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compositionComposition:ZONISAMIDE-100MG
prescription
Prescription Medicine
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Zonegran Tablet is used to treat epilepsy (seizures/fits). It contains Zonisamide, which reduces the abnormal and excessive activity of nerve impulses in the brain that cause fits or seizures. In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, nausea, headache, or uncontrolled movements. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ZONISAMIDE-100MG

Manufacturer/Marketer :

Eisai Pharmaceuticals India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zonegran Tablet

Zonegran Tablet is an oral prescription medication used to treat partial seizures in adults with epilepsy. It is typically prescribed alongside other seizure medications to help control and reduce the frequency of these episodes. By stabilising electrical activity in the brain, it supports overall seizure management.

For Zonegran Tablet to work effectively, you must take it consistently every day at the same times as directed by your doctor. You can take this medication with or without food, but you should swallow the capsules whole with plenty of water. Drinking extra fluids and staying well-hydrated throughout the day can significantly lower your risk of developing kidney stones while on this treatment.

Many people taking Zonegran Tablet experience mild side effects, like drowsiness, dizziness, or a loss of appetite. However, you must contact your doctor immediately if you notice serious symptoms such as severe skin rashes, difficulty breathing, decreased sweating, or sudden mood changes like depression or suicidal thoughts.

Before starting Zonegran Tablet , tell your doctor if you have a history of kidney disease, liver problems, or a sulfa allergy. Do not take this medication if you have had a severe allergic reaction to sulfonamide drugs, as the active ingredient in Zonegran Tablet belongs to this chemical family.

Zonegran Tablet can interact with other medications that cause drowsiness, as well as alcohol, which can worsen dizziness and slow down your reaction times. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should discuss the risks and benefits thoroughly with your doctor before starting this medication.

Uses of Zonegran Tablet

Zonegran Tablet is used to treat partial seizures in adults with epilepsy. The detailed uses of Zonegran Tablet are as follows:

  • Partial seizures in adults with epilepsy: Zonegran Tablet is used as an add-on treatment to help control and reduce the frequency of seizures that start in one specific area of the brain.

Key Benefits

Zonegran Tablet provides critical support for individuals living with epilepsy by reducing the sudden, uncontrolled electrical disturbances in the brain. Achieving better control over these episodes allows patients to experience fewer disruptions in their daily lives. Some of the key benefits patients may experience include:

  • Helps Reduce Seizure Frequency: By controlling excessive electrical activity in the brain, Zonegran Tablet helps reduce the frequency of seizures, supporting more stable day-to-day functioning.
  • Supports Greater Confidence in Daily Life: Better seizure control with Zonegran Tablet can help reduce the uncertainty associated with unexpected seizures, allowing you to carry out daily activities with greater confidence and peace of mind.
  • Enhances Long-Term Epilepsy Management: When used as prescribed, either alone or in combination with other anti-seizure medicines, Zonegran Tablet helps provide effective long-term seizure control and supports overall epilepsy management.
Side effects of Zonegran Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Zonegran Tablet can be taken with or without food as advised by your doctor.
  • It is usually taken once or twice a day or as directed by the doctor.
  • Swallow Zonegran Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Zonegran Tablet Works

Zonegran Tablet contains zonisamide. It works by stabilising the electrical activity in your brain. Under normal conditions, brain cells communicate using controlled electrical signals. During a seizure, these signals become hyperactive and disorganised. The active zonisamide compound in Zonegran Tablet helps block certain sodium and calcium channels in brain cells, which stops the rapid and repetitive firing of these electrical signals. By calming this overactivity, the medication helps prevent a seizure from starting or spreading to other parts of the brain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zonegran Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking Zonegran Tablet if you are pregnant unless prescribed by a doctor to lead to serious birth defects/congenital disabilities. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Zonegran Tablet should not be taken by breastfeeding mothers as it passes into breast milk and could lead to side-effects for breastfed babies.

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Driving

Unsafe

Zonegran Tablet causes drowsiness, sleepiness, and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Zonegran Tablet can be given to children above 6 years if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Zonegran Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Zonegran Tablet

If you take too much Zonegran Tablet , seek emergency medical attention or call your local hospital immediately. Symptoms of an overdose may include extreme drowsiness, slow heart rate, shallow breathing, or fainting.

Diet & Lifestyle Advise

  • Stay highly hydrated: Drink at least 6 to 8 glasses of water daily. This is critical to lower your risk of developing kidney stones, which is a known risk with zonisamide therapy.
  • Avoid overheating: Since Zonegran Tablet can reduce your ability to sweat, avoid extreme heat, saunas, and intense exercise in hot weather. Dress in cool layers and stay in air-conditioned spaces when temperatures rise.
  • Maintain a consistent sleep schedule: Lack of sleep is a well-known trigger for seizures. Aim for 7 to 9 hours of quality sleep each night.
  • Limit alcohol consumption: Alcohol can increase the sedative effects of Zonegran Tablet , making you dangerously drowsy or dizzy, and can also trigger seizures.
  • Keep a seizure diary: Track when your seizures occur, what you were doing, and any side effects you experience. This information is incredibly valuable for your doctor during check-ups.

Health Queries

Can Zonegran 100 cause sexual side effects, such as difficulty getting or keeping a firm erection?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

While difficulty getting or keeping an erection is not among the most common side effects of Zonegran (zonisamide), sexual side effects can occasionally occur. Other factors, including stress or the underlying condition itself, can also play a role. Please don't be discouraged, as there are many ways to manage this. I gently encourage you to discuss this openly with your prescribing doctor. They can help identify the cause and safely adjust your treatment or explore alternative options to help you feel like yourself again.

I have been using Zonegran for the last 6 years, but sometimes I have headaches and increased sleepiness. What should I do?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Headache and increased sleepiness can be side effects of Zonegran, especially with long-term use. Do not stop the medicine on your own, but discuss these symptoms with your doctor. A dose adjustment or review may be needed to reduce these effects.
health query

Have a query?

How Soon It Starts Working

  • The time required for Zonegran Tablet to start to work: The time required for Zonegran Tablet to show its action is not clinically established.
  • The time for which the effects of Zonegran Tablet last: The duration of action for Zonegran Tablet is not clinically established.

What if you forget to take Zonegran Tablet

If you miss a dose of Zonegran Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one. If you miss multiple doses, talk to your doctor or pharmacist for guidance.

Storage

•Store Zonegran Tablet capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Check your skin daily. Contact your doctor immediately if you notice any new rash, itching, or skin peeling, as this medication can cause rare but life-threatening skin reactions.
  • Do not drive or operate heavy machinery until you know how Zonegran Tablet affects you, as it can cause significant drowsiness and slow your reflexes.
  • Monitor your mood closely. Have a family member or caregiver watch for sudden changes in your behaviour, depressive thoughts, or signs of self-harm.
  • Tell all healthcare providers, including your dentist, that you are taking Zonegran Tablet before undergoing any medical procedures or starting new prescriptions.
  • Never stop taking this medicine abruptly. Doing so can cause a severe, continuous state of seizures that can be dangerous.

Drug-Drug Interactions

verifiedApollotooltip
  • Other carbonic anhydrase inhibitors (like topiramate or acetazolamide): Taking these alongside Zonegran Tablet can increase the risk of metabolic acidosis (too much acid in the blood) and kidney stones.
  • Sedatives and sleep aids: Medicines that cause drowsiness, such as benzodiazepines or muscle relaxants, can cause extreme sleepiness when taken with Zonegran Tablet .
  • Certain seizure medications (like phenytoin, carbamazepine, or phenobarbital): These drugs can speed up how your body processes Zonegran Tablet , potentially lowering its effectiveness.
ZonisamideAripiprazole
Severe
ZonisamideAmitriptyline
Severe

Drug-Drug Interactions

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ZonisamideAripiprazole
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Aripiprazole with Zonegran Tablet can increase the risk or severity of Zonegran Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Aripiprazole with Zonegran Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamideAmitriptyline
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Amitriptyline and Zonegran Tablet both increase body temperature while decreasing sweating.

How to manage the interaction:
Zonegran Tablet and Amitriptyline interact, however, if prescribed by a doctor, they can both be used. Some people may experience heat stroke and need to be hospitalized, especially in warm weather and while engaging in intense exercise. Children are especially at risk. If you feel sleepy, uneasy, or lightheaded after taking these medications combined, consult a doctor. Without consulting a doctor, never stop taking medicines.
ZonisamideHaloperidol
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Haloperidol with Zonegran Tablet can increase the risk or severity of developing Zonegran Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Haloperidol with Zonegran Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideRisperidone
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Risperidone with Zonegran Tablet can increase the risk of Zonegran Tablet side effects.

How to manage the interaction:
Taking Risperidone with Zonegran Tablet together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZonisamidePromethazine
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Promethazine with Zonegran Tablet can increase the risk or severity of Zonegran Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Promethazine with Zonegran Tablet together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideBenzatropine
Severe
How does the drug interact with Zonegran Tablet:
Zonegran Tablet can cause Benzatropine to be eliminated from the body faster, leading to lower levels in the blood and possibly reducing its effectiveness.

How to manage the interaction:
Taking Benzatropine with Zonegran Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like feeling too hot, not sweating enough, feeling very tired, dizzy, or lightheaded, it's important to call a doctor right away. They may be able to recommend other options for you that won't cause these problems. Do not discontinue any medications without consulting a doctor.
ZonisamideFlavoxate
Severe
How does the drug interact with Zonegran Tablet:
Co-administration of Flavoxate and Zonegran Tablet may increase body temperature and decrease sweating.

How to manage the interaction:
If you are supposed to take Flavoxate and Zonegran Tablet together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. Drink plenty of fluids during warm weather and when exercising and contact a doctor if you have decreased sweating or a fever. Avoid activities requiring mental alertness such as driving or operating hazardous machinery, until you know how the medications affect you. Do not discontinue any medication without consulting a doctor.
ZonisamideCyproheptadine
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Cyproheptadine with Zonegran Tablet can lead to increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Cyproheptadine with Zonegran Tablet together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
ZonisamideMetformin
Severe
How does the drug interact with Zonegran Tablet:
The combined use of Metformin with Zonegran Tablet may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Co-administration Metformin with Zonegran Tablet can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as weakness, muscle pain, respiratory distress, consult a doctor immediately. Do not stop using any medication without a doctor's advice.
ZonisamideTrihexyphenidyl
Severe
How does the drug interact with Zonegran Tablet:
Coadministration of Trihexyphenidyl with Zonegran Tablet can increase the risk or severity of Zonegran Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Trihexyphenidyl with Zonegran Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while taking Zonegran Tablet can severely increase central nervous system side effects like dizziness, confusion, and drowsiness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Zonegran Tablet belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy (seizures/fits).
Zonegran Tablet consists of zonisamide, which decreases the brain's excessive and abnormal nerve activity by blocking sodium and calcium currents in your brain and body. This reduces abnormal electrical activity between your nerve cells.
Zonegran Tablet should be used with caution during hot weather, as it may increase the chance of having a heat stroke. Inform your doctor if you have heat intolerance or fever. To avoid this condition, it is advisable to drink a lot of cold fluid and water and move to a cooler place, especially in summer.
No, Zonegran Tablet is not a habit-forming drug. However, it can cause side effects, especially when you stop taking it suddenly.
Consult your doctor before taking Zonegran Tablet if you have had kidney stones. Your doctor will prescribe Zonegran Tablet only if the benefits outweigh the risks. Zonegran Tablet should be taken with caution in patients with kidney stones. You may be at increased risk of developing more kidney stones. Reduce the risk of kidney stones by drinking sufficient water.
Consult your doctor before taking Zonegran Tablet if you have glaucoma. Zonegran Tablet is contraindicated in patients with narrow-angle glaucoma. Zonegran Tablet may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.
Zonegran Tablet contains Zonisamide as an active ingredient.
If you suddenly stop taking Zonegran Tablet , your seizures may become worse. If required, your doctor will probably decrease your dose gradually.
In patients taking Zonegran Tablet , severe muscle pain and/or weakness develop either in the presence or absence of a fever. It is recommended that you consult your doctor; they will perform specific tests to evaluate muscle damage and treat it accordingly.
Although the Food and Drug Administration (FDA) has not officially approved Zonegran Tablet for children, quite a few research studies have shown that it has been given to children of various ages (even infants) with generally good results. However, it should be provided under the supervision of a doctor.
No, it does not impact on birth control pills. No reported interactions have been established as of now.
Zonegran Tablet is excreted by the kidneys; patients with renal impairment or renal disease should be treated cautiously.
In some cases, you may experience certain common side effects such as dizziness, irritability, loss of appetite, memory impairment, double vision, confusion, depression, constipation, nausea, headache, and uncontrolled movements. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Symptoms of overdose may include slow heartbeat, slowed breathing, dizziness, fainting and coma (loss of consciousness for a period of time).
Zonegran Tablet may help control your condition but will not cure it. It may take two weeks or longer before you feel the full benefit of Zonegran Tablet .
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Taking more than the recommended dosage does not provide additional benefits and can increase the risk of adverse effects.
Avoid consuming alcohol along with Zonegran Tablet as it could lead to increased dizziness and sleepiness.
Yes, some people experience a loss of appetite and subsequent weight loss while taking Zonegran Tablet . If you notice a significant or sudden drop in weight, talk to your doctor to manage this effect safely.
No, you must never stop taking Zonegran Tablet suddenly, even if you feel completely well. Stopping abruptly can cause your seizures to return more frequently or become harder to control. Talk to your doctor before making any changes to your medication schedule.
Yes, Zonegran Tablet can increase your risk of developing kidney stones. To help prevent this, it is very important to drink plenty of water throughout the day. Talk to your doctor immediately if you experience sharp pain in your back or side or see blood in your urine.
Taking Zonegran Tablet during pregnancy may pose risks to an unborn baby, including developmental issues. However, uncontrolled seizures also present serious risks to both the mother and baby. If you are pregnant or planning to become pregnant, talk to your doctor immediately to discuss the safest treatment plan.
You should contact your doctor right away or seek emergency medical care if you develop any skin rash, peeling, or hives while taking Zonegran Tablet . This medicine can cause rare but severe, life-threatening allergic skin reactions. Talk to your doctor or pharmacist if you notice any skin changes.
Yes, Zonegran Tablet can cause mood changes, depression, anxiety, or even thoughts of self-harm in some patients. It is vital to monitor your emotional well-being closely and have loved ones look out for changes in your behaviour. Talk to your doctor immediately if you experience new or worsening mental health symptoms.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

1st Floor, B Wing,Marwah Centre, Krishanlal Marwah Marg, Andheri ( East ), Mumbai - 400072, India
Other Info - ZON0025

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