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compositionComposition:CLOBETASOL-0.05%W/W+MICONAZOLE-2%W/W
prescription
Prescription Medicine
info
Topzee-M Cream 15 gm

Topzee-M Cream is used to reduce swelling, itching, and redness caused due to certain fungal skin infections. It contains Clobetasol and Miconazole (antifungal), which kills fungi and inhibits the release of certain chemical messengers in the body that cause redness, itching, and swelling. Some people may experience dry skin, itching, irritation, redness, or burning sensation at the site of application. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLOBETASOL-0.05%W/W+MICONAZOLE-2%W/W

Manufacturer/Marketer :

Atopic laboratories Pvt Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Topzee-M Cream

Topzee-M Cream is a topical medication prescribed to treat skin infections that are complicated by inflammation, redness, and severe itching. It is specifically designed to target skin conditions where a fungal infection and inflammatory symptoms coexist. By addressing both the underlying infection and the body's inflammatory response, it helps restore the skin to a healthy state.

To achieve the best results, you should apply Topzee-M Cream consistently at the same times every day as directed by your healthcare provider. Cleaning the affected area and drying it thoroughly before application helps the medicine work efficiently. Supporting your treatment with simple habits, such as keeping the skin dry and wearing loose clothing, can speed up your recovery.

While using Topzee-M Cream, you may experience mild, temporary side effects like a light burning or stinging sensation where the cream is applied. These symptoms usually go away on their own as your skin adjusts. However, if you experience severe skin irritation, thinning of the skin, or signs of an allergic reaction, stop using it and consult your doctor immediately.

Do not use this medicine if you have certain skin conditions, such as viral infections (like chickenpox or herpes) or tuberculosis of the skin. Talk to your doctor before starting Topzee-M Cream if you have poor blood circulation, a weakened immune system, or skin thinning. It is also important to tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding so they can evaluate if this treatment is safe for you.

Inform your doctor about all other topical creams, ointments, or cosmetics you use, as they may interact with this medicine. Avoid consuming alcohol or smoking heavily if you have chronic skin issues, as these habits can worsen skin inflammation and delay healing.

Uses of Topzee-M Cream

Topzee-M Cream is used to treat certain inflammatory skin conditions that are associated with fungal infections. It helps relieve symptoms while treating the underlying fungal growth.

  • Fungal skin infections with inflammation: Topzee-M Cream helps treat conditions such as athlete's foot, jock itch, and ringworm when they are accompanied by significant redness, swelling, itching, and irritation.
  • Infected eczema and dermatitis: It helps relieve inflammation, redness, scaling, and discomfort in eczema or dermatitis that has become complicated by a fungal infection.
  • Psoriasis with fungal complications: In selected cases, it may be used for localised psoriatic lesions that have developed a secondary fungal infection, helping to reduce both inflammation and fungal growth.
     

Key Benefits

Topzee-M Cream provides dual-action treatment by combining an antifungal medicine with a potent anti-inflammatory corticosteroid.

  • Provides rapid relief from itching: It helps reduce persistent itching and irritation associated with inflamed fungal skin infections.
  • Reduces redness and swelling: The corticosteroid component helps decrease inflammation, redness, warmth, and discomfort in the affected area.
  • Treats the fungal infection: The antifungal component works to stop the growth of fungi and help clear the infection.
  • Promotes skin healing: By controlling both infection and inflammation, it supports the recovery of damaged skin.
  • Improves daily comfort: Relief from itching, irritation, and visible skin changes can help improve comfort during daily activities and sleep.
  • Helps prevent further skin damage: Reducing the urge to scratch may lower the risk of additional skin irritation, injury, or secondary infections.
Side effects of Topzee-M Cream 15 gm
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
  • Mild hair follicle inflammation often heals on its own without needing treatment.
  • You can apply a warm saltwater or vinegar solution to the affected area with a washcloth, or use over-the-counter antibiotics, oatmeal lotion, or hydrocortisone cream for relief.
  • Avoid making the affected area worse by not shaving, scratching, or wearing tight clothes.
  • Apply a warm compress to the area 3-4 times a day for 15-20 minutes to help speed up healing.
  • Do not scratch, squeeze, or pop any bumps, as this may lead to infection or other problems.
  • If self-care methods fail, consult a doctor for further treatment and advice.
  • Shield your skin from the sun by using sunscreen, seeking shade, and wearing protective clothing.
  • Please don't smoke, as it damages the skin and reduces blood flow.
  • Treat your skin gently by limiting bath time, using mild cleansers, and shaving carefully.
  • Eat a healthy diet of fruits, vegetables, whole grains, and lean proteins.
  • Stay hydrated by drinking plenty of water.
  • Manage stress through sleep, exercise, meditation, and enjoyable activities.
  • Additionally, use moisturizers to coat your skin with a protective barrier, and consider wearing sun-protective clothing.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.

Directions for Use

To achieve the best results, use Topzee-M Cream exactly as directed by your doctor and apply it consistently throughout the prescribed treatment period.

  • Wash your hands thoroughly with soap and water before applying the medication.
  • Gently clean the affected area and pat it completely dry before application.
  • Apply a thin layer of Topzee-M Cream to the affected skin and rub it in gently until absorbed.
  • Do not apply more than the recommended amount, as using a thicker layer will not improve effectiveness and may increase the risk of side effects.
  • Wash your hands after applying the medicine, unless your hands are the area being treated.
  • Avoid getting the medication into your eyes, nose, mouth, or other sensitive areas. If accidental contact occurs, rinse thoroughly with water.
  • Do not cover, bandage, or wrap the treated area unless specifically instructed by your doctor.
  • Continue using the medication for the full duration prescribed, even if symptoms improve earlier, to help prevent the infection from returning.

Follow your doctor's instructions regarding how often and how long to use the medication, as prolonged or inappropriate use of clobetasol-containing products may increase the risk of side effects.
 

How Topzee-M Cream Works

Topzee-M Cream works through a combination of two active ingredients that target different aspects of an inflamed skin infection. Together, they provide a comprehensive approach to clearing the infection and soothing the skin. The first active component, clobetasol, is a highly effective topical corticosteroid. When applied to the skin, it stops the production of certain chemical messengers, known as prostaglandins, which cause swelling, redness, and itching. This action rapidly calms the skin's inflammatory response. The second active component, miconazole, is a broad-spectrum antifungal agent. It works by penetrating the fungal cells and disrupting the synthesis of ergosterol, a vital component of the fungal cell membrane. Without a stable membrane, the fungal cells leak their contents and die, effectively stopping the infection from spreading.
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Alcohol

Caution

Interaction of Topzee-M Cream with alcohol is unknown. Please consult a doctor before consuming alcohol while using Topzee-M Cream.

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Pregnancy

Caution

Topzee-M Cream is Category C pregnancy drug and is given to a pregnant woman only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is unknown whether Topzee-M Cream is excreted in human milk. Please consult a doctor before using Topzee-M Cream while breastfeeding.

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Driving

Safe if prescribed

Topzee-M Cream usually does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Topzee-M Cream in patients with Liver problems, please consult a doctor.

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Kidney

Caution

If you have any concerns regarding the use of Topzee-M Cream in patients with Kidney problems, please consult a doctor.

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Children

Caution

Topzee-M Cream should be used with caution in children below 12 years if prescribed by a doctor. Topzee-M Cream is not recommended for use in children below 2 years as in neonates and infants, absorption of Topzee-M Cream by immature skin may be enhanced and kidney may be immature.

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Heart

Consult your doctor

Please consult your doctor before using Topzee-M Cream if you have pre-existing heart problems. Your doctor will prescribe Topzee-M Cream if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giivng Topzee-M Cream to geriatric patients. Your doctor will prescribe Topzee-M Cream if the benefits outweigh the risks.

What if I have taken an overdose of Topzee-M Cream

Do not apply Topzee-M Cream in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects.

Diet & Lifestyle Advise

Managing a fungal skin infection effectively involves a combination of medication and smart daily habits. These tips can help prevent the spread of the infection and support faster skin healing:

  • Keep the skin dry: Fungi thrive in warm, moist environments. Always dry your skin thoroughly after bathing, paying special attention to skin folds, between the toes, and the groin area.
  • Wear breathable fabrics: Opt for loose-fitting clothing made from natural fibers like cotton. This allows air circulation and prevents sweat buildup on the skin.
  • Avoid sharing personal items: To prevent spreading the fungal infection to others or reinfecting yourself, do not share towels, clothing, bedding, or hairbrushes.
  • Wash clothes regularly: Wash towels, socks, and underwear in hot water and dry them thoroughly to kill any fungal spores.
  • Do not scratch: Although the infected area may itch, scratching can damage the skin barrier and introduce bacterial infections. If the itching is severe, talk to your doctor.

Have a query?

How Soon It Starts Working

The time required for Topzee-M Cream to start to work: The time required for Topzee-M Cream to show its action is unknown. The time for which the effects of Topzee-M Cream last: The duration of action for Topzee-M Cream is unknown.

What if you forget to take Topzee-M Cream

Apply the missed dose as soon as you can. If it is almost time for the next dose, skip the missed dose and follow your regular schedule. Do not apply an extra amount of Topzee-M Cream to make up for the missed dose.

Storage

•Store the medication at room temperature, preferably below 25°C, in a cool and dry place. •Keep the tube tightly closed when not in use to protect the medicine from moisture and air exposure.

Drug Warnings

  • Inspect the packaging: Always check the tube's protective seal before your first use. Do not use the medicine if the seal is broken or if the cream appears discolored.
  • Avoid sensitive areas: Do not apply Topzee-M Cream on your face, groin, underarms, or skin folds unless specifically instructed by your doctor, as these areas have thinner skin and are more prone to side effects.
  • Limit the treatment duration: Avoid using this cream continuously for more than two to four weeks unless your doctor advises otherwise, to prevent skin thinning or other steroid-related side effects.
  • Protect your eyes: Avoid getting the cream in or near your eyes, nose, or mouth. If accidental contact occurs, rinse thoroughly with plenty of cool water.
  • Do not cover the treated skin: Avoid wearing tight clothing or plastic wraps over the applied area, as this can increase medicine absorption and the risk of systemic side effects.
  • Monitor your skin: If your skin condition does not improve after two weeks of consistent use, or if it worsens, contact your doctor for a re-evaluation.
     

Drug-Drug Interactions

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Before starting your treatment, it is important to inform your healthcare provider about all medications you are currently using, including prescription drugs, over-the-counter medicines, herbal supplements, and other topical treatments.

Drug-Drug Interactions

Topzee-M Cream may interact with other medications, particularly those that affect the skin or blood clotting.

  • Other topical corticosteroids: Using additional steroid creams, ointments, or lotions alongside Topzee-M Cream may increase the risk of skin thinning, irritation, and excessive absorption of steroids into the bloodstream.
  • Oral anticoagulants (such as warfarin): Although miconazole is applied to the skin, some absorption may occur, which could increase the effects of anticoagulant medications and raise the risk of bleeding. Monitoring may be required in certain patients.

Drug-Disease Interactions

Certain skin conditions may be worsened by the corticosteroid component of Topzee-M Cream.

  • Untreated viral or bacterial skin infections: This medication should not be used on untreated infections such as herpes simplex, shingles, chickenpox, or bacterial skin infections, as the steroid component may mask symptoms and allow the infection to worsen.
  • Rosacea: Applying Topzee-M Cream to areas affected by rosacea may aggravate redness, irritation, and inflammation.
  • Perioral dermatitis: Use on skin affected by perioral dermatitis can worsen the condition and increase the appearance of redness, bumps, and irritation around the mouth.
  • Extensive skin damage or broken skin: Applying potent topical steroids to damaged skin may increase systemic absorption and the risk of side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

Topzee-M Cream is used to reduce swelling, itching, and redness caused by certain fungal skin infections.
No, Topzee-M Cream is not recommended to treat acne as it may worsen the condition. Topzee-M Cream is only used to reduce itching, swelling and redness caused due to certain skin infections. However, please consult a doctor before using Topzee-M Cream.
Topzee-M Cream should only be applied to the face if specifically recommended by your doctor. The skin on the face is thin and sensitive, increasing the risk of side effects such as skin thinning, irritation, or changes in skin colour. Do not use it on the face for longer than advised by your doctor, and avoid covering the treated area with dressings or bandages.
Topzee-M Cream should be used with caution in children and only under medical supervision. Children have thinner skin and absorb topical medicines more easily, increasing the risk of side effects such as adrenal suppression, Cushing's syndrome, delayed growth, weight gain, and other steroid-related effects. Always consult a doctor before using Topzee-M Cream in children.
You are recommended to use Topzee-M Cream for as long as your doctor has prescribed it. However, if the condition does not improve after 2 to 4 weeks of treatment with Topzee-M Cream, please consult a doctor.
Yes, Topzee-M Cream may increase blood sugar levels. Therefore, inform your doctor if you have diabetes before taking Topzee-M Cream and regularly monitor blood sugar levels while using Topzee-M Cream.
Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
No. Do not stop using Topzee-M Cream without consulting your doctor, even if your symptoms improve. Stopping treatment too early may worsen the condition, cause the infection to return, or lead to incomplete treatment. Continue using Topzee-M Cream for the duration prescribed by your doctor.
Topzee-M Cream contains Clobetasol (a corticosteroid) and Miconazole (an antifungal). Clobetasol works by inhibiting the release of certain chemical messengers in the body that cause redness, itching, and swelling. These chemicals are normally released when the skin reacts to allergens. On the other hand, Miconazole works by damaging fungal cell membranes, effectively killing the fungi.
The common side effects of Topzee-M Cream include dry skin, itching, irritation, redness, and a burning sensation at the site of application. Most of these side effects do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Do not use Topzee-M Cream in more than the prescribed doses or for a prolonged period, as this may cause adverse effects. Avoid wrapping or covering the treated area with bandages unless advised by your doctor. Do not apply Topzee-M Cream to broken skin or cuts. Do not swallow Topzee-M Cream; in case of accidental swallowing, contact a nearby poison control centre or consult your doctor immediately. Avoid smoking or going near open flames, as Topzee-M Cream is flammable and burns easily. Avoid contact with eyes or mucous membranes; in case of accidental contact, rinse with water immediately.
Using Topzee-M Cream for a long time or at a higher than the recommended dose can make your skin thinner or cause stretch marks. The medicine may get absorbed into the bloodstream and can lead to serious side effects, such as adrenal gland problems, hyperglycemia (high blood sugar), or problems with your eyesight. If you experience an increase in the severity of your symptoms, please consult your doctor.
Store Topzee-M Cream in a cool, dry place away from sunlight. Keep it out of reach of children.
Topzee-M Cream is contraindicated in patients with a known allergy to any of its components. If you are pregnant or a nursing mother, please consult a doctor before using Topzee-M Cream. It is not recommended for use in neonates and infants (up to 2 years) because absorption by immature skin may be enhanced, and their kidneys may be immature, leading to potential toxicity.
Many people begin to feel relief from itching and redness within a few days of starting treatment. However, you should continue using the cream for the full duration prescribed by your healthcare provider to ensure the infection is completely cleared. Talk to your doctor if you see no improvement after two weeks.
You should only use Topzee-M Cream during pregnancy if your doctor determines that the benefits outweigh the potential risks to your baby. If prescribed, it should be used for the shortest time possible on a very small area. Talk to your doctor or pharmacist before using this medicine.
Skin thinning is a serious side effect that can occur with prolonged use of strong topical steroids. If you notice your skin becoming thin, fragile, or bruising easily, stop applying the medicine and contact your doctor immediately. Talk to your doctor for an alternative treatment.
No, you should not use Topzee-M Cream to treat diaper rash. The combination of tight diapers and a warm, wet environment can lead to excessive absorption of the steroid component, which can be harmful to an infant. Talk to your doctor for safer diaper rash treatments.
If your symptoms return after you stop using Topzee-M Cream, do not restart the treatment on your own. Reusing strong topical steroids without medical supervision can worsen skin conditions or lead to steroid dependence. Talk to your doctor for a proper evaluation.

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Reference

  1. Drugs.com Clinical Review Team. Clobetasol Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Miconazole Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. U.S. Food and Drug Administration (FDA). 021535Orig1S003, 021644Orig1S003Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  4. National Health Service (NHS). Clobetasol - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Clobetasol Clobetasol. 1993. [Accessed on 04 Apr. 2019] Check here
  6. Miconazole Miconazole. 1974. [Accessed on 29 Mar. 2019] Check here
  7. Clobetasol Clobetasol. 1994. [Accessed on 04 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Building Zone-B No-6, Aagaman, Vallabhavadi,Near Westend Hotel, Gujarat Collage, Ellisbridge, Ahmedabad – 380006. Gujarat,INDIA
Other Info - TOP0467

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