taking Spnib 100 Tablet , though it is usually temporary. If this concern is affecting your well-being, talk to your doctor or pharmacist for supportive care advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad €“ 380015, Gujarat, India.
Other Info - SPN0004
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