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compositionComposition:ZOLPIDEM-6.25MG
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Prescription Medicine
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Stilnoct 6.25mg Tablet is used in the short-term treatment of insomnia. It contains Zolpidem which relaxes muscles, reduces anxiety, and helps to fall asleep. Some people may experience dizziness, diarrhoea, drowsiness, headache, nausea, vomiting, nose or throat infections, tiredness, stomach pain, double vision, and back pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ZOLPIDEM-6.25MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Stilnoct 6.25mg Tablet

Stilnoct 6.25mg Tablet is used to treat insomnia, specifically helping adults who have difficulty falling or staying asleep. Its medical purpose is to provide short-term relief from sleeplessness and help restore a more stable, natural sleep pattern. This medication is designed to be used only as a temporary aid under a doctor's guidance.

It is typically taken once daily, immediately before bedtime, when you can dedicate a full 7 to 8 hours to sleep. To get the best results, you should take it on an empty stomach, as food can delay how quickly the medicine starts working. Making simple adjustments, such as sticking to a regular sleep schedule and reducing screen time before bed, can significantly improve your results.

Common side effects of this medication include daytime drowsiness, dizziness, and a feeling of being drugged. If you experience complex sleep behaviors—such as sleepwalking, sleep-driving, or preparing food while not fully awake—you must stop taking the medicine and consult your doctor immediately.

Talk to your doctor before starting Stilnoct 6.25mg Tablet if you have a history of depression, breathing problems, or liver damage. Do not take this medicine if you have ever had an allergic reaction to it or if you have experienced sleepwalking after taking it in the past.

This medicine can interact dangerously with alcohol and other sedatives, leading to severe drowsiness and slowed breathing. If you are pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist, as special precautions or a gradually decreasing dose may be necessary.
 

Uses of Stilnoct 6.25mg Tablet

Stilnoct 6.25mg Tablet is a prescription sleep medication used for the short-term treatment of insomnia. It works by affecting certain chemicals in the brain that help promote sleep and improve sleep quality.

  • Insomnia: Stilnoct 6.25mg Tablet helps adults who struggle with falling asleep by shortening the time it takes to drift off.
  • Sleep maintenance issues: In certain forms, Stilnoct 6.25mg Tablet helps individuals who wake up frequently during the night stay asleep longer.
     

Key Benefits

Stilnoct 6.25mg Tablet helps improve sleep quality and duration, allowing individuals with insomnia to get the rest they need for better daily functioning and overall well-being.

  • Faster sleep onset: Stilnoct 6.25mg Tablet provides targeted relief for those struggling with sleeplessness, helping you fall asleep within minutes of taking it.
  • Reduced bedtime anxiety: Its quick action can help reduce the frustration and stress associated with lying awake for long periods.
  • Improved sleep quality: By helping you achieve a more restful night's sleep, it can improve overall sleep satisfaction.
  • Better daytime functioning: Improved sleep may help you wake up feeling more refreshed, with greater energy, alertness, and concentration during the day.
  • Support for mental clarity and focus: Consistent, restorative sleep can enhance cognitive performance, memory, and productivity.
  • Helps break the cycle of insomnia: Short-term use of Stilnoct 6.25mg Tablet may help re-establish healthier sleep patterns and support a more stable sleep routine when used as directed by your healthcare provider.
     

Directions for Use

Take this medicine exactly as prescribed by your doctor. Follow these simple steps to ensure you use it safely:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, especially if it is an extended-release formula.
  • Take it on an empty stomach right before you get into bed. Avoid taking it with or immediately after a meal, as this can delay its effects.
  • Only take this medicine if you can stay in bed for a full 7 to 8 hours. Getting up too early can cause severe drowsiness, dizziness, and memory problems.
  • Never take a dose if you have already consumed alcohol or other sedating substances that evening.

Always follow your doctor's exact instructions regarding how and when to take your medication.
 

How Stilnoct 6.25mg Tablet Works

Stilnoct 6.25mg Tablet contains zolpidem, a sedative-hypnotic medicine that is used to help people fall asleep and stay asleep. Zolpidem works by enhancing the effects of GABA, a natural chemical messenger in the brain that helps slow down nerve activity. It attaches to specific GABA receptors in the brain, increasing their calming effect on the central nervous system. This helps reduce brain activity, promotes relaxation, and makes it easier to fall asleep. By helping to calm the brain and nervous system, zolpidem can also help improve sleep quality and reduce nighttime awakenings. Together, these actions help you fall asleep faster, stay asleep longer, and achieve a more restful night's sleep.
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Alcohol

Unsafe

Avoid consumption of alcohol with Stilnoct 6.25mg Tablet as it may increase the risk of dependence, psychomotor impairment (slowdown of thought process and reduced physical movements), sleep walking or sleep driving.

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Pregnancy

Unsafe

Stilnoct 6.25mg Tablet is a Category C pregnancy drug and is not recommended for use during pregnancy as it may cause adverse effects in baby after birth.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Stilnoct 6.25mg Tablet as it may be excreted in breast milk.

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Driving

Unsafe

You may experience dizziness, drowsiness, confusion, decreased alertness, blurred or double vision especially the day after taking Stilnoct 6.25mg Tablet . Therefore, avoid driving if you feel drowsy or dizzy after taking Stilnoct 6.25mg Tablet .

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Liver

Caution

Take Stilnoct 6.25mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Stilnoct 6.25mg Tablet is not recommended for severe liver disease patients.

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Kidney

Caution

Take Stilnoct 6.25mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Stilnoct 6.25mg Tablet is not recommended for children below 18 years of age.

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Heart

Unsafe

Stilnoct 6.25mg Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Consult your doctor

Limited information is available for use in erderly patients. Please consult your doctor.

What if I have taken an overdose of Stilnoct 6.25mg Tablet

Do not take more than the prescribed dose of Stilnoct 6.25mg Tablet as it may cause overdose. The symptoms of overdose include confusion, severe drowsiness, fainting, shallow breathing, lightheadedness or coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

To get the most benefit from Stilnoct 6.25mg Tablet and improve your sleep quality, consider the following evidence-based habits:

  • Limit caffeine and nicotine: Avoid coffee, tea, sodas, and smoking for at least 4 to 6 hours before bedtime, as these stimulants interfere with falling asleep.
  • Avoid heavy late-night meals: Eat dinner at least 2 to 3 hours before bed. High-fat or heavy meals can delay how fast the medicine is absorbed, making it less effective.
  • Establish a consistent sleep schedule: Go to bed and wake up at the same time every day, even on weekends, to help regulate your body's natural clock.
  • Create a restful sleep environment: Keep your bedroom dark, quiet, and cool. Use blackout curtains, earplugs, or a white noise machine if needed.
  • Unwind before bed: Spend the hour before sleep doing relaxing activities, such as reading a physical book or taking a warm bath, and avoid using smartphones, tablets, or computers.
     
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How Soon It Starts Working

The time required for Stilnoct 6.25mg Tablet to start to work: Stilnoct 6.25mg Tablet ideally shows its action within 30 minutes to 2 hours after administration. The time for which the effects of Stilnoct 6.25mg Tablet last: The effect of Stilnoct 6.25mg Tablet lasts for 6 to 8 hours.

What if you forget to take Stilnoct 6.25mg Tablet

If you miss a dose of Stilnoct 6.25mg Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Stilnoct 6.25mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F and 77°F). •Keep the medication in its original container.

Drug Warnings

  • Plan for a full night's sleep: Only take Stilnoct 6.25mg Tablet when you are certain you can sleep for 7 to 8 hours before you need to be active or drive.
  • Never mix with alcohol: Consuming alcohol with this medication can lead to dangerous levels of sedation, slowed breathing, and severe dizziness.
  • Be alert for sleep behaviors: Alert your family or housemates that you are taking this medication so they can monitor you for sleepwalking or other sleep-related actions you may not remember.
  • Avoid driving or operating machinery: Do not drive or perform hazardous tasks the morning after taking Stilnoct 6.25mg Tablet until you are completely sure you are fully awake and alert.
  • Use only for short periods: This medication is typically prescribed for short-term use (usually 1 to 2 weeks). Long-term use can lead to dependence or reduced effectiveness.
  • Check tablet appearance: Before taking your medication, inspect the tablet to ensure it is intact and has not crumbled or changed color.
     

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Drug-Drug Interaction Summary:

Stilnoct 6.25mg Tablet can interact with several medications that affect the central nervous system or alter how the drug is metabolized. Inform your healthcare provider about all medicines, supplements, and herbal products you are taking before starting treatment.

  • Other medicines that cause drowsiness: Combining Stilnoct 6.25mg Tablet with opioids, muscle relaxants, anti-anxiety medications, sedating antidepressants, or antihistamines can cause severe drowsiness, respiratory depression, profound sedation, or coma.
  • Ketoconazole, itraconazole, or ritonavir: These medicines can slow down how your body processes Stilnoct 6.25mg Tablet , increasing drug levels in the bloodstream and raising the risk of side effects.
  • Rifampin: May speed up how your body clears Stilnoct 6.25mg Tablet , making the medication less effective at helping you sleep.

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Drug-Food Interaction Summary:

Certain foods and beverages may affect how quickly Stilnoct 6.25mg Tablet works or increase the risk of side effects.

  • High-fat meals: Taking Stilnoct 6.25mg Tablet with or immediately after a high-fat meal can significantly delay its absorption, causing it to take longer to help you fall asleep.
  • Grapefruit and grapefruit juice: May increase the levels of Stilnoct 6.25mg Tablet in your blood, potentially leading to excessive drowsiness and other side effects.
  • Alcohol: Avoid alcohol while taking Stilnoct 6.25mg Tablet , as it can greatly increase drowsiness, impair coordination and judgment, and raise the risk of serious breathing problems.

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FAQs

Stilnoct 6.25mg Tablet is used in the short-term treatment of insomnia.
No, you are not recommended to take Stilnoct 6.25mg Tablet with hydrocodone or other opioid pain killers such as oxycodone, naloxone and tramadol as co-administration of these medicines with Stilnoct 6.25mg Tablet may increase the risk of difficulty in breathing, drowsiness, coma and even death. However, before using Stilnoct 6.25mg Tablet with any other medicines, you are advised to contact your doctor so that the dose may adjusted to use safely.
You are recommended to take Stilnoct 6.25mg Tablet just before bedtime as it helps to sleep quickly and improve the quality of sleep. If you forget to take Stilnoct 6.25mg Tablet at night, do not take it in the day time as it may cause drowsiness, confusion and dizziness.
No, Stilnoct 6.25mg Tablet is not recommended for depression patients as it may worsen the condition and increase self-harming or suicidal thoughts. Therefore, if you are suffering from depression or have history of depression, please inform your doctor before taking Stilnoct 6.25mg Tablet .
Yes, Stilnoct 6.25mg Tablet may cause dependence (mental and physical effects caused due to compulsion of taking Stilnoct 6.25mg Tablet ) if used in high doses and for prolonged time. This risk of dependency on Stilnoct 6.25mg Tablet increases in patients who have a history of drug or alcohol abuse.
Stilnoct 6.25mg Tablet helps you sleep better by increasing the activity of a chemical in your brain called GABA (Gamma-aminobutyric acid). This chemical calms your nerves and makes you feel relaxed, which helps you fall asleep. It also relaxes your muscles and reduces feelings of anxiety.
The common side effects of Stilnoct 6.25mg Tablet include dizziness, diarrhoea, drowsiness, headache, nausea, vomiting, nose or throat infections, tiredness, stomach pain, double vision, and back pain. Most of these side effects are mild and usually resolve on their own. However, if the side effects persist or worsen, please consult your doctor.
Stilnoct 6.25mg Tablet can cause sedation (state of sleepiness) and relaxation. Some people might misuse it in an attempt to get high from its sedative effects, so it is important to take Stilnoct 6.25mg Tablet only as prescribed by your doctor.
Yes, Stilnoct 6.25mg Tablet can be abused, especially if taken in higher doses or without a prescription from your doctor. This is more commonly seen in people with a history of drug abuse and alcohol consumption. Therefore, Stilnoct 6.25mg Tablet should be taken only as prescribed by the doctor.
While there might not be direct drug-drug interactions between Stilnoct 6.25mg Tablet and prednisone, both can affect your central nervous system. Please consult your doctor before taking Stilnoct 6.25mg Tablet with prednisone.
Stilnoct 6.25mg Tablet is mainly used to treat insomnia (difficulty falling asleep) and isn’t usually prescribed for anxiety (feelings of fear and uneasiness). While Stilnoct 6.25mg Tablet can have a calming effect that might temporarily ease anxiety, it’s not considered a suitable long-term solution for anxiety disorders. Consult the doctor for appropriate treatment.
The symptoms of Stilnoct 6.25mg Tablet overdose include confusion, somnolence (drowsiness), problems with breathing or heart function, and in severe cases, coma (a prolonged loss of consciousness). If you take too much Stilnoct 6.25mg Tablet , call your doctor right away or seek emergency treatment.
You should avoid drinking alcohol while taking Stilnoct 6.25mg Tablet , as it may increase the risk of psychomotor impairment (slowdown of thought processes and reduced physical movements), dependence, sleepwalking, or sleep driving. Avoid the intake of caffeine and St John’s wort (herbal medicine for treating depression), as they can make the medication less effective. If you feel dizzy, drowsy, confused, or have blurred vision after taking Stilnoct 6.25mg Tablet , please avoid driving or using machines.
You should not take Stilnoct 6.25mg Tablet if you are allergic to any of its ingredients. Stilnoct 6.25mg Tablet is classified as a Category C pregnancy drug and is not recommended for use during pregnancy. If you are a breastfeeding mother, please avoid taking Stilnoct 6.25mg Tablet , as it may be excreted in breast milk. If you have kidney or liver problems, breathing issues, severe muscle weakness, sleep apnea (a condition in which breathing stops and starts repeatedly during sleep), or a history of depression or mental illness, please consult your doctor before taking Stilnoct 6.25mg Tablet .
No, you should not take Stilnoct 6.25mg Tablet with food or immediately after a meal, as doing so may reduce its effectiveness. It will work faster if you take Stilnoct 6.25mg Tablet on an empty stomach.
Stilnoct 6.25mg Tablet should be taken as prescribed by a healthcare provider. It should only be used for a short term (usually 2-4 weeks) to treat insomnia (difficulty falling asleep) because your body gets used to this medicine quickly, which may lead to dependence (addiction to the drug).
Yes, Stilnoct 6.25mg Tablet can cause dry mouth as a common side effect. This occurs because it affects neurotransmitters in the brain that influence saliva production. Regarding weight, Stilnoct 6.25mg Tablet is not directly linked to significant weight gain or loss, but some people may experience changes in appetite that could indirectly affect their weight. If you have concerns about these side effects, discuss them with your doctor.
Stilnoct 6.25mg Tablet generally starts working within 30 minutes after taking it. It is usually recommended to take it right before you plan to sleep.
Do not stop taking Stilnoct 6.25mg Tablet without consulting your doctor, especially if you have taken it for longer than two weeks. If you suddenly stop taking Stilnoct 6.25mg Tablet , you may experience withdrawal symptoms such as shakiness, lightheadedness, stomach and muscle cramps, nausea, vomiting, sweating, tiredness, uncontrollable crying, nervousness, panic attacks, difficulty falling asleep or staying asleep, uncontrollable shaking of a part of your body, and, rarely, seizures. The doctor will reduce the dose gradually to prevent withdrawal symptoms.
To improve your sleep without medication, establish a consistent sleep schedule by going to bed and waking up at the same time each day. Create a relaxing bedtime routine, limit screen time before sleep, and make sure your sleep environment is dark, cool, and quiet. Regular exercise during the day can also help promote better sleep. Avoid caffeine, cigarettes, alcohol, heavy meals, and exercise for a few hours before bedtime.
Insomnia is a disorder of sleep associated with problems in falling asleep or staying asleep. It may be acute (short-term) or chronic (long-term) in nature. Acute insomnia may last from one night to a few weeks and occurs due to stress or changes in life. Chronic insomnia may last from more than 3 nights per week to more than 3 months.
Insomnia is mostly caused by depression, stress, anxiety, jet lag, shift work, uncomfortable sleeping conditions, chronic illness, certain medications, and the intake of substances like caffeine, nicotine, or alcohol.
No, you should only take Stilnoct 6.25mg Tablet if you have a full 7 to 8 hours left to sleep. Taking it with less time remaining can cause severe drowsiness, dizziness, and memory problems the next day. Talk to your doctor if you frequently wake up during the night.
Stilnoct 6.25mg Tablet is generally intended for short-term use, usually for a few days up to two weeks. Taking it for longer periods can increase the risk of physical or psychological dependence and decrease its effectiveness. Talk to your doctor about the safest timeline for your treatment.
If you or your family members notice that you are sleepwalking, sleep-driving, eating, or performing other activities while not fully awake, stop taking Stilnoct 6.25mg Tablet immediately. These behaviors can be highly dangerous. Contact your healthcare provider right away. Talk to your doctor to find a safer sleep solution.
Absolutely not. Drinking alcohol while taking Stilnoct 6.25mg Tablet can lead to severe drowsiness, breathing difficulties, loss of coordination, and even coma. It is highly dangerous to combine the two. Talk to your doctor about how to safely manage your sleep without alcohol.
Some people may experience daytime drowsiness, dizziness, or a "drugged" feeling the morning after taking Stilnoct 6.25mg Tablet . This is more likely if you do not get a full 7 to 8 hours of sleep or if you take a higher dose. If grogginess persists, do not drive or operate machinery. Talk to your doctor about adjusting your therapy.
Taking Stilnoct 6.25mg Tablet during the late stages of pregnancy can cause severe drowsiness or breathing issues in the newborn baby. It should only be used if the potential benefits outweigh the risks. Talk to your doctor or pharmacist if you are pregnant, planning to become pregnant, or breastfeeding.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.8188 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 019908S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Zolpidem Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Zolpidem - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Daniel Bouchette, Hossein Akhondi, Judy Quick. Zolpidem. National Institute of Health. NLM. National Centre for Biotechnology Information. Statpearls. May 2022. [Accessed on 29th August 2022]Check here
  6. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 29th August 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.

Therapeutic Class

[SEDATIVE-HYPNOTIC DRUGS]

Habit Forming

Yes
Other Info - STI0032

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