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compositionComposition:THIOTEPA-15MG
prescription
Prescription Medicine
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Thiother 15mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours. It contains Thiotepa, which works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

THIOTEPA-15MG

Manufacturer/Marketer :

Therdose Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Thiother 15mg Injection

Thiother 15mg Injection is an injectable prescription medicine used to treat certain types of cancer, including breast and ovarian cancers. It is also used to prepare patients for bone marrow or stem cell transplants by clearing out existing bone marrow cells to make room for healthy new donor cells.

Because Thiother 15mg Injection is given as an injection or infusion, your healthcare team will schedule and administer your doses at specific intervals. While you do not need to worry about taking it with food, staying well-hydrated before and after each session is very important. Making simple lifestyle adjustments, such as getting plenty of rest and eating small, frequent meals, can help your body cope with the treatment.

While receiving this medicine, you may experience common side effects like nausea, vomiting, or temporary hair loss. However, you must contact your doctor immediately if you face serious side effects, such as a fever, chills, or unusual bleeding and bruising.

Before starting treatment, talk to your doctor if you have kidney disease, liver damage, or a history of heart problems. Do not take this medicine if you have had a severe allergic reaction to it in the past, have severely reduced bone marrow function, or have previously developed aplastic anemia (a rare but serious failure of the bone marrow to produce blood cells) after receiving Thiother 15mg Injection or a similar medicine. Tell your doctor if you are receiving other treatments that suppress the bone marrow, such as certain chemotherapy medicines.

Thiother 15mg Injection can interact with live vaccines and other treatments that weaken your immune system, which can increase your risk of severe infections. You should also consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine can harm an unborn baby.

Uses of Thiother 15mg Injection

This medicine is used to treat certain cancers and to prepare the body for stem cell or bone marrow transplantation. The detailed uses of this medicine are as follows:

  • Breast Cancer: Thiother 15mg Injection helps by stopping the growth and spread of rapidly dividing cancer cells in the breast tissue.
  • Ovarian Cancer: It works to control and reduce advanced ovarian tumors when other standard treatments have not worked.
  • Stem Cell and Bone Marrow Transplant Preparation: It prepares the body for a transplant by destroying diseased bone marrow cells, allowing new, healthy cells to grow.
  • Bladder Cancer: When placed directly into the bladder, it helps prevent superficial bladder tumors from returning after surgery.

Key Benefits

Thiother 15mg Injection helps treat certain cancers and supports successful stem cell or bone marrow transplantation. Its benefits include:

  • Helps destroy rapidly dividing cancer cells, slowing the growth and spread of cancer.
  • Helps reduce tumor burden, which may relieve cancer-related symptoms and improve quality of life.
  • May help achieve longer periods of remission in suitable patients as part of a comprehensive treatment plan.
  • Prepares the body for stem cell or bone marrow transplantation by destroying diseased bone marrow cells.
  • Creates space for healthy transplanted cells to grow and rebuild a functioning immune system after transplantation.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Thiother 15mg Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Thiother 15mg Injection Works

Thiother 15mg Injection belongs to a group of medicines known as alkylating agents. It works by attaching itself to the DNA of rapidly dividing cells, including cancer cells. By damaging the genetic material, it prevents these harmful cells from dividing and multiplying. Because cancer cells grow much faster than most healthy cells in the body, they are highly sensitive to this blocking action, which ultimately leads to their destruction.
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Alcohol

Consult your doctor

It is not known if alcohol affects Thiother 15mg Injection. Please consult your doctor.

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Pregnancy

Unsafe

Thiother 15mg Injection should not be used during pregnancy as it can cause foetal harm. If you are pregnant, think you may be pregnant or are planning for pregnancy, you must inform the doctor before receiving Thiother 15mg Injection.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Thiother 15mg Injection.

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Driving

Caution

Thiother 15mg Injection may cause dizziness, headache, and blurred vision. Therefore, drive or operate heavy machinery only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Thiother 15mg Injection. Monitoring of patients with moderate to severe liver impairment for toxicity is advised.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Thiother 15mg Injection. Monitoring of patients with moderate to severe kidney impairment for toxicity is advised.

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Children

Caution

Thiother 15mg Injection is safe for use in children for the prevention of graft rejection and bone marrow transplantation. Safety and effectiveness for the treatment of breast cancer, ovarian cancer, malignant effusions and bladder cancer have not been established in children.

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Heart

Caution

Thiother 15mg Injection may require caution in patients with heart problems. Therefore, please inform your doctor if you have any heart-related conditions before receiving Thiother 15mg Injection.

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Geriatrics

Caution

Thiother 15mg Injection may require caution and dose adjustment in geriatric patients. Therefore, please consult your doctor before receiving Thiother 15mg Injection.

What if I have taken an overdose of Thiother 15mg Injection

An overdose is highly unlikely because your medical team calculates and monitors your dose carefully. However, if you suspect you have received too much or experience severe symptoms after an infusion, seek immediate medical attention or notify the hospital staff right away.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of water and clear fluids before and after your treatment to help your kidneys flush the medicine from your body.
  • Practice Strict Hygiene: Wash your hands frequently, avoid large crowds, and stay away from people who are actively sick to protect yourself from infections while your immune system is weak.
  • Eat Safe, Cooked Foods: Stick to fully cooked meats and thoroughly washed fruits and vegetables to lower your risk of foodborne illnesses while your blood counts are low.
  • Protect Your Skin: Use gentle, fragrance-free soaps and moisturizers, as your skin may become extra sensitive during treatment.
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How Soon It Starts Working

The time required for Thiother 15mg Injection to start to work: Thiother 15mg Injection ideally shows its action within 5 minutes after administration. The time for which the effects of Thiother 15mg Injection last: The duration of action for Thiother 15mg Injection is unknown.

What if you forget to take Thiother 15mg Injection

Because you will receive this medication from a healthcare professional in a clinic, it is unlikely that you will miss a dose. If you miss a scheduled appointment for your infusion, contact your clinic immediately to reschedule.

Storage

•The dry powder vials are kept in a refrigerator between 2°C and 8°C (36°F to 46°F) and are protected from light.

Drug Warnings

  • Check the Solution: Ensure your nurse inspects the liquid before injection; it should be clear and free of visible floating particles.
  • Monitor the Injection Site: Tell your healthcare team immediately if you feel any burning, pain, or swelling where the needle is inserted, as the medicine must not leak into surrounding tissues.
  • Avoid Live Vaccines: Do not receive any live vaccines (such as MMR or chickenpox vaccines) during your treatment, as your weakened immune system may not be able to handle them.
  • Use Reliable Birth Control: Both men and women must use highly effective birth control during treatment and for at least 6 months after the final dose, or for as long as advised by their treating doctor, to prevent pregnancy.
  • Keep Up with Monitoring: Attend all scheduled blood tests so your doctor can monitor your blood cell counts, liver function, and kidney function. In certain patients, your doctor may also check blood (serum) Thiother 15mg Injection levels to ensure safe and effective dosing.

verifiedApollotooltip
  • Other chemotherapy medicines: Combining Thiother 15mg Injection with other cancer treatments can increase the risk of severe bone marrow suppression and dangerously low blood counts.
  • Live vaccines: May cause severe infections because Thiother 15mg Injection lowers your body's ability to fight off viruses or bacteria.
  • Medicines that affect liver enzymes: Some medications can change how your body processes Thiother 15mg Injection, which may increase the level of the medicine in your blood and lead to more side effects.

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verifiedApollotooltip

  • No clinically significant food interactions are known with Thiother 15mg Injection when used as directed. 

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Thiother 15mg Injection is used to prepare patients for bone marrow transplantation and reduce the risk of graft rejection; breast cancer, ovarian cancer, bladder cancer, serosal cavity neoplastic disease, and malignant effusions caused by cancerous tumours.
Thiother 15mg Injection works by destroying bone marrow cells. This enables the transplantation of new bone marrow cells (haematopoietic progenitor cells), enabling the body to produce healthy blood cells. It helps treat cancer by slowing or stopping the growth of cancer cells in the body.
Thiother 15mg Injection may impair male and female fertility. It may stop sperm production in men and interfere with normal menstrual/period cycle in women. Consult the doctor if you have any concerns.
Thiother 15mg Injection may increase the risk of infections or bleeding. Consult the doctor immediately if you notice unusual bleeding or bruising or any signs of infections such as fever, chills, pale skin, shortness of breath, tiredness, or mouth sores.
No, you should not receive Thiother 15mg Injection if you are pregnant, as it can cause serious harm to an unborn baby. Talk to your doctor about highly effective birth control options before starting treatment. Both men and women should continue using effective contraception for at least 6 months after completing treatment, or for the duration recommended by their doctor.
Yes, temporary hair loss is a common side effect of Thiother 15mg Injection. In most cases, your hair will begin to grow back after you complete your treatment. Talk to your doctor if you have concerns about hair loss.
This medicine is given as an injection or infusion into a vein by a trained healthcare professional. In some cases, it may be put directly into other areas of the body, like the bladder. Talk to your doctor about your specific treatment plan.
It is highly recommended to avoid alcohol during your treatment, as it can worsen side effects like nausea and increase stress on your liver. Talk to your doctor or pharmacist for personalized advice.
This medicine can lower the number of healthy cells in your blood, which increases your risk of infections and bleeding. Regular blood tests help your doctor monitor these levels and ensure it is safe to proceed with your next dose. Talk to your doctor if you experience unusual fatigue or bruising.
You should consult your doctor before receiving any vaccine while being treated with Thiother 15mg Injection. Live vaccines, including live bacterial or viral vaccines and yellow fever vaccine, are generally avoided because Thiother 15mg Injection can weaken the immune system and increase the risk of serious infections. Your doctor can advise which vaccines are appropriate and when they should be given.
A fever or chills can be a sign of a serious infection due to lowered white blood cells. Contact your healthcare team or go to the nearest emergency room immediately. Talk to your doctor if you experience any sudden changes in your health.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - TH18321
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