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  3. Spnib 70 Tablet 60's

Spnib 70 Tablet 60's, Pack of 1 TABLET
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Spnib 70 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Composition :

DASATINIB-70MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Spnib 70 Tablet

Spnib 70 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. Spnib 70 Tablet is used in the treatment of chronic myelogenous leukemia (CML) in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) who are resistant or intolerant to prior therapy, in patients with newly diagnosed chronic Ph+ chronic myelogenous leukemia (CML). This medicine is also used in the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

Spnib 70 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Spnib 70 Tablet may cause certain side effects, such as skin rash, fatigue, headache, musculoskeletal pain, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, GI bleeding, muscle inflammation, myalgia, and difficulty breathing. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Spnib 70 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Spnib 70 Tablet based on the severity of your condition.

Spnib 70 Tablet should be avoided if you are allergic to it or any other components present in it. Before taking Spnib 70 Tablet , caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, cardiac problems, and myelosuppression as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Spnib 70 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Spnib 70 Tablet

Spnib 70 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. The detailed uses of Spnib 70 Tablet are as follows:<br/>• Chronic Myeloid Leukemia (CML): Spnib 70 Tablet is used to treat chronic myeloid leukemia especially philadelphia chromosome-positive (Ph+) CML, in both newly diagnosed and resistant/intolerant cases.<br/>• Acute Lymphoblastic Leukemia (ALL): Spnib 70 Tablet is used to treat acute lymphoblastic leukemia and also Ph+ ALL, who are newly diagnosed or have relapsed.<br/>

Directions for Use

• Spnib 70 Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.• It is usually taken once a day, or as prescribed by your doctor.• Swallow Spnib 70 Tablet as a whole with water.• Do not crush, chew or break Spnib 70 Tablet .

Medicinal Benefits

Spnib 70 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins (BCR-ABL tyrosine kinase) that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. Spnib 70 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.

How Spnib 70 Tablet Works

Spnib 70 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Spnib 70 Tablet out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Spnib 70 Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.

What if I have taken an overdose of Spnib 70 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Spnib 70 Tablet are unusual bruising or bleeding, fever, sore throat, chills, and/or other signs of infection, shortness of breath, fast heartbeat, headache, pale skin, confusion and tiredness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Spnib 70 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, or gastrointestinal disorders, as the use of Spnib 70 Tablet in these patients may cause serious side effects. Spnib 70 Tablet may cause myelosuppression, fluid retention, gastrointestinal haemorrhage, QT prolongation, congestive heart failure, Left ventricular dysfunction and Myocardial infarction. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Spnib 70 Tablet is given in children above one year of age only if prescribed by the doctor. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DasatinibHalofantrine
Critical
DasatinibPimozide
Critical

Drug-Drug Interactions

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DasatinibHalofantrine
Critical
How does the drug interact with Spnib 70 Tablet:
Using Halofantrine together with Spnib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 70 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
DasatinibPimozide
Critical
How does the drug interact with Spnib 70 Tablet:
Using Pimozide together with Spnib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 70 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibDronedarone
Critical
How does the drug interact with Spnib 70 Tablet:
Using dronedarone together with Spnib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Spnib 70 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibMesoridazine
Critical
How does the drug interact with Spnib 70 Tablet:
Using Mesoridazine together with Spnib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Spnib 70 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibDicoumarol
Severe
How does the drug interact with Spnib 70 Tablet:
Using Spnib 70 Tablet together with Dicoumarol may increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Spnib 70 Tablet and Dicoumarol, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DasatinibFentanyl
Severe
How does the drug interact with Spnib 70 Tablet:
Coadministration of Spnib 70 Tablet with Fentanyl may significantly increase the blood levels and effects of fentanyl.

How to manage the interaction:
Although there is an interaction between Fentanyl and Spnib 70 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience excessive sleepiness, difficulty breathing, and/or shortness of breath. Do not discontinue using any medications without consulting a doctor.
DasatinibPosaconazole
Severe
How does the drug interact with Spnib 70 Tablet:
Taking Spnib 70 Tablet with Posaconazole may significantly increase the blood levels of Spnib 70 Tablet.

How to manage the interaction:
Although using Posaconazole and Spnib 70 Tablet together can result in an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience dizziness, difficulty breathing, heart palpitations, pain or a burning sensation during urination. Do not stop taking any medications without consulting a doctor.
DasatinibDeferiprone
Severe
How does the drug interact with Spnib 70 Tablet:
Using Deferiprone together with Spnib 70 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Spnib 70 Tablet and Deferiprone, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DasatinibBCG vaccine
Severe
How does the drug interact with Spnib 70 Tablet:
Using BCG vaccine together with Spnib 70 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although taking Spnib 70 Tablet and BCG vaccine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you notice any symptoms like Cramps, difficulty having a bowel movement, relaxed and calm feeling, sleepiness or unusual drowsiness, or weight loss contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DasatinibAspirin
Severe
How does the drug interact with Spnib 70 Tablet:
Coadministration of Spnib 70 Tablet with Aspirin may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Aspirin and Spnib 70 Tablet, you can take these medicines together if prescribed by a doctor. However, if you notice bruising, swelling, vomiting, headache, dizziness, or weakness inform a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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DASATINIB-70MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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DASATINIB-70MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice can significantly increase the blood levels and effects of Spnib 70 Tablet. Avoid consumption of Grapefruit juice with Spnib 70 Tablet. However, contact a doctor if you experience dizziness, shortness of breath, heart palpitations, pain, or burning during urination.

Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Spnib 70 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Spnib 70 Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Spnib 70 Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Spnib 70 Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Spnib 70 Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Spnib 70 Tablet . Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Spnib 70 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Spnib 70 Tablet or until you become alert.

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Liver

Caution

Use Spnib 70 Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Spnib 70 Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Spnib 70 Tablet is safe for use in children above one year of age if prescribed by the doctor.

Have a query?

FAQs

Spnib 70 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

Spnib 70 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.

Spnib 70 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Spnib 70 Tablet as antacids may alter the absorption of this medicine.

Country of origin

INDIA

Manufacturer/Marketer address

D' Block, 3Rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - SPN0002

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021986s7s8lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a607063.html
  3. https://go.drugbank.com/drugs/DB01254
  4. https://www.sprycel.com/

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