apollo
0
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofajak Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Read more
rxMedicinePrescription drug

Whats That

tooltip
socialProofing22 people bought
in last 7 days

Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofajak Tablet

Tofajak Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofajak Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofajak Tablet if you are pregnant or breastfeeding. Tofajak Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofajak Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Tofajak Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Tofajak Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofajak Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofajak Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofajak Tablet Works

Tofajak Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tofajak Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

What if I have taken an overdose of Tofajak Tablet

Take Tofajak Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tofajak Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofajak Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofajak Tablet . Tofajak Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

verifiedApollotooltip
TofacitinibItraconazole
Severe
TofacitinibTemsirolimus
Severe

Drug-Drug Interactions

Login/Sign Up

TofacitinibItraconazole
Severe
How does the drug interact with Tofajak Tablet:
Taking Itraconazole with Tofajak Tablet may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Tofajak Tablet and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
TofacitinibTemsirolimus
Severe
How does the drug interact with Tofajak Tablet:
Taking Tofajak Tablet with Temsirolimus may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofajak Tablet and Temsirolimus, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibThalidomide
Severe
How does the drug interact with Tofajak Tablet:
Taking Thalidomide with Tofajak Tablet may increase the risk of infection.

How to manage the interaction:
Although taking thalidomide and Tofajak Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TofacitinibClozapine
Severe
How does the drug interact with Tofajak Tablet:
When Tofajak Tablet and Clozapine are taken together, that may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Tofajak Tablet and Clozapine, but it can be taken if prescribed by a doctor. Your doctor can recommend other options that won't cause problems when taken together. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibStreptozocin
Severe
How does the drug interact with Tofajak Tablet:
Taking Tofajak Tablet with Streptozocin may increase the risk of infection.

How to manage the interaction:
Although taking Streptozocin and Tofajak Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibCiclosporin
Severe
How does the drug interact with Tofajak Tablet:
Co-administration of Tofajak Tablet with cyclosporine may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Tofajak Tablet can be taken with ciclosporin if prescribed by the doctor. Consult the prescriber if you experience side effects such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without a doctor's advice.
TofacitinibTopotecan
Severe
How does the drug interact with Tofajak Tablet:
Taking Tofajak Tablet with Topotecan may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofajak Tablet and Topotecan, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibRuxolitinib
Severe
How does the drug interact with Tofajak Tablet:
Using Tofajak Tablet together with ruxolitinib can increase the risk of infections.

How to manage the interaction:
Although taking Tofajak Tablet and Ruxolitinib together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibVincristine
Severe
How does the drug interact with Tofajak Tablet:
Taking Tofajak Tablet with Vincristine may increase the risk of infection.

How to manage the interaction:
Co-administration of Vincristine with Tofajak Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibDaratumumab
Severe
How does the drug interact with Tofajak Tablet:
Using Tofajak Tablet together with daratumumab may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Tofajak Tablet and Daratumumab, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

Login/Sign Up

TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofajak Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofajak Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Tofajak Tablet Substitute

Substitutes safety advice
  • TFCT NIB Tablet 10's

    by AYUR

    43.52per tablet
  • Betrecep 5 mg Tablet 14's

    by Others

    28.58per tablet
  • Tofadoz Tablet 10's

    by AYUR

    44.24per tablet
  • Tofe-5 Tablet 10's

    by AYUR

    17.10per tablet
  • Tofashine 5 mg Tablet 10's

    by Others

    37.71per tablet
bannner image

Alcohol

Caution

It is not known if alcohol interacts with Tofajak Tablet , so please consult a doctor.

bannner image

Pregnancy

Unsafe

Tofajak Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofajak Tablet and for 4 weeks after discontinuation.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofajak Tablet . Please consult a doctor if you have any concerns.

bannner image

Driving

Safe

Tofajak Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofajak Tablet is not recommended for patients with severe liver problems.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Tofajak Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

Tofajak Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Tofajak Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofajak Tablet . Consult your doctor before taking Tofajak Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofajak Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofajak Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofajak Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Tofajak Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Tofajak Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Tofajak Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Tofajak Tablet may begin working within 2-8 weeks after starting the treatment.

Tofajak Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofajak Tablet , inform the doctor if you are taking tocilizumab.

Prior to starting Tofajak Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - TOF0037

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
whatsapp Floating Button