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compositionComposition:TENOFOVIR ALAFENAMIDE-25MG
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Prescription Medicine
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Tentide AF 25 Tablet is used to treat chronic hepatitis B virus (HBV) infection. It contains Tenofovir alafenamide which works by inhibiting HBV replication and clears the infection. In some cases, this medicine may cause side effects like headaches, diarrhoea, nausea, vomiting, and rash. Keep the doctor informed about your health condition and the medications you are taking.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

TENOFOVIR ALAFENAMIDE-25MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tentide AF 25 Tablet

Tentide AF 25 Tablet is a prescription medication used to treat long-term (chronic) hepatitis B virus infection in adults and adolescents. It helps manage the virus, preventing it from multiplying and causing severe liver problems. This medication is essential for keeping the viral load in your body as low as possible over time.

For the best results, you must take Tentide AF 25 Tablet consistently every single day at the same time. You can take this tablet with or without food, but keeping a strict routine helps you remember your daily dose. Supporting your treatment with liver-friendly lifestyle choices, such as avoiding alcohol and eating a balanced diet, can further support your long-term health.

While taking Tentide AF 25 Tablet , some people may experience mild side effects like headaches, cough, or joint pain. However, you must contact your healthcare provider immediately if you experience signs of severe liver issues, such as yellowing of your skin or eyes, dark urine, or severe stomach pain.

Before you begin taking this medicine, inform your doctor if you have other health conditions, especially kidney problems or an untreated HIV infection. Do not take this if you are allergic to any of its ingredients, or if you have untreated HIV, as taking this medicine alone can make the HIV virus much harder to treat in the future.

This medicine can interact with certain other treatments, such as tuberculosis drugs or herbal supplements, which can reduce its effectiveness. If you are pregnant, breastfeeding, or an older adult, consult your doctor to discuss whether this medication is safe for your specific situation

Uses of Tentide AF 25 Tablet

Your doctor may prescribe Tentide AF 25 Tablet to treat the following conditions:

  • Chronic Hepatitis B Virus (HBV) Infection: Tentide AF 25 Tablet helps by slowing down the growth of the hepatitis B virus in the body, which reduces the viral load and protects the liver from long-term damage and scarring.

 

Key Benefits

Tentide AF 25 Tablet provides several clinically proven benefits that help protect your long-term health and well-being:

  • Reduces Viral Activity: By keeping the virus from replicating, it lowers the amount of hepatitis B virus in your blood to highly manageable or undetectable levels.
  • Protects Liver Health: It significantly lowers the risk of developing severe complications like liver scarring (cirrhosis) or liver failure, helping your liver function normally.
  • Kidney and Bone Safety: Compared to older antiviral options, this formulation is highly targeted, meaning it delivers the active treatment directly to liver cells while being gentler on your kidneys and bones.
Side effects of Tentide AF 25 Tablet
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Tentide AF 25 Tablet can be taken with meals for better effectiveness.
  • It is usually taken once daily or as advised by your doctor.
  • Swallow Tentide AF 25 Tablet as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Tentide AF 25 Tablet Works

Tentide AF 25 Tablet contains tenofovir alafenamide which belongs to a class of antiviral medicines known as nucleoside reverse transcriptase inhibitors (NRTIs). Once inside your body, the medicine is targeted directly to your liver cells, where the hepatitis B virus attempts to replicate. The medicine works by mimicking the natural building blocks that the virus needs to copy its genetic material. When the virus attempts to use the medicine to replicate itself, the drug blocks the specific enzyme responsible for copying the viral DNA. This halts the replication process, effectively stopping the virus from multiplying and protecting healthy liver cells from infection.
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Alcohol

Unsafe

Avoid drinking alcohol. Consuming alcohol while using Tentide AF 25 Tablet may worsen the condition.

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Pregnancy

Caution

Tentide AF 25 Tablet is not recommended during pregnancy. However, your doctor may prescribe it for you during pregnancy if he/she feels that the benefit to you outweighs the risk. You should not take Tentide AF 25 Tablet without the doctor's advice.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Tentide AF 25 Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Tentide AF 25 Tablet can cause dizziness. If you feel dizzy when taking Tentide AF 25 Tablet , do not drive and use any tools or machines.

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Liver

Caution

Consult your doctor before taking Tentide AF 25 Tablet if you have a liver impairment or any concerns regarding this. Your doctor will weigh the benefits and any potential risks before prescribing them to you.

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Kidney

Caution

Consult your doctor before taking Tentide AF 25 Tablet if you have kidney impairment or any concerns regarding this. Your doctor will weigh the benefits and any potential risks before prescribing them to you.

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Children

Unsafe

Should not use Tentide AF 25 Tablet in children below 12 years of age.

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Heart

Consult your doctor

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Limited information is available regarding the usage of Tentide AF 25 Tablet in elders, so please consult a doctor if you have any concerns.

What if I have taken an overdose of Tentide AF 25 Tablet

If you accidentally take more than your prescribed dose, seek emergency medical care or call a poison control centre immediately. Keep the medication packaging with you so the healthcare providers know exactly what you took.

Diet & Lifestyle Advise

Supporting your liver health while taking Tentide AF 25 Tablet can improve your overall treatment outcomes. Consider these evidence-based tips:

  • Avoid alcohol entirely: Alcohol puts extra strain on your liver and can speed up liver damage, countering the benefits of your medication.
  • Eat a liver-friendly diet: Focus on whole foods, including fresh vegetables, fruits, lean proteins, and whole grains. Minimise processed foods, excess sugars, and saturated fats.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys filter waste and process your medication efficiently.
  • Maintain a healthy weight: Being overweight can cause fat buildup in the liver, which can worsen hepatitis B complications. Regular, moderate exercise can help manage your weight.
  • Avoid raw or undercooked shellfish: People with chronic liver conditions are highly susceptible to severe infections from bacteria sometimes found in raw seafood.
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How Soon It Starts Working

The time required for Tentide AF 25 Tablet to start to work: Tentide AF 25 Tablet ideally shows its action within 1 hour of administration. The time for which the effects of Tentide AF 25 Tablet last: Tentide AF 25 Tablet effect lasts for 24 hours.

What if you forget to take Tentide AF 25 Tablet

If you miss a dose, take it as soon as you remember on that same day. If it is almost time for your next daily dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store the tablets at room temperature, between 20°C and 25°C (68°F to 77°F).• Keep the tablets in their original container with the lid tightly closed to protect them from moisture and light.

Drug Warnings

Do not stop taking this medicine abruptly: Stopping your treatment suddenly can cause a severe, life-threatening flare-up of your hepatitis B infection. Always consult your doctor before making any changes.

  • Check your HIV status: Ensure you are tested for HIV before starting Tentide AF 25 Tablet . If you have undiagnosed or untreated HIV, taking this medicine alone can cause the HIV virus to become resistant to future treatments.
  • Monitor your lab results: Attend all scheduled appointments for blood work. Your doctor will need to monitor your liver function, viral load, and kidney health regularly.
  • Prevent spreading the virus: Remember that taking Tentide AF 25 Tablet does not prevent you from passing hepatitis B to others through sexual contact or blood exposure. Use appropriate protection and do not share needles or personal items like razors.
  • Inspect your tablets: Before taking your daily dose, inspect the tablet. Do not take it if it is discoloured, crumbling, or if the packaging has been damaged.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines, as they may interact with Tentide AF 25 Tablet .

  • Antiseizure medicines (like carbamazepine, phenytoin, or phenobarbital): These can reduce the levels of Tentide AF 25 Tablet in your blood, making it less effective at fighting the virus.
  • Tuberculosis medications (like rifampin or rifabutin): These drugs can significantly lower the concentration of Tentide AF 25 Tablet in your body, reducing its ability to control the infection.
  • Herbal remedies (such as St. John's wort): Taking this supplement can lower the effectiveness of your antiviral treatment.
Tenofovir alafenamideCidofovir
Critical
Tenofovir alafenamideAciclovir
Severe

Drug-Drug Interactions

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Tenofovir alafenamideCidofovir
Critical
How does the drug interact with Tentide AF 25 Tablet:
Coadministration of Cidofovir and Tentide AF 25 Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Cidofovir and Tentide AF 25 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Tenofovir alafenamideAciclovir
Severe
How does the drug interact with Tentide AF 25 Tablet:
Coadministration of Aciclovir with Tentide AF 25 Tablet may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking aciclovir with Tentide AF 25 Tablet can result in an interaction. However, if the benefits outweigh the risks, your doctor will prescribe them. Contact a doctor immediately if you experience symptoms such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medication without consulting your doctor.
Tenofovir alafenamideHuman immunoglobulin
Severe
How does the drug interact with Tentide AF 25 Tablet:
Taking Human immunoglobulin with Tentide AF 25 Tablet, may raise the risk of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Tentide AF 25 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Tenofovir alafenamideCisplatin
Severe
How does the drug interact with Tentide AF 25 Tablet:
The combined use of Cisplatin and Tentide AF 25 Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Cisplatin and Tentide AF 25 Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Tenofovir alafenamideTobramycin
Severe
How does the drug interact with Tentide AF 25 Tablet:
Taking Tentide AF 25 Tablet with tobramycin can increase the risk of kidney problems.

How to manage the interaction:
Although taking Tentide AF 25 Tablet and Tobramycin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without a doctor's advice.
Tenofovir alafenamideVancomycin
Severe
How does the drug interact with Tentide AF 25 Tablet:
Coadministration of Vancomycin with Tentide AF 25 Tablet can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Tentide AF 25 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamideIbuprofen
Severe
How does the drug interact with Tentide AF 25 Tablet:
The combined use of Tentide AF 25 Tablet and Ibuprofen can cause kidney problems.

How to manage the interaction:
Co-administration of Tentide AF 25 Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Tenofovir alafenamideTacrolimus
Severe
How does the drug interact with Tentide AF 25 Tablet:
Taking tacrolimus with Tentide AF 25 Tablet will have additive effect and may increase risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Tentide AF 25 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Tenofovir alafenamidevalacyclovir
Severe
How does the drug interact with Tentide AF 25 Tablet:
Co-administration of Tentide AF 25 Tablet with valacyclovir may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tentide AF 25 Tablet and valacyclovir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased urination, weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without consulting a doctor.
Tenofovir alafenamideFlurbiprofen
Severe
How does the drug interact with Tentide AF 25 Tablet:
Co-administration of Tentide AF 25 Tablet with Flurbiprofen can increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Tentide AF 25 Tablet with Flurbiprofen can possibly result in an interaction, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Tentide AF 25 Tablet when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Tentide AF 25 Tablet belongs to the group of medicines known as ‘antiviral medicines used to treat chronic hepatitis B virus (HBV) infection.
Tentide AF 25 Tablet contains ‘tenofovir alfenamide’. It inhibits HBV replication by merging into viral DNA via HBV reverse transcriptase, resulting in the termination of the DNA chain. This prevents the virus from producing new viruses and cleans up your infection.
No, Tentide AF 25 Tablet is a prescribed medication given by a physician for treating HBV infection or Chronic hepatitis B. It is recommended not to take it on your own.
Tentide AF 25 Tablet should be taken in the dose and for the duration prescribed by your doctor based on your medical condition.
The main symptoms include yellowing of eyes and skin, flu-like symptoms, pale stools and dark-coloured urine.
A blood test (HBsAg blood test) can be used to determine if you have hepatitis B or have ever had it.
Practising safe sex and other lifestyle changes along with Tentide AF 25 Tablet might lower the risk of HIV transmission. However, it may not prevent the spread of hepatitis B virus (HBV) to other people.
Yes, Tentide AF 25 Tablet is safe if taken in the dose and duration prescribed by the doctor.
Tentide AF 25 Tablet should be swallowed as a whole with water; do not crush or chew it.
Take another dose of Tentide AF 25 Tablet if you have vomited within an hour of taking the medicine. However, you may not need to take another dose if it has been more than an hour. Take the next dose at the scheduled time.
If you miss a dose of Tentide AF 25 Tablet take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Tentide AF 25 Tablet may cause side effects like headaches, diarrhoea, vomiting, feeling sick (nausea), and rash. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, Tentide AF 25 Tablet does not cure chronic hepatitis B, but it helps manage the condition by stopping the virus from multiplying. This lowers the amount of virus in your body and prevents severe liver damage. Talk to your doctor to understand your long-term treatment plan.
If you are pregnant or planning to become pregnant, you should discuss this with your healthcare provider. Your doctor will weigh the benefits of controlling your hepatitis B infection against any potential risks to the baby. Talk to your doctor for personalised guidance.
It is highly recommended that you avoid alcohol completely while taking Tentide AF 25 Tablet . Alcohol causes additional stress and damage to your liver, which can worsen hepatitis B and make your treatment less effective. Talk to your doctor about safe lifestyle choices.
Chronic hepatitis B is a long-term condition, and most patients need to take Tentide AF 25 Tablet for several years, or even indefinitely. Stopping the medication early can cause the virus to become active again and lead to severe liver flares. Talk to your doctor before making any changes.
Some medications, including certain antiseizure drugs, antibiotics, and herbal supplements, can interfere with how Tentide AF 25 Tablet works. Always provide your doctor and pharmacist with a complete list of everything you take, including over-the-counter products. Talk to your doctor or pharmacist before starting any new medicine.
Watch for symptoms like yellowing of your skin or the whites of your eyes, unusually dark urine, severe abdominal pain, persistent nausea, and unusual fatigue. If you notice any of these signs, seek medical attention immediately. Talk to your doctor if you experience any unusual symptoms.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - TEN0458
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