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compositionComposition:SODIUM VALPROATE-500MG
prescription
Prescription Medicine
info
Valproval 500 CR Tablet 10's

Valproval 500 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It helps reduce mood swings and improve impulsive behaviour.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-500MG

Manufacturer/Marketer :

Prevego Healthcare & Research Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Valproval 500 CR Tablet

Valproval 500 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, Valproval 500 CR Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain.

Valproval 500 CR Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. This helps in controlling seizures.

Take Valproval 500 CR Tablet as prescribed by your doctor. Valproval 500 CR Tablet may cause side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Talk to your doctor if you experience these side effects persistently.

Please do not stop taking Valproval 500 CR Tablet without consulting your doctor to avoid worsening of seizures. Do not take Valproval 500 CR Tablet if you are pregnant, as it could cause serious congenital disabilities. Consult your doctor before taking Valproval 500 CR Tablet if you are breastfeeding.

Uses of Valproval 500 CR Tablet

Valproval 500 CR Tablet is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Valproval 500 CR Tablet are as follows:

  • Seizure Management: Valproval 500 CR Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: Valproval 500 CR Tablet can be used in the treatment of bipolar disorder, aiding in mood stabilisation and reducing the frequency of mood swings.
  • Migraine: Valproval 500 CR Tablet is used to help prevent migraine headaches. It reduces the frequency and severity of migraine attacks by stabilising nerve activity in the brain.

Key Benefits

When used as prescribed, Valproval 500 CR Tablet may offer the following benefits

For Epilepsy:

  • Regulates a variety of seizure types, such as absence, focal, and generalised seizures.
  • Reduces the frequency and intensity of seizures by stabilising aberrant electrical activity in the brain.
  • Beneficial either alone or in conjunction with other antiepileptic medications.
  • Both adults and children with epilepsy can benefit from it.

For Bipolar disorder:

  • Stabilises mood, which aids in the management of acute manic episodes.
  • Reduce mood fluctuations and stop manic relapses.
  • Helpful for patients who don't react well to lithium.
  • Reduces impulsive behaviour, agitation, and irritation.

For Migraine:

  • Helps prevent migraine attacks when taken regularly.
  • Reduces the frequency of migraine episodes.
  • Decreases the severity and duration of headaches.
  • Stabilises overactive nerve signals involved in migraines.
  • Improves the quality of life in people with recurrent migraines.
Side effects of Valproval 500 CR Tablet
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.

Directions for Use

  • Valproval 500 CR Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Valproval 500 CR Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Valproval 500 CR Tablet Works

Valproval 500 CR Tablet contains 'Sodium valproate' as an active ingredient. • For seizures, it decreases the excessive and abnormal nerve activity in the brain. Thereby, it helps in controlling seizures. • For Bipolar disorder, it increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. • For Migraine, it controls abnormal nerve signals and prevents the chain of events that trigger migraine attacks, helping reduce the frequency and severity of migraines.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valproval 500 CR Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Valproval 500 CR Tablet belongs to pregnancy category D. Avoid taking Valproval 500 CR Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valproval 500 CR Tablet may pass into breastmilk. Consult your doctor before taking Valproval 500 CR Tablet if you are breastfeeding.

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Driving

Unsafe

Valproval 500 CR Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Valproval 500 CR Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Valproval 500 CR Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

It is unknown whether Valproval 500 CR Tablet is safe for use in cardiac patients or not. Please consult your physician.

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Geriatrics

Caution

Valproval 500 CR Tablet should be given with caution in elderly patients due to age-related side effects. Seek medical advice before using Valproval 500 CR Tablet .

What if I have taken an overdose of Valproval 500 CR Tablet

An overdose of Valproval 500 CR Tablet may cause headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Healthy eating habits:

  • To preserve general health, eat a diet rich in fruits, vegetables, whole grains, and lean meats.
  • Eat fewer greasy and fried foods to ease the liver's burden.
  • To lessen upset stomach, drink enough water and eat at regular times.

Lifestyle changes:

  • Steer clear of recreational drugs and alcohol, as they can exacerbate seizures and negative effects.
  • Sleep deprivation can cause mood swings or seizures, so make sure you get enough sleep and control your stress.

Stress management:

  • To lower stress, engage in relaxation methods like yoga, meditation, or deep breathing.
  • Walking is a gentle kind of exercise that might enhance mental health.
  • When you're feeling overwhelmed, ask friends, family, or a counsellor for emotional assistance.

Have a query?

How Soon It Starts Working

  • The time required for Valproval 500 CR Tablet to start to work: Valproval 500 CR Tablet ideally shows its action within 2 hours after administration.
  • The time for which the effects of Valproval 500 CR Tablet last: The effect of Valproval 500 CR Tablet lasts for 24 hours.

What if you forget to take Valproval 500 CR Tablet

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Valproval 500 CR Tablet if you are allergic to any of its contents.
  • Inform your doctor if you have liver problems, porphyria (blood disorder), urine-related problems (like urea cycle disorder), diabetes, an immune system disorder or kidney problems.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Valproval 500 CR Tablet .
  • Contact your doctor if your child gets her first period during the treatment with Valproval 500 CR Tablet .
  • Do not take Valproval 500 CR Tablet if you are pregnant unless prescribed by the doctor, as it can cause serious congenital disabilities.
  • Consult your doctor before taking Valproval 500 CR Tablet if you are breastfeeding.
  • Valproval 500 CR Tablet may cause drowsiness and dizziness, so drive only if you are alert.
  • Avoid consuming alcohol along with Valproval 500 CR Tablet as it could lead to increased dizziness and sleepiness.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Taking Valproval 500 CR Tablet with the following medication classes may cause adverse reactions.

  • Drugs used for seizures (phenytoin, carbamazepine)
    • Potential effect: May cause altered blood levels and increased toxicity.
  • Blood thinner (warfarin)
    • Potential effect: May increase the risk of bleeding.
  • Antibiotics (imipenem, meropenem)
    • Potential effect: May reduce the effectiveness of Valproval 500 CR Tablet .
  • Anti-psychotic drugs (quetiapine, olanzapine)
    • Potential effect: May cause sedation and CNS side effects.
  • Drugs used for depression (clonazepam, diazepam)
    • Potential effect: May cause sedation and CNS side effects.

Drug-Food Interactions: Avoid alcohol consumption while taking Valproval 500 CR Tablet as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Inform your doctor if you have a history of the following conditions before taking Valproval 500 CR Tablet , as it may worsen your condition or cause complications.

  • Depression
  • Liver disease
  • Urea cycle disorders
  • Suicidal tendency
  • HIV disease
  • Thrombocytopenia (low levels of platelets)
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateLithium
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Valproval 500 CR Tablet:
Combining Sodium phenylbutyrate and Valproval 500 CR Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Valproval 500 CR Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Lithium with Valproval 500 CR Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Valproval 500 CR Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Meropenam and Valproval 500 CR Tablet together can reduce the effect of Valproval 500 CR Tablet.

How to manage the interaction:
Co-administration of Meropenam and Valproval 500 CR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Valproval 500 CR Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Valproval 500 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Vorinostat with Valproval 500 CR Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Valproval 500 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Valproval 500 CR Tablet:
Using buprenorphine together with Valproval 500 CR Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Valproval 500 CR Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Valproval 500 CR Tablet:
The combined use of Ertapenem and Valproval 500 CR Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Valproval 500 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Teriflunomide and Valproval 500 CR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Valproval 500 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Leflunomide and Valproval 500 CR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Valproval 500 CR Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Valproval 500 CR Tablet:
Co-administration of Ketamine and Valproval 500 CR Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Valproval 500 CR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Valproval 500 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).
Valproval 500 CR Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Valproval 500 CR Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.
Valproval 500 CR Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Do not discontinue Valproval 500 CR Tablet without consulting your doctor. To treat your condition effectively, continue taking Valproval 500 CR Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valproval 500 CR Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.
Birth-control pills like oestrogen-containing products may affect the way Valproval 500 CR Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.
Valproval 500 CR Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.
Valproval 500 CR Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valproval 500 CR Tablet . In rare cases, Valproval 500 CR Tablet can be a contributing factor in male infertility.
Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.
Valproval 500 CR Tablet may change the results of liver enzymes, urine and blood tests. Inform the person doing the tests that you are taking Valproval 500 CR Tablet .
Store Valproval 500 CR Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Valproval 500 CR Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
No, avoid consumption of alcohol while taking Valproval 500 CR Tablet as it may cause increased dizziness and sleepiness.
Yes, Valproval 500 CR Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.
No, taking higher than the recommended dose of Valproval 500 CR Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Valproval 500 CR Tablet as it may cause an overdose.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1500 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. National Health Service (NHS). Sodium Valproate - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Valproate Sodium Intravenous Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. Valproic acid [Package Leaflet]. 2023. [Accessed on 06 Apr. 2024] Check here
  5. Valproate sodium [Prescribing Information]. 2013. [Accessed on 18 Sep. 2024] Check here
  6. Rahman M, Awosika AO, Nguyen H Valproic Acid. [Updated 2024 Mar 19]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Check here
  7. Valproic Acid: MedlinePlus Drug InformationMedlinePlus. Sulfasalazine [Internet]. U.S. National Library of Medicine; 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

4-6, Bora Bazar St, Borabazar Precinct, Ballard Estate, Fort, Mumbai, Maharashtra 400001
Other Info - VAL0465

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