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compositionComposition:METFORMIN-500MG+TENELIGLIPTIN-20MG
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Prescription Medicine
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Tenlimac M 500 Tablet is used to treat type 2 diabetes mellitus. It works by decreasing liver glucose production, lowering intestinal glucose uptake and increasing insulin levels in the body. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, headache, and stomach ache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METFORMIN-500MG+TENELIGLIPTIN-20MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tenlimac M 500 Tablet

Tenlimac M 500 Tablet is a prescription medicine used to manage type 2 diabetes in adults. It contains metformin and teneligliptin, which work together to lower and control blood sugar levels when diet, exercise, or treatment with a single medicine is not enough. Keeping blood sugar within the target range may help reduce the risk of long-term diabetes-related complications.

Take Tenlimac M 500 Tablet regularly and exactly as prescribed by your doctor. It is usually taken with or after a meal to help reduce digestive side effects such as nausea or an upset stomach. Continue following the recommended diet and exercise plan, as these are important parts of diabetes management.

Some people may experience nausea, diarrhoea, stomach discomfort, or headache. Low blood sugar may occur when Tenlimac M 500 Tablet is taken with insulin or certain other diabetes medicines. Seek urgent medical help if you develop severe stomach pain that spreads to the back or symptoms of lactic acidosis, such as unusual tiredness, muscle pain, difficulty breathing, severe weakness, or feeling unusually cold.

Tell your doctor before starting Tenlimac M 500 Tablet if you have kidney or liver problems, heart failure, severe dehydration, or a serious infection. Do not take this medicine if you have severe kidney impairment, diabetic ketoacidosis, or an allergy to metformin, teneligliptin, or any other ingredient in the medicine.

Tell your doctor about all medicines you take, especially insulin, other diabetes medicines, steroids, diuretics, or blood pressure medicines. Avoid excessive alcohol intake because it may increase the risk of lactic acidosis and affect blood sugar control. If you are pregnant, planning a pregnancy, breastfeeding, or an older adult, consult your doctor before taking this medicine.

Uses of Tenlimac M 500 Tablet

Your doctor may prescribe Tenlimac M 500 Tablet to manage the following condition: 

  • Type 2 Diabetes Mellitus: Tenlimac M 500 Tablet helps lower high blood glucose levels by improving how your body processes insulin and reducing the amount of sugar produced by your liver.

Key Benefits

Taking Tenlimac M 500 Tablet brings several long-term and daily benefits to help you manage your health safely:

  • Stable Daily Blood Sugar: It helps prevent rapid blood sugar spikes after meals, allowing you to maintain steadier energy levels throughout the day.
  • Protection Against Serious Complications: By keeping your blood sugar within target ranges, it lowers your risk of developing diabetes-related complications, such as kidney damage, nerve pain, and vision loss.
  • Two Treatments in One Tablet: Combining two active therapies into a single daily tablet simplifies your routine, making it easier to stick to your treatment plan.
Side effects of Tenlimac M 500 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Tenlimac M 500 Tablet can be taken with or without food. However, taking it with food may help reduce stomach upset.
  • It is recommended to take Tenlimac M 500 Tablet once daily or as advised by your doctor.
  • Swallow Tenlimac M 500 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Tenlimac M 500 Tablet Works

Tenlimac M 500 Tablet contains metformin and teneligliptin, which work in different ways to help control blood sugar levels. Metformin reduces the amount of sugar released by the liver. It also helps the body respond better to insulin, allowing cells to take in and use sugar from the blood more effectively. Teneligliptin belongs to a group of medicines called DPP-4 inhibitors. It increases the activity of natural hormones called incretins, which help the pancreas release more insulin when blood sugar levels are high. These hormones also reduce the amount of sugar released by the liver. Together, metformin and teneligliptin help lower and control blood sugar levels throughout the day.
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Alcohol

Caution

Alcohol may increase the risk of side effects and worsen the condition.

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Pregnancy

Caution

Tenlimac M 500 Tablet is a category C drug. So, it should be used only when the benefits of this medicine outweigh the risks.

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Breast Feeding

Caution

Tenlimac M 500 Tablet should not be used in breastfeeding mothers as it may get secreted in the breast milk and cause unwanted effects in the nursing babies.

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Driving

Caution

Tenlimac M 500 Tablet may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Tenlimac M 500 Tablet .

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Liver

Caution

Tenlimac M 500 Tablet should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tenlimac M 500 Tablet should be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Tenlimac M 500 Tablet is not recommended for use in children below 18 years of age.

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Heart

Caution

Tenlimac M 500 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Tenlimac M 500 Tablet .

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Geriatrics

Caution

Limited information is available regarding the usage of Tenlimac M 500 Tablet in elders, so please consult a doctor if you have any concerns.

What if I have taken an overdose of Tenlimac M 500 Tablet

If you suspect an overdose, seek emergency medical care immediately. An overdose can cause dangerously low blood sugar or a serious medical emergency called lactic acidosis, which requires urgent treatment in a hospital.

Diet & Lifestyle Advise

  • Manage Carb Intake: Focus on complex, low-glycaemic carbohydrates like leafy greens, whole grains, and legumes to avoid sharp blood sugar spikes after meals.
  • Exercise Regularly: Aim for 150 minutes of moderate physical activity (such as brisk walking) per week. Muscle movement helps your body use insulin more efficiently.
  • Monitor Your Sugar Levels: Keep a regular log of your blood sugar levels as advised by your doctor to help track how your body responds to the medicine.
  • Limit Alcohol Consumption: Restrict alcohol intake because it can cause sudden drops in blood sugar and significantly increase your risk of lactic acidosis.

Health Queries

How should my mother adjust her daily diabetes medications, Glimestar M2 Forte (half a tablet twice a day) and Tenlimac M500 (half a tablet twice a day), now that her fasting and after-meal blood sugar levels are rising while taking a 5-day course of the steroid Wysolone 40 mg (with 3 days left) for swelling after cataract eye surgery?

Veda Maddala

Veda Maddala

M Pharmacy

I understand it can be worrying to see rising blood sugar levels. Steroids like Wysolone (prednisolone) commonly cause a temporary increase in blood glucose. Since your mother has only three days left of her steroid course, her blood sugar levels should start to return to her baseline once she finishes it. Please do not adjust her doses of Glimestar M2 Forte (glimepiride/metformin) or Tenlimac M500 (teneligliptin/metformin) on your own. Keep monitoring her levels closely and share these readings with her doctor or endocrinologist immediately; they may suggest a temporary insulin or medication adjustment to keep her safe and comfortable during these remaining days.

What adjustments or treatments are recommended for a diabetes patient taking Tenlimac M 500, Human Mixtard, and Human Basalog who is experiencing fluctuating blood sugar levels, dizziness, sleeping less than two hours a night, constipation, poor appetite, and joint pain?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

I hear your concerns and understand how exhausting this must be. Having fluctuating blood sugars along with dizziness, poor sleep, and appetite loss is very challenging. Your symptoms, especially dizziness, could be linked to rapid blood sugar changes. Please consult your doctor soon to review your regimen of Tenlimac M (teneligliptin/metformin), Human Mixtard, and Human Basalog. They may need to safely adjust your insulin doses or check for nutritional gaps causing your constipation and joint pain. For now, try to stay hydrated, eat small, frequent meals, and monitor your blood sugar closely. We are here to support you.

I have lost my prescription and cannot reach my doctor; could you please tell me the correct timing and schedule for taking my diabetes medications?Tenlimac M 500, Mylamin, and Gluformin G1?especially in relation to my previous daily routine of taking Eliptin before breakfast, Gluconorm VG-1 before afternoon and night meals, and Mymi-D after lunch?

Veda Maddala

Veda Maddala

M Pharmacy

Gluformin G1 (glimepiride/metformin) is taken shortly before breakfast. Tenlimac M 500 (teneligliptin/metformin) is usually taken with your morning or evening meal. Mylamin (methylcobalamin), similar to your previous Mymi-D, is best taken once daily after lunch. Because both Gluformin G1 and Tenlimac M 500 contain metformin, taking them incorrectly can lower your blood sugar. Please consult a local pharmacist today to safely confirm your exact dosing schedule from their records. Watch for any shakiness or dizziness.

What alternative diabetes medications can I take to safely control my high blood sugar, since my current treatment of Tenlimac M and Glimpli-2mg is not working and is causing frequent, burning urination, and my previous medication, Glimp-MP 1, caused bad side effects like weight gain and shortness of breath?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Your frequent, burning urination while taking Tenlimac M and Glimpli-2mg needs prompt evaluation by your doctor, as it could be a urinary tract infection. The shortness of breath and weight gain you experienced with Glimp-MP 1 were likely side effects of its pioglitazone component. Fortunately, there are other generic classes of medication, such as alternative DPP-4 inhibitors or GLP-1 receptor agonists, that can safely manage your blood sugar. Please consult your doctor soon to safely adjust your treatment and address your urinary symptoms.
health query

Have a query?

How Soon It Starts Working

The time required for Tenlimac M 500 Tablet to start to work: Tenlimac M 500 Tablet starts to show its action within 1 to 2 hours of administration. The time for which the effects of Tenlimac M 500 Tablet last: Tenlimac M 500 Tablet effect lasts for 24 hours.

What if you forget to take Tenlimac M 500 Tablet

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Tenlimac M 500 Tablet tablets at controlled room temperature, ideally between 15°C and 30°C. •Keep the tablets inside their original blister packaging until you are ready to take them, as this protects them from moisture and direct light.

Drug Warnings

  • Check the packaging: Make sure the blister strip is intact. Do not take the tablet if the packaging is damaged or the tablet looks different from usual.
  • Carry a quick source of sugar: Keep glucose tablets, glucose gel, or fruit juice with you, especially if you also take insulin or other medicines that may cause low blood sugar.
  • Inform your healthcare team before surgery: Tell your doctor, dentist, or surgeon that you are taking Tenlimac M 500 Tablet before any planned procedure. They will advise whether you need to stop taking it temporarily.
  • Tell your doctor before a contrast scan: Inform your doctor if you are having an X-ray, CT scan, or another imaging test that uses an injected contrast dye. Depending on your kidney function and the type of procedure, you may need to stop Tenlimac M 500 Tablet temporarily and restart it only after your doctor confirms that it is safe.
  • Take care when driving: Tenlimac M 500 Tablet does not usually affect driving when taken alone. However, low blood sugar may occur when it is used with insulin or certain other diabetes medicines. Do not drive or operate machinery if you feel dizzy, shaky, weak, confused, or unable to concentrate.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction Summary:

The following medicines may interact with Tenlimac M 500 Tablet and require closer monitoring or dose adjustments:

  • Other diabetes medications: Taking this medicine with insulin or sulfonylureas may increase the risk of low blood sugar.
  • Diuretics and steroids: Water pills and corticosteroids can raise your blood sugar, making this medicine less effective.
  • Beta-blockers: These blood pressure medicines can mask warning signs of low blood sugar, such as a rapid heart rate or palpitations.
Teneligliptin + MetforminIomeprol
Critical
Teneligliptin + MetforminIopamidol
Critical

Drug-Drug Interactions

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Teneligliptin + MetforminIomeprol
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of iomeprol with Tenlimac M 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between metformin and Tenlimac M 500 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIopamidol
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between metformin and iopamidol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminGatifloxacin
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Tenlimac M 500 Tablet with gatifloxacin can cause both hypoglycemia (low blood glucose) and, less frequently, hyperglycemia (high blood glucose).

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and gatifloxacin, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience headache, dizziness, sleepiness, nervousness, confusion, tremors (shaking of hands and legs), hunger, weakness, sweating, or fast heartbeats. Do not discontinue without consulting a doctor.
Teneligliptin + MetforminIodixanol
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of iodixanol with Tenlimac M 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and iodixanol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIodamide
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Tenlimac M 500 Tablet with iodamide can increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and iodamide, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIopromide
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of iopromide with Tenlimac M 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between iopromide and Tenlimac M 500 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminMetrizamide
Critical
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Tenlimac M 500 Tablet and metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and metrizamide, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminMethazolamide
Severe
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Tenlimac M 500 Tablet with methazolamide may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and methazolamide, they can be taken together if prescribed by a doctor. However, if you experience weakness, muscle pain, fatigue, less desire to eat, slow or irregular heartbeat, breathing difficulty, or chills, contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
Teneligliptin + MetforminAcetazolamide
Severe
How does the drug interact with Tenlimac M 500 Tablet:
Co-administration of Tenlimac M 500 Tablet with Acetazolamide may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and acetazolamide, they can be taken together if prescribed by a doctor. However, if you experience weakness, muscle pain, difficulty breathing, dizziness, chest pain or discomfort, fatigue, or less desire to eat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminTopiramate
Severe
How does the drug interact with Tenlimac M 500 Tablet:
Coadministration of Tenlimac M 500 Tablet and topiramate may increase the risk of lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Tenlimac M 500 Tablet and topiramate, it can be taken if prescribed by a doctor. However, if you experience weakness, muscle pain, fatigue, less desire to eat, slow or irregular heartbeat, breathing difficulty, or chills, consult a doctor immediately. Do not stop using any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Drug-Food Interaction Summary:

Certain foods or drinks may affect the safety or tolerability of Tenlimac M 500 Tablet . Important interactions include:

  • Alcohol: Avoid heavy drinking while taking this medicine. Alcohol increases the danger of lactic acidosis and can cause unpredictable shifts in blood sugar.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Tenlimac M 500 Tablet is used to treat Type 2 diabetes mellitus. It improves glycaemic control in diabetic patients who do not react well to Metformin alone.
Tenlimac M 500 Tablet is a combination of two antidiabetic medicines, Metformin and Teneligliptin. It works by increasing insulin production, helping to restore your body's appropriate response to insulin, especially in muscle and fatty tissues, thereby lowering your elevated blood sugar levels.
Hypoglycemia refers to low blood glucose levels. Tenlimac M 500 Tablet may cause hypoglycemia. Hypoglycemia can occur if you miss or delay your food, drink alcohol, engage in intense exercise, or take other antidiabetic medicine along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. So, it is always advised to carry glucose tablets or sugar candies with you.
Yes, Tenlimac M 500 Tablet is safe to use if taken in the dose and duration prescribed by the doctor.
Tenlimac M 500 Tablet may cause nausea and vomiting as side effects. Consume bland food and water, avoid foods with strong smells, spicy food, caffeine, alcohol and carbonated drinks.
Tenlimac M 500 Tablet is contraindicated in people who are allergic to any of its components, patients having severe ketoacidosis, diabetic coma or pre-coma, type 1 diabetes, severe infection, severe trauma and severe external injury and in patients with a history of lactic acidosis.
Tenlimac M 500 Tablet can cause lactic acidosis, a rare but serious metabolic complication. Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.
Long-term use of Tenlimac M 500 Tablet may lead to vitamin B12 deficiency as Tenlimac M 500 Tablet might interfere with the absorption of vitamin B12. Consult the doctor if you experience symptoms of vitamin B12 deficiency like tingling sensations and numbness in hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance.
Store Tenlimac M 500 Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.
Tenlimac M 500 Tablet is not recommended during pregnancy as its safety in pregnant women is unknown. Contact the doctor if you are pregnant, planning for pregnancy or think you may be pregnant.
Tenlimac M 500 Tablet is not recommended for nursing mothers as this medicine may get secreted in the breast milk and cause unwanted effects in the nursing babies. Contact the doctor if you are breastfeeding.
Tenlimac M 500 Tablet is not recommended for use in children below 18 years of age.
Overdose of Tenlimac M 500 Tablet might cause lactic acidosis. Symptoms of lactic acidosis may include nausea, vomiting, and weakness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Side effects of Tenlimac M 500 Tablet include nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, sweating, palpitations, and vision problems. Consult the doctor if any of the side effects persist or worsen.
Consult the doctor if you have severe joint pain after taking Tenlimac M 500 Tablet . The doctor might ask you to discontinue the medicine if appropriate.
Take Tenlimac M 500 Tablet with or after a meal unless your doctor advises otherwise. Taking it with food may help reduce nausea, stomach discomfort, and other digestive side effects. Contact your doctor if these symptoms continue or become difficult to manage.
Tenlimac M 500 Tablet is generally considered weight-neutral, meaning it usually does not cause significant weight gain. However, changes in weight may vary between individuals. Continue following the diet and physical activity plan recommended by your healthcare team.
Type 2 diabetes usually requires long-term treatment. Continue taking Tenlimac M 500 Tablet for as long as your doctor recommends, even if you feel well, because high blood sugar may not cause noticeable symptoms. Do not stop taking the medicine without consulting your doctor.
If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor before taking Tenlimac M 500 Tablet . Your doctor will recommend the most suitable treatment based on your blood sugar levels and individual health needs.
Tenlimac M 500 Tablet does not usually affect the ability to drive. However, low blood sugar may occur when it is taken with insulin or certain other diabetes medicines. Do not drive if you feel dizzy, shaky, weak, confused, or unable to concentrate.
No. Tenlimac M 500 Tablet helps control blood sugar but does not cure type 2 diabetes. Taking the medicine regularly and following your recommended diet, physical activity, and blood sugar monitoring plan can help manage the condition and reduce the risk of complications.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.

Therapeutic Class

[ANTIDIABETICS AND ANTIHYPERGLYCEMICS]

Habit Forming

No
Other Info - TEN0686
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