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  3. Nise Gel 5 gm

Nise Gel 5 gm, Pack of 1 OINTMENT
Nise Gel 5 gm, Pack of 1 OINTMENT
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Nise Gel 5 gm is used to treat musculoskeletal pain. It works by blocking the release of certain chemicals that cause pain and inflammation and inhibiting the transmission of pain signals to the brain. In some cases, this medicine may cause side effects such as redness, itching, irritation or a burning sensation at the site of application. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

CAPSAICIN-0.25MG + MENTHOL-50MG + METHYL SALICYLATE-100MG + NIMESULIDE-10MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

TOPICAL

Return Policy :

Not Returnable

Expires on or after :

About Nise Gel 5 gm

Nise Gel 5 gm belongs to a class of medications called 'topical analgesic' (pain killer) primarily used to relieve joint pain, low back pain, muscle sprain and sports injuries. Besides this, it also reduces pain and swelling in muscles and joints in the conditions of joint disorders like osteoarthritis and rheumatoid arthritis. Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time.

Nise Gel 5 gm is a combination of four painkillers/analgesics: Nimesulide, Capsaicin, Methyl salicylate and one cooling agent (Menthol). Nimesulide and Methyl salicylate belong to the class of non-steroidal anti-inflammatory drug (NSAIDs) or painkillers that works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin is an analgesic that works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. This action of cooling and warming up distracts from the pain and helps improve blood circulation.

Nise Gel 5 gm is only for external use. Take a small amount of Nise Gel 5 gm on the finger and apply it as a thin layer on the clean and dry affected area. Avoid contact of Nise Gel 5 gm with nose, ears, mouth or eyes. If Nise Gel 5 gm comes in contact with these areas accidentally, rinse with water thoroughly. Your doctor will advise you how often you use Nise Gel 5 gm based on your medical condition. In some cases, you may experience redness, itching, irritation or a burning sensation at the site of application. Most of these side effects of Nise Gel 5 gm do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Nise Gel 5 gm or any other medicines, please tell your doctor. If pregnant or breastfeeding, please inform your doctor before taking Nise Gel 5 gm. Do not consume alcohol with Nise Gel 5 gm as it may increase the risk of stomach bleeding. Do not apply heat or wrap the treated area of the skin with bandages. Avoid using Nise Gel 5 gm in more than prescribed doses or on a large area of skin for a prolonged time, as it may cause adverse effects. Do not apply Nise Gel 5 gm on cuts, wounds or damaged skin. If you have asthma, high blood pressure, diabetes, blood clots, bleeding in the stomach or intestines, stomach ulcers, oedema (swelling due to fluid retention or overload), liver, kidney or heart problems, inform your doctor before taking Nise Gel 5 gm.

Uses of Nise Gel 5 gm

Treatment of Musculoskeletal pain

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Take a small amount of Nise Gel 5 gm on the fingertip and apply it as a thin layer on the clean and dry affected area as advised by your doctor.• Nise Gel 5 gm is only for external use. Avoid contact of the Nise Gel 5 gm with the nose, mouth or eyes. In case of accidental contact with these areas, rinse with water thoroughly.

Medicinal Benefits

Nise Gel 5 gm is a combination of three painkillers/analgesics (Nimesulide, Capsaicin, Methyl salicylate) and one cooling agent (Menthol). Nimesulide and Methyl salicylate belong to the class of non-steroidal anti-inflammatory drug (NSAIDs) or painkillers that works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin is an analgesic that works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. Cooling and warming up distracts from the pain and helps improve blood circulation.

How Nise Gel 5 gm Works

Nise Gel 5 gm is a combination of four painkillers/analgesics: Nimesulide, Capsaicin, Methyl salicylate and one cooling agent (Menthol). Nimesulide and Methyl salicylate belong to the class of non-steroidal anti-inflammatory drug (NSAIDs) or painkillers that works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin is an analgesic that works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. This action of cooling and warming up distracts from the pain and helps improve blood circulation.

Storage

Keep Nise Gel 5 gm out of the sight and reach of children.
Side effects of Nise Gel 5 gm
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Nise Gel 5 gm

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Nise Gel 5 gm or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Nise Gel 5 gm. Do not consume alcohol with Nise Gel 5 gm as it may increase the risk of stomach bleeding. Do not apply heat or wrap the treated area of the skin with bandages. Avoid using Nise Gel 5 gm in more than prescribed doses or on a large area of skin for a prolonged time, as it may cause adverse effects. Do not apply Nise Gel 5 gm on cuts, wounds or damaged skin. Wait for a minimum of 10 minutes before wearing clothes or gloves over the treated area. If you have asthma, high blood pressure, diabetes, blood clots, bleeding in the stomach or intestines, stomach ulcers, edema (swelling due to fluid retention), liver, kidney or heart problems, inform your doctor before taking Nise Gel 5 gm.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy body weight, as obesity may also cause joint pains. Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.
  • Include more glucosamine, chondroitin sulfate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
  • In the chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids, which help in reducing inflammation (redness and swelling) and protect the heart.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Besides this, you can use a footrest if required.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANALGESICS

Nise Gel 5 gm Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with Nise Gel 5 gm as it may increase the risk of stomach bleeding.

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Pregnancy

Caution

The safety of Nise Gel 5 gm in pregnancy is unknown. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Caution

It is unknown whether Nise Gel 5 gm is excreted in human milk. Please consult a doctor before using Nise Gel 5 gm while breastfeeding.

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Driving

Safe if prescribed

Nise Gel 5 gm usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Use Nise Gel 5 gm with caution, especially if you have a history of liver disease. Please consult a doctor for appropriate dose adjustments.

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Kidney

Caution

Use Nise Gel 5 gm with caution, especially if you have a history of Kidney diseases/conditions. Please consult a doctor for appropriate dose adjustments.

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Children

Caution

The safety of Nise Gel 5 gm in children is unknown. Please consult your doctor.

Have a query?

FAQs

Nise Gel 5 gm is used to relieve joint pain, low back pain, muscle sprain and sports injuries. Besides this, it also reduces pain and swelling in conditions like osteoarthritis and rheumatoid arthritis.

Nise Gel 5 gm is a combination of four painkillers/analgesics: Nimesulide, Capsaicin, Methyl salicylate and one cooling agent (Menthol). Nimesulide and Methyl salicylate works by blocking the release of certain chemical messengers in the brain responsible for causing pain and symptoms of inflammation such as redness and swelling. Capsaicin works by affecting the chemical messenger in the brain (neurotransmitter) that transmits pain signals to the brain, thereby reducing the perception of pain. Menthol acts as a cooling agent that relieves pain initially by cooling the skin, followed by warming it up. Cooling and warming up distracts from the pain and helps improve blood circulation.

You are recommended to avoid using Nise Gel 5 gm if you have had any recent bypass heart surgery, heart attack, stroke, gastrointestinal bleeding (bloody stool), or ulcer of the stomach or intestine. Elderly (more than 65 years of age) or smokers are at greater risk of having gastrointestinal bleeding, so they should use Nise Gel 5 gm with caution.

No, you are not recommended to apply Nise Gel 5 gm on wounds, cuts, burn, rash, infected areas or peeling skin. However, please consult a doctor before using Nise Gel 5 gm.

Yes, Nise Gel 5 gm may cause skin irritation at the site of application as a common side effect. It is not necessary for everyone using Nise Gel 5 gm to experience this side effect. However, if the irritation persists or worsens, please consult a doctor.

Patients with heart failure are not advised to take Nise Gel 5 gm because painkillers may alter blood substance levels and make blood clots more likely. These blood clots have the potential to block and constrict your heart's artery, leading to a heart attack.

You are recommended to take a shower, bathe or wash the treated area of skin after 1 hour of applying Nise Gel 5 gm for effective results.

No, Nise Gel 5 gm does not cure arthritis. Nise Gel 5 gm is only used to relieve symptoms of arthritis-like joint pain, swelling and stiffness.

Nise Gel 5 gm is for external use only. Take a small amount of Nise Gel 5 gm on the finger and apply as a thin layer on the clean and dry affected area and surrounding skin. Avoid contact with the eyes, mouth, or nose. If accidental contact occurs, rinse thoroughly with water. Be sure to wash your hands before and after application.

No, Nise Gel 5 gm, is not a steroid. It belongs to the class of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).

While using Nise Gel 5 gm, you are recommended to tell your doctor if you are allergic to the active substances of Nise Gel 5 gm and if you have kidney, liver, or heart disease, diabetes, asthma, high blood pressure, bleeding in the stomach or intestines, stomach ulcers, and edema. Avoid using Nise Gel 5 gm on cuts, wounds, or damaged skin. Avoid consuming alcohol while using it to reduce the risk of stomach bleeding. Do not apply heat or tightly wrap the treated area. Use only as directed, and avoid excessive or prolonged application to prevent adverse effects.

If you forget to use Nise Gel 5 gm, then apply as soon as you remember. Avoid applying more to make up for the missed one. If you have any concerns, contact your doctor.

You are not recommended to stop using Nise Gel 5 gm without consulting your doctor, even if you feel better as stopping early might affect the treatment's effectiveness. Always follow your doctor’s instructions.

Nise Gel 5 gm is generally safe for most patients when used as per the dose and duration advised by a doctor. Follow the instructions given by your doctor. Do not self-medicate.

No, Nise Gel 5 gm is not an antibiotic. It contains capsaicin, menthol methyl salicylate, and nimesulide as its active substances, used to relieve pain and inflammation associated with conditions like muscle aches, joint pain, and sprains.

Both Nise Gel 5 gm and paracetamol are pain-relieving medications. Using them together is generally not advised, as it may raise the risk of gastric ulcers and bleeding. It is essential to consult your doctor before taking Nise Gel 5 gm with paracetamol or other medicines.

No, Nise Gel 5 gm does not contain aspirin.

Nise Gel 5 gm may be used for headaches, but only when prescribed by a doctor. It has been shown to help with mild migraines and can be effective for headaches when used as directed. However, it is not recommended for long-term use in cases of recurring headaches. If you experience frequent headaches, consult your doctor for proper treatment.

Nise Gel 5 gm does not cause drowsiness as it works locally and applied to the skin. Nise Gel 5 gm active ingredients work directly on the area to relieve pain. Inform your doctor if your symptoms worsen while using Nise Gel 5 gm.

You are recommended to consult your doctor before using Nise Gel 5 gm with other medicines.

Nise Gel 5 gm may be taken with aspirin as no interactions have been observed. However, please consult a doctor before using Nise Gel 5 gm with aspirin or other medicines to avoid potential interactions.

No, Nise Gel 5 gm is not banned in India.

It is unknown if Nise Gel 5 gm passes into breast milk and if it can harm the baby. Therefore, consult a doctor before using Nise Gel 5 gm if you are breastfeeding.

You are recommended to take a doctor’s advice before using Nise Gel 5 gm if you are pregnant or planning for pregnancy.

Nise Gel 5 gm may be safe for asthma patients. However, it's advisable to inform your doctor if you have a history of asthma. Do not self-medicate.

Nise Gel 5 gm causes side effects such as irritated skin, burning sensation, stinging sensation, red skin or rashes, erythema (redness of skin or mucous membranes), and desquamation (peeling skin). Consult your doctor if these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - NIS0063

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:48 AM IST

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Reference

  1. https://www.nhs.uk/conditions/nsaids/
  2. https://www.medindia.net/doctors/drug_information/nimesulide.html
  3. https://www.drugs.com/cdi/methyl-salicylate-menthol-and-capsaicin-cream-and-ointment.html

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