Trexo 5 Tablet 10's
MRP ₹97.5
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Composition :
METHOTREXATE-5MG
Manufacturer/Marketer :
Indiabulls Pharmaceuticals Pvt Ltd
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Trexo 5 Tablet
Trexo 5 Tablet is used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis.
It is also used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas (cancer that starts in the lymphatic system).
Trexo 5 Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time.
Trexo 5 Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. It treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.
In some cases, Trexo 5 Tablet may cause side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, and lowered resistance to infections. You are advised to talk to your doctor if you experience these side effects persistently.
Do not take Trexo 5 Tablet if you are pregnant or breastfeeding. Trexo 5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.
Uses of Trexo 5 Tablet
Trexo 5 Tablet is used in the treatment of rheumatoid arthritis, psoriatic arthritis, psoriasis, and cancer. The detailed uses of Trexo 5 Tablet are as follows:
- Treatment of Rheumatoid Arthritis: Trexo 5 Tablet is commonly prescribed to manage the symptoms of rheumatoid arthritis, reducing inflammation and pain in the joints.
- Management of Psoriasis: Trexo 5 Tablet can be used to treat severe psoriasis, helping to clear the skin and reduce scaling.
- Chemotherapy for Certain Cancers: Trexo 5 Tablet may be utilised in lower doses as part of a chemotherapy treatment regimen for specific types of cancers, such as osteosarcoma or certain leukaemias.
- Autoimmune Disease Management: Trexo 5 Tablet is sometimes used to manage other autoimmune conditions, where it helps to suppress the immune system and reduce abnormal immune responses.
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Directions for Use
- Take Trexo 5 Tablet with food or as advised by your doctor.
- It is advised to take Trexo 5 Tablet once a week; however, follow your doctor’s recommendation regarding the dosage and duration.
- Swallow Trexo 5 Tablet as a whole with a glass of water.
- Do not crush, break, or chew it.
Medicinal Benefits
- Trexo 5 Tablet is used to treat rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain in joints. It slows or prevents joint damage and disease progression.
- It helps treat psoriasis by suppressing the overactive immune response that causes skin cell overgrowth. It reduces scaling, redness, and thickness of psoriatic plaques.
- Trexo 5 Tablet is used in the management of breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas.
- It works by interfering with DNA synthesis, thereby stopping or slowing the growth of cancer cells.
- It helps manage inflammation in the digestive tract.
- Provides disease control by modulating the immune system.
- Offers long-term relief from autoimmune and inflammatory conditions.
- Improves treatment outcomes in certain cancers by preventing abnormal cell growth.
How Trexo 5 Tablet Works
Trexo 5 Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Trexo 5 Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. Trexo 5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.
Storage
• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
What if I have taken an overdose of Trexo 5 Tablet
Do not take more than the prescribed dose of Trexo 5 Tablet as it may cause overdose leading to severe toxic reactions. The symptoms of overdose include unusual weakness, nausea, vomiting, easy bruising or bleeding, mouth sores, decreased urination, coughing up blood or vomit that looks like coffee grounds and black or bloody stools. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
Drug Warnings
- Do not take Trexo 5 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding.
- Talk to your doctor before taking Trexo 5 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs.
- Trexo 5 Tablet may cause dizziness and fatigue, so drive only if you are alert.
- Take Trexo 5 Tablet exactly as directed by the doctor, as it may cause serious problems if not taken in the dose and duration prescribed by the doctor.
- Stop taking Trexo 5 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.
- Inform your doctor if you are taking any other medicines, including supplements and herbal products.
Drug-Drug Interactions
MethotrexateEtretinate
Critical
Severe
Drug-Drug Interactions
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MethotrexateEtretinate
Critical
How does the drug interact with Trexo 5 Tablet:
Co-administration of Etretinate with Trexo 5 Tablet may increase the risk or severity of liver problems.
How to manage the interaction:
Taking Etretinate with Trexo 5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
Co-administration of Etretinate with Trexo 5 Tablet may increase the risk or severity of liver problems.
How to manage the interaction:
Taking Etretinate with Trexo 5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with amoxicillin can increase the levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and amoxicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
Co-administration of Trexo 5 Tablet with amoxicillin can increase the levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and amoxicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
Severe
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with cladribine can increase the risk or severity of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between cladribine and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
Co-administration of Trexo 5 Tablet with cladribine can increase the risk or severity of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between cladribine and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
Coadministration of Trexo 5 Tablet with piroxicam can increase the levels and side effects.
How to manage the interaction:
Although there is a possible interaction between piroxicam and Trexo 5 Tablet, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
Coadministration of Trexo 5 Tablet with piroxicam can increase the levels and side effects.
How to manage the interaction:
Although there is a possible interaction between piroxicam and Trexo 5 Tablet, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with Lansoprazole can increase the blood levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Co-administration of Trexo 5 Tablet with Lansoprazole can increase the blood levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet and esomeprazole can increase the blood levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although taking Esomeprazole with Trexo 5 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
Co-administration of Trexo 5 Tablet and esomeprazole can increase the blood levels and side effects of Trexo 5 Tablet.
How to manage the interaction:
Although taking Esomeprazole with Trexo 5 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
MethotrexateNafcillin
Severe
How does the drug interact with Trexo 5 Tablet:
Coadministration of Trexo 5 Tablet with nafcillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between nafcillin and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, nausea, vomiting, mouth ulcers, sore throat, body aches, or other flu-like symptoms, consult the doctor.
Coadministration of Trexo 5 Tablet with nafcillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between nafcillin and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, nausea, vomiting, mouth ulcers, sore throat, body aches, or other flu-like symptoms, consult the doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
The combined use of entecavir with Trexo 5 Tablet may increase levels of Entecavir, and increase the risk or severity of kidney damage.
How to manage the interaction:
Although there is a possible interaction between entecavir and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
The combined use of entecavir with Trexo 5 Tablet may increase levels of Entecavir, and increase the risk or severity of kidney damage.
How to manage the interaction:
Although there is a possible interaction between entecavir and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateOxacillin
Severe
How does the drug interact with Trexo 5 Tablet:
Coadministration of Trexo 5 Tablet with oxacillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between oxacillin and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
Coadministration of Trexo 5 Tablet with oxacillin can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between oxacillin and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
Severe
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with etanercept can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between etanercept and Trexo 5 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
Co-administration of Trexo 5 Tablet with etanercept can increase the risk of developing serious infections.
How to manage the interaction:
Although there is a possible interaction between etanercept and Trexo 5 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
Arthritis:
- Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help in improving joint flexibility and pain management.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Acupuncture, massage and physical therapy may also be helpful.
- Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
- Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
- Avoid smoking and alcohol consumption.
Psoriasis:
- Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
- Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
- Avoid processed foods, refined sugars, and fatty foods.
- Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
- Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
- Reducing stress and maintaining a good sleep cycle would be helpful.
- Avoiding getting in contact with harsh soaps, detergents and rough fabrics.
Cancer:
- Consume a healthy diet and exercise regularly to maintain a proper weight.
- Avoid smoking and alcohol consumption.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
- Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
- Get optimal sleep; rest well.
Habit Forming
No
Therapeutic Class
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Alcohol
Unsafe
You are recommended to avoid alcohol consumption while taking Trexo 5 Tablet .
Pregnancy
Unsafe
Trexo 5 Tablet may cause serious birth defects. It is not recommended to take Trexo 5 Tablet while you are pregnant.
Breast Feeding
Unsafe
Trexo 5 Tablet passes into breast milk. Avoid breastfeeding whilst on treatment with Trexo 5 Tablet .
Driving
Caution
Trexo 5 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.
Liver
Caution
Do not take Trexo 5 Tablet if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking Trexo 5 Tablet .
Kidney
Caution
Please consult your doctor if you have kidney impairment before taking Trexo 5 Tablet .
Children
Caution
Trexo 5 Tablet should be used with caution in children and only if prescribed by the doctor.
Heart
Trexo 5 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.
Geriatrics
Safe if prescribed
Trexo 5 Tablet can be safely used in elderly patients with proper monitoring and individualised care.
FAQs
Country of origin
INDIA
Manufacturer/Marketer address
Indiabulls Pharmaceuticals Limited Is M €“ 62 & 63, First Floor, Connaught Place, New Delhi €“ 11000
Other Info - TRE0263
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Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdfhttp://www.hpra.ie/img/uploaded/swedocuments/pil-2167015-11052016181932-635985875740562500.pdf
- https://www.cipla.com/sites/default/files/Methotrexate%202.5%20mg%20%E2%80%93%20Patient%20Card%20-%20Risk%20Minimisation%20Information%20for%20Patients.pdf
- https://www.stmarkshospital.nhs.uk/wp-content/uploads/2014/07/IBD_methotrexate_leaflet.pdf
- https://www.drugs.com/methotrexate.html
- https://medlineplus.gov/druginfo/meds/a682019.html
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