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  1. Home
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  3. Zupion-SR Tablet 10's

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Zupion-SR Tablet 10's, Pack of 10 TABLETS
Zupion-SR Tablet 10's, Pack of 10 TABLETS
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Synonym :

BUPROPION HYDROCHLORIDE

Composition :

BUPROPION-150MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zupion-SR Tablet

Zupion-SR Tablet is used in the treatment of depression. It is also used to help people stop smoking. Depression is a mood disorder that affects a person's day-to-day life. 

Zupion-SR Tablet contains Bupropion, which works by increasing the level of a chemical messenger (serotonin) in the brain responsible for improving mood and physical symptoms of depression. Hence, it helps to improve mood.

In some cases, you may experience side effects, such as nausea, headache, dizziness, vomiting, insomnia (difficulty in sleeping), fever, constipation, sweating, impaired concentration, and dry mouth. If you experience these side effects persistently, consult your doctor.

Tell your doctor if you are allergic to Zupion-SR Tablet . Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Uses of Zupion-SR Tablet

Zupion-SR Tablet is used in the treatment of depression and smoking addiction. The detailed uses of Zupion-SR Tablet are as follows:

  • Treats Depression: Zupion-SR Tablet is used to manage major depressive disorder (MDD) by improving mood, energy levels, and concentration through its action on dopamine and norepinephrine in the brain.
  • Aids in Smoking Cessation: Zupion-SR Tablet helps people quit smoking by reducing cravings and withdrawal symptoms, making it easier to stop tobacco use.
  • Manages Seasonal Affective Disorder (SAD): Zupion-SR Tablet may also be prescribed to prevent episodes of depression that occur seasonally, especially during winter months.

Have a query?

Directions for Use

  • Zupion-SR Tablet should be taken with food to avoid stomach upset.
  • It is usually taken 3-4 times a day. However, your doctor may adjust the dose and duration of Zupion-SR Tablet based on your medical condition.
  • Swallow Zupion-SR Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Zupion-SR Tablet is effective in managing major depressive disorder by improving mood, relieving feelings of sadness, and reducing associated physical and emotional symptoms.
  • It is prescribed to aid people in quitting smoking by reducing cravings and withdrawal symptoms.
  • It contains Bupropion, which works by increasing certain chemical messengers (such as dopamine and norepinephrine) in the brain, thereby improving mood and energy levels.
  • Enhancing brain activity may help alleviate tiredness, lack of interest, and low motivation often associated with depression.
  • Regular use as prescribed can improve overall quality of life by stabilising mood and supporting emotional balance.

How Zupion-SR Tablet Works

Zupion-SR Tablet contains Bupropion, which is used to treat depression. It works by increasing the level of a chemical messenger (serotonin) in the brain responsible for improving mood and physical symptoms of depression. Hence, it helps to improve mood.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zupion-SR Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zupion-SR Tablet
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Lie down or take a nap in dark and quiet room.
  • To avoid dehydration, drink plenty of fluids.
  • In case of mild to moderate migraine, you can take over-the-counter pain relievers like paracetamol or ibuprofen.
  • Apply an ice pack or cool cloth on your forehead.
  • Try relaxation techniques such as yoga, meditation, or deep breathing to reduce stress and relax.
  • Avoid foods and drinks that trigger migraine such as chocolate, alcohol, cheese, caffeine, processed meats, artificial sweeteners and dried fruits.
  • Manage your stress by eating healthy, exercising and a regular sleep schedule.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Zupion-SR Tablet

Take Zupion-SR Tablet only as prescribed by the doctor. Avoid exceeding the recommended dose as it could lead to severe side effects. Symptoms of overdose may include seizures, loss of consciousness, rapid/pounding heartbeat, and hallucinations. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Zupion-SR Tablet if you are allergic to any of its ingredients.
  • Tell your doctor if you are taking antidepressants, antipsychotic medication, or antihypertensives, especially if you are taking MAO inhibitors (medicine to treat depression).
  • Patients with liver diseases, diabetes, heart disease and bleeding disorders should use Zupion-SR Tablet with caution.
  • Please do not stop the treatment abruptly, as it can cause withdrawal reactions.
  • Zupion-SR Tablet may cause suicidal thoughts and worsen anxiety.
  • Zupion-SR Tablet is used with caution in children and adolescents under 18 years of age, as it increases suicidal tendencies in this population.
  • It is also habit-forming, so always take it in the dose and duration prescribed by a doctor, and never self-medicate.

Drug-Drug Interactions

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BupropionTranylcypromine
Critical
BupropionIsocarboxazid
Critical

Drug-Drug Interactions

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BupropionTranylcypromine
Critical
How does the drug interact with Zupion-SR Tablet:
Taking tranylcypromine with Zupion-SR Tablet can increase the risk of severe high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Zupion-SR Tablet can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
BupropionIsocarboxazid
Critical
How does the drug interact with Zupion-SR Tablet:
Using Zupion-SR Tablet together with isocarboxazid can cause blood pressure to get dangerously high.

How to manage the interaction:
Taking Isocarboxazid with Zupion-SR Tablet can cause an interaction, consult a doctor before taking it. Consult a doctor if you experience headache, sleep disturbances, tremor, restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop using any medications without talking to a doctor.
BupropionSafinamide
Critical
How does the drug interact with Zupion-SR Tablet:
Taking Safinamide with Zupion-SR Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Safinamide with Zupion-SR Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
BupropionRasagiline
Critical
How does the drug interact with Zupion-SR Tablet:
Taking Rasagiline with Zupion-SR Tablet can cause increased blood pressure.

How to manage the interaction:
Taking rasagiline with Zupion-SR Tablet is not recommended as it can result in an interaction but can be taken if a doctor has advised it. However, if you experience headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, and rapid heartbeat contact a doctor. Do not discontinue any medications without consulting a doctor.
BupropionMetoclopramide
Critical
How does the drug interact with Zupion-SR Tablet:
Co-administration of Metoclopramide with Zupion-SR Tablet can increase the levels of Metoclopramide and increase the risk or severity of developing seizures (fits).

How to manage the interaction:
Taking Metoclopramide with Zupion-SR Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
BupropionBlinatumomab
Severe
How does the drug interact with Zupion-SR Tablet:
Taking Zupion-SR Tablet may with Blinatumomab can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Blinatumomab and Zupion-SR Tablet, but it can be taken if prescribed by a doctor. If you're taking multiple medications, doctor can recommend other options that won't cause any problems when taken together. If you notice any unusual symptoms like seizures or if you have a medical condition or head injury, it's important to contact adoctor right away. Do not discontinue any medications without consulting a doctor.
BupropionLithium
Severe
How does the drug interact with Zupion-SR Tablet:
Taking Zupion-SR Tablet with lithium can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of Zupion-SR Tablet along with lithium can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties or cessation, lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BupropionCyclobenzaprine
Severe
How does the drug interact with Zupion-SR Tablet:
Zupion-SR Tablet is capable of causing seizures in rare cases, and combining it with cyclobenzaprine, may enhance the risk. If you are old, going through alcohol or drug withdrawal, have a history of seizures, or have a disorder affecting the central nervous system, such as a brain tumour or head trauma, you may be more vulnerable.

How to manage the interaction:
Co-administration of Zupion-SR Tablet along with cyclobenzaprine can possibly lead to an interaction, it can be taken if recommended by your doctor . While taking these medications, you should avoid or restrict your usage of alcohol. Avoid tasks that need mental attention, such as driving or operating dangerous machinery, until you have a better understanding of how the medications impact you.However, if you have any questions or concerns, see your doctor. Your doctor may be able to prescribe non-interfering alternatives. Do not discontinue any medications without first consulting your doctor.
BupropionParoxetine
Severe
How does the drug interact with Zupion-SR Tablet:
Combining Zupion-SR Tablet with paroxetine can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of Zupion-SR Tablet along with paroxetine can lead to an interaction, it can be taken if recommended by a doctor. While taking these medications, you should avoid driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
BupropionFludrocortisone
Severe
How does the drug interact with Zupion-SR Tablet:
Taking Zupion-SR Tablet with fludrocortisone can increase the risk of causing seizures(fits).

How to manage the interaction:
Co-administration of Zupion-SR Tablet along with fludrocortisone can lead to an interaction, but it can be taken if recommended by a doctor. While taking these medications, you should avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Engage in regular exercise, which can help lower anxiety by releasing endorphins and promoting better sleep.
  • Find humour in your daily life. Try to watch light-hearted shows to help relieve stress.
  • You can try increasing your mindfulness by including yoga, meditation, cognitive therapy and mindfulness-based stress reduction.
  • Drink enough water to stay hydrated and limit consumption of alcohol and caffeine to relieve anxiety.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than consuming a high amount of simple carbohydrates found in processed foods.
  • Herbs like turmeric, ginger and chamomile contain anti-inflammatory properties. Including this stuff in meals can reduce inflammation caused by anxiety disorders.
  • Reduce your intake of alcohol, caffeine, added sugar, high salt, and fat. Especially, trans fats may also help reduce inflammation.
  • You should include antioxidants in your daily diet, such as ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

Yes

Therapeutic Class

ANTIDEPRESSANT

Zupion-SR Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zupion-SR Tablet as it may cause serious side effects.

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Pregnancy

Caution

Zupion-SR Tablet is a pregnancy category B drug. If you have already taken this medicine before becoming pregnant, consult your doctor immediately. It can pose a small risk of problems for an unborn baby. Your doctor might prescribe this medicine during pregnancy if the benefits outweigh the risks.

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Breast Feeding

Caution

In very small quantities, Zupion-SR Tablet enters the breast milk and may have negative effects on breastfed babies. If the infant is in good health, it may be prescribed. Please see your doctor, though, if the baby stops eating as well as usual after taking Zupion-SR Tablet or starts sleeping a lot more than usual.

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Driving

Unsafe

Do not drive after taking Zupion-SR Tablet as it may cause drowsiness and interfere with your driving ability.

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Liver

Caution

Zupion-SR Tablet to be taken with caution, especially if you have a history of liver diseases. Your doctor may adjust the dose if required based on your condition.

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Kidney

Caution

Zupion-SR Tablet to be taken with caution, especially if you have a history of kidney disease. Your doctor may adjust the dose if required based on your condition.

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Children

Unsafe

Zupion-SR Tablet is not recommended for use in children below 18 years. Its safety and efficacy are not established in children.

FAQs

Zupion-SR Tablet is used in the treatment of depression. It is also used to help people stop smoking.

Zupion-SR Tablet contains Bupropion, primarily used in treating depression. In addition to this, it is also used by people who are addicted to smoking. It works by increasing serotonin levels. Serotonin is a chemical messenger in the brain responsible for improving mood and physical symptoms of depression. Hence, it helps to improve mood.

Certain side effects of Zupion-SR Tablet can be dealt with simple tips, such as if you experience dry mouth, you can chew sugar-free gum or take sugar-free sweets. If you are sweating a lot while taking Zupion-SR Tablet , wear loose clothing and use a strong antiperspirant. If you cannot sleep after taking Zupion-SR Tablet , prefer to take it in the morning to avoid sleep disturbances. If you feel sleepy after taking Zupion-SR Tablet , avoid taking it in the evening and limit your alcohol intake. If you feel tired or weak after taking Zupion-SR Tablet , sit or lie down until you feel better. If you feel that the side effects are worsening, please consult your doctor.

Yes, it is safe to use Zupion-SR Tablet if prescribed by your doctor. However, there may be an increased risk of experiencing suicidal tendencies in children, adolescents and young adults.

Taking Zupion-SR Tablet in more than the recommended dose can cause unpleasant side effects such as dizziness, tremor, agitation, convulsion, coma, nausea, vomiting, changes in heart rhythm, decreased blood pressure and changes in body fluid/salt balance.

In elderly patients, the risk of side effects is higher when taking Zupion-SR Tablet . For elderly patients, dose adjustment may be required, or your doctor may prescribe an alternative medication safe for the elderly.

No, Zupion-SR Tablet does not help with anxiety and sleeplessness. It is used to treat depression.

Though Bupropion may have a low risk of addiction, Zupion-SR Tablet does not cause addiction if taken in the dose and duration prescribed by the doctor.

Factors that can increase the chances of seizures with Zupion-SR Tablet are sudden and large increments in dose, bulimia or anorexia nervosa (eating disorder), history of head trauma or prior seizure, central nervous system (CNS) tumour, the presence of severe hepatic cirrhosis, and concomitant medications that lower the seizure threshold.

It is very rare to develop eye problems like redness, pain, and blurred vision with Zupion-SR Tablet . Please consult the doctor if you experience any eye problems during treatment with Zupion-SR Tablet .

Avoid exceeding the prescribed dose and use Zupion-SR Tablet cautiously with medicines that might lower the seizure threshold such as antipsychotics, antidepressants, theophylline, and systemic steroids.

Zupion-SR Tablet may cause high blood pressure, therefore, let the doctor know if you have hypertension or if you are taking medicines used to treat high blood pressure.

Zupion-SR Tablet may cause side effects such as nausea, headache, dizziness, vomiting, insomnia (difficulty in sleeping), fever, constipation, sweating, allergic reaction, impaired concentration, and dry mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to consult your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZUP0004

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 25, 2025 | 11:23 AM IST

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Reference

  1. https://www.drugs.com/bupropion.html#:~:text=Bupropion%20is%20an%20antidepressant%20medication,listed%20in%20this%20medication%20guide.
  2. https://medlineplus.gov/druginfo/meds/a695033.html
  3. https://www.medicines.org.uk/emc/files/pil.3827.pdf

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