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Nintib 100 Soft Gelatin Capsule is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NINTEDANIB-100MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nintib 100 Soft Gelatin Capsule

Nintib 100 Soft Gelatin Capsule is a prescription medicine used to treat adults with chronic lung conditions that cause progressive scarring, such as idiopathic pulmonary fibrosis. This medicine is designed to help slow down the decline in lung function by targeting the pathways that lead to lung tissue stiffening. By reducing this scarring process, it helps preserve your remaining lung function and capacity.

To achieve the best results, you must take Nintib 100 Soft Gelatin Capsule consistently every day exactly as your doctor directs. It is highly recommended to take this capsule with food and a full glass of water to help manage common stomach-related side effects. Incorporating healthy habits, such as stopping smoking and staying well-hydrated, can also support your overall lung health during treatment.

The most common side effects associated with this medication include diarrhoea, nausea, and stomach pain. It is important to watch for these symptoms and consult your doctor immediately if you experience severe diarrhoea, signs of liver damage, or unusual bleeding.

Do not take this if you are pregnant, planning to become pregnant, or have severe liver damage. Before starting this treatment, you must tell your doctor if you have a history of heart disease, liver problems, high blood pressure, or bleeding disorders.

Nintib 100 Soft Gelatin Capsule may interact with certain medicines, including blood thinners, and smoking may reduce the amount of medicine in your body. Older adults can generally use this medicine, but they may need closer monitoring because liver problems and other health conditions are more common with age. Tell your doctor if you have any liver problems. People with mild liver impairment may need a lower dose and closer monitoring, while Nintib 100 Soft Gelatin Capsule is generally not recommended for those with moderate or severe liver impairment. If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor before starting treatment.

Uses of Nintib 100 Soft Gelatin Capsule

Your doctor may prescribe this medicine to treat several conditions, including:

  • Idiopathic Pulmonary Fibrosis (IPF): Nintib 100 Soft Gelatin Capsule helps slow the progressive scarring and stiffening of the lungs, making it easier to maintain your breathing capacity over time.
  • Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Nintib 100 Soft Gelatin Capsule reduces the rate of decline in lung function in patients who have lung scarring related to autoimmune connective tissue diseases.
  • Chronic Fibrosing Interstitial Lung Diseases (ILDs) with a Progressive Phenotype: Nintib 100 Soft Gelatin Capsule helps manage various long-term lung conditions where scarring continues to worsen despite other treatments, helping to preserve vital lung volume.

Key Benefits

The primary benefit of Nintib 100 Soft Gelatin Capsule is its ability to protect and preserve your lung function over time. By targeting the underlying chemical signals that cause tissue scarring, this medicine helps you maintain your breathing capacity and perform daily tasks more comfortably.

  • Slower disease progression: It significantly reduces the speed at which lung scarring worsens, allowing you to maintain your active daily routines for a longer period.
  • Lower risk of sudden worsening: It helps lower the risk of sudden, severe breathing crises, which are medically known as acute exacerbations.
  • Better control over breathing decline: Regular use helps stabilise your overall lung health, giving you more predictability in managing your symptoms.
Side effects of Nintib 100 Soft Gelatin Capsule
  • Do not scratch the affected region to avoid discomfort and infection.
  • Avoid spicy and fatty foods and caffeine and alcohol as they can worsen diarrhoea and irritate the skin.
  • Frequently wash your hands to avoid infection.
  • Clean the skin with fragrance-free, soft wipes to reduce inflammation.
  • Let your doctor know if the rash is severe, widespread, or painful.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.
  • Follow a low-fiber, soft food diet with easily digestible liquids and pureed foods.
  • Begin with clear liquids like water, broth, and electrolyte drinks.
  • Progress to soft foods like mashed potatoes, applesauce, plain yogurt, scrambled eggs, and well-cooked rice.
  • Avoid high-fiber foods, raw vegetables, tough meats, spicy foods, and irritants to the digestive tract.
  • Eat smaller, frequent meals to reduce digestive strain.
  • Stay hydrated with plenty of fluids, avoiding sugary drinks.
  • Chew food thoroughly to aid digestion.
  • Avoid strenuous activities and rest when needed.
  • Before altering your diet, seek guidance from your healthcare provider.
  • Always follow your doctor's instructions on dietary restrictions and medical supervision.

Directions for Use

  • Nintib 100 Soft Gelatin Capsule should be taken with meals to enhance its effectiveness.
  • It is recommended to take Nintib 100 Soft Gelatin Capsule twice daily or as advised by your doctor.
  • Swallow Nintib 100 Soft Gelatin Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Nintib 100 Soft Gelatin Capsule Works

Nintib 100 Soft Gelatin Capsule contains nintedanib, which works by blocking certain proteins called tyrosine kinases. These proteins send signals that encourage cells in the lungs to grow and produce collagen, a major part of scar tissue. Too much scar tissue can make the lungs thick and stiff, making it harder to breathe. By blocking these signals, nintedanib helps slow the buildup of scar tissue and the decline in lung function. It does not remove existing lung scarring or cure the condition, but it may help preserve lung function for longer.
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Alcohol

Caution

It is not known if alcohol interacts with Nintib 100 Soft Gelatin Capsule . However, as a precautionary measure, you are recommended not to consume alcohol with the Nintib 100 Soft Gelatin Capsule to avoid unpleasant side effects.

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Pregnancy

Unsafe

Nintib 100 Soft Gelatin Capsule is listed as pregnancy category D. Because Nintib 100 Soft Gelatin Capsule can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Nintib 100 Soft Gelatin Capsule .

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide whether Nintib 100 Soft Gelatin Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Nintib 100 Soft Gelatin Capsule may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Consult your doctor

Dose adjustment may be needed. Nintib 100 Soft Gelatin Capsule is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Dose adjustment may be needed. Nintib 100 Soft Gelatin Capsule is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Unsafe

Nintib 100 Soft Gelatin Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Nintib 100 Soft Gelatin Capsule should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Nintib 100 Soft Gelatin Capsule .

What if I have taken an overdose of Nintib 100 Soft Gelatin Capsule

If you take more than your prescribed dose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Stay hydrated by drinking water throughout the day, which helps prevent dehydration if you experience diarrhoea.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating small portions of bland foods throughout the day can make eating easier.
  • Avoid smoking completely: Smoking speeds up lung damage and can significantly reduce how well Nintib 100 Soft Gelatin Capsule works in your body.
  • Get regular liver tests: Attend all scheduled appointments for blood tests, as your doctor needs to monitor your liver health closely during treatment.
  • Avoid grapefruit and grapefruit juice: This fruit can affect how your body processes the medicine, potentially increasing the risk of side effects.
health query

Have a query?

How Soon It Starts Working

The time required for Nintib 100 Soft Gelatin Capsule to start to work: The exact onset time of Nintib 100 Soft Gelatin Capsule has not been clinically established. 

The time for which the effects of Nintib 100 Soft Gelatin Capsule last: The duration of Nintib 100 Soft Gelatin Capsule ’s effect is clinically not established.

What if you forget to take Nintib 100 Soft Gelatin Capsule

If you miss a dose, skip the missed dose entirely and take your next capsule at your next regularly scheduled time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Nintib 100 Soft Gelatin Capsule at room temperature, specifically between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original blister pack or container to protect it from direct light and moisture.

Drug Warnings

  • Use reliable birth control: Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after stopping Nintib 100 Soft Gelatin Capsule , as it can cause severe harm to an unborn baby.
  • Watch for unusual bleeding: Tell your doctor immediately if you notice blood in your stool, cough up blood, or experience frequent nosebleeds.
  • Monitor your blood pressure: This medication can raise your blood pressure, so check it regularly at home and share the results with your doctor.
  • Check your skin and eyes: Regularly look for signs of yellowing (jaundice), which could indicate a liver problem.
  • Tell all your healthcare providers: Inform your dentist or surgeon that you take Nintib 100 Soft Gelatin Capsule before any procedure, as it can affect wound healing.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Nintib 100 Soft Gelatin Capsule and require closer monitoring or dose adjustments:

  • Blood thinners: Taking this medicine with anticoagulants (such as warfarin) can increase your risk of serious bleeding.
  • Enzyme blockers: Strong CYP3A4 inhibitors (like ketoconazole or erythromycin) can increase the levels of Nintib 100 Soft Gelatin Capsule in your blood, making side effects more likely.
  • Enzyme inducers: Medicines like rifampicin can lower the level of Nintib 100 Soft Gelatin Capsule in your blood, making it less effective.
  • Laxatives: Combining this medicine with laxatives can worsen severe diarrhoea.
NintedanibLomitapide
Severe
NintedanibFosphenytoin
Severe

Drug-Drug Interactions

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NintedanibLomitapide
Severe
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Co-administration of Lomitapide and Nintib 100 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Nintib 100 Soft Gelatin Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Nintib 100 Soft Gelatin Capsule with Fosphenytoin can reduce the levels of Nintib 100 Soft Gelatin Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Nintib 100 Soft Gelatin Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Taking Phenobarbital and Nintib 100 Soft Gelatin Capsule can drastically lower Nintib 100 Soft Gelatin Capsule levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Nintib 100 Soft Gelatin Capsule can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Dexamethasone may lower the blood levels of Nintib 100 Soft Gelatin Capsule, making the medication less effective in treating your condition.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Nintib 100 Soft Gelatin Capsule if prescribed by the doctor. Contact a doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Co-administration of Leflunomide and Nintib 100 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Nintib 100 Soft Gelatin Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Phenytoin and Nintib 100 Soft Gelatin Capsule may decrease the blood levels of Nintib 100 Soft Gelatin Capsule, which may reduce Nintib 100 Soft Gelatin Capsule's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Nintib 100 Soft Gelatin Capsule together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibRifapentine
Severe
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Nintib 100 Soft Gelatin Capsule and Rifapentine can reduce the blood levels of Nintib 100 Soft Gelatin Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nintib 100 Soft Gelatin Capsule and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Nintib 100 Soft Gelatin Capsule and primidone can reduce the blood levels of Nintib 100 Soft Gelatin Capsule.

How to manage the interaction:
Although there is an interaction between Nintib 100 Soft Gelatin Capsule and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Nintib 100 Soft Gelatin Capsule with Carbamazepine can reduce the levels and effects of Nintib 100 Soft Gelatin Capsule.

How to manage the interaction:
Although taking carbamazepine and Nintib 100 Soft Gelatin Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Nintib 100 Soft Gelatin Capsule:
Coadministration of Teriflunomide and Nintib 100 Soft Gelatin Capsule can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Nintib 100 Soft Gelatin Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.

Drug-Food Interactions

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Certain foods or drinks may affect the safety or tolerability of Nintib 100 Soft Gelatin Capsule . Important interactions include:

  • Alcohol: Alcohol may increase the risk of liver problems and worsen side effects such as nausea, dizziness, or stomach discomfort. Ask your doctor whether it is safe to drink alcohol during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Nintib 100 Soft Gelatin Capsule is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.
Nintib 100 Soft Gelatin Capsule helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better.
Avoid smoking before starting the treatment while taking Nintib 100 Soft Gelatin Capsule as smoking might alter the effectiveness of Nintib 100 Soft Gelatin Capsule .
Nintib 100 Soft Gelatin Capsule should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Nintib 100 Soft Gelatin Capsule until your doctor asks you to stop it.
If you have any surgery, including dental surgery, please inform your doctor if you are taking Nintib 100 Soft Gelatin Capsule as your doctor might stop Nintib 100 Soft Gelatin Capsule before undergoing surgery.
In elderly patients, the risk of side effects is higher if you are taking Nintib 100 Soft Gelatin Capsule . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
It is not recommended to discontinue the Nintib 100 Soft Gelatin Capsule without consulting your healthcare provider. Abruptly stopping the medication can lead to disease progression or other complications. Consult your healthcare provider for personalised guidance if you have concerns or experience side effects.
If you forget to take a dose of Nintib 100 Soft Gelatin Capsule , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects.
Common side effects of Nintib 100 Soft Gelatin Capsule may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity in some individuals. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, inform your doctor.
Nintib 100 Soft Gelatin Capsule is not recommended for use in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns before Nintib 100 Soft Gelatin Capsule .
Yes, you should always take Nintib 100 Soft Gelatin Capsule with food. This helps to reduce common stomach-related side effects like nausea and diarrhoea. Talk to your doctor or pharmacist if you struggle to manage stomach issues.
If you develop diarrhoea, drink plenty of fluids to avoid dehydration and contact your doctor immediately. They may recommend an over-the-counter anti-diarrhoeal medicine or adjust your dose. Talk to your doctor or pharmacist before taking any new medicine.
No, Nintib 100 Soft Gelatin Capsule does not cure lung scarring, and it cannot reverse scar tissue that has already formed. Instead, it works to slow down the progression of the disease and preserve your remaining lung function. Talk to your doctor or pharmacist for more information.
You should limit or avoid alcohol while taking Nintib 100 Soft Gelatin Capsule because both alcohol and this medicine can put stress on your liver, increasing your risk of liver damage. Talk to your doctor or pharmacist about safe alcohol limits.
Your doctor will order regular blood tests to monitor your liver function. Since this medicine can cause liver damage, checking your blood helps ensure the medicine is safe for you to continue. Talk to your doctor or pharmacist if you have concerns about these tests.
No, you should not take Nintib 100 Soft Gelatin Capsule if you are pregnant or planning to become pregnant, as it can cause severe harm to an unborn baby. Women who can get pregnant must use highly effective birth control during treatment and for at least 3 months after. Talk to your doctor or pharmacist about safe options.

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - NIN0052
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