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  3. Xadomet-GP2 Tablet 10's

Xadomet-GP2 Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Xadomet-Gp2 Tab is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

GLIMEPIRIDE-2MG + METFORMIN-500MG + PIOGLITAZONE-15MG

Manufacturer/Marketer :

DR CURE PHARMACEUTICALS INDIA PVT LTD

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Xadomet-Gp2 Tab

Xadomet-Gp2 Tab belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance).

Xadomet-Gp2 Tab is a combination of three antidiabetic drugs, namely: Glimepiride, Metformin, and Pioglitazone. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Pioglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

Take Xadomet-Gp2 Tab as prescribed by your doctor. You are advised to take Xadomet-Gp2 Tab for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Most of these side effects of Xadomet-Gp2 Tab do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Xadomet-Gp2 Tab or any other medicines, please tell your doctor. Xadomet-Gp2 Tab is not recommended for children. Avoid breastfeeding while taking Xadomet-Gp2 Tab as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Xadomet-Gp2 Tab as it may harm the unborn baby. Xadomet-Gp2 Tab should be used with caution in elderly patients. Avoid alcohol consumption with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Xadomet-Gp2 Tab .

Uses of Xadomet-Gp2 Tab

Treatment of Type 2 diabetes mellitus

Directions for Use

• Xadomet-Gp2 Tab can be taken with food to avoid stomach upset or as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Xadomet-Gp2 Tab as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Xadomet-Gp2 Tab contains three antidiabetic drugs (Glimepiride, Metformin and Voglibose) used in the treatment of type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin reduces the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enables cells to remove glucose from blood more effectively. Also, it decreases the amount of glucose produced by the liver and preserves the functioning of beta cells in the pancreas that produces insulin. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

How Xadomet-Gp2 Tab Works

Xadomet-Gp2 Tab is a combination of three antidiabetic drugs, namely: Glimepiride, Metformin, and Pioglitazone. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Pioglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

Storage

Keep Xadomet-Gp2 Tab out of reach and sight of children.

What if I have taken an overdose of Xadomet-Gp2 Tab

Take Xadomet-Gp2 Tab only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include loss of consciousness, lactic acidosis (buildup of lactic acid in the blood), and pancreatitis (inflammation of the pancreas). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Xadomet-Gp2 Tab or any other medicines, please tell your doctor. Xadomet-Gp2 Tab is not recommended for children. Avoid breastfeeding while taking Xadomet-Gp2 Tab as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Xadomet-Gp2 Tab as it may harm the unborn baby. Xadomet-Gp2 Tab should be used with caution in elderly patients. Avoid alcohol consumption with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Xadomet-Gp2 Tab . Take short, frequent meals and avoid prolonged fasting while taking Xadomet-Gp2 Tab . Beware of symptoms of hypoglycemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interactions

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MetforminMetrizamide
Critical
MetforminIodamide
Critical

Drug-Drug Interactions

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MetforminMetrizamide
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIodamide
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Xadomet-GP2 Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopamidol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopromide with Xadomet-GP2 Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Xadomet-GP2 Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIomeprol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iomeprol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoversol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Ioversol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopentol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iohexol with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Iopanoic acid with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Xadomet-GP2 Tablet:
Co-administration of Ioglycamic acid with Xadomet-GP2 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Xadomet-GP2 Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.

  • Maintain healthy body weight as obesity is also related to the onset of diabetes.

  • Maintain a low fat and a low sugar diet. Replace carbohydrates-containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.

  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Xadomet-Gp2 Tab Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

bannner image

Pregnancy

Unsafe

Xadomet-Gp2 Tab is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Xadomet-Gp2 Tab as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Xadomet-Gp2 Tab if you are breastfeeding.

bannner image

Driving

Caution

Xadomet-Gp2 Tab may decrease alertness in some people. Therefore, drive only if you are alert after taking Xadomet-Gp2 Tab .

bannner image

Liver

Caution

Take Xadomet-Gp2 Tab with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Xadomet-Gp2 Tab with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Unsafe

Xadomet-Gp2 Tab is not recommended for children as the safety and effectiveness were not established.

Have a query?

FAQs

Xadomet-Gp2 Tab is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Xadomet-Gp2 Tab contains Glimepiride, Metformin and Pioglitazone. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, Xadomet-Gp2 Tab helps to control blood sugar levels.

Xadomet-Gp2 Tab may increase the risk of low blood sugar levels especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meal. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to take Xadomet-Gp2 Tab with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Xadomet-Gp2 Tab with other medicines.

In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.

You are not recommended to stop taking Xadomet-Gp2 Tab on your own as discontinuing Xadomet-Gp2 Tab suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Xadomet-Gp2 Tab , please consult your doctor so that alternative medicine may be prescribed.

Yes, Xadomet-Gp2 Tab may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.

You are recommended to avoid consumption of alcohol with Xadomet-Gp2 Tab as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.

Yes, Xadomet-Gp2 Tab may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.

Store Xadomet-Gp2 Tab at room temperature, in a dry place. Keep out of sight and reach of children.

Xadomet-Gp2 Tab may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

No.248/13, 2Nd Floor, 67Th Cross, 5Th Block, Rajajinagar, Bangalore - 560010
Other Info - XAD0003

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Amaryl-MP-API-Aug-2018.pdf?la=en
  2. https://www.drugs.com/mtm/glimepiride.html#interactions
  3. https://www.drugs.com/metformin.html#interactions
  4. https://www.drugs.com/mtm/pioglitazone.html#interactions

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