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compositionComposition:TRETINOIN-0.04%W/W
prescription
Prescription Medicine
info
Trunex MS Aqueous Gel 15 gm
Trunex MS Aqueous Gel 15 gm
Trunex MS Aqueous Gel 15 gm

Trunex MS Aqueous Gel is used to treat acne (pimples) and sun-damaged skin. It contains Tretinoin, (a form of vitamin A) that loosens and unblocks pores on the skin's surface by reducing the oil secretion in the skin. This prevents the formation of pimples, whiteheads, and blackheads. Some people may experience side effects such as dry skin, peeling, redness, burning, itching, or stinging sensation of the skin. Avoid sun exposure while using this medicine, as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use a sunscreen lotion while going out to protect your skin from sunburn.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRETINOIN-0.04%W/W

Manufacturer/Marketer :

Klm Laboratories Pvt Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trunex MS Aqueous Gel

Trunex MS Aqueous Gel is a prescription topical treatment primarily used to clear acne breakouts and address skin concerns like fine wrinkles and dark spots. By encouraging the rapid renewal of skin cells, this medication helps to keep pores clear and improve overall skin texture. It is a highly effective, dermatologist-recommended solution for maintaining a smoother and clearer complexion.

To achieve the best results, you must use Trunex MS Aqueous Gel consistently and exactly as directed by your healthcare provider, typically applying it in the evening. It should always be applied to clean, completely dry skin to minimise irritation. Combining this medication with daily sun protection and a gentle, hydrating skincare routine will significantly support your progress and protect your skin barrier.

While using this medicine, you may experience mild temporary side effects, including dryness, redness, and peeling as your skin adjusts. These reactions are usually manageable, but you should contact your doctor right away if you experience severe burning, swelling, or blistering of the skin.

Do not use this medicine if you are pregnant or planning to become pregnant, as topical retinoids can pose serious risks during pregnancy. You should also talk to your doctor before starting Trunex MS Aqueous Gel if you have sensitive skin conditions such as eczema or rosacea or if you currently have a severe sunburn.

Before starting your treatment, let your doctor know if you are using other topical products containing peeling agents like salicylic acid or benzoyl peroxide, as combining them can cause severe skin irritation. If you are breastfeeding or are an older adult, talk to your doctor or pharmacist to ensure that this treatment is safe and appropriate for you.

Uses of Trunex MS Aqueous Gel

Trunex MS Aqueous Gel is used to clear acne breakouts and address skin concerns like fine wrinkles and dark spots. The detailed uses of Trunex MS Aqueous Gel are as follows:

  • Acne vulgaris: Trunex MS Aqueous Gel helps clear active pimples, blackheads, and whiteheads while preventing new blemishes from forming deep within the pores.
  • Fine wrinkles: Trunex MS Aqueous Gel improves skin texture and gradually smooths out superficial fine lines by accelerating the removal of older skin cells.
  • Hyperpigmentation: Trunex MS Aqueous Gel helps fade dark spots, sun spots, and uneven skin colouration by promoting a faster turnaround of surface skin cells.

Key Benefits

Trunex MS Aqueous Gel helps manage acne and improve overall skin appearance by targeting the underlying causes of breakouts and supporting healthy skin renewal. With regular use, this medicine offers several key benefits:

  • Helps Reduce Acne Breakouts: Trunex MS Aqueous Gel works to reduce the formation of pimples, blackheads, and other acne lesions by addressing the factors that contribute to clogged pores and inflammation. This helps promote clearer skin and reduces the frequency of new breakouts.
  • Supports Skin Healing and Mark Reduction: By encouraging skin cell turnover, this medicine helps fade post-acne marks and dark spots over time. Regular use can contribute to a more even-looking complexion and improved skin texture.
  • Promotes Smoother, Healthier-Looking Skin: Trunex MS Aqueous Gel supports the natural renewal of the skin's surface, helping to improve overall skin smoothness and appearance. Continued treatment may enhance skin tone and texture, contributing to healthier-looking skin and greater confidence.
Side effects of Trunex MS Aqueous Gel 15 gm
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Sunburns can occur commonly. Cover the area that is affected to avoid extended exposure.
  • Apply a clean, dampened towel to the affected skin for relief.
  • Take a cool bath by adding baking soda to water.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet that heals the allergy or burns.
  • Apply a skin-calming lotion, gel or moisturiser frequently.

Directions for Use

Always follow your doctor's exact instructions when using Trunex MS Aqueous Gel. For safe and effective topical application, follow these steps:

  • Wash your hands thoroughly before applying the medicine.
  • Gently wash the affected skin with a mild, non-medicated cleanser and pat it dry with a clean towel.
  • Wait 20 to 30 minutes to ensure your skin is completely dry, as applying the medicine to damp skin can cause severe irritation.
  • Apply a small, pea-sized amount of Trunex MS Aqueous Gel to cover the entire affected area, smoothing it gently into the skin while avoiding your eyes, lips, and the creases of your nose.
  • Wash your hands immediately after application to prevent transferring the medicine to highly sensitive areas.

How Trunex MS Aqueous Gel Works

Trunex MS Aqueous Gel works at a cellular level by speeding up your skin's natural renewal process. Normally, skin cells take several weeks to mature, rise to the surface, and shed. This medicine accelerates this cycle, causing old cells to shed more rapidly so that new, healthy cells can take their place. By increasing cell turnover, Trunex MS Aqueous Gel prevents dead skin cells and natural oils from sticking together and blocking your pores. Keeping the pores clear prevents acne from developing. This rapid shedding process also pushes damaged, pigmented, or wrinkled outer skin cells away, revealing fresher and more evenly textured skin underneath.
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Alcohol

Caution

Interaction of alcohol with Trunex MS Aqueous Gel is unknown. Please consult a doctor before consuming alcohol while using Trunex MS Aqueous Gel.

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Pregnancy

Unsafe

Trunex MS Aqueous Gel is Category C pregnancy drug and is considered unsafe for pregnant women. Therefore, if you are pregnant, inform your doctor before using Trunex MS Aqueous Gel.

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Breast Feeding

Caution

It is unknown whether Trunex MS Aqueous Gel is excreted in human milk. Please consult a doctor before using Trunex MS Aqueous Gel while breastfeeding.

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Driving

Safe if prescribed

Trunex MS Aqueous Gel usually does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Trunex MS Aqueous Gel in patients with liver problems, please consult a doctor.

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Kidney

Caution

If you have any concerns regarding the use of Trunex MS Aqueous Gel in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Trunex MS Aqueous Gel is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Exercise caution while taking Trunex MS Aqueous Gel, if you have any heart problems. Please consult your physician.

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Geriatrics

Safe if prescribed

Trunex MS Aqueous Gel is safe for use in elderly patients if recommended by the doctor.

What if I have taken an overdose of Trunex MS Aqueous Gel

Do not apply Trunex MS Aqueous Gel in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects such as peeling, redness or discomfort.

Diet & Lifestyle Advise

  • Apply a broad-spectrum sunscreen with an SPF of 30 or higher every single morning, as this medicine makes your skin highly sensitive to UV damage.
  • Wear protective clothing, such as wide-brimmed hats and sunglasses, when spending time outdoors.
  • Simplify your daily routine by using a gentle, fragrance-free moisturiser to manage dryness and support your skin barrier.
  • Avoid facial waxing, chemical peels, and harsh physical exfoliants on the treated areas, as your skin will be too sensitive for these procedures.
  • Stay hydrated by drinking plenty of water daily to support overall skin health from the inside out.
     

Have a query?

How Soon It Starts Working

The time required for Trunex MS Aqueous Gel to start to work: The time required for Trunex MS Aqueous Gel to show its action is unknown. The time for which the effects of Trunex MS Aqueous Gel last: The duration of action for Trunex MS Aqueous Gel is unknown.

What if you forget to take Trunex MS Aqueous Gel

Apply the missed dose as soon as you can. If it is almost time for the next dose, skip the missed dose and follow your regular schedule. Do not apply an extra amount of Trunex MS Aqueous Gel to make up for the missed dose.

Storage

• Store Trunex MS Aqueous Gel at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the container tightly closed when not in use to protect the medicine from air and moisture.

Drug Warnings

  • Always apply this medicine in the evening, as exposure to light can break down the active ingredients and reduce their effectiveness.
  • Never apply Trunex MS Aqueous Gel to broken, wounded, sunburnt, or eczematous skin.
  • Keep the product clear of your eyes, mouth, and nostrils; if contact occurs, rinse the area immediately with plenty of cool water.
  • Be prepared for a temporary increase in acne during the first few weeks of use; this is a normal process as deep-seated blockages are pushed to the surface.
  • Inspect the tube or packaging before use; do not use the medicine if the protective seal is broken or if the product has changed colour.
     

Drug-Drug Interactions

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Drug-Drug Interactions:

  • Salicylic acid or benzoyl peroxide: Can cause extreme skin dryness, peeling, and irritation when applied at the same time as Trunex MS Aqueous Gel.
  • Sulphur or resorcinol: May significantly increase skin sensitivity and peeling; use with caution.
  • Other topical retinoids: Combining similar skin treatments increases the risk of severe skin barrier damage.

Drug-Disease Interactions:

  • Eczema or rosacea: Can trigger intense irritation, redness, and flare-ups of these inflammatory skin conditions.
  • Sunburn: Applying this medicine to sunburnt skin can delay healing and cause extreme pain.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Trunex MS Aqueous Gel is primarily used to treat acne (pimples) and sun-damaged skin.
Trunex MS Aqueous Gel may increase the skin sensitivity to sunlight in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen with a minimum SPF 15 and wear protective clothing while going out to prevent sunburn.
You are recommended to use cosmetics after 1 hour of applying Trunex MS Aqueous Gel but avoid cosmetics with a strong drying effect as they may increase skin irritation. If you are using any cosmetics, clean your face before applying Trunex MS Aqueous Gel again.
Yes, Trunex MS Aqueous Gel may cause skin irritation, burning sensation or itching at the site of application. Extreme weather conditions such as cold or wind may cause more irritation in patients using Trunex MS Aqueous Gel containing products. However, if the irritation worsens, stop using Trunex MS Aqueous Gel and consult a doctor.
Yes, applying a gentle moisturizer is highly recommended while using Trunex MS Aqueous Gel to help prevent dryness, peeling, and irritation. Use a fragrance-free moisturizer and allow Trunex MS Aqueous Gel to absorb completely before applying it. Regular moisturizing, especially in the morning, can improve skin comfort during treatment.
Trunex MS Aqueous Gel does not remove wrinkles completely or repair skin damaged by the sun. Trunex MS Aqueous Gel may reduce fine wrinkles, especially when used along with other skincare products.
You are recommended to use Trunex MS Aqueous Gel for as long as your doctor has prescribed it. However, the course of treatment with Trunex MS Aqueous Gel takes up to 6 months for effective results.
Acne is a skin condition that is common and occurs when hair follicles are blocked with dead skin cells and oil.
Trunex MS Aqueous Gel increases cell turnover on your skin, which can promote new cell growth at the site of your scarring. As a result, it may help to reduce acne scars.
Limited research available. So, seek medical attention from your dermatologist.
Trunex MS Aqueous Gel can be a safe, effective treatment option for acne.
No. Trunex MS Aqueous Gel should not be used during pregnancy or if you are planning to become pregnant, as topical retinoids may pose risks to an unborn baby. Inform your doctor if you are pregnant, planning a pregnancy, or become pregnant during treatment.
Skin peeling is a common effect of Trunex MS Aqueous Gel because it increases skin cell turnover, causing old skin cells to shed more rapidly. During the first few weeks of treatment, mild peeling and dryness are expected as your skin adjusts. Using a gentle moisturizer, avoiding excessive sun exposure, and applying the medicine as directed can help. If peeling becomes severe, painful, or causes significant irritation, reduce the frequency
Some patients see improvements in acne within 2 to 4 weeks, but it typically takes 8 to 12 weeks of consistent use to notice significant changes in skin texture, fine lines, or dark spots. Talk to your doctor if you see no improvement after 12 weeks.
It is highly recommended to use Trunex MS Aqueous Gel only at night. Sunlight can degrade the medication, making it less effective, and the treatment increases your skin's vulnerability to UV damage during the day. Talk to your doctor for personalised advice.
It is best to avoid physical scrubs, facial brushes, and chemical exfoliants while using Trunex MS Aqueous Gel. This medicine already provides deep exfoliation, and combining it with other products can cause severe skin damage. Talk to your doctor before adding new products.
This is a common effect known as skin purging. As cell turnover speeds up, it brings deep, developing pimples to the surface all at once, which temporarily worsens acne. This phase typically resolves within a few weeks, but talk to your doctor if severe irritation continues.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 021108S015Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Tretinoin Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. DailyMed - TRETINOIN gel [Internet]. Dailymed.nlm.nih.gov. 2025 [Accessed on 7th July 2025] Check here
  4. Ortho-McNeil Pharmaceutical, Inc. U.S. Food & Drug Administration. [Revised in June 2022] [Accessed on 24th June 2022] docs/label/2002/16921s21s22s25lbl.pdf Check here
  5. DPT Laboratories. U.S. Food & Drug Administration. [Revised in January 2012] [Accessed on 24th June 2022] docs/label/2013/202567Orig1s000lbl.pdf Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 7th July 2025]Check here

Country of origin

INDIA

Manufacturer/Marketer address

KLM LABORATORIES PVT LTD, 1004, Hubtown Viva, Jogeshwari (E), Mumbai-400060, Maharashtra, India.
Other Info - TRU0429

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