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Metacin Suppositories 5's
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Delivery Information
More about the Product
Composition :
PARACETAMOL-250MG
Manufacturer/Marketer :
Themis Medicare Ltd
Consume Type :
Rectal
Expires on or after :
Jan-27
Return Policy :
Not Returnable
About Metacin 250 mg Suppositories
Metacin 250 mg Suppositories is a rectal suppository used to reduce fever and relieve mild-to-moderate pain. This medicine is designed for situations where taking oral medications is not possible, such as during severe nausea, vomiting, or when a patient cannot swallow easily. It helps soothe discomfort from headaches, common colds, or minor aches.
For best results, use this medicine consistently as directed by your healthcare professional. It is typically used on an as-needed basis rather than on a regular daily schedule. Preparing your body by trying to empty your bowels before inserting the suppository can help ensure proper absorption. Additionally, resting in bed and drinking small, frequent sips of water can support your body's natural recovery process.
While using Metacin 250 mg Suppositories, some people may experience mild side effects like minor rectal discomfort or irritation. However, you should stop using this medicine and consult a doctor immediately if you experience severe signs, such as a serious skin rash, hives, or swelling of the face.
Talk to your doctor before starting this medicine if you have underlying health issues, particularly liver disease, kidney problems, or if you regularly consume alcohol. Do not take this if you are allergic to the active ingredient or any of the inactive ingredients used to make the suppository.
It is important to avoid combining this product with other pain-relieving medicines to prevent accidental liver damage. Always consult your doctor or pharmacist if you are pregnant, breastfeeding, or managing treatments for elderly individuals to ensure this is the safest option.
Uses of Metacin 250 mg Suppositories
Your doctor may prescribe Metacin 250 mg Suppositories to help manage the following conditions:
- Fever reduction: Metacin 250 mg Suppositories helps lower a high body temperature by acting on the brain's heat-regulating centre, making it ideal for managing fevers caused by infections or viruses.
- Mild to moderate pain: Metacin 250 mg Suppositories targets the pathways that transmit pain signals, providing effective relief for headaches, muscle aches, toothaches, and post-surgery discomfort.
- Pain relief when oral intake is restricted: Metacin 250 mg Suppositories serves as a reliable alternative for patients who are unable to take oral medications due to severe vomiting, nausea, or unconsciousness.
Key Benefits
When used as directed as part of your treatment plan, this medicine may provide the following benefits:
- Alternative route of delivery: When severe nausea or swallowing difficulties make taking tablets impossible, this medicine ensures you can still receive necessary pain and fever relief without irritating your stomach.
- Fast-acting comfort: The rectal lining contains many blood vessels, allowing the medication to dissolve and absorb efficiently into the body to start relieving your symptoms quickly.
- Restful recovery: By safely lowering your fever and easing body aches, this medicine helps you sleep and rest comfortably, which is essential for your body to heal.
Side effects of Metacin Suppositories
Overcome Medication-Induced Nausea: A 9-Step Plan
- Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
- Divide your daily food intake into smaller, more frequent meals to reduce nausea.
- Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
- Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
- Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
- Use ginger (tea, ale, or candies) to help relieve nausea.
- Get adequate rest and also avoid strenuous activities that can worsen nausea.
- Talk to your doctor about taking anti-nausea medication if your nausea is severe.
- Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
- Preventing Vomiting (Before it Happens)
- Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
- Having a small meal before taking your medication can help reduce nausea and vomiting.
- Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
- Managing Vomiting (If it Happens)
- Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
- What to Do if Vomiting Persists
- Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
- Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
- Reduced alcohol intake can enhance liver enzyme function.
- Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
- Liver function tests regularly can help manage increased levels of AST.
- Drink water or other clear fluids.
- To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
- Include bland foods like rice, toast, crackers, and rice in your diet.
- Avoid lying down immediately after eating as it may cause indigestion or heartburn.
- Avoid acidic and spicy food as it may cause indigestion.
- Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
- Consume vitamin C-rich foods as they aid iron absorption.
- Limit tea, cocoa, and coffee as these can slow iron absorption.
- Exercise regularly; however, do not overdo it.
- Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
- Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
- Protect your skin from extreme heat and try to apply wet compresses.
- Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
- Tell your doctor immediately if you experience shortness of breath after taking medication.
- Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
- Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
- For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
- Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
- Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
- Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Directions for Use
- Follow your doctor's instructions on the dosage and timing of this medication.
- The suppository should be inserted into the rectum (back passage) by removing the plastic wrapper.
- Wash your hands before and after inserting the suppository.
- Try to sit still for a minute or two and then wash your hands.
How Metacin 250 mg Suppositories Works
Metacin 250 mg Suppositories works by targeting the central nervous system to block the chemical messengers in the brain that signal pain to the body. By raising your pain threshold, it helps reduce the sensation of discomfort from various sources.
To manage fever, the medicine acts on the hypothalamus, which is the brain's thermostat. It prompts the body to release excess heat by dilating blood vessels near the skin and increasing sweat production, gently lowering your temperature back to normal.
Alcohol
Consult your doctor
It is not known if alcohol affects Metacin 250 mg Suppositories. Please consult your doctor if you have any concerns.
Pregnancy
Caution
Please consult your doctor if you are pregnant; your doctor will prescribe Metacin 250 mg Suppositories only if the benefits outweigh the risks.
Breast Feeding
Consult your doctor
Please consult your doctor if you are breastfeeding; your doctor will decide if Metacin 250 mg Suppositories can be taken by lactating mothers or not.
Driving
Safe if prescribed
Metacin 250 mg Suppositories is unlikely to affect your ability to drive.
Liver
Consult your doctor
Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid using Metacin 250 mg Suppositories if you have severe liver problems.
Kidney
Consult your doctor
Dose adjustment may be needed. Please consult your doctor if you have kidney problems or any concerns regarding this.
Children
Safe if prescribed
Metacin 250 mg Suppositories is safe for use in children if prescribed by the doctor. The dose and duration of the medicine will be decided by the physician
Heart
Safe if prescribed
Metacin 250 mg Suppositories is considered safe for patients with heart conditions when used within the recommended dosage. Please consult your doctor if you have any concerns.
Geriatrics
Safe if prescribed
Metacin 250 mg Suppositories is generally safe for elderly patients when given at prescribed doses, but total daily dose should be monitored to avoid toxicity.
What if I have taken an overdose of Metacin 250 mg Suppositories
If you suspect an overdose, seek emergency medical help immediately. An overdose of this medicine can cause severe liver damage, which may not show any immediate symptoms but can be life-threatening if left untreated.
Diet & Lifestyle Advise
- Stay hydrated: Sip water, clear soups, or electrolyte solutions regularly, as fevers can cause your body to lose fluids quickly.
- Create a restful environment: Keep your room cool and quiet to help lower your body temperature and allow your body to heal.
- Use cool compresses: Placing a cool, damp cloth on your forehead can provide additional physical comfort alongside the medication.
- Avoid alcohol entirely: Drinking alcohol while using this medicine increases the risk of severe liver damage, so it must be avoided.
Have a query?
How Soon It Starts Working
The time required for Metacin 250 mg Suppositories to start to work: The time required for Metacin 250 mg Suppositories to show its action is unknown. The time for which the effects of Metacin 250 mg Suppositories last: Metacin 250 mg Suppositories effect last for 4 to 6 hours.
Storage
•Store Metacin 250 mg Suppositories suppositories in a cool place, strictly below 25°C (77°F). •Keep the suppositories in their original wrappers until you are ready to use them to protect them from moisture and light.
What if you forget to take Metacin 250 mg Suppositories
If you are using this medicine on a scheduled basis and miss a dose, insert it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not use a double dose to make up for a missed one.
Drug Warnings
- Inspect the packaging: Always check the suppository wrapper before use; if it is torn, punctured, or damaged, discard it safely.
- Do not cut suppositories: Do not attempt to split or cut the suppository to reduce the dose, as the active ingredient may not be distributed evenly.
- Check other medications: Always read the labels of other over-the-counter cough, cold, or sinus remedies to ensure they do not contain the same active pain reliever, preventing accidental double dosing.
- Empty bowels beforehand: Whenever possible, try to have a bowel movement before inserting the medicine so it can absorb fully without being expelled.
- Keep them firm: If a suppository feels too soft to insert, keep it in the refrigerator for 10 to 15 minutes before unwrapping it.
Drug-Drug Interactions
Drug-Drug Interaction Summary:
- Other pain relievers: Combining this medicine with other products containing the same active ingredient increases the risk of severe liver damage.
- Blood thinners: Daily, long-term use of this medicine may increase the risk of bleeding when taken alongside blood-thinning medications like warfarin.
Severe
ParacetamolMipomersen
Severe
Drug-Drug Interactions
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Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Metacin Suppositories and Leflunomide may increase the risk of liver problems.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Metacin Suppositories and Leflunomide may increase the risk of liver problems.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Mipomersen with Metacin Suppositories may increase the risk or severity of liver injury.
How to manage the interaction:
There may be a possibility of interaction between Metacin Suppositories and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
Co-administration of Mipomersen with Metacin Suppositories may increase the risk or severity of liver injury.
How to manage the interaction:
There may be a possibility of interaction between Metacin Suppositories and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Metacin Suppositories and Valdecoxib may increase the risk or severity of adverse effects.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
Co-administration of Metacin Suppositories and Valdecoxib may increase the risk or severity of adverse effects.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Teriflunomide with Metacin Suppositories may increase the risk or severity of Liver problems.
How to manage the interaction:
Taking Metacin Suppositories with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Co-administration of Teriflunomide with Metacin Suppositories may increase the risk or severity of Liver problems.
How to manage the interaction:
Taking Metacin Suppositories with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Lomitapide and Metacin Suppositories may increase the risk of severity of liver injury.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Lomitapide and Metacin Suppositories may increase the risk of severity of liver injury.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of ketamine and Metacin Suppositories may decrease the effectiveness of Ketamine which could result in a higher blood level.
How to manage the interaction:
Although taking Ketamine and Metacin Suppositories together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
Co-administration of ketamine and Metacin Suppositories may decrease the effectiveness of Ketamine which could result in a higher blood level.
How to manage the interaction:
Although taking Ketamine and Metacin Suppositories together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Metacin Suppositories and Ketoconazole may increase the risk of liver injury.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
Co-administration of Metacin Suppositories and Ketoconazole may increase the risk of liver injury.
How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
Severe
How does the drug interact with Metacin Suppositories:
Co-administration of Metacin Suppositories may decrease the excretion rate of Oxazepam which could result in a higher serum level.
How to manage the interaction:
Although there is a possible interaction between Oxazepam and Metacin Suppositories, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Metacin Suppositories may decrease the excretion rate of Oxazepam which could result in a higher serum level.
How to manage the interaction:
Although there is a possible interaction between Oxazepam and Metacin Suppositories, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
Drug-Food Interaction Summary:
- Alcohol: Drinking alcohol while taking this medicine significantly increases the risk of liver damage.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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FAQs
Metacin 250 mg Suppositories belongs to the group of analgesics (pain killers), and antipyretics (fever-reducing agents) used to treat mild to moderate pain and fever in adults and children.
Metacin 250 mg Suppositories prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain.
Metacin 250 mg Suppositories acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.
Consult your doctor before taking Metacin 250 mg Suppositories with warfarin or blood thinners as taking them together may increase the risk of bleeding.
Avoid using Metacin 250 mg Suppositories for longer durations as it may cause headache. Also, do not exceed the recommended dosage as an overdose may be injurious to the liver.
Metacin 250 mg Suppositories when taken with zidovudine (anti-viral medication) might lower the white blood cell count. Therefore, consult your doctor before taking Metacin 250 mg Suppositories with other medicines.
Yes, this rectal medicine is specifically designed for times when you cannot keep oral medicines down due to vomiting or severe nausea. It bypasses the stomach completely to provide relief. If your vomiting is severe or continuous, talk to your doctor.
If the suppository has softened, place it in its foil wrapper under cold running water or in the refrigerator for 10 to 15 minutes until it hardens. Do not unwrap it while it is soft. If you need help with using this medicine, talk to your doctor.
Suppositories are safe and effective for infants, but the dose must be carefully calculated based on the child's weight and age. Never guess the dose for a child. Before giving this medicine to an infant, talk to your doctor.
Yes, since this medicine is inserted rectally and does not irritate the stomach lining like some oral anti-inflammatory drugs, it is generally safer for patients with stomach ulcers. However, to confirm if it is safe for your specific health history, talk to your doctor.
If the suppository slips out immediately and remains completely intact, you can gently reinsert it. If it has been inside for more than 15 minutes, it has likely melted, and you should not insert another one right away. If you are unsure whether the dose was absorbed, talk to your doctor.
No, you should avoid alcohol while using this medicine. Both alcohol and the active ingredient in this medication are processed by the liver, and combining them can significantly increase the risk of liver damage. If you regularly consume alcohol, talk to your doctor.
You must avoid taking other over-the-counter medicines containing the same active ingredient to prevent an accidental overdose. To find out which pain relievers are safe to combine, talk to your doctor.
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Reference
- Paracetamol Paracetamol. 2015. [Accessed on 17 Jun. 2019]Check here
- Paracetamol for adults: painkiller to treat aches, pains and fever [Internet]. nhs. uk. 2025 [Accessed on 17th September 2025]Check here
- Freo U, et al. Paracetamol: A review of guideline recommendations. J Clin Med. 2021. [Accessed on 17th September 2025]Check here
- Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 12th August 2022]Check here
- Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 12th August 2022]Check here
- Central Drugs Standard Control Organisation (CDSCO). [Accessed on 02 Apr. 2019]Check here
Country of origin
India
Manufacturer/Marketer address
11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Therapeutic Class
[ANALGESIC AND ANTIPYRETIC AGENT]
Habit Forming
No
Other Info - MET1277
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