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compositionComposition:METOLAZONE-2.5MG
prescription
Prescription Medicine
info
Metadure 2.5mg Tablet
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METOLAZONE-2.5MG

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Metadure 2.5mg Tablet

Metadure 2.5mg Tablet is a prescription medicine used to treat excess fluid accumulation and swelling in the body. Doctors commonly prescribe it to help patients who have fluid buildup caused by congestive heart failure or kidney disorders. It is also used to help lower and manage high blood pressure. 

For the best results, you should take this medicine consistently every day, usually once daily in the morning. You can take it with or without food, but it is best to choose one way and stick to it with every dose. Adopting a low-salt diet and staying active can also greatly improve how well this medicine works for you.

While taking this medicine, you might experience mild side effects like dizziness, mild headaches, or muscle cramps. However, if you experience serious symptoms such as severe muscle weakness, a fast or irregular heartbeat, or extreme dry mouth and thirst, you must contact your doctor immediately.

Do not take this medicine if you are unable to pass urine or if you have severe liver damage. Before starting, tell your doctor if you have a history of gout, diabetes, or kidney disease, as they may need to adjust your treatment plan.

This medication can interact with other drugs like pain relievers and certain heart medicines, and drinking alcohol while taking it can make you feel dangerously dizzy. If you are pregnant, planning a pregnancy, or breastfeeding, discuss the potential benefits and risks of treatment with your doctor before using Metadure 2.5mg Tablet. Your doctor will determine whether this medicine is appropriate for your individual situation.

Uses of Metadure 2.5mg Tablet

Metadure 2.5mg Tablet may be prescribed for the following conditions: 

  • Fluid retention (oedema): Metadure 2.5mg Tablet helps your body get rid of extra water and salt caused by heart failure or kidney disease, reducing uncomfortable swelling in your legs, ankles, and abdomen. In some patients with severe or resistant fluid retention, it may be used together with other diuretics under close medical supervision.
  • High blood pressure (hypertension): Metadure 2.5mg Tablet helps lower blood pressure by reducing excess salt and fluid in the body, which decreases the volume of fluid circulating in the blood vessels and reduces strain on the cardiovascular system.

Key Benefits

Metadure 2.5mg Tablet helps remove excess fluid and reduce blood pressure by increasing the amount of salt and water eliminated through the urine. This helps relieve symptoms associated with fluid retention and supports cardiovascular health.

  • Reduces Swelling: Helps remove excess fluid from the body, relieving swelling in the legs, ankles, and feet.
  • Improves Breathing: Helps reduce fluid accumulation in the lungs, making breathing easier, particularly in people with heart failure.
  • Lowers Blood Pressure: Helps maintain healthy blood pressure levels and reduces strain on the heart and blood vessels.
  • Supports Heart Health: Effective control of fluid retention and blood pressure may help lower the risk of heart-related complications.
  • Improves Daily Comfort: By reducing fluid buildup and swelling, it may help improve mobility and overall quality of life.

Directions for Use

To use Metadure 2.5mg Tablet safely and effectively, follow these instructions: 

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take your dose exactly as your healthcare provider has directed. It is usually best to take it in the morning to prevent frequent trips to the bathroom from interrupting your sleep.

Always follow your doctor's exact instructions, and do not change your dose or stop taking it without talking to them first.

How Metadure 2.5mg Tablet Works

Metolazone in Metadure 2.5mg Tablet belongs to a group of medicines known as water tablets, or diuretics. It works mainly in a part of the kidneys called the distal convoluted tubule, where it increases the amount of salt and water removed from the body through urine. This excess salt and fluid is then eliminated from your body, helping reduce fluid build-up and swelling. By lowering the total amount of fluid circulating in your blood vessels, it also helps reduce blood pressure and decreases the workload on your heart. Unlike some other diuretics, metolazone may continue to be effective even when kidney function is reduced, which is why it is sometimes used in people with certain kidney disorders under medical supervision.
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Alcohol

Caution

Consuming alcohol with Metadure 2.5mg Tablet may cause a decrease in blood pressure, leading to dizziness and fatigue. Therefore, avoid alcohol consumption during treatment with Metadure 2.5mg Tablet.

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Pregnancy

Unsafe

Metadure 2.5mg Tablet is not recommended during pregnancy. Consult the doctor if you are pregnant, think you may be pregnant or are planning a pregnancy.

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Breast Feeding

Unsafe

Metadure 2.5mg Tablet is not recommended during breastfeeding. Consult the doctor if you are breastfeeding.

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Driving

Caution

Metadure 2.5mg Tablet may cause dizziness and fatigue. Avoid driving or operating heavy machinery if you experience these symptoms.

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Liver

Consult your doctor

Please consult the doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Metadure 2.5mg Tablet should be used with caution in patients with severe renal impairment. Please consult the doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Metadure 2.5mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Safe if prescribed

Metadure 2.5mg Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Metadure 2.5mg Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Metadure 2.5mg Tablet

Do not take more than the prescribed dose of Metadure 2.5mg Tablet as it may cause an overdose. The symptoms of overdose include stomach upset, drowsiness, fainting, dizziness, coma and slow or difficult breathing. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Follow a Low-Salt Diet: Limit sodium intake as advised by your doctor, as excess salt can cause fluid retention and reduce the effectiveness of Metadure 2.5mg Tablet.
  • Maintain Healthy Potassium Levels: Include potassium-rich foods such as bananas, oranges, and leafy green vegetables if recommended by your doctor, as this medicine may lower potassium levels.
  • Stand Up Slowly: Rise gradually from sitting or lying positions to help reduce dizziness and prevent falls.
  • Monitor Fluid Intake: Follow your doctor's advice regarding fluid intake, especially if you have heart failure or other conditions requiring fluid restrictions.

Have a query?

How Soon It Starts Working

The time required for Metadure 2.5mg Tablet to start to work: Metadure 2.5mg Tablet ideally shows its action within 1 hour after administration.

The time for which the effects of Metadure 2.5mg Tablet last: The effect of Metadure 2.5mg Tablet lasts for 12 to 24 hours.

What if you forget to take Metadure 2.5mg Tablet

If you miss a dose of Metadure 2.5mg Tablet, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the bottle tightly closed in a dry place to protect it from moisture. Do not store this medication in the bathroom cabinet.

Drug Warnings

  • Take Early in the Day: Take Metadure 2.5mg Tablet earlier in the day, preferably before evening, to reduce sleep disturbances caused by frequent urination.
  • Attend Regular Blood Tests: Keep all laboratory appointments so your doctor can monitor kidney function and electrolyte levels, including potassium and sodium.
  • Avoid Alcohol: Do not consume alcohol while taking this medicine, as it may increase dizziness, lightheadedness, and the risk of low blood pressure.
  • Protect Your Skin from Sunlight: Use sunscreen and wear protective clothing when outdoors, as this medicine may increase sensitivity to sunlight.

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Metadure 2.5mg Tablet:

  • Other Blood Pressure Medicines: Taking Metadure 2.5mg Tablet with other blood pressure-lowering medicines may cause excessive lowering of blood pressure and increase the risk of dizziness.
  • NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may reduce the effectiveness of Metadure 2.5mg Tablet and increase the risk of kidney problems.
  • Lithium: Metadure 2.5mg Tablet may increase lithium levels in the body and raise the risk of lithium toxicity.

Drug-Food Interactions

Inform your doctor about any foods, supplements, or herbal products you regularly consume, as they may affect treatment with Metadure 2.5mg Tablet:

  • Natural Liquorice: Avoid consuming large amounts of natural liquorice, as it may worsen potassium loss and increase the risk of side effects.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Metadure 2.5mg Tablet, as it may worsen your condition or require closer monitoring.

  • Anuria: Do not take this medicine if you have severe kidney failure with an inability to produce urine.
  • Severe Liver Disease: This medicine may not be suitable for people with severe liver impairment.
  • Diabetes: Use with caution if you have diabetes, as Metadure 2.5mg Tablet may increase blood sugar levels.
  • Gout: Inform your doctor if you have a history of gout, as this medicine may trigger gout attacks in some individuals.
  • Sulfonamide Allergy: Inform your doctor if you have had an allergic reaction to sulfonamide-containing medicines, as Metadure 2.5mg Tablet may not be suitable for some people with a history of severe sulfonamide hypersensitivity. 
MetolazoneCisapride
Critical
MetolazonePimozide
Severe

Drug-Drug Interactions

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MetolazoneCisapride
Critical
How does the drug interact with Metadure 2.5mg Tablet:
Using Cisapride together with Metadure 2.5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Metadure 2.5mg Tablet with Cisapride is not recommended, but can be taken if prescribed by the doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not discontinue any medication without consulting a doctor.
MetolazonePimozide
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Using Pimozide together with Metadure 2.5mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Metadure 2.5mg Tablet and pimozide together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include an irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or pounding heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, and feeling like you might throw up. Do not stop using any medications without a doctor's advice.
MetolazoneAmiodarone
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Coadministration of Amiodarone together with Metadure 2.5mg Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Metadure 2.5mg Tablet interact, they can be used if prescribed by a doctor. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, Weakness, tiredness, drowsiness, confusion, painful muscle cramping, dizziness, nausea, or vomiting, get medical attention. Do not discontinue any medications without consulting a doctor.
MetolazoneCalcitriol
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Co-administration of Metadure 2.5mg Tablet with Calcitriol can cause blood calcium levels to become too high.

How to manage the interaction:
Although there is an interaction, calcitriol can be taken with Metadure 2.5mg Tablet if prescribed by the doctor. Consult the doctor if you experience symptoms such as dizziness, drowsiness, weakness, lethargy, headache, nausea, vomiting, or seizures. Do not discontinue the medication without consulting a doctor.
MetolazoneZiprasidone
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Co-administration of Ziprasidone together with Metadure 2.5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Metadure 2.5mg Tablet and Ziprasidone together can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
MetolazoneTizanidine
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Coadministration of Tizanidine and Metadure 2.5mg Tablet may cause low blood pressure.

How to manage the interaction:
Taking Tizanidine with Metadure 2.5mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not stop using any medications without talking to a doctor.
MetolazoneArsenic trioxide
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Using arsenic trioxide together with Metadure 2.5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Arsenic trioxide and Metadure 2.5mg Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, make sure to contact a doctor right away. These symptoms include changes in your heart rhythm, feeling dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, having trouble thinking clearly, muscle pain, or feeling sick to your stomach. Do not stop using any medications without talking to a doctor.
MetolazoneDroperidol
Severe
How does the drug interact with Metadure 2.5mg Tablet:
Using Droperidol together with Metadure 2.5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Metadure 2.5mg Tablet and Droperidol, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include an irregular heart rhythm, diarrhea or vomiting, complications, sudden dizziness or lightheadedness, fainting, difficulty breathing, heart palpitations, weakness, feeling sleepy or confused, muscle pain, or feeling nauseous or vomiting. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Metadure 2.5mg Tablet is used to treat fluid retention (oedema) and high blood pressure (hypertension).

Metadure 2.5mg Tablet helps the kidneys remove water from the body and lower blood pressure.

Please do not stop taking Metadure 2.5mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Metadure 2.5mg Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Metadure 2.5mg Tablet.

Metadure 2.5mg Tablet may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary sun exposure. Wear protective clothing and use sunscreen whilst going out.

Metadure 2.5mg Tablet may cause light-headedness, dizziness, and fainting when you get up too quickly from a lying position. To prevent this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

No, Metadure 2.5mg Tablet is not a steroid. It is a diuretic medication used to treat oedema (fluid retention) caused by kidney disease, heart failure or other medical conditions.

While using Metadure 2.5mg Tablet, you should know that this medication may make you dizzy or drowsy. Be cautious and avoid activities that require focus and attention, such as driving or operating machinery.

Metadure 2.5mg Tablet typically starts working within 1-1.5 hours, although the exact timing can vary from person to person. Factors such as the severity of the condition, dosage, and individual metabolism can influence how quickly it takes effect. Once it starts working, the effects of Metadure 2.5mg Tablet can last for up to 12-24 hours.

It is essential to exercise caution when considering taking any medications together including fexofenadine. Unless your doctor recommends, taking Metadure 2.5mg Tablet and Fexofenadine together is generally not advisable. Potential interactions or side effects may occur, and your doctor can assess whether the combination is safe and necessary for your specific situation. Always consult your doctor or healthcare professional before combining medications, and never take medications without their recommendation.

Continue taking Metadure 2.5mg Tablet as directed by your doctor. The duration of treatment varies depending on your condition and response to Metadure 2.5mg Tablet. Follow your doctor's instructions and schedule regular check-ups to monitor your progress and adjust treatment as needed.

Metadure 2.5mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, and constipation. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

It is highly recommended to take Metadure 2.5mg Tablet in the morning. Taking it late in the day or at night will likely cause you to wake up multiple times to urinate, which can disrupt your sleep. Talk to your doctor if you need advice on scheduling your dose.

This medicine helps remove fluid, but it can also cause your body to lose important minerals like potassium and sodium. Regular blood tests help your doctor monitor these levels and check how well your kidneys are working to keep you safe. Talk to your doctor if you have questions about your blood tests.

Dizziness can happen, especially when you stand up quickly. Try rising slowly from sitting or lying down. If the dizziness is severe, makes you feel faint, or does not go away, sit or lie down immediately and talk to your doctor.

You should avoid taking pain relievers like ibuprofen or naproxen without consulting a professional, as these can make Metadure 2.5mg Tablet less effective and strain your kidneys. For safe pain relief options, talk to your doctor or pharmacist.

Yes, Metadure 2.5mg Tablet can cause your body to lose potassium through your urine, which may lead to low potassium levels. Your doctor may suggest adding potassium-rich foods to your diet or taking a potassium supplement. Talk to your doctor to see what is right for you.

It is best to avoid alcohol while taking Metadure 2.5mg Tablet. Alcohol can combine with this medicine to significantly lower your blood pressure, which can lead to severe dizziness, lightheadedness, or fainting. Talk to your doctor if you have concerns about alcohol use.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.13419 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 017386S043Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. MedlinePlus. A682345 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Metolazone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Metolazone tablets. 2001. [Accessed on 19 Mar. 2019] Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020] Check here
  7. Mayoclinic. metolazone. [Accessed on 10 Sep 2019]Check here

Country of origin

India
Other Info - ME88538
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