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compositionComposition:CALCIUM ACETATE-1334MG
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Prescription Medicine
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Zerofos DS Tablet is used to prevent high phosphate levels in the blood. It is commonly used to treat kidney failure in individuals undergoing regular haemodialysis or continuous ambulatory peritoneal dialysis (CAPD). Zerofos DS Tablet helps protect bones, blood vessels, and the heart by preventing complications such as bone weakness, itching, and calcium–phosphate deposits in tissues.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CALCIUM ACETATE-1334MG

Manufacturer/Marketer :

Alniche Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zerofos DS Tablet

Zerofos DS Tablet is an oral medication primarily used to lower high phosphorus levels in the blood of patients with severe kidney disease who are on dialysis. When kidneys are not working properly, they cannot remove excess phosphorus, which can lead to serious bone and heart problems. This medicine works by binding to phosphorus in your food so your body does not absorb it.

To get the best results, you must take Zerofos DS Tablet consistently with every meal and snack. Because it works directly on the food you eat, taking it without food makes it ineffective. Along with taking this medicine, following a low-phosphorus diet recommended by your healthcare provider is crucial for managing your condition.

Some people may experience mild side effects, such as mild constipation, nausea, or an upset stomach. However, you should contact your doctor immediately if you experience severe symptoms like confusion, muscle weakness, or extreme tiredness, which can be signs of excessively high calcium levels in your blood.

Talk to your doctor before taking Zerofos DS Tablet if you have any pre-existing health conditions, especially a history of kidney stones or high calcium levels. Do not take this if you already have high calcium levels in your blood, as this medication can make your condition worse.

This medicine can interact with several other drugs, including certain antibiotics and thyroid medications, by preventing your body from absorbing them properly. While there is no direct interaction with alcohol, drinking alcohol can worsen dehydration and electrolyte balance in kidney disease. Talk to your doctor or pharmacist if you are pregnant, breastfeeding, or an older adult, as your dosing or monitoring needs may differ.

Uses of Zerofos DS Tablet

Your doctor may prescribe Zerofos DS Tablet to treat the following conditions:

  • High phosphorus levels in kidney disease (Hyperphosphatemia): Zerofos DS Tablet helps by binding to phosphorus from the food in your digestive tract, preventing it from entering your bloodstream and keeping your levels within a safe range.

Key Benefits

Zerofos DS Tablet helps control high phosphate levels in people with chronic kidney disease undergoing dialysis. By lowering phosphate absorption from food, it helps maintain a healthier mineral balance and reduces the risk of complications affecting the bones, blood vessels, and other organs.

  • Helps control blood phosphate levels: Reduces the amount of phosphate absorbed from food, helping keep phosphorus levels within the target range.
  • Supports bone health: Maintaining healthy phosphate levels helps protect bones, reducing the risk of bone pain, fractures, and other complications of chronic kidney disease.
  • Helps protect the heart and blood vessels: By preventing excess phosphate from building up in the body, it helps reduce the risk of calcium-phosphate deposits in blood vessels and other soft tissues.
  • Supports long-term kidney disease management: Keeping phosphate levels under control contributes to better mineral balance and supports overall health and quality of life during long-term dialysis treatment.
Side effects of Zerofos DS Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Zerofos DS Tablet can be taken with meals to prevent stomach upset or as advised by your doctor.
  • It is usually taken twice daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew or break it.

How Zerofos DS Tablet Works

Zerofos DS Tablet contains calcium acetate, which works locally in your digestive tract as a chemical binder. When you take this medicine with a meal or snack, it immediately mixes with the food in your stomach and intestines. It acts like a magnet, attaching itself directly to the phosphorus present in your diet. Once attached, it forms a large compound that your digestive system cannot absorb. Instead of entering your blood, this bound phosphorus is safely carried through your digestive tract and passed out of your body in your stool. This highly targeted process successfully lowers your daily phosphorus absorption, protecting your kidneys and blood vessels.
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Alcohol

Unsafe

Avoid the consumption of alcohol as it may cause some side effects and make Zerofos DS Tablet less effective.

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Pregnancy

Consult your doctor

Zerofos DS Tablet should not be used in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Zerofos DS Tablet should not be used in nursing mothers unless clearly necessary. Inform your doctor if you are breastfeeding.

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Driving

Safe if prescribed

Zerofos DS Tablet does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

If you have liver problems, inform your doctor before taking Zerofos DS Tablet . Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney conditions, inform your doctor before taking Zerofos DS Tablet . Your doctor may adjust the dose of this medicine based on your condition.

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Children

Consult your doctor

Safety and effectiveness in pediatric patients have not been established. Please consult your doctor.

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Heart

Caution

Zerofos DS Tablet can be taken by individuals with heart problems, but only under medical supervision. Excess calcium may worsen conditions like arterial calcification or interact with heart medications, so dosage and timing must be carefully managed.

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Geriatrics

Caution

Geriatric patients can take Zerofos DS Tablet , but they may be more sensitive to its effects. Careful dosing and regular monitoring of calcium levels are important to prevent complications such as hypercalcemia.

What if I have taken an overdose of Zerofos DS Tablet

If you suspect an overdose, seek immediate medical attention or contact your local emergency services. Taking too much of this medicine can cause dangerously high calcium levels in your blood, which requires prompt medical care.

Diet & Lifestyle Advise

  • Follow your prescribed low-phosphorus diet: Strictly follow the meal plan recommended by your doctor or renal dietitian to help keep your blood phosphorus levels within the target range.
  • Limit high-phosphorus foods: Reduce your intake of foods naturally rich in phosphorus, such as dairy products, nuts, seeds, beans, chocolate, dark cola drinks, whole grains, and processed foods containing phosphate additives.
  • Choose kidney-friendly foods: Include foods recommended by your healthcare provider that are lower in phosphorus while ensuring you receive adequate nutrition for your overall health.
  • Keep a food diary: Record your daily meals and snacks to help identify hidden sources of phosphorus and allow your healthcare team to adjust your diet if needed.
  • Attend regular blood tests: Keep all scheduled laboratory appointments to monitor your blood phosphorus, calcium, and parathyroid hormone (PTH) levels so your treatment can be adjusted appropriately.
health query

Have a query?

How Soon It Starts Working

  • The time required for Zerofos DS Tablet to start to work: The onset time of Zerofos DS Tablet has not been clinically established.
  • The time for which the effects of Zerofos DS Tablet last: The duration of Zerofos DS Tablet ’s effect is clinically not established.

What if you forget to take Zerofos DS Tablet

Take the missed dose with your next meal or snack if it is close to your usual mealtime. If you skip a meal entirely, skip that dose of Zerofos DS Tablet as well. Do not take a double dose to make up for a missed one.

Storage

•Store Zerofos DS Tablet at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the packaging before use: Make sure the blister pack or bottle seal is intact and that the tablets or capsules are not damaged, discoloured, or expired before taking the medicine.
  • Avoid extra calcium unless advised: Do not take over-the-counter calcium supplements or calcium-containing antacids while using Zerofos DS Tablet unless your doctor specifically recommends them.
  • Separate other oral medicines: Take other oral medications at least 2 hours before or 2 hours after taking Zerofos DS Tablet , as it may reduce their absorption and make them less effective.
  • Watch for signs of high calcium levels: Contact your doctor if you develop persistent nausea, vomiting, severe constipation, unusual thirst, frequent urination, muscle weakness, or confusion, as these may indicate high blood calcium levels.
  • Inform your healthcare providers: Tell your doctor, dentist, and pharmacist that you are taking Zerofos DS Tablet before starting any new medicine or undergoing any medical or dental procedure.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain antibiotics (such as ciprofloxacin, levofloxacin, and doxycycline): Taking Zerofos DS Tablet at the same time can significantly decrease the absorption and effectiveness of these antibiotics.
  • Thyroid medications (such as levothyroxine): Zerofos DS Tablet may bind to thyroid hormone replacements, lowering their effectiveness in your body.
  • Vitamin D analogues: Combining these with Zerofos DS Tablet may increase the risk of developing dangerously high calcium levels in your blood.
Calcium acetateDolutegravir
Severe
Calcium acetateLymecycline
Severe

Drug-Drug Interactions

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Calcium acetateDolutegravir
Severe
How does the drug interact with Zerofos DS Tablet:
Co-administration of Dolutegravir with Zerofos DS Tablet can reduce the effectiveness of dolutegravir.

How to manage the interaction:
Taking Dolutegravir with Zerofos DS Tablet together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take dolutegravir at least two hours before or six hours after the Zerofos DS Tablet dose. Do not discontinue any medications without consulting a doctor.
Calcium acetateLymecycline
Severe
How does the drug interact with Zerofos DS Tablet:
Zerofos DS Tablet may interfere with the absorption of lymecycline and reduce its effectiveness.

How to manage the interaction:
Zerofos DS Tablet may interfere with the absorption of lymecycline and reduce its effectiveness. Although there is an interaction, Zerofos DS Tablet can be taken with lymecycline if prescribed by the doctor.
Calcium acetateDemeclocycline
Severe
How does the drug interact with Zerofos DS Tablet:
Co-administration of Zerofos DS Tablet may interfere with the absorption of Demeclocycline and reduce its effectiveness.

How to manage the interaction:
Taking Zerofos DS Tablet may interfere with the absorption of Demeclocycline and reduce its effectiveness. Therefore, Zerofos DS Tablet and demeclocycline should not be taken orally at the same time. Maintaining a gap of 2-4 hours between both medicines is advised. Do not discontinue the medication without consulting a doctor.
Calcium acetateDoxycycline
Severe
How does the drug interact with Zerofos DS Tablet:
Co-administration of doxycycline with Zerofos DS Tablet can reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between Zerofos DS Tablet and doxycycline, it can be taken together if prescribed by a doctor. It is adviced to take doxycycline 2 hrs before or 6 hours after taking Zerofos DS Tablet. Do not stop using any medications without talking to a doctor.
Calcium acetateOxytetracycline
Severe
How does the drug interact with Zerofos DS Tablet:
Co-administration of Oxytetracycline when taken along with Zerofos DS Tablet lowers the levels of either medication. This interaction applies to the oral forms of both medications.

How to manage the interaction:
Although taking Oxytetracycline and Zerofos DS Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Calcium-rich foods and beverages: Eating large amounts of dairy products or drinking calcium-fortified juices while taking this medicine can increase your risk of high blood calcium levels.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MINERALS]

FAQs

Zerofos DS Tablet is used to manage elevated phosphate levels in the blood of people with chronic kidney disease. It helps manage high blood phosphate levels and reduces the risk of complications.
Zerofos DS Tablet controls phosphate levels by removing phosphate from the food you eat before it enters the bloodstream. Thus, it helps prevent high phosphate levels in the bloodstream.
High phosphorus levels often do not cause symptoms on their own. However, excess phosphorus in your blood can remove calcium from your bones and other tissues, leading to low calcium (hypocalcemia). Low calcium can cause symptoms such as muscle cramps, bone and joint discomfort, weak bones, and itchy skin or a rash.
It is not recommended for use if you are allergic to any components present in Zerofos DS Tablet , if you have high levels of calcium in your blood or urine, or if you have low levels of phosphate in your blood.
Doctors will test your blood phosphate level to see if you have excess phosphorus. If your phosphate level is higher than 4.5 mg/dL, your doctor may order additional tests to rule out kidney disease.
Zerofos DS Tablet may cause side effects such as nausea, vomiting, diarrhoea and constipation. If these side effects persist or worsen, please consult your doctor.
Milk, paneer, cheese, curd, and other dairy products, as well as Chinese cabbage, broccoli, and kale, are good sources of calcium.
If you have a kidney problem or a kidney stone, tissue calcification (deposit of calcium in body tissues) and if you are taking water pills, medicine for heart failure or any other calcium-containing medicines or supplements, inform your doctor.
Yes, Zerofos DS Tablet is a health supplement and taking too much of it can be harmful. An overdose can cause stomach discomfort. If you think you have taken too much of Zerofos DS Tablet , seek medical help immediately.
If you skip a meal or snack, you should also skip your dose of Zerofos DS Tablet for that meal. Because the medication requires food to bind phosphorus, taking it without eating is unnecessary and could cause your calcium levels to rise too high. Talk to your doctor or pharmacist if you frequently skip meals.
No, you should not take your thyroid medication at the same time. Zerofos DS Tablet can bind to thyroid hormones like levothyroxine in your stomach, preventing your body from absorbing them. You should separate these medications by several hours. Talk to your doctor or pharmacist to set up a safe dosing schedule.
It is not fully known if Zerofos DS Tablet is safe for an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss the risks and benefits with your healthcare provider. Your doctor will help decide if this medication is appropriate for you. Talk to your doctor for personalised advice.
Regular blood tests are necessary to monitor both your phosphorus and calcium levels. This helps your doctor verify that the medicine is working and ensure your calcium levels do not rise to unsafe limits. Based on these results, your doctor may adjust your treatment. Talk to your doctor about your testing schedule.
You should swallow the tablets or capsules whole with water. Chewing or crushing them is generally not recommended unless your doctor or pharmacist specifically advises you to do so. If you have trouble swallowing your pills, talk to your doctor about alternative options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

S-14, 1St Floor, Janta Market, Rajouri Garden, New Delhi, 110 027
Other Info - ZER0200

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