Key Screening Tests During Pregnancy
Pregnancy screening tests follow a predictable trimester-wise schedule. Here is what to expect.
First Trimester (Up to 13 Weeks)
The first trimester checkup involves several foundational investigations:
- Blood group and Rh factor to detect Rh incompatibility early.
- Complete blood count (CBC) to check for anaemia.
- Blood glucose (fasting or random) to flag pre-existing diabetes.
- VDRL or RPR for syphilis screening.
- HIV, Hepatitis B surface antigen (HBsAg), and Rubella IgG serology.
- Thyroid function test (TSH), as thyroid disorders affect foetal brain development.
- Urine routine and culture to detect asymptomatic urinary infections.
- Double marker test during the first trimester, typically around 11 to 14 weeks, combined with a nuchal translucency (NT) ultrasound, can assess the risk of chromosomal conditions such as Down syndrome.
The NT ultrasound measures fluid at the back of the foetal neck and is one of the earliest structural assessments available.
Non-invasive prenatal testing (NIPT) analyses cell-free DNA from a maternal blood sample and can be done from around 10 weeks onwards. It is a highly sensitive and specific screening test for common chromosomal conditions, but it is not a diagnostic test. Your doctor can advise whether it is appropriate based on your individual circumstances.
Second Trimester (14 to 27 Weeks)
As pregnancy progresses, monitoring becomes more focused on foetal growth, maternal health, and preparation for delivery.
During the second trimester, screening and monitoring focus on your baby's development and identifying conditions that may need further assessment.
- Anomaly Scan: (level 2 ultrasound) at 18 to 20 weeks: this detailed foetal structural scan checks organs, limbs, the spine, and placental position, and is when most major structural differences are identified.
- Triple or Quadruple Marker Test: between 15 and 20 weeks, if not done earlier.
- Gestational Diabetes Screening: glucose challenge test (GCT) or oral glucose tolerance test (OGTT) at 24 to 28 weeks.
- Haemoglobin Recheck: at around 28 weeks.
Third Trimester (28 Weeks Onwards)
As you enter the third trimester, monitoring focuses on foetal growth, maternal health, and identifying any concerns that may require closer observation.
- Growth Scan and Doppler Study: at 28 to 32 weeks to assess foetal size and blood flow through the umbilical cord.
- Group B Streptococcus (GBS) Swab: at 35 to 37 weeks where available and clinically advised.
- Repeat Blood Count and Blood Pressure Monitoring: ongoing monitoring during the third trimester.
- Cardiotocography (CTG): if indicated, to monitor foetal heart rate patterns.
Pregnancy screening tests are not diagnostic on their own. An abnormal result leads to further evaluation, not an immediate conclusion.