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  3. Xafinact 50 Tablet 10's

Xafinact 50 Tablet 10's, Pack of 10 TABLETS
Xafinact 50 Tablet 10's, Pack of 10 TABLETS
Xafinact 50 Tablet 10's, Pack of 10 TABLETS
Xafinact 50 Tablet 10's, Pack of 10 TABLETS
Xafinact 50 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Xafinact 50 Tablet is used to treat Parkinson's disease. It contains Safinamide which works by increasing the amount of dopamine (a chemical messenger that is needed to control movement) in the brain. In some cases, this medicine may cause side effects such as dizziness, headache, nausea, insomnia, and sleepiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

SAFINAMIDE-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Xafinact 50 Tablet

Xafinact 50 Tablet is used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, and difficulty in walking, coordination and balance. 

Xafinact 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Xafinact 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects of  Xafinact 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Xafinact 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Xafinact 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Xafinact 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Xafinact 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Xafinact 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs.

Uses of Xafinact 50 Tablet

Treatment of Parkinson's disease

Have a query?

Directions for Use

• Xafinact 50 Tablet can be taken with or without food.• It is recommended to take Xafinact 50 Tablet once daily at the same time each day or as advised by your doctor.• Swallow Xafinact 50 Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Xafinact 50 Tablet belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. It works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

How Xafinact 50 Tablet Works

Xafinact 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Storage

keep Xafinact 50 Tablet out of sight and reach of children.
Side effects of Xafinact 50 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Pounding in the ears needs immediate medical attention when you hear abnormal sounds through your ears.
  • Get a physical examination, and an ENT will help identify factors that led to ear pounding.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and use a white noise machine to reduce the pounding sound in your ear. Soft music and low-volume radio can also help if there is no white noise machine.
  • Take a balanced diet and limit your intake of caffeine, alcohol and nicotine.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.

What if I have taken an overdose of Xafinact 50 Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Xafinact 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Xafinact 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Xafinact 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Xafinact 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Xafinact 50 Tablet should be used caution with liver diseases. Xafinact 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour.

Drug-Drug Interactions

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SafinamideMilnacipran
Critical
SafinamideMirtazapine
Critical

Drug-Drug Interactions

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SafinamideMilnacipran
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Milnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Milnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideMirtazapine
Critical
How does the drug interact with Xafinact 50 Tablet:
Using Mirtazapine together with Xafinact 50 Tablet can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Xafinact 50 Tablet and Mirtazapine together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideTrazodone
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Trazodone can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Trazodone is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTryptophan
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Tryptophan can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Tryptophan is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideIsocarboxazid
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Isocarboxazid with Xafinact 50 Tablet can increase the risk of Hypertension(high BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Isocarboxazid is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideAmoxapine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Amoxapine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Amoxapine is not recommended, as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideProcarbazine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Procarbazine with Xafinact 50 Tablet can increase the risk of hypertension(High BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Procarbazine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamidePhenelzine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Phenelzine with Xafinact 50 Tablet can increase the risk of hypertension(high BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTapentadol
Critical
How does the drug interact with Xafinact 50 Tablet:
Using Tapentadol together with Xafinact 50 Tablet can increase the risk of high blood pressure and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Xafinact 50 Tablet and Tapentadol together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideClomipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Clomipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clomipramine with Xafinact 50 Tablet can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Xafinact 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Xafinact 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease, including grains and leafy foods, as this food is rich in vitamins, fibres, and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans, and solid fats found in nuts, olive oil, fish, and eggs in their diet. However, limit the consumption of sugar.

  • Avoid intake of high-protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole wheat bread, oatmeal, brown rice or pasta.

  • Eat more fibre-rich foods to ease constipation.

  • Drink plenty of water to avoid headaches due to dehydration.

  • Avoid the consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Xafinact 50 Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Xafinact 50 Tablet may cause excessive drowsiness with alcohol, decreasing alertness and affecting your vision.

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Pregnancy

Unsafe

Xafinact 50 Tablet may be unsafe to use during pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Xafinact 50 Tablet . Please consult your doctor before taking Xafinact 50 Tablet .

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Breast Feeding

Unsafe

Xafinact 50 Tablet may be unsafe to use in breastfeeding mothers. Your doctor will weigh the benefits and potential risks before prescribing Xafinact 50 Tablet . Please consult your doctor before taking Xafinact 50 Tablet .

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Driving

Caution

Xafinact 50 Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Xafinact 50 Tablet should be used with caution in patients with liver disease. A dose adjustment of Xafinact 50 Tablet may be needed. So please consult your doctor before taking Xafinact 50 Tablet .

bannner image

Kidney

Caution

Xafinact 50 Tablet should be used with caution in patients with kidney disease. A dose adjustment of Xafinact 50 Tablet may be needed. So please consult your doctor before taking Xafinact 50 Tablet .

bannner image

Children

Unsafe

Xafinact 50 Tablet is not recommended for use in children under 12 years.

FAQs

Xafinact 50 Tablet is used to treat the signs and symptoms of Parkinson's disease.

Xafinact 50 Tablet works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

Do not double the dosage to compensate for a missed one. One can skip the missed portion and take the next dosage at the standard time of the following day.

Yes, Xafinact 50 Tablet is not recommended in albinism (an inherited condition that causes a lack of colour in the skin, hair and eyes), retinal degeneration, uveitis (inflammation of the middle layer of the eye (uvea)), inherited retinopathy or severe progressive diabetic retinopathy.

Do not stop Xafinact 50 Tablet suddenly; it may cause side effects like confusion, stiff muscles and a high fever. So please consult your doctor before stopping the medicine.

The time it takes for Xafinact 50 Tablet to work can vary depending on the specific medication mechanism and the individual health condition status.

Xafinact 50 Tablet contains Safinamide, which is used in combination with other medications to treat adults with Parkinson's disease.

In some individuals, Xafinact 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects do not require medical attention and gradually resolve over time. However, if any persists or worsens, please consult your doctor.

Xafinact 50 Tablet can be taken with a glass of water. Do not chew, break, or crush it. Follow your doctor's instructions regarding dose and duration and complete the entire course as prescribed.

Xafinact 50 Tablet belongs to pregnancy category C, which means that animal studies have shown potential risks to the fetus, but there are no good studies in pregnant women. As a result, the medication should only be used during pregnancy if the potential benefits justify the possible risks. Always consult your healthcare provider for personalized guidance.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - XAF0005

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/product/2159/smpc#PRODUCTINFO
  2. https://www.webmd.com/drugs/2/drug-173493/safinamide-oral/details
  3. https://www.drugs.com/mtm/safinamide.html#uses
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207145lbl.pdf
  5. https://www.rxlist.com/consumer_xadago_safinamide/drugs-condition.htm

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