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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Topocit-5 Tablet 10's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Apellon Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Topocit-5 Tablet 10's

Topocit-5 Tablet 10's is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Topocit-5 Tablet 10's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Topocit-5 Tablet 10's will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Topocit-5 Tablet 10's with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Topocit-5 Tablet 10's if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Topocit-5 Tablet 10's if you are pregnant or breastfeeding. Topocit-5 Tablet 10's is not recommended for use in children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Topocit-5 Tablet 10's

'Topocit-5 Tablet 10's is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Topocit-5 Tablet 10's are as follows:
• Treatment of Rheumatoid Arthritis: Topocit-5 Tablet 10's helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
• Management of Psoriatic Arthritis: Topocit-5 Tablet 10's treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
• Treatment of Ulcerative Colitis: Topocit-5 Tablet 10's helps to induce and maintain remission in moderate to severe ulcerative colitis.
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Directions for Use

• Topocit-5 Tablet 10's can be taken with or without food. • It is recommended to take Topocit-5 Tablet 10's 1-2 times a day, depending on your medical condition, or as prescribed by your doctor. • Swallow Topocit-5 Tablet 10's as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Topocit-5 Tablet 10's belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. 

Topocit-5 Tablet 10's is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Topocit-5 Tablet 10's Works

Topocit-5 Tablet 10's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Topocit-5 Tablet 10's

Take Topocit-5 Tablet 10's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Topocit-5 Tablet 10's if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Topocit-5 Tablet 10's.

Avoid taking Topocit-5 Tablet 10's if you are pregnant or breastfeeding. Topocit-5 Tablet 10's is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects. Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Topocit-5 Tablet 10's, which helps the physician decide the best treatment plan.

Store Topocit-5 Tablet 10's at room temperature. You are advised not to chew, crush or break the medicine. Keep the medicine out of reach of children. Please do not take more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)
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Alcohol

Caution

It is not known if alcohol interacts with Topocit-5 Tablet 10's, so please consult a doctor.

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Pregnancy

Unsafe

Topocit-5 Tablet 10's must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Topocit-5 Tablet 10's and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Topocit-5 Tablet 10's. Please consult a doctor if you have any concerns.

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Driving

Safe

Topocit-5 Tablet 10's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Topocit-5 Tablet 10's is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Topocit-5 Tablet 10's is not recommended for children below 18 years as safety and effectiveness were not established.

Have a query?

FAQs

Topocit-5 Tablet 10's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Topocit-5 Tablet 10's works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Topocit-5 Tablet 10's. Consult your doctor before taking Topocit-5 Tablet 10's if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Topocit-5 Tablet 10's. Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Topocit-5 Tablet 10's might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Topocit-5 Tablet 10's if you are trying to become pregnant or if you have any concerns regarding this.

Topocit-5 Tablet 10's affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Topocit-5 Tablet 10's is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Topocit-5 Tablet 10's may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Topocit-5 Tablet 10's may begin working within 2-8 weeks after starting the treatment.

Topocit-5 Tablet 10's should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Topocit-5 Tablet 10's, inform the doctor if you are taking tocilizumab.

Prior to starting Topocit-5 Tablet 10's, active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

No. 8/2, Sarvpriya Vihar, Sarvapriya Vihar, New Delhi-110016, Delhi, India
Other Info - TOP0622

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