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compositionComposition:DIVALPROEX SODIUM-200MG
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Prescription Medicine
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VALPROL CR EC 200MG TABLET is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DIVALPROEX SODIUM-200MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About VALPROL CR EC 200MG TABLET

name is a prescription medication primarily used to control and prevent various types of seizures. It is also prescribed to treat manic episodes associated with bipolar disorder and to prevent migraine headaches in adults. By balancing certain natural chemicals in the brain, it helps manage these neurological and mood-related conditions effectively.

To achieve the best results, you must take VALPROL CR EC 200MG TABLET consistently at the exact same times every day as directed by your doctor. You can take this medication with or without food, though taking it with meals can help prevent stomach upset. Incorporating stable daily routines, such as managing stress, maintaining a regular sleep schedule, and avoiding alcohol, can significantly support your treatment progress.

While taking VALPROL CR EC 200MG TABLET, some people may experience mild side effects, such as nausea, sleepiness, or mild dizziness. However, you must contact your doctor immediately if you experience serious symptoms, such as severe upper stomach pain, yellowing of your skin or eyes, or unusual changes in your mood or behaviour.

Before starting VALPROL CR EC 200MG TABLET, tell your doctor if you have a history of liver problems, pancreas issues, or genetic metabolic disorders. Do not take this medication if you have active liver disease, a mitochondrial disorder, or if you are pregnant, as it can cause serious harm to an unborn baby. Talk to your doctor to find out if this medicine is safe for your specific health history.

This medication can interact with other prescription drugs, alcohol, and certain lifestyle habits, which may change how the medicine works or increase side effects. For example, drinking alcohol while taking this medicine can cause extreme sleepiness and increase the risk of liver issues. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss safer treatment options.

Uses of VALPROL CR EC 200MG TABLET

VALPROL CR EC 200MG TABLET is used to control and prevent various types of seizures. The detailed uses of VALPROL CR EC 200MG TABLET are as follows:

  • Epilepsy and Seizures: VALPROL CR EC 200MG TABLET helps reduce the frequency and intensity of seizures by calming overactive electrical activity in the brain.
  • Bipolar Mania: VALPROL CR EC 200MG TABLET treats periods of extreme highs, irritability, or excitement by balancing chemical signals in the brain to help stabilise your mood.
  • Migraine Prevention: VALPROL CR EC 200MG TABLET reduces the number of migraine attacks you experience when taken daily, helping prevent severe head pain before it starts.

Key Benefits

VALPROL CR EC 200MG TABLET helps manage certain neurological conditions by stabilising electrical activity in the brain. Depending on the condition being treated, it helps control seizures, stabilise mood, or reduce the frequency of migraine attacks, supporting better daily functioning and quality of life.

  • Helps Control Seizures: By reducing abnormal electrical activity in the brain, VALPROL CR EC 200MG TABLET helps decrease the frequency of seizures, allowing you to carry out daily activities with greater safety and confidence.
  • Supports Mood Stability: For individuals with bipolar disorder, VALPROL CR EC 200MG TABLET helps reduce mood swings and prevent manic episodes, promoting a more balanced emotional state and improving day-to-day functioning.
  • Helps Prevent Migraine Attacks: When used for migraine prevention, VALPROL CR EC 200MG TABLET helps reduce the frequency of migraine episodes, allowing you to enjoy your daily activities with fewer painful interruptions and less reliance on rescue pain medicines.
Side effects of Valprol CR EC 200 mg Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • VALPROL CR EC 200MG TABLET can be taken with or without food, or as advised by the doctor.
  • It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
  • Swallow VALPROL CR EC 200MG TABLET as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

How VALPROL CR EC 200MG TABLET Works

Inside the brain, nerve cells communicate using electrical and chemical signals. Sometimes, these signals become hyperactive or unbalanced, leading to seizures, mood swings, or migraines. VALPROL CR EC 200MG TABLET works by increasing the activity of a natural chemical messenger in the brain called gamma-aminobutyric acid (GABA). GABA acts as a natural brake system, calming down overactive nerve cells and restoring balance. This soothing effect prevents the sudden electrical rushes that cause seizures and helps stabilise your overall brain activity.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking VALPROL CR EC 200MG TABLET, as it may cause increased dizziness.

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Pregnancy

Unsafe

VALPROL CR EC 200MG TABLET belongs to pregnancy category D. Avoid taking VALPROL CR EC 200MG TABLET if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

VALPROL CR EC 200MG TABLET may pass into breastmilk. Consult your doctor before taking VALPROL CR EC 200MG TABLET if you are breastfeeding.

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Driving

Unsafe

VALPROL CR EC 200MG TABLET causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

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Liver

Unsafe

VALPROL CR EC 200MG TABLET should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

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Children

Caution

VALPROL CR EC 200MG TABLET can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

VALPROL CR EC 200MG TABLET can be given in elderly patients with extreme caution due to the serious adverse effects.

What if I have taken an overdose of VALPROL CR EC 200MG TABLET

If you take too much of this medication, seek immediate emergency medical care or contact your local poison control centre. Symptoms of an overdose may include extreme sleepiness, shallow breathing, weak muscles, or a slow heartbeat.

Diet & Lifestyle Advise

  • Keep a consistent sleep schedule of 7 to 8 hours per night, as sleep deprivation is a known trigger for seizures, manic episodes, and migraines.
  • Stay properly hydrated throughout the day, as dehydration can worsen side effects like dizziness and headaches.
  • Avoid alcohol entirely while taking this medication, as it severely interacts with VALPROL CR EC 200MG TABLET to cause extreme sleepiness and increases the risk of liver complications.
  • Maintain a detailed symptom diary to track the frequency of your seizures, mood changes, or migraine triggers, and share this information during your medical check-ups.
health query

Have a query?

How Soon It Starts Working

  • The time required for VALPROL CR EC 200MG TABLET to start to work: The time required for VALPROL CR EC 200MG TABLET to show its action is unknown.
  • The time for which the effects of VALPROL CR EC 200MG TABLET last: The duration of action for VALPROL CR EC 200MG TABLET is unknown.

What if you forget to take VALPROL CR EC 200MG TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your normal routine. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

•Store VALPROL CR EC 200MG TABLET at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original container with the lid tightly closed to protect it from moisture and direct light.

Drug Warnings

  • Do not stop taking VALPROL CR EC 200MG TABLET suddenly, even if you feel completely fine, as abrupt discontinuation can trigger severe, continuous seizures.
  • If you are of childbearing age, use a highly effective form of birth control while taking this medicine to prevent unplanned pregnancies due to the risk of severe birth defects.
  • Check your body regularly for any unusual bruising, purple spots, or bleeding from the gums, and notify your doctor immediately if they occur.
  • Avoid driving, riding a bicycle, or operating machinery until you are certain how this medicine affects your alertness and coordination.
  • Keep a medical ID card in your wallet or wear an emergency alert bracelet to notify medical personnel that you are taking this medication in an emergency.

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin: Taking aspirin can increase the amount of VALPROL CR EC 200MG TABLET in your blood, which may raise your risk of experiencing harmful side effects.
  • Other seizure medications (such as phenytoin, carbamazepine, or phenobarbital): These drugs can change how your body processes VALPROL CR EC 200MG TABLET, which may require your doctor to adjust your doses.
  • Blood thinners (such as warfarin): Combining these with VALPROL CR EC 200MG TABLET can increase your risk of bleeding or bruising.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol can cause severe drowsiness and dizziness and significantly increases the risk of developing liver damage.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

VALPROL CR EC 200MG TABLET belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, VALPROL CR EC 200MG TABLET is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.
VALPROL CR EC 200MG TABLET contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. VALPROL CR EC 200MG TABLET increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.
VALPROL CR EC 200MG TABLET helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.
VALPROL CR EC 200MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.
Do not discontinue VALPROL CR EC 200MG TABLET without consulting your doctor. To treat your condition effectively, continue taking VALPROL CR EC 200MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking VALPROL CR EC 200MG TABLET. Your doctor will reduce the dose gradually to avoid worsening of seizures.
VALPROL CR EC 200MG TABLET may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with VALPROL CR EC 200MG TABLET. Avoid getting pregnant while taking VALPROL CR EC 200MG TABLET as it could lead to serious birth defects. Do not stop taking VALPROL CR EC 200MG TABLET and consult your doctor immediately if you become pregnant.
VALPROL CR EC 200MG TABLET may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking VALPROL CR EC 200MG TABLET.
Topiramate (anticonvulsant) should not be taken along with VALPROL CR EC 200MG TABLET as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It is crucial to consult with your doctor before discontinuing VALPROL CR EC 200MG TABLET. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
VALPROL CR EC 200MG TABLET is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
VALPROL CR EC 200MG TABLET can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.
Yes, VALPROL CR EC 200MG TABLET can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking VALPROL CR EC 200MG TABLET, it's essential to consult with your doctor.
Yes, VALPROL CR EC 200MG TABLET can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking VALPROL CR EC 200MG TABLET, seeking medical attention is crucial.
Avoid consumption of alcohol while taking VALPROL CR EC 200MG TABLET, as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking VALPROL CR EC 200MG TABLET, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
An overdose of VALPROL CR EC 200MG TABLET can be a severe medical emergency. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you or someone you know has taken an overdose of VALPROL CR EC 200MG TABLET, please seek immediate medical attention.
Yes, temporary hair thinning or loss can occur in some people taking VALPROL CR EC 200MG TABLET. This effect is usually temporary and reversible once the medication is stopped or adjusted, but you should never stop taking it on your own. Talk to your doctor or pharmacist if you notice significant hair changes.
Your doctor will order regular blood tests to check the level of the medicine in your body, monitor your liver health, and measure your blood clotting cells (platelets). This helps ensure the medicine is working safely and effectively. Talk to your doctor about your testing schedule.
Yes, you can take VALPROL CR EC 200MG TABLET with food. In fact, taking it during or immediately after a meal is highly recommended if you experience nausea or stomach upset. Talk to your doctor or pharmacist if stomach discomfort persists.
Yes, drowsiness and dizziness are common side effects of VALPROL CR EC 200MG TABLET, especially when you first start taking it or when your dose is increased. Avoid driving or operating machinery until you know how it affects you. Talk to your doctor if the sleepiness interferes with your daily life.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and return to your regular schedule; do not double the dose. Talk to your doctor or pharmacist if you frequently miss doses.
Moderate amounts of caffeine from coffee or tea are generally fine, but excessive caffeine can trigger migraines or affect your sleep patterns, which may interfere with your treatment goals. Talk to your doctor or pharmacist for personalised dietary advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 018723S037Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. DailyMed Database. Fdadrugxsl.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Divalproex Sodium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 April 2025]Check here
  5. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 10 April 2025]Check here
  6. Depakote Formulations. [Accessed on 02 Jun. 2026]Check here
  7. Sanofi India — Pharmaceutical Products. Sanofi.com [Internet]. [Accessed on 2026 Jan 1]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - VAL0020

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