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compositionComposition:CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MG
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Prescription Medicine
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ZYVEN OD PLUS 50MG TABLET is used to treat depression. It contains clonazepam and desvenlafaxine which work by increasing the levels of chemical messengers in the brain that help maintain mental balance. In some cases, this medicine may cause side effects such as nausea, tiredness, constipation, confusion, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MG

Manufacturer/Marketer :

Gkm New Pharma

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ZYVEN OD PLUS 50MG TABLET

ZYVEN OD PLUS 50MG TABLET is a combination prescription medicine taken orally to treat depression associated with anxiety and manage panic symptoms. It blends two distinct active ingredients to help stabilise mood and reduce sudden, overwhelming feelings of fear or worry. By acting directly on chemical messengers in the brain, it supports a more balanced and stable state of mind.

For the best results, you should take this medicine consistently every day at the same time, exactly as prescribed by your doctor. You can take it with or without food, though taking it with a meal may help reduce mild stomach upset. Making supportive lifestyle changes, such as maintaining a consistent sleep routine and engaging in regular, gentle physical activity, can significantly enhance the effectiveness of your treatment.

While taking ZYVEN OD PLUS 50MG TABLET, you may experience common side effects like nausea, dry mouth, or mild sleepiness. These symptoms are often temporary and resolve as your body adapts, but you should contact your doctor immediately if you experience severe mood changes, worsening anxiety, or signs of an allergic reaction. Your safety is paramount, and your healthcare team is there to help manage any troubling reactions.

Do not take this if you have a known allergy to any of its active components, severe breathing difficulties, or acute narrow-angle glaucoma. Before starting this medication, it is vital to talk to your doctor if you have a history of liver damage, kidney disease, seizures, or bleeding disorders. Sharing your full medical history ensures this treatment is safe for your specific health profile.

This medicine can interact with alcohol, which dramatically increases the risk of severe drowsiness and slow breathing, so it is highly recommended to avoid alcohol completely during treatment. You should also inform your doctor if you are taking other sleeping pills, strong pain relievers, or blood thinners to avoid dangerous interactions. If you are pregnant, planning to become pregnant, breastfeeding, or an elderly individual, always consult your doctor before starting this medication, as special precautions may apply.

Uses of ZYVEN OD PLUS 50MG TABLET

ZYVEN OD PLUS 50MG TABLET is used to treat depression associated with anxiety and manage panic symptoms. The detailed uses of ZYVEN OD PLUS 50MG TABLET are as follows:

  • Depression with associated anxiety: ZYVEN OD PLUS 50MG TABLET helps relieve persistent feelings of sadness, loss of interest, and emotional exhaustion while simultaneously calming the constant physical and mental tension caused by anxiety.
  • Panic disorder: This medicine helps reduce the frequency and severity of sudden panic attacks, managing distressing symptoms such as a racing heart, trembling, and unexpected fear.
     

Key Benefits

ZYVEN OD PLUS 50MG TABLET helps manage anxiety and depression by combining medicines that provide both short-term relief of anxiety symptoms and long-term improvement in mood. Together, they help restore emotional balance and improve daily functioning.

  • Helps Relieve Anxiety and Improve Mood: ZYVEN OD PLUS 50MG TABLET helps reduce excessive worry, nervousness, and persistent low mood, allowing you to feel calmer and more emotionally balanced.
  • Reduces Physical Symptoms of Anxiety: By calming the nervous system, ZYVEN OD PLUS 50MG TABLET helps relieve symptoms such as muscle tension, trembling, restlessness, and panic, making everyday activities more comfortable.
  • Supports Better Sleep and Long-Term Wellbeing: By improving mood and reducing anxiety, ZYVEN OD PLUS 50MG TABLET helps promote restful sleep, reduces nighttime anxiety, and supports long-term mental wellness when taken regularly as prescribed.
     

Directions for Use

  • Take ZYVEN OD PLUS 50MG TABLET with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow the medicines as a whole with a glass of water.
  • Do not crush, chew, or break it.

How ZYVEN OD PLUS 50MG TABLET Works

As a combination medication, ZYVEN OD PLUS 50MG TABLET works through two distinct mechanisms to address both mood and anxiety symptoms simultaneously. Desvenlafaxine is an active ingredient classified as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine, two vital chemical messengers in the brain. These chemicals play a key role in regulating your mood, alertness, and emotional stability. Clonazepam belongs to a group of medicines called benzodiazepines. It works by boosting the effects of gamma-aminobutyric acid (GABA), a natural calming chemical in the brain. By enhancing GABA activity, it slows down excessive electrical signals in the central nervous system, which rapidly reduces acute anxiety, muscle tension, and panic symptoms. Clonazepam is generally intended as a short-term adjunct to treatment, providing rapid relief of anxiety and panic symptoms while the antidepressant component reaches its full therapeutic effect. Your doctor will determine how long it should be continued.
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Alcohol

Caution

Avoid consumption of alcohol while taking ZYVEN OD PLUS 50MG TABLET as it may cause an increased sedative effect.

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Pregnancy

Unsafe

ZYVEN OD PLUS 50MG TABLET may cause toxic effects on the fetus. So, it is not recommended for pregnant women or planning to become pregnant. Consult your doctor for further advice.

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Breast Feeding

Caution

ZYVEN OD PLUS 50MG TABLET should be used with caution in breastfeeding mothers. Your doctor may advise you to stop breastfeeding while taking this medication.

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Driving

Caution

Do not drive or operate heavy machinery as this me ZYVEN OD PLUS 50MG TABLET may cause drowsiness.

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Liver

Caution

ZYVEN OD PLUS 50MG TABLET should be used with caution in patients with severe liver impairment. Dose adjustments may be required in such cases.

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Kidney

Caution

ZYVEN OD PLUS 50MG TABLET should be used with caution in patients with kidney problems. Dose adjustments may be required in such cases. Consult the doctor if you have concerns about using ZYVEN OD PLUS 50MG TABLET in patients with kidney problems.

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Children

Caution

ZYVEN OD PLUS 50MG TABLET should not be used in children unless prescribed by a child specialist.

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Heart

Caution

ZYVEN OD PLUS 50MG TABLET can be used in heart patients due to the increased risk of side effects. Please consult your physician if you have any concerns.

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Geriatrics

Caution

ZYVEN OD PLUS 50MG TABLET should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of ZYVEN OD PLUS 50MG TABLET

In case of an accidental overdose, seek emergency medical attention or contact a nearby hospital immediately. Symptoms of an overdose may include extreme drowsiness, confusion, slow reflexes, or difficulty breathing. Do not wait for severe symptoms to appear before seeking help.

Diet & Lifestyle Advise

  • Avoid alcohol completely, as it can dangerously intensify the drowsy effects of this medication and impair your breathing or coordination.
  • Limit your intake of caffeine, including coffee, energy drinks, and certain teas, as excess caffeine can counter the calming effects of the medicine and trigger anxiety symptoms.
  • Stay well-hydrated throughout the day and eat a diet rich in fibre (fruits, vegetables, and whole grains) to help prevent constipation, which can be a common side effect of this treatment.
  • Establish a relaxing, consistent sleep schedule to help manage daytime drowsiness and support your body’s natural healing processes.
     
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How Soon It Starts Working

The time required for ZYVEN OD PLUS 50MG TABLET to start to work: ZYVEN OD PLUS 50MG TABLET ideally starts to show its action within 1 to 2 hours of administration. The time for which the effects of ZYVEN OD PLUS 50MG TABLET last: ZYVEN OD PLUS 50MG TABLET effect lasts for 24 hours.

What if you forget to take ZYVEN OD PLUS 50MG TABLET

If you miss a dose of ZYVEN OD PLUS 50MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

•Do not drive, operate machinery, or perform tasks requiring intense mental focus until you are certain how ZYVEN OD PLUS 50MG TABLET affects your alertness. •Do not stop taking ZYVEN OD PLUS 50MG TABLET suddenly, as your body needs time to adjust; your doctor will help you by gradually a

Drug Warnings

  • Do not drive, operate machinery, or perform tasks requiring intense mental focus until you are certain how ZYVEN OD PLUS 50MG TABLET affects your alertness.
  • Do not stop taking ZYVEN OD PLUS 50MG TABLET suddenly, as your body needs time to adjust; your doctor will help you by gradually adjusting the dose downward when it is time to discontinue.
  • Always inspect the blister pack or bottle before taking your dose; do not take tablets that appear discoloured, broken, or damp.
  • Inform any surgeon, dentist, or emergency medical professional that you are taking ZYVEN OD PLUS 50MG TABLET before undergoing any medical procedures.
  • Keep a written list of all prescription drugs, over-the-counter medicines, and herbal supplements you take, and share it with your healthcare provider to ensure safe co-administration.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Co-administration can lead to a dangerous, life-threatening condition called serotonin syndrome. You must wait at least 14 days after stopping an MAOI before starting ZYVEN OD PLUS 50MG TABLET.
  • Opioids and Sleeping Pills: Taking these alongside ZYVEN OD PLUS 50MG TABLET can cause severe drowsiness, profound sedation, slow breathing, or coma.
  • Blood Thinners and NSAIDs: Medications like aspirin, warfarin, or ibuprofen may increase your risk of bruising or bleeding when taken with desvenlafaxine.
     
Desvenlafaxine + ClonazepamIsocarboxazid
Critical
Desvenlafaxine + ClonazepamSodium oxybate
Critical

Drug-Drug Interactions

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Desvenlafaxine + ClonazepamIsocarboxazid
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking isocarboxazid with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and isocarboxazid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, weakness, headache, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamSodium oxybate
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking desvenlafaxine and clonazepam with sodium oxybate can result in breathing issues, low blood pressure, and an increased chance of side effects.

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and sodium oxybate, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, sleepiness, difficulty concentrating, lightheadedness, or confusion. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamTranylcypromine
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking tranylcypromine with desvenlafaxine and clonazepam may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and tranylcypromine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamProcarbazine
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking procarbazine with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and procarbazine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience headache, confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamRasagiline
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking rasagiline with desvenlafaxine and clonazepam can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and rasagiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamSafinamide
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Taking safinamide with desvenlafaxine and clonazepam can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and safinamide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamPhenelzine
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Co-administration of phenelzine with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and phenelzine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience headache, weakness, confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamSelegiline
Critical
How does the drug interact with Zyven Od Plus 50mg Tablet:
Co-administration of selegiline with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Desvenlafaxine + ClonazepamHydrocodone
Severe
How does the drug interact with Zyven Od Plus 50mg Tablet:
Co-administration of desvenlafaxine and clonazepam with hydrocodone may cause respiratory depression (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and hydrocodone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, sleepiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
Desvenlafaxine + ClonazepamSufentanil
Severe
How does the drug interact with Zyven Od Plus 50mg Tablet:
Co-administration of sufentanil with desvenlafaxine and clonazepam can increase the risk of breathing problems and also increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and sufentanil, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, sleepiness, dizziness, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: This is considered a theoretical or moderate interaction. Grapefruit may affect the metabolism of clonazepam in some individuals, potentially increasing drowsiness or other side effects. As a precaution, discuss grapefruit consumption with your doctor or pharmacist during treatment. 
CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

ZYVEN OD PLUS 50MG TABLET is used to treat depression.
ZYVEN OD PLUS 50MG TABLET is a combination of two drugs: clonazepam and paroxetine. Clonazepam works by increasing levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.
When you start taking ZYVEN OD PLUS 50MG TABLET, some patients might experience increased suicidal thoughts or actions. If you feel agitated or aggressive, visit your doctor. Also, do not miss any appointment with your doctor that is scheduled.
Do not discontinue ZYVEN OD PLUS 50MG TABLET without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually, continue taking ZYVEN OD PLUS 50MG TABLET for as long as prescribed. Moreover, stopping this medicine suddenly may result in withdrawal symptoms. Do not be reluctant to speak with your doctor if you feel any difficulty while taking ZYVEN OD PLUS 50MG TABLET.
ZYVEN OD PLUS 50MG TABLET may cause drowsiness. Avoid activities requiring full attention, such as driving, and operating machinery while using this medication. Abruptly stopping ZYVEN OD PLUS 50MG TABLET may result in significant withdrawal symptoms. Therefore, consult your doctor to gradually reduce the dosage before discontinuing use. This medication is habit-forming, so use it only exactly as prescribed by your doctor. Avoid alcohol consumption while taking ZYVEN OD PLUS 50MG TABLET, as it may cause severe side effects. ZYVEN OD PLUS 50MG TABLET is not safe for use during pregnancy or if you are planning to conceive. Discuss with your doctor about changing/replacing the medicine with safer alternatives. To prevent dependency, take the medication strictly as directed by your doctor and avoid self-medication.
ZYVEN OD PLUS 50MG TABLET may cause weight gain due to increased appetite and mood changes. If you notice any weight changes, exercise regularly, stay hydrated, eat nutritious-rich food, get enough sleep, cut down on carbs and processed foods, reduce your intake of sugary beverages, and eat fibre-rich food.
Yes, ZYVEN OD PLUS 50MG TABLET may cause sleepiness as a common side effect. If you experience sleepiness, avoid driving or operating heavy machinery until you are fully alert.
Yes, ZYVEN OD PLUS 50MG TABLET may cause low sexual desire, erectile dysfunction, and ejaculation disorder. Consult the doctor if you notice any of these symptoms.
No, you should not drink alcohol while taking ZYVEN OD PLUS 50MG TABLET as it may lead to increased drowsiness or dizziness. Always consult the doctor for specific guidance based on your condition.
ZYVEN OD PLUS 50MG TABLET may take several weeks to show noticeable improvement in symptoms. However, the time can vary depending on the individual and the condition being treated. Therefore, always follow your doctor's guidance and continue taking the medication exactly as prescribed for best results.
ZYVEN OD PLUS 50MG TABLET should be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.
Yes, you can take ZYVEN OD PLUS 50MG TABLET with or without food. However, if you experience mild nausea or stomach upset when taking it, taking your dose with a light meal may help. Talk to your doctor if stomach issues persist.
Generally, ZYVEN OD PLUS 50MG TABLET is not recommended during pregnancy unless your doctor decides the benefits outweigh the potential risks to the developing baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to discuss safe treatment alternatives.
No, you must never stop taking this medicine abruptly. Doing so can cause severe withdrawal symptoms such as extreme irritability, sweating, dizziness, and worsening anxiety. Your doctor will provide a schedule for gradually reducing your dose safely. Talk to your doctor before making any changes.
It is best to limit your intake of caffeine while taking ZYVEN OD PLUS 50MG TABLET. Caffeine is a stimulant that can increase your heart rate and trigger anxiety, which can reduce the calming benefits of your medication. Talk to your doctor or pharmacist for personalised dietary advice.
One of the active ingredients in ZYVEN OD PLUS 50MG TABLET is clonazepam, which belongs to the benzodiazepine class. Benzodiazepines carry a risk of physical and psychological dependence, particularly with long-term use. Your doctor will monitor your progress closely to minimise this risk. Talk to your doctor if you have any concerns.
Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Never take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 021992S030Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Clonazepam With Paxil 703 0 1800 Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Clonazepam Clonazepam. 2018. [Accessed on 23 Apr. 2019]Check here
  4. MedlinePlus MedlinePlus. [Accessed on 23 Apr. 2019]Check here
  5. Hajira Basit; Chadi I. Kahwaji. Clonazepam. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2022. [Accessed on 27th February 2023]Check here
  6. Neuraxpharm UK Limited. Clonazepam Neuraxpharm 0.5 mg, 1 mg and 2 mg. Electronic Medicines Compendium. [Revised in October 2021]. [Accessed on 27th February 2023]Check here

Country of origin

India

Manufacturer/Marketer address

No 5 And 6,pipdic Electronic Park,pipdic Electronic Park,thirubhuvanai,puducherry,605107, Thirubuva, Pondicherry-605107, India
Other Info - ZYV0007

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