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Trisertain 40 Tablet 10's
Trisertain 40 Tablet 10's
Trisertain 40 Tablet 10's
Trisertain 40 Tablet 10's
Trisertain 40 Tablet 10's

Trisertain 40 Tablet is used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. It works by relaxing and widening the narrowed blood vessels. It reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Also, it removes extra water/fluid and certain electrolyte overload from the body. Thus, it lowers fluid overload and high blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke. In some cases, it may cause common side effects such as nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, headache, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MG+OLMESARTAN MEDOXOMIL-40MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trisertain 40 Tablet

Trisertain 40 Tablet is an oral prescription medication used to treat high blood pressure (hypertension). It is typically prescribed when a single medicine or a dual-combination therapy is not enough to control your blood pressure. Lowering high blood pressure helps decrease your risk of serious cardiovascular events like strokes or heart attacks.

For this medication to work effectively, you must take Trisertain 40 Tablet consistently every day, exactly as your doctor prescribes. You can take it with or without food, but taking it at the same time each day helps maintain steady blood pressure levels. Incorporating a low-sodium diet and regular physical activity can further support your blood pressure goals.

While taking Trisertain 40 Tablet , some patients may experience mild side effects such as dizziness, headache, or ankle swelling. However, if you experience severe symptoms like chest pain, rapid heartbeat, or signs of an allergic reaction, contact your healthcare provider immediately. Always monitor how you feel and report any unusual changes to your doctor.

Do not take this if you are pregnant, as it can cause serious harm or death to an unborn baby. You should also talk to your doctor before starting Trisertain 40 Tablet if you have kidney disease, liver damage, diabetes, or severe electrolyte imbalances. Your healthcare provider will determine if this triple-combination therapy is safe for your specific health profile.

Trisertain 40 Tablet can interact with other blood pressure drugs, potassium supplements, and certain pain relievers, which may cause your blood pressure to drop too low or affect kidney function. Drinking alcohol while taking this medicine can also worsen dizziness and lightheadedness. Pregnant or breastfeeding individuals should not use this medication, and elderly patients should consult their doctor for careful monitoring.

Uses of Trisertain 40 Tablet

Trisertain 40 Tablet is prescribed to help manage high blood pressure and reduce the health risks associated with uncontrolled hypertension. Common uses include:

  • High Blood Pressure (Hypertension): Trisertain 40 Tablet helps lower elevated blood pressure when other single or dual-drug treatments fail to achieve target levels.
  • Reduction of Cardiovascular Risks: By successfully controlling blood pressure, Trisertain 40 Tablet helps lower the risk of experiencing life-threatening events such as strokes and heart attacks.

 

Key Benefits

By combining three complementary blood pressure medicines into a single treatment, Trisertain 40 Tablet provides several important benefits, including:

  • Triple-Action Blood Pressure Control: Uses three different mechanisms to help lower and maintain healthy blood pressure levels.
  • Convenient Once-Daily Treatment: Combines three active ingredients into a single tablet, reducing the number of medicines that need to be taken each day.
  • Reduces Cardiovascular Risk: Helps lower the likelihood of complications associated with uncontrolled hypertension, including heart attack and stroke.
  • Protects Vital Organs: Supports the long-term health of the heart, kidneys, blood vessels, and other organs that can be damaged by persistently high blood pressure.
  • Supports Daily Well-Being: Helps maintain stable blood pressure control, allowing you to carry out daily activities with greater confidence and peace of mind.
     
Side effects of Trisertain 40 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Trisertain 40 Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Trisertain 40 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Trisertain 40 Tablet Works

Trisertain 40 Tablet works through the combined actions of its three active ingredients, which target blood pressure in different ways to help relax blood vessels and reduce fluid retention. Olmesartan medoxomil is an angiotensin receptor blocker (ARB). It works by blocking a natural substance in the body that tightens blood vessels, allowing the blood vessels to relax and widen, which lowers blood pressure. Amlodipine belongs to a class called calcium channel blockers. It relaxes the muscles of your heart and blood vessels, preventing them from constricting and making it easier for blood to flow throughout your body. Hydrochlorothiazide is a diuretic, often referred to as a 'water pill.' It helps your kidneys remove excess salt and water from your body through urine, which reduces the overall volume of fluid in your blood vessels and lowers your blood pressure.
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Alcohol

Unsafe

You are recommended not to consume alcohol and Trisertain 40 Tablet to avoid unpleasant side effects like drowsiness, dizziness, and liver damage.

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Pregnancy

Unsafe

Trisertain 40 Tablet is not recommended during pregnancy as it contains Olmesartan, which is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).

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Breast Feeding

Unsafe

Trisertain 40 Tablet is known to pass breast milk, but its effect on the baby is unknown. So, before breastfeeding, let your doctor know about this. Either you need to stop breastfeeding for using Trisertain 40 Tablet or stop taking Trisertain 40 Tablet .

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Driving

Caution

Drive with caution; Trisertain 40 Tablet usually causes drowsiness and affects driving ability.

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Liver

Caution

Trisertain 40 Tablet to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Trisertain 40 Tablet to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Children

Caution

Efficacy and safety of Trisertain 40 Tablet have not been established in children. If prescribed, it should be strictly under medical supervision and only if the benefits outweigh the harm.

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Heart

Caution

Trisertain 40 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Trisertain 40 Tablet .

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Geriatrics

Caution

Trisertain 40 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Trisertain 40 Tablet .

What if I have taken an overdose of Trisertain 40 Tablet

If you suspect an overdose or experience severe dizziness, fainting, or an unusually fast or slow heart rate after taking too much medication, seek immediate emergency medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Limit Sodium Intake: Reduce your daily salt intake by avoiding processed foods and choosing fresh ingredients, as sodium can raise blood pressure and counteract the effects of Trisertain 40 Tablet .
  • Stay Hydrated Carefully: While hydrochlorothiazide is a diuretic that removes fluid, it is important to maintain a healthy balance of fluids. Drink a moderate amount of water throughout the day, and discuss fluid guidelines with your doctor.
  • Monitor Potassium Levels: Olmesartan can sometimes increase potassium levels, while hydrochlorothiazide can decrease them. Consult your healthcare provider before using salt substitutes containing potassium or taking potassium supplements.
  • Engage in Regular Moderate Exercise: Aim for at least 30 minutes of moderate cardiovascular exercise, like brisk walking, most days of the week, with your doctor's approval.
  • Monitor Your Blood Pressure: Keep a log of your blood pressure readings at home to share with your doctor during checkups.
     

Have a query?

How Soon It Starts Working

  • The time required for Trisertain 40 Tablet to start to work: The time required for Trisertain 40 Tablet to show its action is unknown.
  • The time for which the effects of Trisertain 40 Tablet last: The effect of Trisertain 40 Tablet lasts for 24 hours.

What if you forget to take Trisertain 40 Tablet

If you miss a dose of Trisertain 40 Tablet , take it as soon as you remember on that day. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Trisertain 40 Tablet tablets at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original container to protect it from light and moisture. Do not store it in the bathroom cabinet where humidity levels can change.

Drug Warnings

  • Rise slowly from sitting or lying positions: This medication can cause a sudden drop in blood pressure when you stand up, leading to dizziness or fainting.
  • Check your skin regularly: Hydrochlorothiazide can make your skin more sensitive to sunlight. Wear sunscreen, protective clothing, and limit direct sun exposure to prevent severe sunburns.
  • Get routine blood work: Your doctor will need to perform periodic blood tests to check your kidney function and monitor your electrolyte levels (such as potassium, sodium, and magnesium).
  • Avoid driving if dizzy: Do not drive, operate machinery, or perform tasks requiring alertness until you know how Trisertain 40 Tablet affects you.
  • Inform your surgeon: If you are scheduled for any surgery or dental procedure, let your surgeon or dentist know you are taking Trisertain 40 Tablet , as it can interact with anesthetics.

 

Drug-Drug Interactions

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Drug-Drug Interactions

Trisertain 40 Tablet can interact with medicines that affect kidney function, potassium levels, blood pressure control, or lithium concentrations, including:

  • Lithium: Taking Trisertain 40 Tablet with lithium may increase lithium levels in your blood to dangerous levels, leading to toxicity.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Pain relievers like ibuprofen or naproxen can reduce the blood-pressure-lowering effect of Trisertain 40 Tablet and increase the risk of kidney damage.
  • Potassium Supplements or Potassium-Sparing Diuretics: Combining these with olmesartan can raise blood potassium levels too high, affecting your heart rhythm.
  • Other Blood Pressure Medications: Taking other antihypertensives alongside Trisertain 40 Tablet can significantly increase the risk of excessively low blood pressure and kidney issues.

Drug-Food Interactions

Certain foods and beverages may affect blood pressure control or alter the way some components of this medicine work in the body, including:

  • Alcohol: Drinking alcohol while taking Trisertain 40 Tablet can amplify blood-pressure-lowering effects, increasing dizziness, lightheadedness, and the risk of fainting.
  • Grapefruit and Grapefruit Juice: Grapefruit can interact with amlodipine, potentially increasing the level of the medication in your body and raising the risk of side effects.

Drug-Disease Interactions

Trisertain 40 Tablet may require special caution in people with conditions affecting kidney function, liver function, blood sugar control, or urine production, including:

  • Kidney Disease: Severe kidney impairment may require caution, as the diuretic component may lose efficacy and worsen kidney function.
  • Liver Damage: Because some components are processed by the liver, patients with liver issues must be closely monitored to prevent medication buildup.
  • Diabetes: The hydrochlorothiazide component may affect blood sugar control. Your doctor may need to adjust your diabetes medications.
  • Anuria: Do not take Trisertain 40 Tablet if you are unable to pass urine, as the diuretic component will not work and can be dangerous.
     
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilCisapride
Critical
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilDofetilide
Critical

Drug-Drug Interactions

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Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilCisapride
Critical
How does the drug interact with Trisertain 40 Tablet:
Taking Cisapride and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Trisertain 40 Tablet together is generally avoided as it can possibly result in an interaction, but it can be taken if advised by your doctor. However, consult the doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without a doctor's advice.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilDofetilide
Critical
How does the drug interact with Trisertain 40 Tablet:
Taking Dofetilide and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Trisertain 40 Tablet and Hydrochlorothiazide is not recommended as it can result in an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilDantrolene
Critical
How does the drug interact with Trisertain 40 Tablet:
Using Trisertain 40 Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Trisertain 40 Tablet with Dantrolene can cause an interaction, but it can be taken if prescribed by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilAliskiren
Critical
How does the drug interact with Trisertain 40 Tablet:
Using aliskiren together with olmesartan may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Olmesartan medoxomil with Aliskiren is not recommended as it can cause an interaction, but it can be taken if advised by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or a slow or irregular heartbeat. Do not stop using any medications without consulting a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilEnzalutamide
Severe
How does the drug interact with Trisertain 40 Tablet:
Using a combination of Trisertain 40 Tablet and enzalutamide may drastically lower amlodipine blood levels, making the medicine less effective.

How to manage the interaction:
Taking Trisertain 40 Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilArsenic trioxide
Severe
How does the drug interact with Trisertain 40 Tablet:
Co-administration of Arsenic trioxide and Trisertain 40 Tablet can increase the risk of an irregular heart rhythm, which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Arsenic trioxide and Trisertain 40 Tablet together is avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, consult the doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, fast heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not stop using any medications without a doctor's advice.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilRifapentine
Severe
How does the drug interact with Trisertain 40 Tablet:
Coadministration of Trisertain 40 Tablet and Rifapentine may significantly reduce the blood levels of amlodipine, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between Trisertain 40 Tablet and Rifapentine, but it can be taken if prescribed by a doctor. If you have any symptoms, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilLithium
Severe
How does the drug interact with Trisertain 40 Tablet:
Taking lithium with Trisertain 40 Tablet may significantly increase the blood levels of lithium.

How to manage the interaction:
Although taking Trisertain 40 Tablet alongside lithium can lead to interaction, they can be taken if prescribed by a doctor. However, if you develop sleepiness, dizziness, confusion, loose stools, vomiting, muscular weakness, muscle incoordination, a shaking sensation, blurred vision, ringing in the ears, excessive thirst, and/or increased urination, consult a doctor. Do not stop using any medications without talking to a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilRifabutin
Severe
How does the drug interact with Trisertain 40 Tablet:
Using Trisertain 40 Tablet and rifabutin together may lower amlodipine blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Trisertain 40 Tablet with rifabutin, it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
Amlodipine + Hydrochlorothiazide + Olmesartan medoxomilLisinopril
Severe
How does the drug interact with Trisertain 40 Tablet:
Coadministration of Amlodipine, Hydrochlorothiazide, and Olmesartan medoxomil with lisinopril may increase potassium levels in the blood.

How to manage the interaction:
Although taking Amlodipine, Hydrochlorothiazide, and Olmesartan medoxomil together with lisinopril may lead to an interaction, it can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.50MG+OLMESARTAN MEDOXOMIL-40MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.50MG+OLMESARTAN MEDOXOMIL-40MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Trisertain 40 Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Trisertain 40 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Trisertain 40 Tablet is used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body.
Trisertain 40 Tablet is a combination of three‚ medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil relaxes and widens the narrowed blood vessels. Amlodipine reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Trisertain 40 Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.
It is unlikely that Trisertain 40 Tablet affects fertility in men or women. However, in some cases, some water pills like hydrochlorothiazide may lead to erectile dysfunction. For the best advice, please consult your doctor.
Please inform your doctor before surgery if you are taking Trisertain 40 Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anesthesia.
Do not use Trisertain 40 Tablet if you are pregnant, planning for pregnancy, or unable to urinate. If you have diabetes and taking Trisertain 40 Tablet with other blood pressure-lowering pills like aliskiren, immediately stop taking both together and consult a doctor.
Trisertain 40 Tablet can be taken with or without food or as advised by the doctor.
To control high blood pressure, it’s important to follow a balanced diet that includes proteins, whole grains, and fiber-rich fruits and vegetables. Limit your intake of carbohydrates, salt, and sugar. Before making any changes to your diet or eating habits, consult your doctor. Regular exercise and weight loss are also recommended. Avoid smoking and drinking.
You may feel dizzy after taking Trisertain 40 Tablet as it is one of its side effects. Avoid driving if you feel dizzy. This condition doesn’t require any medical treatment as it will gradually reduce over time. Consult your doctor, if the condition persists longer.
Trisertain 40 Tablet does not usually cause weight gain. Change your lifestyle and maintain a balanced diet if you observe any changes in your weight. However, in rare cases, chronic diarrhea with weight loss may occur. If the patient experiences diarrhea while taking Trisertain 40 Tablet and the cause is unknown, consult a doctor.
Trisertain 40 Tablet includes side effects such as painful joints, fast heartbeat, skin rash or itchiness, chest tightness, shortness of breath, weak muscles, swelling of feet, hands, or ankles. Please, consult your doctor if you experience any of these side effects.
Take the Trisertain 40 Tablet whole with a glass of water; do not crush or chew it. To help you remember, try to take it at the same time every day.
Before taking Trisertain 40 Tablet , inform your doctor if you have kidney, liver or heart disease, diabetes, or asthma. Also, let your doctor know about all the medications you might be taking.
You are recommended to be cautious while driving or operating machinery after taking Trisertain 40 Tablet as it may cause drowsiness which affects the driving ability.
Inform your doctor about all the medications you are currently taking, as Trisertain 40 Tablet may interact with other drugs, potentially causing harmful reactions. It may interact with medications such as antidepressants (lithium), heart rhythm drugs (digoxin), blood thinners (aspirin), antidiabetics (metformin, insulin), erectile dysfunction treatments (sildenafil), cholesterol-lowering drugs (simvastatin), immune-suppressants (cyclosporine), other anti-hypertensives (atenolol), pain relievers (ibuprofen), and ulcer medications (carbenoxolone).
No, you should not take Trisertain 40 Tablet if you are pregnant or planning to conceive. The olmesartan component can cause serious harm or even death to an unborn baby, especially during the second and third trimesters. If you suspect you are pregnant, stop taking the medication and talk to your doctor immediately.
Trisertain 40 Tablet lowers your blood pressure, which can sometimes cause a temporary drop in blood supply to your brain when you change positions quickly. To prevent this, try rising slowly from a sitting or lying position. If the dizziness persists or causes fainting, talk to your doctor.
It is highly recommended to limit or avoid alcohol while taking Trisertain 40 Tablet . Alcohol can expand your blood vessels, which combined with this medication can cause your blood pressure to drop too low, resulting in severe dizziness or fainting.
Yes, amlodipine, one of the active ingredients in Trisertain 40 Tablet , can cause fluid retention leading to mild swelling in your ankles or feet. If you notice sudden, painful, or severe swelling, talk to your doctor.
Because Trisertain 40 Tablet contains a diuretic (water pill) that increases urination, it is generally best to take it in the morning to avoid waking up during the night to use the bathroom. However, you should follow your doctor's specific advice on when to take your dose.
You should avoid consuming large amounts of grapefruit or grapefruit juice, as it can raise levels of amlodipine in your body. Additionally, avoid using potassium-based salt substitutes without consulting your healthcare provider first.
No, you should not stop taking Trisertain 40 Tablet even if you feel completely fine and your blood pressure readings are normal. High blood pressure often has no symptoms, and stopping the medicine can cause your blood pressure to spike dangerously.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8529 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. National Center for Biotechnology Information (NCBI). Pmc1994014 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Amlodipine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. National Health Service (NHS). Amlodipine - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  6. Olmesartan medoxomil, amlodipine, hydrochlorothiazide. 2010. [Accessed on 11 Apr. 2019] Check here
  7. Hydrochlorothiazide, olmesartan medoxomil, amlodipine besilate. 2018. [Accessed on 11 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - TRI1412

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