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compositionComposition:GEMIFLOXACIN-320MG
prescription
Prescription Medicine
info
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Topgem 320 mg Tablet is an antibiotic used to treat or prevent certain bacterial infections of nose, throat, urinary tract, lungs (pneumonia), skin, and soft tissues. It contains Gemifloxacin, which kills bacteria and treats the infection. It may cause side effects such as rash, vomiting, headache, dizziness, stomach pain, nausea, and diarrhoea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GEMIFLOXACIN-320MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Topgem 320 mg Tablet

Topgem 320 mg Tablet is a prescription antibiotic used to treat certain bacterial infections, particularly infections of the respiratory tract such as community-acquired pneumonia and bacterial flare-ups of chronic bronchitis. It belongs to the fluoroquinolone class of antibiotics and works by killing susceptible bacteria, helping relieve symptoms and prevent the infection from spreading. This medicine is effective only against bacterial infections and will not treat viral illnesses such as the common cold or flu.

You should take this medication once a day at the same time to maintain a constant level of medicine in your body. It can be taken with or without food, but drinking plenty of water during your treatment is highly recommended. Resting your body and staying hydrated will also support your recovery process.

While taking this medicine, you might experience mild side effects like nausea or diarrhoea. However, if you experience sudden joint pain, severe watery diarrhoea, or tingling in your hands and feet, you must contact your doctor immediately.

Do not take this if you have a history of tendon problems, a slow or irregular heartbeat, or a known allergy to similar antibiotics. It is also important to tell your doctor if you have a history of muscle weakness, kidney issues, or seizures before starting this medication.

This medicine can interact with antacids, multivitamins containing iron or zinc, and certain blood thinners, which can make the antibiotic less effective or increase side effects. Pregnant or breastfeeding women, as well as elderly individuals, should consult their doctor before using this medicine to ensure it is safe for them.

Uses of Topgem 320 mg Tablet

Topgem 320 mg Tablet is prescribed to treat bacterial infections caused by susceptible bacteria. Common uses include:

  • Bacterial flare-ups of chronic bronchitis: Topgem 320 mg Tablet helps by killing the bacteria causing sudden worsening of breathing difficulties, coughing, and mucus production in people with long-term lung issues.
  • Community-acquired pneumonia: Topgem 320 mg Tablet treats mild-to-moderate lung infections caught in everyday life by targeting and destroying the specific bacteria responsible for the infection.
     

Key Benefits

Topgem 320 mg Tablet is a fluoroquinolone antibiotic that treats bacterial infections by stopping the growth and multiplication of bacteria. It helps relieve infection-related symptoms and promotes a faster recovery.

  • Treats Bacterial Infections: Effectively eliminates susceptible bacteria responsible for respiratory and other bacterial infections.
  • Relieves Infection Symptoms: Helps reduce fever, cough, chest discomfort, and other symptoms associated with bacterial infections.
  • Promotes Faster Recovery: By controlling the infection, it supports quicker healing and helps you return to your normal daily activities.
  • Helps Prevent Infection Progression: Early and complete treatment reduces the risk of the infection worsening or spreading to other parts of the body.
  • Convenient Once-Daily Dosing: The once-daily dosing schedule makes it easier to complete the full course of treatment as prescribed.
Side effects of Topgem 320 mg Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Topgem 320 mg Tablet can be taken with or without food, or as advised by a doctor.
  • It is advised to take Topgem 320 mg Tablet exactly as prescribed by your doctor, following the recommended dosage and duration to get optimal results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Topgem 320 mg Tablet Works

Topgem 320 mg Tablet contains gemifloxacin, which belongs to a class of medicines known as quinolone antibiotics. It works by blocking two essential bacterial enzymes that bacteria need to copy and repair their DNA. Without these enzymes, the bacteria cannot multiply or repair themselves, leading to their rapid destruction. This action stops the spread of the infection, allowing the body's natural immune system to clear the remaining bacteria and begin the healing process.
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Alcohol

Caution

Alcohol is not known to cause any unpleasant side effects if taken along with Topgem 320 mg Tablet. But intake of alcohol with Topgem 320 mg Tablet may damage your liver. So intake of Topgem 320 mg Tablet should be avoided with Topgem 320 mg Tablet.

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Pregnancy

Caution

Topgem 320 mg Tablet is a pregnancy Category C medicine. It is not known whether Topgem 320 mg Tablet will affect pregnant women or fetus or not. Hence, the intake of Topgem 320 mg Tablet should be avoided if you are pregnant or planning to become pregnant as it may harm the baby.

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Breast Feeding

Caution

Topgem 320 mg Tablet is excreted in human milk. But the amount of Topgem 320 mg Tablet absorbed by the nursing infant is unknown. So, it should not be taken while breastfeeding.

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Driving

Caution

Topgem 320 mg Tablet can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

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Liver

Caution

Topgem 320 mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose if there are symptoms of nausea, vomiting, loss of appetite, dark-coloured urine, or yellowing of skin/eye.

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Kidney

Caution

Topgem 320 mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

The safety and efficacy of Topgem 320 mg Tablet are not studied in children below the age of 18 years.

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Heart

Caution

Topgem 320 mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Topgem 320 mg Tablet.

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Geriatrics

Caution

Topgem 320 mg Tablet can be given in elderly patients with extreme caution due to the risk of increased side effects

What if I have taken an overdose of Topgem 320 mg Tablet

If you take too much of this medication, seek emergency medical care or contact a poison control centre immediately. Symptoms of an overdose may include severe dizziness, tremors, or seizures.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids, especially water, throughout the day. This helps prevent crystals from forming in your urine and keeps your kidneys flushing the medicine safely.
  • Avoid dairy and calcium-rich foods close to your dose: Do not eat or drink calcium-fortified juices, milk, yoghurt, or other dairy products at the same time as this medicine, as calcium can prevent your body from absorbing the drug properly. Take the medicine 2 hours before or 2 hours after these foods.
  • Rest your joints: Avoid strenuous physical exercise or heavy lifting while taking this medication. This class of medicine can weaken tendons, and resting helps minimise the risk of injury.
  • Protect your skin from the sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing, a hat, and high-SPF sunscreen when going outdoors, and avoid tanning beds.
health query

Have a query?

How Soon It Starts Working

The time required for Topgem 320 mg Tablet to start to work: Topgem 320 mg Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Topgem 320 mg Tablet last: The effect of Topgem 320 mg Tablet lasts for 24 hours.

What if you forget to take Topgem 320 mg Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Topgem 320 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F) •Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Watch for Tendon Problems: Stop taking Topgem 320 mg Tablet and contact your doctor immediately if you develop sudden pain, swelling, or inflammation in a tendon.
  • Separate from Antacids and Mineral Supplements: Take Topgem 320 mg Tablet at least 2 hours before or 3 hours after antacids containing magnesium or aluminium, or supplements containing iron, zinc, or multivitamins, to ensure proper absorption.
  • Use Caution While Driving: Avoid driving or operating machinery until you know how Topgem 320 mg Tablet affects you, as it may cause dizziness or confusion.
  • Do Not Share Your Medicine: Take Topgem 320 mg Tablet only as prescribed and never share it with others, even if they have similar symptoms.
  • Report Nervous System Symptoms Promptly: Contact your doctor immediately if you experience mood changes, anxiety, confusion, hallucinations, difficulty sleeping, or other unusual neurological symptoms while taking this medicine.

Drug-Drug Interactions

verifiedApollotooltip

Topgem 320 mg Tablet may interact with certain medicines. Inform your doctor if you are taking any of the following:

  • Antacids and mineral supplements: Medicines containing magnesium, aluminium, calcium, iron, or zinc can bind to Topgem 320 mg Tablet in your stomach, drastically reducing how much medicine your body absorbs.
  • Blood thinners (like warfarin): Combining this medicine with blood thinners can increase the risk of bleeding. Your doctor may need to monitor your blood clotting times more closely.
  • Medicines that affect heart rhythm: Taking this with certain heart medications or antidepressants can increase the risk of dangerous irregular heart rhythms.
GemifloxacinZiprasidone
Critical
GemifloxacinFerrous fumarate
Severe

Drug-Drug Interactions

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GemifloxacinZiprasidone
Critical
How does the drug interact with Topgem 320 mg Tablet:
Coadministration of Topgem 320 mg Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Topgem 320 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
GemifloxacinFerrous fumarate
Severe
How does the drug interact with Topgem 320 mg Tablet:
Taking ferrous fumarate with Topgem 320 mg Tablet may significantly decreases the levels and effects of Topgem 320 mg Tablet.

How to manage the interaction:
Although taking Ferrous Fumarate and Topgem 320 mg Tablet together can cause an interaction, they can be taken together if prescribed by a doctor. It is recommended to take Topgem 320 mg Tablet 4 hours before or 6 hours after the consumption of ferrous fumarate. Do not stop using any medications without talking to your doctor.
GemifloxacinFludrocortisone
Severe
How does the drug interact with Topgem 320 mg Tablet:
Combining Fludrocortisone with Topgem 320 mg Tablet can increase the risk of tendinopathy.

How to manage the interaction:
Co-administration of Fludrocortisone with Topgem 320 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher if you are also taking oral corticosteroids. Contact your doctor immediately if you experience tendinitis (Inflammation to muscle present in hand), tendon rupture, prolonged disability, pain, swelling, or inflammation. Do not discontinue any medications without consulting your doctor.
GemifloxacinInsulin degludec
Severe
How does the drug interact with Topgem 320 mg Tablet:
Taking insulin degludec with Topgem 320 mg Tablet affects blood glucose levels, which may cause hyperglycaemia (high blood glucose) and hypoglycaemia (low blood glucose) less frequently.

How to manage the interaction:
There could be a possible interaction between insulin degludec and Topgem 320 mg Tablet but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience hypoglycaemia or hyperglycaemia. Symptoms of hypoglycaemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycaemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
GemifloxacinDeflazacort
Severe
How does the drug interact with Topgem 320 mg Tablet:
Topgem 320 mg Tablet can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone), and the risk may be increased when combined with other drugs such as deflazacort.

How to manage the interaction:
Although there is an interaction, Topgem 320 mg Tablet can be taken with deflazacort if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from your doctor. Do not stop using any medications without first talking to your doctor.
GemifloxacinInsulin detemir
Severe
How does the drug interact with Topgem 320 mg Tablet:
Co-administration of Topgem 320 mg Tablet and Insulin detemir can have an impact on blood sugar levels. There have been reports of both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).

How to manage the interaction:
Although taking Topgem 320 mg Tablet and Insulin detemir together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor, if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, sweat, palpitations, and rapid heartbeat, increased hunger, thirst, and urine. It is recommended to maintain blood glucose levels. Do not discontinue any medications without a doctor's advice.
GemifloxacinInsulin glargine
Severe
How does the drug interact with Topgem 320 mg Tablet:
Taking insulin glargine with Topgem 320 mg Tablet affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Topgem 320 mg Tablet and Insulin glargine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweating, palpitation, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
GemifloxacinEscitalopram
Severe
How does the drug interact with Topgem 320 mg Tablet:
Combining Topgem 320 mg Tablet with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Escitalopram with Topgem 320 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of these symptoms - dizziness, lightheadedness, fainting, palpitations, abnormal heart rhythm, shortness of breath, or severe diarrhea or vomiting - contact your doctor right away. Do not stop using any medications without talking to your doctor.
GemifloxacinBetamethasone
Severe
How does the drug interact with Topgem 320 mg Tablet:
Taking Topgem 320 mg Tablet may cause tendinitis and tendon rupture, and the risk may be increased when combined with Betamethasone.

How to manage the interaction:
Although there is an interaction, betamethasone can be taken with Topgem 320 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience pain, inflammation, or swelling of a tendon area such as the back of the ankle, biceps, shoulder, hand, or thumb. Do not discontinue the medication without consulting a doctor.
GemifloxacinInsulin aspart
Severe
How does the drug interact with Topgem 320 mg Tablet:
Taking insulin aspart with Topgem 320 mg Tablet affects blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia have been reported.

How to manage the interaction:
There could be a possible interaction between insulin aspart and Topgem 320 mg Tablet but can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms of hypoglycemia, which include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, or symptoms of hyperglycemia which may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and beverages may affect how Topgem 320 mg Tablet works. Inform your doctor if you regularly consume any of the following:

  • Calcium-rich foods: Eating dairy products (like milk or yoghurt) or drinking calcium-fortified juices at the same time as your dose can block the absorption of this medicine.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Topgem 320 mg Tablet is used to treat or prevent certain infections caused by bacteria. It is used to treat nose, throat, urinary tract infections, lungs (pneumonia), skin, and soft tissues.
Topgem 320 mg Tablet belongs to a class of drugs known as antibiotics, containing Gemifloxacin, which works by killing bacteria (bactericidal) that cause infections and prevent bacterial cell division. It also inhibits the repairing of bacterial cells. Altogether, it kills bacteria and treats the infection.
Topgem 320 mg Tablet makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.
A common side effect of Topgem 320 mg Tablet is diarrhoea, but you should complete your course. If diarrhoea persists and you observe blood in your stools, please visit your doctor.
No, Topgem 320 mg Tablet should not be taken along with dairy products as it might affect the absorption and efficacy of Topgem 320 mg Tablet. However, you can take it with a meal that includes these foods or drinks.
No. Topgem 320 mg Tablet is an antibacterial medicine that acts only against bacterial infections and not against viral infections causing cold and flu. You should not take Topgem 320 mg Tablet without prior consulting your doctor. Self-medication is dangerous and can lower the efficacy of Topgem 320 mg Tablet, leading to antibiotic resistance.
No, a minimum gap of 2-3 hours should be maintained between the dose of Topgem 320 mg Tablet and antacid as an antacid is known to decrease the absorption and effectiveness of Topgem 320 mg Tablet.
Topgem 320 mg Tablet is known to increase the risk of tendinitis and tendon rupture in all ages. But, the elderly are at increase risk of getting it. So, only take Topgem 320 mg Tablet if prescribed by a doctor in exact dose and duration.
Stopping your medicine too early can allow the strongest bacteria to survive, which can cause the infection to return and make it harder to treat in the future. Always finish the exact course prescribed by your healthcare provider. Talk to your doctor or pharmacist if you experience side effects that make you want to stop.
This medicine is generally not recommended during pregnancy or breastfeeding unless your doctor decides the benefits clearly outweigh the risks. If you are pregnant, planning to become pregnant, or are nursing, talk to your doctor or pharmacist to discuss safer alternative treatments.
It is best to avoid strenuous exercise, heavy lifting, or high-impact activities while taking this medicine. This is because this class of medicine carries a risk of swelling or tearing of the tendons. If you experience any joint or muscle pain, stop exercising and talk to your doctor or pharmacist right away.

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Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - TOP0072
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