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compositionComposition:PRAZIQUANTEL-600MG
prescription
Prescription Medicine
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Zenticide 600mg Tablet is used to treat parasitic infections such as Schistosoma and liver fluke. It contains Praziquantel which works by paralysing the worms. This causes the worms to release their hold on the blood vessels so they can be removed from the body. In some cases, this medicine may cause side effects such as headache, dizziness, abdominal discomfort, nausea, and fever.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRAZIQUANTEL-600MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Zenticide 600mg Tablet

Zenticide 600mg Tablet is a prescription medicine used to treat infections caused by parasitic worms, such as blood flukes and liver flukes. It works by targeting the parasites directly inside the body to clear the infection and prevent further complications. This medication is essential for stopping the spread of these parasites within your organs.

Unlike long-term therapies, this medicine is typically taken as a short-term treatment, often for just one day. You should take the tablets with water during a meal, and you must swallow them whole without chewing. To support your recovery and prevent getting infected again, it is important to practice strict personal hygiene and avoid consuming untreated water or undercooked freshwater fish.

While taking Zenticide 600mg Tablet, you may experience mild side effects like a temporary headache, dizziness, or stomach discomfort. Most of these symptoms go away quickly on their own once the treatment is finished. However, if you experience more serious symptoms such as severe skin rashes, seizures, or an irregular heartbeat, you must contact your doctor immediately.

Before you begin taking this medicine, tell your doctor if you have a history of seizures, heart problems, or kidney disease. Do not take this if you have a parasitic infection in your eyes, known as ocular cysticercosis, as treating this area can cause severe damage to your vision. Your doctor will help determine if this treatment is safe for you.

This medicine can interact with other substances, including alcohol, which can make dizziness and drowsiness much worse. It may also interact with certain seizure medications and antibiotics, making the treatment less effective. If you are pregnant, breastfeeding, or managing health conditions as an older adult, talk to your doctor or pharmacist before starting treatment.

Uses of Zenticide 600mg Tablet

Zenticide 600mg Tablet used in the treatment of parasitic infections. The detailed uses of Zenticide 600mg Tablet are as follows:

  • Schistosomiasis: Zenticide 600mg Tablet helps clear infections caused by blood flukes, which are parasitic flatworms that enter the body through contact with contaminated freshwater.
  • Liver fluke infections: This medicine targets and eliminates parasites that infect the liver and bile ducts, which typically occur after eating raw or undercooked freshwater fish.
  • Lung fluke infections: Zenticide 600mg Tablet is used to treat parasitic infections in the lungs, usually contracted from eating raw or undercooked crabs or crayfish.

Key Benefits

Zenticide 600mg Tablet helps treat parasitic worm infections by killing the parasites responsible for the disease, helping your body recover and reducing the risk of long-term complications.

Benefits may include:

  • Helps clear parasitic worm infections, often with a single treatment as prescribed.
  • Relieves symptoms such as abdominal pain, fever, fatigue, and blood in the urine or stool as the infection resolves.
  • Helps prevent further tissue damage and reduces the risk of long-term complications, such as organ damage and scarring, through early treatment.
  • Supports recovery by eliminating the parasites, allowing you to regain strength and return to your daily activities.
  • May help reduce the risk of nutritional deficiencies associated with chronic parasitic infections.
Side effects of Zenticide 600mg Tablet
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Directions for Use

  • Zenticide 600mg Tablet can be taken with meals to enhance absorption and maximize its effectiveness.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Zenticide 600mg Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Zenticide 600mg Tablet Works

Zenticide 600mg Tablet works by disrupting the physical structure of the parasites. Once you take the medicine, it rapidly increases the flow of calcium into the parasite's outer layer. This sudden shift causes the worm’s muscles to contract severely and paralyse them almost instantly. Once the parasites are paralysed, they can no longer cling to the walls of your blood vessels or organs. They detach from the host tissues, allowing your body's natural immune system to target, destroy, and safely flush them out of your body.
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Alcohol

Caution

Avoid alcohol consumption as it might cause increased dizziness.

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Pregnancy

Caution

Zenticide 600mg Tablet belongs to pregnancy category B. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if clearly needed.

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Breast Feeding

Unsafe

Zenticide 600mg Tablet may pass into breastmilk. Avoid breastfeeding whilst taking Zenticide 600mg Tablet and during the subsequent 72 hours/3 days.

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Driving

Unsafe

Zenticide 600mg Tablet may cause dizziness. Avoid driving or operating machinery on the day of treatment and the following day.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Zenticide 600mg Tablet in patients with liver impairment. Zenticide 600mg Tablet should be used with caution in patients with moderate to severe liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Zenticide 600mg Tablet in patients with kidney impairment.

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Children

Caution

Safety of Zenticide 600mg Tablet in children below 4years has not been established.

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Heart

Caution

Zenticide 600mg Tablet should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Zenticide 600mg Tablet.

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Geriatrics

Caution

Zenticide 600mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Talk to your doctor if you have any concerns.

What if I have taken an overdose of Zenticide 600mg Tablet

If you suspect an overdose or if someone has accidentally swallowed too many tablets, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Support kidney function: Drink plenty of safe, clean water throughout the day to help support your kidneys as they process the medicine and flush out waste.
  • Avoid high-risk foods: Avoid eating raw, undercooked, or salted freshwater fish, crabs, and crayfish, as these are primary sources of parasitic fluke infections.
  • Prevent re-exposure: Avoid swimming, wading, or bathing in freshwater lakes, rivers, or streams in areas where parasite infections are common. Use chlorinated pools or safe municipal water instead.
  • Maintain good hygiene: Practice thorough hand hygiene by washing your hands with soap and clean water before preparing food, eating, and after using the restroom to prevent reinfection.
health query

Have a query?

How Soon It Starts Working

The time required for Zenticide 600mg Tablet to start to work: The time required for Zenticide 600mg Tablet to show its action is unknown. The time for which the effects of Zenticide 600mg Tablet last: Zenticide 600mg Tablet effect lasts for 6 hours.

What if you forget to take Zenticide 600mg Tablet

Since this medication is usually taken as a single-day treatment, take the missed dose as soon as you remember. If it is already time for your next scheduled dose on that day, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure what to do.

Storage

• Store Zenticide 600mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid hazardous activities: Do not drive, operate machinery, or perform tasks that require complete alertness on the day you take this medicine and the day after, as it can cause significant drowsiness and slower reflexes.
  • Avoid grapefruit products: Avoid eating grapefruit or drinking grapefruit juice while taking this medicine, as it can raise the levels of the drug in your body and increase the risk of side effects.
  • Discuss seizure history: If you have a history of seizures or epilepsy, notify your doctor before starting treatment, as they may need to monitor you closely.
  • Share your travel history: Always tell your doctor about any recent international travel, especially to tropical areas where other parasitic diseases are common, to ensure this treatment is safe for you.

Drug-Drug Interactions

verifiedApollotooltip
  • Antibiotic (e.g., rifampin): May significantly lower the levels of Zenticide 600mg Tablet in your body, making it less effective.
  • Seizure medicines (e.g., phenytoin, carbamazepine, phenobarbital): May speed up how your body processes Zenticide 600mg Tablet, reducing its ability to clear the parasites.
  • Stomach acid reducer (e.g., cimetidine): May increase the concentration of Zenticide 600mg Tablet in your blood, which may raise your risk of side effects.
  • Corticosteroid (e.g., dexamethasone): May lower the levels of Zenticide 600mg Tablet in your body, potentially decreasing its effectiveness against the infection.
PraziquantelCarbamazepine
Critical
PraziquantelPhenobarbital
Critical

Drug-Drug Interactions

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PraziquantelCarbamazepine
Critical
How does the drug interact with Zenticide 600mg Tablet:
When Zenticide 600mg Tablet is taken with Carbamazepine, it may decrease the blood levels of Zenticide 600mg Tablet, which may make Zenticide 600mg Tablet less effective in treating your condition.

How to manage the interaction:
Taking Carbamazepine with Zenticide 600mg Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
PraziquantelPhenobarbital
Critical
How does the drug interact with Zenticide 600mg Tablet:
Using Zenticide 600mg Tablet together with Phenobarbital may significantly reduce the blood levels of Zenticide 600mg Tablet, which may make the medication less effective.

How to manage the interaction:
Taking Phenobarbital with Zenticide 600mg Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
PraziquantelPhenytoin
Critical
How does the drug interact with Zenticide 600mg Tablet:
Using Zenticide 600mg Tablet together with phenytoin may significantly reduce the blood levels of Zenticide 600mg Tablet leading decreased effectiveness.

How to manage the interaction:
Taking Phenytoin with Praziquantelcan is not recommended as it cause an interaction, it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
PraziquantelPrimidone
Critical
How does the drug interact with Zenticide 600mg Tablet:
Taking Zenticide 600mg Tablet with primidone can lower the levels of Zenticide 600mg Tablet in your blood, which leads to a decreased therapeutic effect.

How to manage the interaction:
Taking Primidone with Zenticide 600mg Tablet is not recommended. Please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PraziquantelDexamethasone
Severe
How does the drug interact with Zenticide 600mg Tablet:
Taking Dexamethasone may reduce the blood levels of Zenticide 600mg Tablet, making the medication less effective.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Zenticide 600mg Tablet if prescribed by the doctor. Consult a doctor if your symptoms worsen or your condition changes. Do not discontinue the medication without a doctor's advice.
PraziquantelFosphenytoin
Severe
How does the drug interact with Zenticide 600mg Tablet:
When Zenticide 600mg Tablet is taken with Fosphenytoin, it can cause the body to break down Zenticide 600mg Tablet faster. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Fosphenytoin and Zenticide 600mg Tablet, but it can be taken if prescribed by a doctor. If you experience symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit juice: Consuming grapefruit or its juice can interfere with how your body breaks down this medicine, leading to higher drug levels in your blood and increased side effects like extreme dizziness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIHELMINTICS]

FAQs

Zenticide 600mg Tablet is used to treat parasitic infections, including Schistosomiasis and liver fluke infection.
Zenticide 600mg Tablet kills the parasites by paralysing the worms. This causes the worms to release their hold on the blood vessels so that they can be removed from the body. Thereby, Zenticide 600mg Tablet helps treat schistosomiasis and liver fluke infections.
To treat your infection effectually, continue taking Zenticide 600mg Tablet for as long as it has been prescribed by the doctor. Do not be reluctant to speak with the doctor if you experience any difficulty while taking Zenticide 600mg Tablet.
Concomitant administration of Zenticide 600mg Tablet with rifampin is not recommended as therapeutically effective blood levels of Zenticide 600mg Tablet may not be achieved when taken together. Consult your doctor if you are taking rifampin; your doctor may prescribe alternate medicine. However, if treatment with Zenticide 600mg Tablet is necessary, rifampin should be discontinued 4 weeks before starting Zenticide 600mg Tablet. Rifampin can be restarted one day after the completion of treatment with Zenticide 600mg Tablet.
Zenticide 600mg Tablet is unlikely to cause diarrhoea. Eat non-spicy food and drink plenty of fluids if you experience diarrhoea. If you notice bloody diarrhoea, consult your doctor immediately.
Avoid taking Zenticide 600mg Tablet if you have parasitic eye infections, as killing the parasite might cause blindness. Talk to your doctor if you have any concerns regarding this.
Yes. Zenticide 600mg Tablet is effective treatment for Schistosomiasis infections (Infection with the type of worm that lives in the bloodstream) and Liver fluke infections (Infection with a type of worm that lives in or nearer the liver), when it is taken as directed by the physician.
Yes. Zenticide 600mg Tablet may cause dizziness in some cases. Do not drive a vehicle or do anything that requires mental focus until you feel normal.
Do not take Zenticide 600mg Tablet if you are allergic to any of its ingredients, have a parasitic eye infection, or are pregnant. Additionally, breastfeeding should be avoided while taking Zenticide 600mg Tablet and for 3 days after finishing the medication. It's also important to note that Zenticide 600mg Tablet has not been proven safe for children under 4 years old, so be sure to consult a doctor before giving it to your child.
Store Zenticide 600mg Tablet in its original container, tightly closed. Follow the storage instructions on the label. Dispose of any unused medicine safely. Keep out of reach of children, pets, and others to avoid accidental consumption.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Zenticide 600mg Tablet is safe when used correctly, but like all medicines, it can have some side effects. To ensure safe use, it's important to talk to a healthcare professional before taking it. They will provide guidance and instructions on how to use Zenticide 600mg Tablet effectively. By following their advice, you can minimize the risk of side effects and use the medication safely.
The common side effects of Zenticide 600mg Tablet may include headache, dizziness, abdominal discomfort, nausea, and fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
It is highly recommended to take Zenticide 600mg Tablet with a meal and a full glass of water. Taking this medicine with food helps your body absorb it more effectively and helps prevent an upset stomach. Talk to your doctor or pharmacist if you have concerns about taking your dose.
The active components in Zenticide 600mg Tablet have a naturally bitter taste. To prevent this bitterness from causing nausea, gagging, or vomiting, you should swallow the tablets whole with water and avoid chewing or crushing them. Talk to your doctor or pharmacist if you find it difficult to swallow tablets.
Zenticide 600mg Tablet starts working quickly, paralyzing the parasites within hours of your first dose. Most people only need to take the medicine for a single day to successfully clear the infection. Talk to your doctor or pharmacist about your specific recovery expectations.
You should avoid drinking alcohol on the day you take Zenticide 600mg Tablet and for at least 48 hours after your treatment ends. Alcohol can worsen common side effects like dizziness, drowsiness, and headaches. Talk to your doctor or pharmacist for more safety advice.
If you are pregnant or planning to become pregnant, you should discuss the benefits and potential risks with your doctor before starting treatment. Your doctor will evaluate your condition and determine if this is the safest option for you. Talk to your doctor or pharmacist for personalized guidance.
This medicine can pass into breast milk. It is generally advised to stop breastfeeding on the day you take Zenticide 600mg Tablet and for 72 hours after your final dose to prevent your baby from absorbing the medication. Talk to your doctor or pharmacist for advice on how to safely feed your baby during this time.
No, Zenticide 600mg Tablet is specifically designed to treat infections caused by flukes and schistosoma parasites. It does not work against other common worms like pinworms, hookworms, or roundworms. Talk to your doctor or pharmacist to make sure you are using the correct medicine for your diagnosis.
If you vomit within one to two hours of taking your dose, the medicine may not have been fully absorbed into your system. Do not take an extra tablet on your own. Talk to your doctor or pharmacist immediately to find out if you need to repeat the dose.

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Reference

  1. U.S. Food and Drug Administration (FDA). 018714S012Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Praziquantel Pregnancy and Lactation Reference Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. DailyMed Database. Druginfo.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A608048 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Praziquantel Praziquantel. 2014. [Accessed on 31 Mar. 2019]Check here
  6. Praziquantel. NIH National Library of Medicine. National Center for Biotechnology Information. August 2022. [Accessed on 6th August 2022]Check here
  7. Macleods Pharmaceuticals Limited. Praziquantel. [Revised in April 2020] [Accessed on 6th August 2022] 0.pdfCheck here

Country of origin

India
Other Info - ZE75470
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