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compositionComposition:DIVALPROEX-750MG
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Prescription Medicine
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DIVALPROEX-750MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trend XR 750 Tablet

Trend XR 750 Tablet is a prescription medication primarily used to treat and control various types of seizures. It is also prescribed to manage the manic phases of bipolar disorder and to prevent migraine headaches from occurring. This medication works by stabilising electrical activity in the brain to help manage these conditions.

Divalproex is available in different formulations, including delayed-release and extended-release products. These formulations are not always interchangeable on a milligram-for-milligram basis. Do not switch between different brands or release forms unless specifically instructed by your doctor.

To get the best results, you must take Trend XR 750 Tablet consistently every day at the same times as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Eating a balanced diet and keeping a regular sleep schedule can also support your treatment and improve how you feel.

While taking this medication, you may experience mild side effects such as sleepiness, dizziness, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious signs like severe abdominal pain, persistent nausea, or yellowing of your skin or eyes.

Before starting Trend XR 750 Tablet , tell your doctor if you have a history of liver disease, kidney problems, or mitochondrial disorders. Do not take this if you have active liver damage or a family history of severe liver issues, as this medication can worsen these conditions.

This medicine can interact with alcohol and certain other medications, which may cause extreme drowsiness or increase the risk of liver damage. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor, as special precautions are required for these groups.

Uses of Trend XR 750 Tablet

Trend XR 750 Tablet is used to treat and control various types of seizures. The detailed uses of Trend XR 750 Tablet are as follows:

  • Seizure disorders: Helps control and prevent various types of fits or seizures by calming overactive nerve signals in the brain.
  • Bipolar disorder: Manages manic episodes, helping to stabilise extreme mood swings, hyperactivity, and racing thoughts.
  • Migraine prevention: Reduces the frequency and severity of painful migraine headaches when taken daily as a preventive measure.
     

Key Benefits

Trend XR 750 Tablet helps manage certain neurological and mood-related conditions by stabilising abnormal electrical activity in the brain. By supporting seizure control, emotional stability, and migraine prevention, it can improve daily functioning and overall quality of life. This medicine offers several key benefits:

  • Helps Control Seizure Episodes: Trend XR 750 Tablet helps reduce the frequency and severity of seizures in people with epilepsy. By stabilising nerve activity in the brain, it lowers the likelihood of unexpected seizure episodes, helping improve safety, confidence, and independence in everyday life.
  • Supports Emotional and Mood Stability: For people with bipolar disorder, Trend XR 750 Tablet helps regulate mood fluctuations and reduce the occurrence of mood episodes. This can support more stable relationships, improved concentration, and better participation in daily activities and responsibilities.
  • Helps Prevent Migraine Attacks: Trend XR 750 Tablet can help reduce the number of migraine attacks and headache days experienced over time. By lowering the frequency of migraines, it helps minimise disruptions to work, social activities, and overall quality of life.
     
Side effects of Trend XR 750 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Include fruits, vegetables, and leafy greens rich in vitamins C and K.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Avoid tobacco products as smoking can worsen gum disease.
  • Stay hydrated by drinking water to flush bacteria and food particles.
  • Consider vitamin supplements if deficient to support gum health.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Swish with coconut oil for its antibacterial properties to reduce plaque.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Consult your dentist if gums bleed consistently.
  • Apply a cold compress to the affected area for 10 to 15 minutes multiple times a day.
  • Elevate your head while resting or sleeping to reduce fluid accumulation.
  • Drink lots of water to eliminate excess fluids.
  • Limit salty foods as they can cause water retention.
  • To stimulate lymphatic drainage, gently massage the swollen area.

Directions for Use

Always follow your doctor's exact instructions regarding your dose and schedule. Below are standard guidelines for taking this medication:

  • Swallow the tablet or capsule whole with a full glass of water.
  • Do not crush, chew, or break the medicine, as this can affect how it is released into your body and may irritate your mouth or throat.
  • Take this medicine at the exact times prescribed by your doctor to keep a steady amount in your bloodstream.
  • If you experience stomach upset, try taking your dose with food to help protect your stomach.
     

How Trend XR 750 Tablet Works

Trend XR 750 Tablet works by balancing certain natural chemicals in your brain that transmit nerve signals. When brain cells become overactive, they can trigger seizures, severe mood shifts, or migraine pain. This medicine increases the levels of a calming chemical messenger called gamma-aminobutyric acid (GABA). By boosting GABA levels, Trend XR 750 Tablet helps soothe hyperactive nerve pathways. This action stabilises electrical activity in the brain and prevents the sudden bursts that lead to medical symptoms.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Trend XR 750 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Trend XR 750 Tablet belongs to pregnancy category D. Avoid taking Trend XR 750 Tablet if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Trend XR 750 Tablet may pass into breastmilk. Consult your doctor before taking Trend XR 750 Tablet if you are breastfeeding.

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Driving

Unsafe

Trend XR 750 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Trend XR 750 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Trend XR 750 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

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Heart

Caution

Trend XR 750 Tablet can be used in cardiac patients, but requires careful monitoring.

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Geriatrics

Caution

Trend XR 750 Tablet should be used under caution in geriatric patients for conditions like bipolar mania and seizures. Please consult your physician.

What if I have taken an overdose of Trend XR 750 Tablet

Do not take more than the prescribed dose of Trend XR 750 Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep a consistent sleep schedule: Lack of sleep can trigger seizures and mood episodes, so aim for 7 to 8 hours of restful sleep every night.
  • Track your triggers: Keep a daily diary to log your meals, stress levels, and activities to identify what triggers your migraines or seizures.
  • Stay well-hydrated: Drink plenty of water throughout the day, as dehydration can worsen headaches and affect how your body processes medication.
  • Avoid alcohol entirely: Alcohol can dangerously increase sleepiness and dizziness caused by this medication and elevates the risk of liver damage.
     

Have a query?

How Soon It Starts Working

The time required for Trend XR 750 Tablet to start to work: The time required for Trend XR 750 Tablet to show its action is not clinically established.

The time for which the effects of Trend XR 750 Tablet last: The duration of action for Trend XR 750 Tablet is not clinically established.

What if you forget to take Trend XR 750 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store Trend XR 750 Tablet tablets or capsules at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the bottle tightly closed in a dry place, away from direct sunlight, high heat, and moisture. Avoid storing it in bathroom cabinets where humid

Drug Warnings

  • Monitor your mental health: Pay close attention to sudden changes in mood, anxiety, or depressive feelings, and report them to your doctor immediately.
  • Check your blood tests regularly: Your doctor may schedule routine monitoring during treatment. This commonly includes liver function tests (LFTs), a complete blood count (CBC) to monitor blood cells and platelets, and serum valproate levels to ensure the medicine remains within an appropriate therapeutic range. Do not skip these appointments.
  • Do not stop taking this medicine suddenly: Stopping abruptly can cause severe, continuous seizures that can be dangerous. Always talk to your doctor before making any changes.
  • Avoid driving or operating machinery: Until you know exactly how this medicine affects you, avoid tasks that require alertness, as it can cause significant drowsiness.
  • Inspect your tablets: Before taking your dose, ensure the tablets are intact and have not been exposed to moisture, which can cause them to become sticky or degrade.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Other anti-seizure medicines (e.g., phenytoin or carbamazepine): Taking Trend XR 750 Tablet with certain anticonvulsants may alter the blood levels of either medicine, potentially reducing seizure control or increasing the risk of side effects. Your doctor may need to monitor treatment response and adjust doses accordingly.
  • Blood thinners (e.g., aspirin or warfarin): Combining Trend XR 750 Tablet with anticoagulants or antiplatelet medicines may increase the risk of bruising, bleeding, or prolonged bleeding times. Closer monitoring may be required during treatment.

Drug-Food Interactions

  • Alcohol: Do not consume alcohol while taking Trend XR 750 Tablet . Alcohol can significantly increase drowsiness, impair concentration and coordination, and may increase the risk of liver-related side effects.

Drug-Disease Interactions

  • Liver disease: Do not use Trend XR 750 Tablet if you have active liver disease or a history of severe liver impairment. This medication can cause serious liver injury, and patients with pre-existing liver conditions may be at increased risk of severe complications.
  • Mitochondrial disorders (e.g., Alpers-Huttenlocher syndrome): Patients with certain inherited mitochondrial disorders are at a substantially increased risk of acute liver failure when taking Trend XR 750 Tablet . Use is contraindicated in these individuals.
  • Urea cycle disorders: Do not take Trend XR 750 Tablet if you have a urea cycle disorder. The medicine may increase ammonia levels in the blood, potentially leading to serious neurological complications and hyperammonaemia.
     
Sodium ValproateSodium phenylbutyrate
Critical

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Trend XR 750 Tablet:
Combining Sodium phenylbutyrate and Trend XR 750 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Trend XR 750 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Meropenam and Trend XR 750 Tablet together can reduce the effect of Trend XR 750 Tablet.

How to manage the interaction:
Co-administration of Meropenam and Trend XR 750 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Lithium with Trend XR 750 Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Trend XR 750 Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Teriflunomide and Trend XR 750 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Trend XR 750 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Ketamine and Trend XR 750 Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Trend XR 750 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Leflunomide and Trend XR 750 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Trend XR 750 Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Vorinostat with Trend XR 750 Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Trend XR 750 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Trend XR 750 Tablet:
Using buprenorphine together with Trend XR 750 Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Trend XR 750 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trend XR 750 Tablet:
Co-administration of Trend XR 750 Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Trend XR 750 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trend XR 750 Tablet:
The combined use of Ertapenem and Trend XR 750 Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Trend XR 750 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Trend XR 750 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

Trend XR 750 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Trend XR 750 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Trend XR 750 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Trend XR 750 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Trend XR 750 Tablet only after consulting a doctor.

Trend XR 750 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

No, you should not stop taking Trend XR 750 Tablet without consulting your doctor, even if you feel well or your seizures have stopped. Abrupt discontinuation can worsen your condition and may trigger severe or continuous seizures. If treatment needs to be stopped, your doctor will gradually reduce the dose to minimize risks.

Before taking Trend XR 750 Tablet , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

Trend XR 750 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Trend XR 750 Tablet .

Topiramate (anticonvulsant) should not be taken along with Trend XR 750 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

Trend XR 750 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Yes, Trend XR 750 Tablet can cause sleepiness, tiredness, dizziness, or drowsiness, especially when starting treatment or after a dose increase. Avoid driving or operating machinery until you know how the medicine affects you. If excessive drowsiness persists or becomes troublesome, consult your doctor.

Yes, Trend XR 750 Tablet may cause hair loss or temporary hair thinning in some people. This side effect is often reversible with continued treatment or after dose adjustment. If you notice significant hair loss or if it concerns you, consult your doctor for advice.

Yes, Trend XR 750 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Trend XR 750 Tablet , seeking medical attention is crucial.

Avoid consumption of alcohol while taking Trend XR 750 Tablet as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Trend XR 750 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of Trend XR 750 Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Trend XR 750 Tablet , it's crucial to seek immediate medical attention.

Trend XR 750 Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

No, taking Trend XR 750 Tablet during pregnancy carries a high risk of birth defects and developmental delays in the baby. You must use effective birth control while taking this medicine. If you are planning a pregnancy or become pregnant, talk to your doctor immediately.

Yes, weight gain is a known side effect for some people taking this medicine. Managing your diet and staying physically active can help control this, but if weight gain becomes a concern, talk to your doctor.

It may take several weeks of consistent use before you notice the full benefits of Trend XR 750 Tablet in preventing seizures or stabilising your mood. Do not stop taking it if you do not see immediate results, and talk to your doctor.

No, you should not crush, chew, or break these tablets because they are specially designed to release the medicine slowly into your body. Crushing them can cause too much medicine to be released at once. If you struggle to swallow pills, talk to your doctor.

Generally, moderate caffeine intake is fine, but large amounts can trigger migraines or interfere with your sleep, which might affect your condition. If you notice a connection between caffeine and your symptoms, talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

517, 5th floor, Tulsiani Chambers, Nariman Point, Mumbai, Maharashtra, 400021.
Other Info - TRE0014
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