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compositionComposition:MELATONIN-3MG+ZOLPIDEM-10MG
prescription
Prescription Medicine
info
Zolcalm-10 Tablet 10's
Zolcalm-10 Tablet 10's
Zolcalm-10 Tablet 10's

Zolcalm-10 Tablet is used in the treatment of insomnia. It contains Zolpidem and Melatonin, which relaxes muscles, reduces anxiety, and helps to fall asleep. It may cause side effects such as nausea, headache, diarrhoea, drowsiness, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MELATONIN-3MG+ZOLPIDEM-10MG

Manufacturer/Marketer :

Linux Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Zolcalm-10 Tablet

Zolcalm-10 Tablet is prescribed for the short-term treatment of sleep disturbances, including difficulty falling asleep or staying asleep (insomnia). Its primary medical purpose is to restore a natural sleep cycle and help you achieve deep, restful sleep. It is typically used for individuals suffering from temporary insomnia or sleep cycle disruptions.

This medicine is generally taken once a day, immediately before you go to bed. It is important to use it consistently and exactly as directed by your doctor. For the best results, take this medicine on an empty stomach, and establish a relaxing bedtime routine to help your body prepare for rest.

Some people may experience mild side effects, such as daytime drowsiness or dry mouth. However, if you experience serious side effects, such as confusion, severe dizziness, or performing activities while asleep (like sleepwalking), you must contact your doctor immediately.

Talk to your doctor or pharmacist before starting this medicine if you have a history of liver problems, depression, mental health conditions, or chronic breathing difficulties. Do not take this medicine if you have severe liver damage or severe breathing disorders. If you have previously experienced sleepwalking or other complex sleep behaviours, tell your doctor before starting treatment, as your doctor will carefully assess whether this medicine is appropriate for you.

Taking this medicine with alcohol can cause extreme drowsiness and dangerous breathing difficulties. Always tell your doctor about other medications you are taking, and consult your doctor or pharmacist if you are pregnant, breastfeeding, or an older adult, as safety precautions may vary. This medicine is generally intended for short-term use, usually for no longer than 2 to 4 weeks, unless your doctor advises otherwise. If your sleep problems continue, worsen, or return after treatment, do not increase your dose on your own.

Uses of Zolcalm-10 Tablet

Zolcalm-10 Tablet is used in the treatment of Insomnia (sleeplessness). The detailed use of Zolcalm-10 Tablet is as follows:

  • Insomnia: Helps reduce the time it takes to fall asleep and decreases nightly awakenings.
  • Sleep-wake cycle disruptions: Relieves sleep problems caused by jet lag or irregular sleep schedules, helping reset your internal biological clock.

Key Benefits

Zolcalm-10 Tablet helps improve sleep by making it easier to fall asleep and stay asleep through the night. A better night's rest can leave you feeling more refreshed, alert, and ready for your daily activities.

Benefits may include:

  • Helps you fall asleep more quickly.
  • Reduces frequent waking during the night.
  • Improves overall sleep quality and duration.
  • Supports a more regular and restful sleep pattern.
  • Promotes better daytime alertness, focus, and energy.
  • Provides relief from symptoms of short-term insomnia.
Side effects of Zolcalm-10 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Take this medicine by mouth immediately before bedtime.
  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • Ensure you have a full 7 to 8 hours to dedicate to sleep after taking this medicine.

How Zolcalm-10 Tablet Works

Zolcalm-10 Tablet contains two active components that target sleep through different pathways in the body. • Zolpidem: It belongs to a group of medicines called non-benzodiazepine hypnotics. It enhances the effect of a natural calming chemical in the brain called GABA, helping slow brain activity so you can relax, fall asleep more quickly, and stay asleep. • Melatonin: It is a hormone naturally produced by your body that helps regulate your sleep-wake cycle. This medicine supplies an additional dose of melatonin to reinforce your body's natural sleep signal, helping you recognise that it is time to sleep and supporting a more regular sleep pattern.
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Alcohol

Unsafe

Avoid consumption of alcohol with Zolcalm-10 Tablet as it may increase the risk of dependence, psychomotor impairment (slowdown of thought process, and reduced physical movements), sleepwalking, or sleep-driving.

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Pregnancy

Unsafe

Zolcalm-10 Tablet contains Zolpidem, a Category C pregnancy drug, and is not recommended for use during pregnancy as it may cause adverse effects in the baby after birth.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zolcalm-10 Tablet as it may be excreted in breast milk.

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Driving

Unsafe

You may experience dizziness, drowsiness, confusion, decreased alertness, blurred, or double vision, especially the day after taking Zolcalm-10 Tablet . Therefore, avoid driving if you feel drowsy or dizzy after taking Zolcalm-10 Tablet .

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Liver

Caution

Take Zolcalm-10 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zolcalm-10 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Zolcalm-10 Tablet is not recommended for children below 18 years of age.

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Heart

Caution

Zolcalm-10 Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Unsafe

Zolcalm-10 Tablet is not safe for use in elderly patients due to its serious side effects.

What if I have taken an overdose of Zolcalm-10 Tablet

If you suspect an overdose, seek immediate medical attention or call emergency services. Symptoms of an overdose may include extreme sleepiness, confusion, severe dizziness, or slowed breathing.

Diet & Lifestyle Advise

  • Create a restful bedroom: Keep your bedroom dark, quiet, and comfortably cool to create an environment that supports better sleep.
  • Limit bedtime triggers: Avoid heavy meals, caffeine, and drinking large amounts of fluids close to bedtime to reduce the chance of waking up during the night.
  • Reduce screen time: Switch off phones, televisions, and other electronic devices at least one hour before bed to help your body prepare for sleep.
  • Follow a regular schedule: Go to bed and wake up at the same time every day, including weekends, to help maintain a healthy sleep routine.

Health Queries

Have a query?

How Soon It Starts Working

  • The time required for Zolcalm-10 Tablet to start to work: The time required for Zolcalm-10 Tablet to show its action is unknown.
  • The time for which the effects of Zolcalm-10 Tablet last: The duration of action for Zolcalm-10 Tablet is clinically unknown.

What if you forget to take Zolcalm-10 Tablet

If you forget to take your medicine at bedtime, only take it if you can immediately go to sleep and have a full 7 to 8 hours to remain asleep. If you do not have 7 to 8 hours of sleep time left before you must be active, skip the missed dose entirely and resume your normal schedule the next night. Never take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Take only at bedtime: Take this medicine only when you are ready to go to bed and can sleep for a full night. This helps reduce the risk of feeling sleepy or less alert the next day.
  • Avoid driving or hazardous activities: Do not drive, operate machinery, or do anything that requires full alertness the next morning until you know how this medicine affects you.
  • Watch for unusual sleep behaviours: Stop taking this medicine and contact your doctor immediately if you or your family notice activities such as sleepwalking, eating, driving, or making phone calls while you are asleep.
  • Avoid alcohol completely: Do not drink alcohol while taking this medicine. Alcohol can greatly increase drowsiness and raise the risk of serious side effects.
  • Use only as prescribed: Take this medicine only if it has been prescribed for you. Do not share it with others, as improper use can lead to dependence, misuse, or serious side effects.
  • Not for children: This medicine is generally not recommended for children and adolescents under 18 years of age. Its safety and effectiveness have not been established in this age group.

Drug-Drug Interactions

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  • Sleep Aids or Sedatives (e.g., eszopiclone, zaleplon): Taking these medicines alongside Zolcalm-10 Tablet may increase the risk of severe drowsiness, confusion, and breathing problems.
  • Opioid Pain Relievers (e.g., tramadol, morphine): Taking these medicines alongside Zolcalm-10 Tablet may increase the risk of extreme drowsiness, slowed breathing, coma, or death.
  • Antidepressants or Psychiatric Medicines (e.g., fluoxetine, amitriptyline): Taking these medicines alongside Zolcalm-10 Tablet may increase the risk of excessive drowsiness and other side effects.
Melatonin + ZolpidemSodium oxybate
Critical
Melatonin + ZolpidemSufentanil
Severe

Drug-Drug Interactions

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Melatonin + ZolpidemSodium oxybate
Critical
How does the drug interact with Zolcalm-10 Tablet:
Taking sodium oxybate with Zolcalm-10 Tablet can significantly increase the risk of severity of side effects such as low blood pressure, breathing difficulties, fainting and unconsciousness.

How to manage the interaction:
Although there is an interaction between sodium oxybate and Zolcalm-10 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemSufentanil
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with sufentanil can cause sedation (a state of being relaxed or sleepy).

How to manage the interaction:
Although there is an interaction between Zolcalm-10 Tablet and sufentanil and zolpidem, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemKetamine
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with ketamine increases the effects of zolpidem. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between ketamine and Zolcalm-10 Tablet, it can be taken if a doctor has prescribed it. However, if you experience dizziness, sleepiness, difficulty concentrating, or impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemTapentadol
Severe
How does the drug interact with Zolcalm-10 Tablet:
Coadministration of Zolcalm-10 Tablet with tapentadol can increase the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between Zolcalm-10 Tablet with tapentadol, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, sleepiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemEsketamine
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with esketamine can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between esketamine and Zolcalm-10 Tablet, it can be taken if a doctor has prescribed it. However, if you experience dizziness, sleepiness, difficulty concentrating, or impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemButorphanol
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with butorphanol can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between butorphanol and Zolcalm-10 Tablet, they can be taken together if prescribed by a doctor. However, if you experience dizziness, sleepiness, difficulty concentrating, and impairment in judgment, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemFentanyl
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with fentanyl can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between fentanyl and zolpidem, it can be taken if a doctor has prescribed it. However, if you experience dizziness, sleepiness, difficulty concentrating, and impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemHydrocodone
Severe
How does the drug interact with Zolcalm-10 Tablet:
Coadministration of Zolcalm-10 Tablet with hydrocodone can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between hydrocodone and Zolcalm-10 Tablet, it can be taken if a doctor has prescribed it. However, if you experience dizziness, sleepiness, difficulty concentrating, or impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemMethadone
Severe
How does the drug interact with Zolcalm-10 Tablet:
Coadministration of Zolcalm-10 Tablet with methadone can increase the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between methadone and Zolcalm-10 Tablet, it can be taken if a doctor has prescribed it. However, if you experience dizziness, sleepiness, difficulty concentrating, or impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.
Melatonin + ZolpidemCodeine
Severe
How does the drug interact with Zolcalm-10 Tablet:
Taking Zolcalm-10 Tablet with codeine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between codeine and Zolcalm-10 Tablet, it can be taken together if prescribed by a doctor. However, if you experience dizziness, sleepiness, difficulty concentrating, or impairment in judgment, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-Fat Meals: Consuming fried foods, pizza, burgers, or creamy meals while taking Zolcalm-10 Tablet may delay how quickly the medicine starts working.
  • Alcohol: Consuming alcohol while taking Zolcalm-10 Tablet may increase the risk of extreme drowsiness, confusion, slowed breathing, or impaired alertness.
MELATONIN-3MG+ZOLPIDEM-10MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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MELATONIN-3MG+ZOLPIDEM-10MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine with Zolcalm-10 Tablet may increase the blood levels and effects of Zolcalm-10 Tablet. Avoid taking excessive caffeine consumption while being treated with Zolcalm-10 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[SEDATIVE-HYPNOTIC DRUGS]

FAQs

Zolcalm-10 Tablet is used in the treatment of insomnia.
Zolcalm-10 Tablet is a sleeping pill used to treat insomnia (difficulty in falling or staying asleep). Zolpidem increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) involved in inducing sleep. Melatonin is a natural hormone that helps to maintain the normal sleep cycle (waking up and falling asleep)
No, Zolcalm-10 Tablet is not recommended for depression patients as it may worsen the condition and increase self-harming or suicidal thoughts. Therefore, if you are suffering from depression or have a history of depression, please inform your doctor before taking Zolcalm-10 Tablet .
You are recommended to take Zolcalm-10 Tablet just before bedtime as it helps to sleep quickly and improves sleep quality. If you forget to take Zolcalm-10 Tablet at night, do not take it in the day time as it may cause drowsiness, confusion and dizziness.
No, you are not recommended to take Zolcalm-10 Tablet with hydrocodone or other opioid pain killers such as oxycodone, naloxone, and tramadol as co-administration of these medicines with Zolcalm-10 Tablet may increase the risk of difficulty in breathing, drowsiness, coma, and even death. However, before using Zolcalm-10 Tablet with any other medicines, you are advised to contact your doctor so that the dose may be adjusted to use safely.
Yes, Zolcalm-10 Tablet may cause dependence (mental and physical effects caused due to compulsion of taking Zolcalm-10 Tablet ) if used in high doses and for a prolonged time. This risk of dependency on Zolcalm-10 Tablet increases in patients who have a history of drug or alcohol abuse.
No, you should only take this medicine if you have a full 7 to 8 hours to sleep. Taking it with less sleep time can cause severe morning drowsiness and make activities like driving dangerous. Talk to your doctor if your schedule does not allow a full night's sleep.
No. This medicine is intended for short-term use, usually no longer than 2 to 4 weeks, unless your doctor advises otherwise. Using it every night for longer periods may increase the risk of tolerance, dependence, and withdrawal symptoms if it is stopped suddenly. Your doctor will review your condition if longer treatment is needed.
If you experience sleepwalking or any other sleep behaviours, stop taking the medicine immediately and call your doctor. These side effects can be dangerous and require alternative medical advice.
No, you must completely avoid alcohol while taking this medicine. Combining them can cause severe drowsiness, confusion, and dangerously slow breathing.
Using this medicine during pregnancy is generally not recommended unless deemed necessary by your healthcare provider. Talk to your doctor to weigh the risks and benefits.
Some people may experience morning drowsiness, especially if they do not get a full 7 to 8 hours of sleep. If you feel groggy, avoid driving or operating machinery and talk to your doctor.
It is best to take this medicine on an empty stomach right before bed. Taking it with a heavy meal can delay its effects, meaning it will take longer for you to fall asleep.
If you wake up during the night and forgot your dose, only take it if you still have 7 to 8 hours of uninterrupted sleep time remaining. Otherwise, skip the dose and resume your regular schedule the next night. Talk to your doctor if you have further concerns.
If your sleep does not improve within 7 to 10 days, worsens, or returns after treatment, schedule a follow-up with your doctor. Persistent insomnia may be caused by another medical or mental health condition that requires further evaluation. Do not increase your dose or continue taking the medicine longer than prescribed without medical advice.

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Reference

  1. U.S. Food and Drug Administration (FDA). 019908S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Zolpidem Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. National Health Service (NHS). Zolpidem - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Electronic Medicines Compendium (EMC). Pil.10405 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Drugs H. Zolpidem: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2022 [Accessed on 24 Nov 2025] Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2022 [Accessed on 24 Nov 2025] Check here
  7. [Internet]. Rxlist.com. 2022 [Accessed on 24 Nov 2025]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Plot no: 492, Viduthalai Nagar Extension Near JD Mahal, Pallavaram Thuraipakam Road S.Kulathur,Kovilambakkam, Chennai - 600 117
Other Info - ZOL0174

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