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  3. Thioplan 15 mg Injection 1's

Thioplan 15 mg Injection 1's, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Thioplan 15 mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours. It contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

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Composition :

THIOTEPA-15MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Thioplan 15 mg Injection


Thioplan 15 mg Injection belongs to the group of medicines called alkylating agents used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection. It is also indicated in the treatment of breast cancer, ovarian cancer, bladder cancer, and serosal cavity neoplastic disease. It is also used to treat malignant effusions caused by cancerous tumours.

Thioplan 15 mg Injection contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

Thioplan 15 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Thioplan 15 mg Injection may cause nausea, vomiting, stomach pain, loss of appetite, headache, dizziness, hair loss, unusual tiredness or weakness, and pain at the site of injection. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in Thioplan 15 mg Injection. Do not use Thioplan 15 mg Injection if you are pregnant or breastfeeding. Thioplan 15 mg Injection may cause blurred vision, dizziness, and headache; therefore, drive or operate machinery only if you are alert. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Thioplan 15 mg Injection

Thioplan 15 mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours. The detailed uses of Thioplan 15 mg Injection are as follows:<br/>• Cancer Treatment (Breast, Ovarian, Bladder): Thioplan 15 mg Injection is used to treat various cancers including breast, ovarian, and superficial bladder cancer. It works by damaging the DNA of cancer cells, slowing or stopping their growth and multiplication.<br/>• Malignant Effusions: Thioplan 15 mg Injection helps manage fluid buildup in body cavities (like the lungs or heart lining) caused by cancer. It is administered directly into these cavities to control the spread of malignant cells and reduce symptoms.<br/> • Stem Cell Transplant Conditioning: Thioplan 15 mg Injection is used in combination with other chemotherapy drugs as part of the conditioning regimen before hematopoietic progenitor cell transplantation (HPCT). It helps eliminate cancerous cells and prepare the body for receiving new stem cells.<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Thioplan 15 mg Injection will be administered by a healthcare professional.• Do not self-administer it.

Medicinal Benefits

Thioplan 15 mg Injection belongs to the group of medicines called alkylating agents used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection. It is also indicated in the treatment of breast cancer, ovarian cancer, bladder cancer, and serosal cavity neoplastic disease. It is also used to treat malignant effusions (a condition when fluid collects in the lungs or around the heart) caused by cancerous tumours. Thioplan 15 mg Injection contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

How Thioplan 15 mg Injection Works

Thioplan 15 mg Injection contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Thioplan 15 mg Injection out of reach and sight of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Thioplan 15 mg Injection
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Talk to the doctor if you notice any visual disturbances.
  • Do not drive or operate machinery unless you have a clear vision.
  • Lubricate the eyes and use a warm compress to gently massage the eyes.
  • Keep your eyes protected from harmful sun rays by wearing sunglasses and a hat.
  • Rest well and eat a balanced diet.
  • Use a humidifier and increase fluid intake.

What if I have taken an overdose of Thioplan 15 mg Injection

As Thioplan 15 mg Injection is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not use Thioplan 15 mg Injection if you are allergic to any of its components, if you are pregnant or breastfeeding, or if you are receiving yellow fever vaccination, live virus, or bacterial vaccines. Inform the doctor if you have a weak immune system, liver or kidney problems, heart or lung problems, seizures/fits, if you have previously received or will be receiving radiation (x-ray) therapy or other chemotherapy and if you have/had any medical conditions. Let the doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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ThiotepaCyclophosphamide
Severe
ThiotepaCladribine
Severe

Drug-Drug Interactions

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ThiotepaCyclophosphamide
Severe
How does the drug interact with Thioplan 15 mg Injection:
When Thioplan 15 mg Injection is taken with Cyclophosphamide, can increase the blood levels or add to the medication side effects of cyclophosphamide.

How to manage the interaction:
Although taking Thioplan 15 mg Injection and Cyclophosphamide together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ThiotepaCladribine
Severe
How does the drug interact with Thioplan 15 mg Injection:
Combining Cladribine with Thioplan 15 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Thioplan 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ThiotepaThalidomide
Severe
How does the drug interact with Thioplan 15 mg Injection:
Taking thalidomide together with Thioplan 15 mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Thioplan 15 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThiotepaClozapine
Severe
How does the drug interact with Thioplan 15 mg Injection:
Combining Thioplan 15 mg Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Although taking Thioplan 15 mg Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
ThiotepaInfliximab
Severe
How does the drug interact with Thioplan 15 mg Injection:
When Thioplan 15 mg Injection is taken with Infliximab, it can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Thioplan 15 mg Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ThiotepaMelphalan
Severe
How does the drug interact with Thioplan 15 mg Injection:
Co-administration of Melphalan with Thioplan 15 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Melphalan and Thioplan 15 mg Injection, you can take these medicines together if prescribed by a doctor. If you notice any unusual symptoms or side effects, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
ThiotepaBaricitinib
Severe
How does the drug interact with Thioplan 15 mg Injection:
Coadministration of Thioplan 15 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Thioplan 15 mg Injection and Baricitinib, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ThiotepaCarboplatin
Severe
How does the drug interact with Thioplan 15 mg Injection:
Using Carboplatin with Thioplan 15 mg Injection can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thioplan 15 mg Injection and Carboplatin, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without talking to a doctor.
ThiotepaTofacitinib
Severe
How does the drug interact with Thioplan 15 mg Injection:
Taking Tofacitinib with Thioplan 15 mg Injection may increase the risk of infection.

How to manage the interaction:
Co-administration of Thioplan 15 mg Injection with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
ThiotepaEtanercept
Severe
How does the drug interact with Thioplan 15 mg Injection:
When Etanercept is used with Thioplan 15 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Etanercept with Thioplan 15 mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables, fruits, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Thioplan 15 mg Injection Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

It is not known if alcohol affects Thioplan 15 mg Injection. Please consult your doctor.

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Pregnancy

Unsafe

Thioplan 15 mg Injection should not be used during pregnancy as it can cause foetal harm. If you are pregnant, think you may be pregnant or are planning for pregnancy, you must inform the doctor before receiving Thioplan 15 mg Injection.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Thioplan 15 mg Injection.

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Driving

Caution

Thioplan 15 mg Injection may cause dizziness, headache, and blurred vision. Therefore, drive or operate heavy machinery only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Thioplan 15 mg Injection. Monitoring of patients with moderate to severe liver impairment for toxicity is advised.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Thioplan 15 mg Injection. Monitoring of patients with moderate to severe kidney impairment for toxicity is advised.

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Children

Caution

Thioplan 15 mg Injection is safe for use in children for the prevention of graft rejection and bone marrow transplantation. Safety and effectiveness for the treatment of breast cancer, ovarian cancer, malignant effusions and bladder cancer have not been established in children.

FAQs

Thioplan 15 mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours.

Thioplan 15 mg Injection works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

Thioplan 15 mg Injection may impair male and female fertility. It may stop sperm production in men and interfere with normal menstrual/period cycle in women. Consult the doctor if you have any concerns.

Concomitant use of Thioplan 15 mg Injection with live virus and bacteria vaccination and yellow fever vaccination is not advised as it may cause serious infections. Talk to the doctor if you are undergoing any vaccination.

Thioplan 15 mg Injection may increase the risk of infections or bleeding. Consult the doctor immediately if you notice unusual bleeding or bruising or any signs of infections such as fever, chills, pale skin, shortness of breath, tiredness, or mouth sores.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - THI0234

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:21 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.14220.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208264s000lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a682821.html
  4. https://www.drugs.com/mtm/thiotepa.html

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