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compositionComposition:TACROLIMUS-0.5MG
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Prescription Medicine
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Tacrograf 0.5 Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

TACROLIMUS-0.5MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Tacrograf 0.5 Capsule

Tacrograf 0.5 Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Tacrograf 0.5 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Take Tacrograf 0.5 Capsule as prescribed. You are advised to use Tacrograf 0.5 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Tacrograf 0.5 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacrograf 0.5 Capsule . Avoid alcohol consumption with Tacrograf 0.5 Capsule . Drive only if you are alert, as Tacrograf 0.5 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Tacrograf 0.5 Capsule . Tacrograf 0.5 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Tacrograf 0.5 Capsule

Tacrograf 0.5 Capsule is used to treat various medical conditions. The detailed uses are as follows:

  • Prevention of Organ Transplant Rejection: Tacrograf 0.5 Capsule is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
  • Other Off-Label Uses: In some cases, Tacrograf 0.5 Capsule may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

Key Benefits

  • Tacrograf 0.5 Capsule belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
  • It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
  • It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
  • It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
  • It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.
Side effects of Tacrograf 0.5 Capsule
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Take Tacrograf 0.5 Capsule at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
  • Strictly follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

How Tacrograf 0.5 Capsule Works

Tacrograf 0.5 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.
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Alcohol

Unsafe

Avoid alcohol consumption with Tacrograf 0.5 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Tacrograf 0.5 Capsule .

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Tacrograf 0.5 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Tacrograf 0.5 Capsule .

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Breast Feeding

Consult your doctor

Tacrograf 0.5 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Tacrograf 0.5 Capsule . You should avoid taking Tacrograf 0.5 Capsule during breastfeeding or avoid breastfeeding while on treatment with Tacrograf 0.5 Capsule .

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Driving

Caution

Tacrograf 0.5 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Tacrograf 0.5 Capsule .

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Tacrograf 0.5 Capsule .

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Tacrograf 0.5 Capsule .

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Children

Safe if prescribed

Tacrograf 0.5 Capsule should be used in children in doses as advised by a doctor only.

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Heart

Consult your doctor

Tacrograf 0.5 Capsule can be used in heart patients, especially post-transplant, but it require close monitoring due to risks like arrhythmias, hypertension, and kidney strain. Always consult your cardiologist before starting, as dose adjustments and regular ECG and blood tests may be necessary.

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Geriatrics

Caution

Tacrograf 0.5 Capsule can be taken by geriatric patients, but they require careful monitoring due to increased sensitivity to side effects like kidney dysfunction and high blood pressure. Dose adjustments and regular blood tests are essential to ensure safety and effectiveness.

What if I have taken an overdose of Tacrograf 0.5 Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed of Tacrograf 0.5 Capsule or if you experience any adverse events, please go to the emergency department of the closest hospital.

Diet & Lifestyle Advise

  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
  • Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
  • Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
  • Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
  • Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
  • Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
  • Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
  • Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
  • Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
  • Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.
health query

Have a query?

How Soon It Starts Working

The time required for Tacrograf 0.5 Capsule to start to work: The peak effect of Tacrograf 0.5 Capsule can be observed in 6 hours. The time for which the effects of Tacrograf 0.5 Capsule last: Tacrograf 0.5 Capsule effect lasts for about 2 to 4 days in immediate release, and 3 to 5 days in extended release.

What if you forget to take Tacrograf 0.5 Capsule

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tacrograf 0.5 Capsule out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Tacrograf 0.5 Capsule .
  • If you are pregnant or breastfeeding, consult your doctor before using Tacrograf 0.5 Capsule to ensure it is safe for you and your baby.
  • Avoid alcohol consumption while taking Tacrograf 0.5 Capsule , as it may increase side effects.
  • Drive or operate machinery only if you feel alert, since Tacrograf 0.5 Capsule may occasionally cause vision problems, dizziness, or nervous system disturbances.
  • Inform your doctor before receiving any vaccines, as Tacrograf 0.5 Capsule suppresses the immune system and may reduce the effectiveness of certain vaccines.
  • Tacrograf 0.5 Capsule can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
  • When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
  • Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.

Drug-Drug Interactions

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Drug-Drug Interaction: Inform your doctor if you are taking immunosuppressants (cyclosporine, sirolimus), anti-HIV drugs (nelfinavir), anticonvulsants (phenytoin), antifungals (itraconazole, ketoconazole, voriconazole), antibiotics (erythromycin, clarithromycin), diuretics (triamterene, amiloride) and other medicines.

Drug-Food Interaction: Tacrograf 0.5 Capsule may interact with St. John’s Wort (a herbal supplement to treat depression). Avoid taking grapefruit and grapefruit juice with Tacrograf 0.5 Capsule as it may cause serious side effects. Also, avoid consumption of alcohol with Tacrograf 0.5 Capsule .

Drug-Disease Interaction: If you have liver, kidney or heart problems, inform your doctor before taking Tacrograf 0.5 Capsule .

TacrolimusCidofovir
Critical
TacrolimusSaquinavir
Critical

Drug-Drug Interactions

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TacrolimusCidofovir
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Taking cidofovir with Tacrograf 0.5 Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusThioridazine
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Combining Tacrograf 0.5 Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule with Mifepristone may significantly increase the blood levels of Tacrograf 0.5 Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.5 Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSotalol
Severe
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule together with sotalol can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Tacrograf 0.5 Capsule and sotalol together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
TacrolimusNilotinib
Severe
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule together with nilotinib can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Tacrograf 0.5 Capsule and nilotinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
TacrolimusOxaprozin
Severe
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule with oxaprozin may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tacrograf 0.5 Capsule and oxaprozin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusTofacitinib
Severe
How does the drug interact with Tacrograf 0.5 Capsule:
Taking Tacrograf 0.5 Capsule together with tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although taking Tacrograf 0.5 Capsule and tofacitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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TACROLIMUS-0.5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-0.5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Tacrograf 0.5 Capsule treatment may lead to increased Tacrograf 0.5 Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Tacrograf 0.5 Capsule.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Tacrograf 0.5 Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart.
Tacrograf 0.5 Capsule contains Tacrolimus, an immunosuppressant that works by inhibiting the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.
Tacrograf 0.5 Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as a sore throat or fever.
Tacrograf 0.5 Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for extended periods or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Tacrograf 0.5 Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.
Using Tacrograf 0.5 Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Tacrograf 0.5 Capsule with other medications.
Tacrograf 0.5 Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.
Tacrograf 0.5 Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.
Tacrograf 0.5 Capsule is a macrolide antibiotic with immunosuppressant properties.
Tacrograf 0.5 Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.
Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.
Tacrograf 0.5 Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).
No, Tacrograf 0.5 Capsule does not have an abuse potential as it is not a controlled substance.
Side effects of Tacrograf 0.5 Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 050709S031Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 210115S000,050708S047,050709S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Tacrolimus Granules For Suspension Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Tacrolimus monohydrate [EMC SmPC]. 2018. [Accessed on 17 Apr. 2019]Check here
  6. Tacrolimus [Prescribing Information]. 2022. [Accessed on 01 Aug. 2023]Check here
  7. EMA. PIL. Tacrolimus. [[Accessed on 26.Feb].2020]Check here

Country of origin

INDIA

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - TAC0007
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