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compositionComposition:STREPTOKINASE-1500000IU
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Prescription Medicine
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Stpase 1500000Iu Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis. Stpase 1500000Iu Injection contains Streptokinase, which works by dissolving the harmful blood clots in the blood vessels; this restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

STREPTOKINASE-1500000IU

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Stpase 1500000Iu Injection

Stpase 1500000Iu Injection is a prescription injection used to dissolve harmful blood clots that block blood flow in emergencies. Depending on the specific medicine prescribed, it may be used to treat conditions such as acute heart attack (myocardial infarction), acute ischaemic stroke, pulmonary embolism (blood clot in the lungs), or blocked blood vessels. By rapidly dissolving the clot, it helps restore blood flow, reduce tissue damage, and improve the chances of recovery.

Because Stpase 1500000Iu Injection is an emergency medicine, it is administered only by trained healthcare professionals in a hospital or emergency care setting. It is given as an intravenous injection or infusion, depending on the specific medicine and condition being treated. After treatment, your doctor may recommend long-term medicines, lifestyle changes, and rehabilitation to reduce the risk of future blood clots.

While receiving Stpase 1500000Iu Injection, some people may experience mild bruising, bleeding from the injection site, nausea, or a temporary fall in blood pressure. However, serious bleeding can occur and requires immediate medical attention. Tell your healthcare provider immediately if you notice severe headache, sudden weakness, blood in your urine or stools, coughing up blood, or prolonged bleeding.

Before receiving this medicine, tell your doctor if you have had a recent stroke (unless being treated for an acute ischaemic stroke), major surgery, severe uncontrolled high blood pressure, bleeding disorders, stomach ulcers, or recent serious injuries. Do not receive this medicine if you have active internal bleeding or any condition where thrombolytic therapy is contraindicated.

This medicine can interact with blood thinners, antiplatelet medicines, and medicines that increase bleeding risk. If you are pregnant, breastfeeding, elderly, or have kidney or liver disease, your doctor will carefully assess the benefits and risks before treatment.

Uses of Stpase 1500000Iu Injection

Your doctor may prescribe Stpase 1500000Iu Injection to treat the following conditions:

  • Acute heart attack (myocardial infarction): Helps dissolve blood clots blocking the heart's arteries to restore blood flow and reduce heart muscle damage.
  • Acute ischaemic stroke (where indicated): Restores blood flow to affected areas of the brain when given within the recommended treatment window.
  • Pulmonary embolism: Dissolves blood clots in the lungs to improve circulation and reduce strain on the heart.
  • Blocked blood vessels: Helps restore blood flow in selected patients with severe arterial or catheter-related blockages.

Key Benefits

Stpase 1500000Iu Injection provides rapid clot-dissolving treatment during life-threatening medical emergencies. By restoring blood flow to affected organs, it helps limit permanent tissue damage and improves the chances of recovery when administered promptly.

  • Restores blood circulation: Quickly dissolves blood clots that obstruct blood flow to the heart, lungs, brain, or other vital organs.
  • Reduces organ damage: Early treatment helps minimise permanent injury to the heart muscle, brain tissue, or lungs.
  • Relieves severe symptoms: Helps improve symptoms such as chest pain, shortness of breath, or neurological deficits caused by blocked blood vessels.
  • Supports recovery: By restoring circulation quickly, it improves the likelihood of better long-term outcomes following a thrombotic emergency.
Side effects of Stpase 1500000Iu Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
  • Stpase 1500000Iu Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Stpase 1500000Iu Injection Works

Stpase 1500000Iu Injection belongs to a group of medicines called thrombolytics (fibrinolytic agents). It works by converting plasminogen into plasmin, an enzyme that breaks down fibrin, the protein framework that holds blood clots together. As the fibrin network dissolves, the clot gradually breaks apart, allowing blood to flow normally again. Restoring circulation helps reduce damage to affected organs and improves recovery.
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Alcohol

Caution

Stpase 1500000Iu Injection may not interact with alcohol. However, avoid the consumption of alcohol as it may worsen your health condition.

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Pregnancy

Caution

Stpase 1500000Iu Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy.

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Breast Feeding

Caution

It is unknown whether streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

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Driving

Caution

It is not known whether Stpase 1500000Iu Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Inform your doctor before receiving Stpase 1500000Iu Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Stpase 1500000Iu Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Stpase 1500000Iu Injection is not recommended in neonates, infants and children.

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Heart

Caution

Stpase 1500000Iu Injection is used to treat heart conditions like myocardial infarction by dissolving clots. However, it may cause bleeding or arrhythmias, so it must be given under strict medical supervision.

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Geriatrics

Caution

Geriatric patients can receive Stpase 1500000Iu Injection, especially in cases like acute myocardial infarction. While risks like bleeding and hypotension are higher with age, studies show the benefits often outweigh the risks when used with proper medical supervision.

What if I have taken an overdose of Stpase 1500000Iu Injection

Overdose is extremely rare because the medicine is administered under continuous medical supervision. Excess dosing may increase the risk of severe bleeding and requires immediate specialist management.

Diet & Lifestyle Advise

  • Follow a heart-healthy diet: Eat plenty of vegetables, fruits, whole grains, lean proteins, and limit salt and saturated fat.
  • Take prescribed blood-thinning medicines exactly as directed: Do not stop them without consulting your doctor.
  • Avoid activities with a high risk of injury: Bruising and bleeding may occur more easily after thrombolytic treatment.
  • Stop smoking and limit alcohol intake: Both increase the risk of future cardiovascular disease and bleeding complications.
  • Attend all follow-up appointments: Regular monitoring helps reduce the risk of future clotting events.
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How Soon It Starts Working

The time required for Stpase 1500000Iu Injection to start to work: Stpase 1500000Iu Injection ideally shows its action within 20 minutes after administration. The time for which the effects of Stpase 1500000Iu Injection last: The effect of Stpase 1500000Iu Injection lasts for 6 to 12 hours.

What if you forget to take Stpase 1500000Iu Injection

Since this medicine is administered only in hospitals during emergency treatment, missed doses are unlikely.

Storage

• Stpase 1500000Iu Injection injections are stored and prepared by healthcare professionals in hospitals or healthcare facilities according to the manufacturer's recommendations.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inform your healthcare provider about any recent surgery, injury, or bleeding problems before treatment begins.
  • Avoid unnecessary injections or invasive procedures after receiving this medicine unless advised by your doctor.
  • Report any unusual bleeding immediately, including nosebleeds, blood in urine or stools, or prolonged bleeding from cuts.
  • Use a soft toothbrush and an electric razor if recommended to reduce the risk of minor bleeding after treatment.
  • Carry information about your recent thrombolytic treatment if you require emergency medical care within the following days.

Drug-Drug Interactions

verifiedApollotooltip
  • Anticoagulants (e.g., warfarin, heparin, apixaban, rivaroxaban): Significantly increase the risk of serious bleeding.
  • Antiplatelet medicines (e.g., aspirin, clopidogrel, ticagrelor): May further increase bleeding risk when used together.
  • NSAIDs (e.g., ibuprofen, diclofenac, naproxen): Increase the risk of gastrointestinal bleeding and should be used cautiously.
StreptokinaseDabigatran etexilate
Severe
StreptokinaseEnoxaparin
Severe

Drug-Drug Interactions

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StreptokinaseDabigatran etexilate
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Taking Dabigatran etexilate with Stpase 1500000Iu Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Stpase 1500000Iu Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseEnoxaparin
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Taking Stpase 1500000Iu Injection can enhance the blood-thinning effects of Enoxaparin which can increase the risk or severity.

How to manage the interaction:
Taking Enoxaparin with Stpase 1500000Iu Injection together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like pain in the middle of your back, feeling numb, problems with your bowels or bladder, bleeding, very heavy bleeding that could be dangerous, complications, bruises, feeling dizzy or lightheaded, seeing red or black stools, having a severe headache, bleeding, vomiting, or feeling weak it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
StreptokinaseDeferasirox
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Combining Stpase 1500000Iu Injection with Deferasirox can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Co-administration of Stpase 1500000Iu Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseDalteparin
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Using Stpase 1500000Iu Injection together with dalteparin may increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Stpase 1500000Iu Injection may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
StreptokinaseHeparin
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Taking Heparin with Stpase 1500000Iu Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Heparin and Stpase 1500000Iu Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
StreptokinaseCangrelor
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Co-administration of Cangrelor with Stpase 1500000Iu Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Stpase 1500000Iu Injection and Cangrelor, but it can be taken if prescribed by a doctor. However, consult doctor immediately if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without talking to a doctor.
StreptokinaseRivaroxaban
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Co-administration of Stpase 1500000Iu Injection and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Stpase 1500000Iu Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
StreptokinaseDasatinib
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Coadministration of Dasatinib with Stpase 1500000Iu Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Stpase 1500000Iu Injection with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience bruising, dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
StreptokinaseFondaparinux
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Taking Stpase 1500000Iu Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Stpase 1500000Iu Injection and Fondaparinux, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
StreptokinaseIbrutinib
Severe
How does the drug interact with Stpase 1500000Iu Injection:
Co-administration of Ibrutinib with Stpase 1500000Iu Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Stpase 1500000Iu Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Limit or avoid alcohol after treatment because it may increase the risk of bleeding, particularly if you are also taking blood-thinning medicines.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIFIBRINOLYTIC AGENTS]

FAQs

Yes. Bleeding is one of the most common adverse effects of Stpase 1500000Iu Injection. Minor bleeding or bruising may occur, but severe or persistent bleeding requires immediate medical attention. Contact your medical team immediately if you have heavy or continuous bleeding, unusual or extensive bruising, blood in your urine or stool, vomiting blood, or other signs of serious bleeding.
Tell your doctor about all medicines you are taking before receiving Stpase 1500000Iu Injection. Anticoagulants and medicines that inhibit platelet function, such as aspirin, may increase the risk of bleeding and should only be used if specifically advised by your doctor. Do not start any new medicine without consulting your doctor or medical team.
Stpase 1500000Iu Injection starts working almost immediately after it is injected into the vein to dissolve the blood clot. Talk to your doctor for more details about your specific recovery timeline.
No, Stpase 1500000Iu Injection must be injected by a trained healthcare professional in a hospital or specialized clinic where you can be closely monitored. Talk to your doctor if you have questions about where your treatment will take place.
Stpase 1500000Iu Injection is generally avoided during pregnancy unless it is a life-saving emergency, as it carries a risk of bleeding for both mother and baby. Talk to your doctor to understand the risks and benefits.
The active effects of Stpase 1500000Iu Injection on your body's clotting system can last for several hours to a day after the infusion is stopped. Talk to your doctor to learn more about post-treatment monitoring.
The most serious risk associated with Stpase 1500000Iu Injection is severe internal bleeding, including bleeding in the brain. Your medical team will monitor you constantly during treatment to minimise this risk. Talk to your doctor if you have concerns.
Your body can develop defence proteins (antibodies) against Stpase 1500000Iu Injection after you receive it, making a second dose less effective or more likely to cause allergic reactions if given within 5 days to 12 months. Talk to your doctor if you have received this medicine in the past.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MIMS Drug Reference Compendium. Streptokinase Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db00086 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Print Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Streptokinase Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Zachary Edwards; Shivaraj Nagalli. Streptokinase. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 20th March 2023]Check here
  6. Tetris Pharma Ltd. Streptokinase 2,50,000 IU. Electronic Medicines Compendium (EMC). [Revised in September 2019]. [Accessed on 20th March 2023]Check here

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - STP0001
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