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compositionComposition:METOLAZONE-2.5MG
prescription
Prescription Medicine
info
TOLAZ 2.5MG TABLET
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METOLAZONE-2.5MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TOLAZ 2.5MG TABLET

TOLAZ 2.5MG TABLET is a prescription medicine used to treat excess fluid accumulation and swelling in the body. Doctors commonly prescribe it to help patients who have fluid buildup caused by congestive heart failure or kidney disorders. It is also used to help lower and manage high blood pressure. 

For the best results, you should take this medicine consistently every day, usually once daily in the morning. You can take it with or without food, but it is best to choose one way and stick to it with every dose. Adopting a low-salt diet and staying active can also greatly improve how well this medicine works for you.

While taking this medicine, you might experience mild side effects like dizziness, mild headaches, or muscle cramps. However, if you experience serious symptoms such as severe muscle weakness, a fast or irregular heartbeat, or extreme dry mouth and thirst, you must contact your doctor immediately.

Do not take this medicine if you are unable to pass urine or if you have severe liver damage. Before starting, tell your doctor if you have a history of gout, diabetes, or kidney disease, as they may need to adjust your treatment plan.

This medication can interact with other drugs like pain relievers and certain heart medicines, and drinking alcohol while taking it can make you feel dangerously dizzy. If you are pregnant, planning a pregnancy, or breastfeeding, discuss the potential benefits and risks of treatment with your doctor before using TOLAZ 2.5MG TABLET. Your doctor will determine whether this medicine is appropriate for your individual situation.

Uses of TOLAZ 2.5MG TABLET

TOLAZ 2.5MG TABLET may be prescribed for the following conditions: 

  • Fluid retention (oedema): TOLAZ 2.5MG TABLET helps your body get rid of extra water and salt caused by heart failure or kidney disease, reducing uncomfortable swelling in your legs, ankles, and abdomen. In some patients with severe or resistant fluid retention, it may be used together with other diuretics under close medical supervision.
  • High blood pressure (hypertension): TOLAZ 2.5MG TABLET helps lower blood pressure by reducing excess salt and fluid in the body, which decreases the volume of fluid circulating in the blood vessels and reduces strain on the cardiovascular system.

Key Benefits

TOLAZ 2.5MG TABLET helps remove excess fluid and reduce blood pressure by increasing the amount of salt and water eliminated through the urine. This helps relieve symptoms associated with fluid retention and supports cardiovascular health.

  • Reduces Swelling: Helps remove excess fluid from the body, relieving swelling in the legs, ankles, and feet.
  • Improves Breathing: Helps reduce fluid accumulation in the lungs, making breathing easier, particularly in people with heart failure.
  • Lowers Blood Pressure: Helps maintain healthy blood pressure levels and reduces strain on the heart and blood vessels.
  • Supports Heart Health: Effective control of fluid retention and blood pressure may help lower the risk of heart-related complications.
  • Improves Daily Comfort: By reducing fluid buildup and swelling, it may help improve mobility and overall quality of life.
Side effects of Tolaz 2.5mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat fatty fish rich in omega-3 fatty acids to reduce inflammation.
  • Add whole grains such as brown rice, quinoa, and whole wheat bread to your diet for a nutritional boost.
  • Add nuts and seeds like almonds, walnuts, chia seeds for anti-inflammatory benefits.
  • Eat dark leafy greens like spinach, kale, collard greens for antioxidants.
  • Include berries like blueberries, strawberries, raspberries for anti-inflammatory properties.
  • Rest and take a break from usual activities.
  • Apply ice for 15-20 minutes, 3 times a day to reduce pain and inflammation.
  • Use compression with a stretchable bandage or wrap to lessen swelling and provide support.
  • Avoid strenuous activities and rest the affected area.
  • Try light stretching with gentle exercises to maintain flexibility.
  • Consider OTC pain medications like ibuprofen or acetaminophen but consult a doctor before taking any medication.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

To use TOLAZ 2.5MG TABLET safely and effectively, follow these instructions: 

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take your dose exactly as your healthcare provider has directed. It is usually best to take it in the morning to prevent frequent trips to the bathroom from interrupting your sleep.

Always follow your doctor's exact instructions, and do not change your dose or stop taking it without talking to them first.

How TOLAZ 2.5MG TABLET Works

Metolazone in TOLAZ 2.5MG TABLET belongs to a group of medicines known as water tablets, or diuretics. It works mainly in a part of the kidneys called the distal convoluted tubule, where it increases the amount of salt and water removed from the body through urine. This excess salt and fluid is then eliminated from your body, helping reduce fluid build-up and swelling. By lowering the total amount of fluid circulating in your blood vessels, it also helps reduce blood pressure and decreases the workload on your heart. Unlike some other diuretics, metolazone may continue to be effective even when kidney function is reduced, which is why it is sometimes used in people with certain kidney disorders under medical supervision.
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Alcohol

Caution

Consuming alcohol with TOLAZ 2.5MG TABLET may cause a decrease in blood pressure, leading to dizziness and fatigue. Therefore, avoid alcohol consumption during treatment with TOLAZ 2.5MG TABLET.

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Pregnancy

Unsafe

TOLAZ 2.5MG TABLET is not recommended during pregnancy. Consult the doctor if you are pregnant, think you may be pregnant or are planning a pregnancy.

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Breast Feeding

Unsafe

TOLAZ 2.5MG TABLET is not recommended during breastfeeding. Consult the doctor if you are breastfeeding.

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Driving

Caution

TOLAZ 2.5MG TABLET may cause dizziness and fatigue. Avoid driving or operating heavy machinery if you experience these symptoms.

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Liver

Consult your doctor

Please consult the doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

TOLAZ 2.5MG TABLET should be used with caution in patients with severe renal impairment. Please consult the doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

TOLAZ 2.5MG TABLET is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Safe if prescribed

TOLAZ 2.5MG TABLET is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

TOLAZ 2.5MG TABLET should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of TOLAZ 2.5MG TABLET

Do not take more than the prescribed dose of TOLAZ 2.5MG TABLET as it may cause an overdose. The symptoms of overdose include stomach upset, drowsiness, fainting, dizziness, coma and slow or difficult breathing. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Follow a Low-Salt Diet: Limit sodium intake as advised by your doctor, as excess salt can cause fluid retention and reduce the effectiveness of TOLAZ 2.5MG TABLET.
  • Maintain Healthy Potassium Levels: Include potassium-rich foods such as bananas, oranges, and leafy green vegetables if recommended by your doctor, as this medicine may lower potassium levels.
  • Stand Up Slowly: Rise gradually from sitting or lying positions to help reduce dizziness and prevent falls.
  • Monitor Fluid Intake: Follow your doctor's advice regarding fluid intake, especially if you have heart failure or other conditions requiring fluid restrictions.

Have a query?

How Soon It Starts Working

The time required for TOLAZ 2.5MG TABLET to start to work: TOLAZ 2.5MG TABLET ideally shows its action within 1 hour after administration.

The time for which the effects of TOLAZ 2.5MG TABLET last: The effect of TOLAZ 2.5MG TABLET lasts for 12 to 24 hours.

What if you forget to take TOLAZ 2.5MG TABLET

If you miss a dose of TOLAZ 2.5MG TABLET, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the bottle tightly closed in a dry place to protect it from moisture. Do not store this medication in the bathroom cabinet.

Drug Warnings

  • Take Early in the Day: Take TOLAZ 2.5MG TABLET earlier in the day, preferably before evening, to reduce sleep disturbances caused by frequent urination.
  • Attend Regular Blood Tests: Keep all laboratory appointments so your doctor can monitor kidney function and electrolyte levels, including potassium and sodium.
  • Avoid Alcohol: Do not consume alcohol while taking this medicine, as it may increase dizziness, lightheadedness, and the risk of low blood pressure.
  • Protect Your Skin from Sunlight: Use sunscreen and wear protective clothing when outdoors, as this medicine may increase sensitivity to sunlight.

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with TOLAZ 2.5MG TABLET:

  • Other Blood Pressure Medicines: Taking TOLAZ 2.5MG TABLET with other blood pressure-lowering medicines may cause excessive lowering of blood pressure and increase the risk of dizziness.
  • NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may reduce the effectiveness of TOLAZ 2.5MG TABLET and increase the risk of kidney problems.
  • Lithium: TOLAZ 2.5MG TABLET may increase lithium levels in the body and raise the risk of lithium toxicity.

Drug-Food Interactions

Inform your doctor about any foods, supplements, or herbal products you regularly consume, as they may affect treatment with TOLAZ 2.5MG TABLET:

  • Natural Liquorice: Avoid consuming large amounts of natural liquorice, as it may worsen potassium loss and increase the risk of side effects.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking TOLAZ 2.5MG TABLET, as it may worsen your condition or require closer monitoring.

  • Anuria: Do not take this medicine if you have severe kidney failure with an inability to produce urine.
  • Severe Liver Disease: This medicine may not be suitable for people with severe liver impairment.
  • Diabetes: Use with caution if you have diabetes, as TOLAZ 2.5MG TABLET may increase blood sugar levels.
  • Gout: Inform your doctor if you have a history of gout, as this medicine may trigger gout attacks in some individuals.
  • Sulfonamide Allergy: Inform your doctor if you have had an allergic reaction to sulfonamide-containing medicines, as TOLAZ 2.5MG TABLET may not be suitable for some people with a history of severe sulfonamide hypersensitivity. 
OlanzapineRopinirole
Critical
OlanzapinePramipexole
Critical

Drug-Drug Interactions

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OlanzapineRopinirole
Critical
How does the drug interact with Tolaz 2.5mg Tablet:
When Ropinirole is taken with Tolaz 2.5mg Tablet, it may reduce the effectiveness of ropinirole.

How to manage the interaction:
Taking Ropinirole with Tolaz 2.5mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.
OlanzapinePramipexole
Critical
How does the drug interact with Tolaz 2.5mg Tablet:
Taking Tolaz 2.5mg Tablet with Pramipexole can increase the risk and severity of side effects and reduce the effectiveness of Pramipexole.

How to manage the interaction:
Co-administration of Tolaz 2.5mg Tablet and Pramipexole is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
OlanzapinePotassium citrate
Critical
How does the drug interact with Tolaz 2.5mg Tablet:
Taking Tolaz 2.5mg Tablet with Potassium citrate can increase the irritant effects of potassium on your stomach and upper intestine.

How to manage the interaction:
Co-administration of Tolaz 2.5mg Tablet and Potassium citrate is not recommended as it leads to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapinePotassium chloride
Critical
How does the drug interact with Tolaz 2.5mg Tablet:
Taking Tolaz 2.5mg Tablet with Potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Co-administration of Tolaz 2.5mg Tablet and Potassium chloride is not recommended as it leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapineChlordiazepoxide
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
Co-administration of Tolaz 2.5mg Tablet with chlordiazepoxide may significantly increase the occurrence side effects.

How to manage the interaction:
Taking Tolaz 2.5mg Tablet and chlordiazepoxide together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as low blood pressure, rapid breathing, weak pulse, muscle weakness, drowsiness, dizziness, or slurred speech, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapineTetrabenazine
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
Co-administration of Tetrabenazine and Tolaz 2.5mg Tablet can increase the risk of an irregular heart rhythm and the severity of side effects associated with Tolaz 2.5mg Tablet.

How to manage the interaction:
Co-administration of Tetrabenazine and Tolaz 2.5mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, fever, heat intolerance, excessive sweating, stiffness, difficulty moving or swallowing, sudden dizziness, lightheadedness, fainting, and fast or pounding heartbeats, contact your doctor immediately. Avoid activities requiring mental alertness, such as driving or operating machinery, until you know how these medications affect you and do not discontinue any medications without consulting your doctor.
OlanzapineOndansetron
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
The combined use of Ondansetron and Tolaz 2.5mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Ondansetron and Tolaz 2.5mg Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OlanzapineHydromorphone
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
Combining Tolaz 2.5mg Tablet with Hydromorphone can cause central nervous system depression such as Tolaz 2.5mg Tablet can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Tolaz 2.5mg Tablet and Hydromorphone together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.
OlanzapineAlfentanil
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
Combining Tolaz 2.5mg Tablet with Alfentanil can cause central nervous system depression such as Tolaz 2.5mg Tablet can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Tolaz 2.5mg Tablet and Alfentanil together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.
OlanzapineMetrizamide
Severe
How does the drug interact with Tolaz 2.5mg Tablet:
The combined use of Metrizamide and Tolaz 2.5mg Tablet can increase the risk of seizures as Metrizamide is injected directly into the spine.

How to manage the interaction:
Taking Tolaz 2.5mg Tablet with Metrizamide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have seizures or a head injury, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

TOLAZ 2.5MG TABLET is used to treat fluid retention (oedema) and high blood pressure (hypertension).

TOLAZ 2.5MG TABLET helps the kidneys remove water from the body and lower blood pressure.

Please do not stop taking TOLAZ 2.5MG TABLET without consulting your doctor. To treat your condition effectually, continue taking TOLAZ 2.5MG TABLET for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking TOLAZ 2.5MG TABLET.

TOLAZ 2.5MG TABLET may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary sun exposure. Wear protective clothing and use sunscreen whilst going out.

TOLAZ 2.5MG TABLET may cause light-headedness, dizziness, and fainting when you get up too quickly from a lying position. To prevent this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

No, TOLAZ 2.5MG TABLET is not a steroid. It is a diuretic medication used to treat oedema (fluid retention) caused by kidney disease, heart failure or other medical conditions.

While using TOLAZ 2.5MG TABLET, you should know that this medication may make you dizzy or drowsy. Be cautious and avoid activities that require focus and attention, such as driving or operating machinery.

TOLAZ 2.5MG TABLET typically starts working within 1-1.5 hours, although the exact timing can vary from person to person. Factors such as the severity of the condition, dosage, and individual metabolism can influence how quickly it takes effect. Once it starts working, the effects of TOLAZ 2.5MG TABLET can last for up to 12-24 hours.

It is essential to exercise caution when considering taking any medications together including fexofenadine. Unless your doctor recommends, taking TOLAZ 2.5MG TABLET and Fexofenadine together is generally not advisable. Potential interactions or side effects may occur, and your doctor can assess whether the combination is safe and necessary for your specific situation. Always consult your doctor or healthcare professional before combining medications, and never take medications without their recommendation.

Continue taking TOLAZ 2.5MG TABLET as directed by your doctor. The duration of treatment varies depending on your condition and response to TOLAZ 2.5MG TABLET. Follow your doctor's instructions and schedule regular check-ups to monitor your progress and adjust treatment as needed.

TOLAZ 2.5MG TABLET may cause side effects such as nausea, vomiting, diarrhoea, and constipation. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

It is highly recommended to take TOLAZ 2.5MG TABLET in the morning. Taking it late in the day or at night will likely cause you to wake up multiple times to urinate, which can disrupt your sleep. Talk to your doctor if you need advice on scheduling your dose.

This medicine helps remove fluid, but it can also cause your body to lose important minerals like potassium and sodium. Regular blood tests help your doctor monitor these levels and check how well your kidneys are working to keep you safe. Talk to your doctor if you have questions about your blood tests.

Dizziness can happen, especially when you stand up quickly. Try rising slowly from sitting or lying down. If the dizziness is severe, makes you feel faint, or does not go away, sit or lie down immediately and talk to your doctor.

You should avoid taking pain relievers like ibuprofen or naproxen without consulting a professional, as these can make TOLAZ 2.5MG TABLET less effective and strain your kidneys. For safe pain relief options, talk to your doctor or pharmacist.

Yes, TOLAZ 2.5MG TABLET can cause your body to lose potassium through your urine, which may lead to low potassium levels. Your doctor may suggest adding potassium-rich foods to your diet or taking a potassium supplement. Talk to your doctor to see what is right for you.

It is best to avoid alcohol while taking TOLAZ 2.5MG TABLET. Alcohol can combine with this medicine to significantly lower your blood pressure, which can lead to severe dizziness, lightheadedness, or fainting. Talk to your doctor if you have concerns about alcohol use.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.13419 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 017386S043Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. MedlinePlus. A682345 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Metolazone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Metolazone tablets. 2001. [Accessed on 19 Mar. 2019] Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020] Check here
  7. Mayoclinic. metolazone. [Accessed on 10 Sep 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - TOL0009

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