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  3. Tacronex-Pg 15Ml Liq

Tacronex-Pg 15Ml Liq, Pack of 1 SOLUTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Tacronex-PG Solution is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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Composition :

TACROLIMUS-0.03%W/V

Manufacturer/Marketer :

Inex Medicaments Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tacronex-PG Solution

Tacronex-PG Solution is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Tacronex-PG Solution contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Take Tacronex-PG Solution as prescribed. You are advised to use Tacronex-PG Solution for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Tacronex-PG Solution do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacronex-PG Solution. Avoid alcohol consumption with Tacronex-PG Solution. Drive only if you are alert, as Tacronex-PG Solution may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Tacronex-PG Solution. Tacronex-PG Solution may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Tacronex-PG Solution

Tacronex-PG Solution is used to treat various medical conditions. The detailed uses are as follows:

  • Prevention of Organ Transplant Rejection: Tacronex-PG Solution is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
  • Other Off-Label Uses: In some cases, Tacronex-PG Solution may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

Directions for Use

  • Take Tacronex-PG Solution at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
  • Strictly follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

Medicinal Benefits

  • Tacronex-PG Solution belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
  • It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
  • It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
  • It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
  • It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.

How Tacronex-PG Solution Works

Tacronex-PG Solution contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tacronex-PG Solution out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Tacronex-Pg 15Ml Liq
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Eat a well-balanced diet, and avoid highly processed foods.
  • Regular exercise can help prevent ascites.
  • Maintain a healthy weight, as obesity is a risk factor for ascites.
  • Limit salt intake; try to consume no more than 2,000–4,000 milligrams of salt per day.
  • Avoid alcohol, as it can damage your liver and increase the risk of cirrhosis.
  • Practice safe sex, unprotected sex can lead to hepatitis, which can damage the liver and cause cirrhosis.
  • Get vaccinated for diseases like hepatitis, influenza, and pneumococcal.
Here's a comprehensive approach to managing medication-triggered high blood pressure (hypertension):
  • Inform your doctor if you experience high blood pressure symptoms after starting a new medication or changing your medication regimen.
  • To reduce high blood pressure symptoms, your doctor may change your medication regimen or dose.
  • Monitor your blood pressure regularly to track changes and potential side effects.
  • Make lifestyle changes, such as following a healthy diet, exercising regularly, and reducing sodium intake.
  • Consider incorporating stress-reducing activities, like meditation or deep breathing exercises, into your daily routine.
  • Create a personalized plan with your doctor to manage high blood pressure, which may include additional medications, therapies, or lifestyle modifications.
  • Follow up with your doctor on a frequent basis to assess progress, change treatment plans, and address any concerns or issues.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Tacronex-PG Solution

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed of Tacronex-PG Solution or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

  • Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Tacronex-PG Solution.
  • If you are pregnant or breastfeeding, consult your doctor before using Tacronex-PG Solution to ensure it is safe for you and your baby.
  • Avoid alcohol consumption while taking Tacronex-PG Solution, as it may increase side effects.
  • Drive or operate machinery only if you feel alert, since Tacronex-PG Solution may occasionally cause vision problems, dizziness, or nervous system disturbances.
  • Inform your doctor before receiving any vaccines, as Tacronex-PG Solution suppresses the immune system and may reduce the effectiveness of certain vaccines.
  • Tacronex-PG Solution can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
  • When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
  • Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.

Drug-Drug Interactions

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TacrolimusCidofovir
Critical
TacrolimusZiprasidone
Critical

Drug-Drug Interactions

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TacrolimusCidofovir
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking cidofovir with Tacronex-Pg 15Ml Liq can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with Mifepristone may significantly increase the blood levels of Tacronex-Pg 15Ml Liq, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusThioridazine
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Combining Tacronex-Pg 15Ml Liq with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacronex-Pg 15Ml Liq with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusFluconazole
Severe
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Fluconazole may increase the blood levels of Tacronex-Pg 15Ml Liq and may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction, fluconazole can be taken with Tacronex-Pg 15Ml Liq if prescribed by the doctor. However, consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TacrolimusLithium
Severe
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with lithium may increase risk of kidney problems.

How to manage the interaction:
Although taking Tacronex-Pg 15Ml Liq and lithium together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusTelithromycin
Severe
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking Tacronex-Pg 15Ml Liq with telithromycin may significantly increase the blood levels of Tacronex-Pg 15Ml Liq, which may lead to severe side effects such as infections, diabetes, kidney problems, high blood pressure, heart problems and hyperkalemia(high potassium levels in blood).

How to manage the interaction:
Although taking Tacronex-Pg 15Ml Liq and telithromycin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusAmiloride
Severe
How does the drug interact with Tacronex-Pg 15Ml Liq:
Taking amiloride with Tacronex-Pg 15Ml Liq may increase potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm, and cardiac arrest in extreme cases).

How to manage the interaction:
Although taking Tacronex-Pg 15Ml Liq and amiloride together may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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TACROLIMUS-0.03%W/VGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-0.03%W/VGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Tacronex-Pg 15Ml Liq treatment may lead to increased Tacronex-Pg 15Ml Liq levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Tacronex-Pg 15Ml Liq.

Diet & Lifestyle Advise

  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
  • Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
  • Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
  • Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
  • Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
  • Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
  • Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
  • Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
  • Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
  • Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS
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Alcohol

Unsafe

Avoid alcohol consumption with Tacronex-PG Solution as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Tacronex-PG Solution.

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Tacronex-PG Solution and if you are a woman of childbearing age, use effective contraceptive methods while using Tacronex-PG Solution.

bannner image

Breast Feeding

Consult your doctor

Tacronex-PG Solution may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Tacronex-PG Solution. You should avoid taking Tacronex-PG Solution during breastfeeding or avoid breastfeeding while on treatment with Tacronex-PG Solution.

bannner image

Driving

Caution

Tacronex-PG Solution may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Tacronex-PG Solution.

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Tacronex-PG Solution.

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Tacronex-PG Solution.

bannner image

Children

Safe if prescribed

Tacronex-PG Solution should be used in children in doses as advised by a doctor only.

Have a query?

FAQs

Tacronex-PG Solution is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart.

Tacronex-PG Solution contains Tacrolimus, an immunosuppressant that works by inhibiting the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Tacronex-PG Solution may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as a sore throat or fever.

Tacronex-PG Solution may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for extended periods or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Tacronex-PG Solution because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.

Using Tacronex-PG Solution with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Tacronex-PG Solution with other medications.

Tacronex-PG Solution may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.

Tacronex-PG Solution is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.

Tacronex-PG Solution is a macrolide antibiotic with immunosuppressant properties.

Tacronex-PG Solution should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.

Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.

Tacronex-PG Solution decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).

No, Tacronex-PG Solution does not have an abuse potential as it is not a controlled substance.

Side effects of Tacronex-PG Solution include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Inex House , Plot No : 22 , Villa 'A&B', Second Floor , Rajiv Street, Kamaraj Nagar,, Keelkattalai, Chennai, Tamil Nadu 600117
Other Info - TAC0076

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 31, 2025 | 12:12 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  2. https://www.medsafe.govt.nz/consumers/cmi/t/tacrolimussandozcap.pdf
  3. https://www.astellas.com/us/system/files/prografwpi_3.pdf
  4. https://www.medicines.org.uk/emc/product/461/smpc
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210115s000,050708s047,050709s040lbl.pdf
  6. https://www.drugs.com/cdi/tacrolimus-granules-for-suspension.html
  7. https://www.astellas.com/us/system/files/prografinstructionstouse_2.pdf

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