Apollo
logo
0
  1. Home
  2. salt
  3. Daunorubicin

Daunorubicin

About Daunorubicin

Daunorubicin is a specialised chemotherapy medicine used to treat specific blood cancers, such as acute myeloid leukaemia and acute lymphocytic leukaemia. It works by interfering with the genetic material of cancer cells, preventing them from multiplying and spreading throughout the body. This helps control the disease and allows your bone marrow to produce healthy blood cells once again.

Because this medicine is given as an injection into a vein, it is given in scheduled treatment cycles by healthcare professionals in a hospital or clinic. Consistent attendance at all your scheduled clinical appointments is critical to ensure the treatment works effectively.

An echocardiogram test checks your heart function, including how effectively your heart pumps blood. A baseline test before starting treatment helps your doctor identify any existing heart problems and monitor changes during therapy. Since it is injected, food intake does not alter how the drug is absorbed, but eating regular, nutritious meals can help support your body through the treatment cycles.

During your treatment, you may experience common side effects like nausea, vomiting, temporary hair loss, or red-colored urine. However, you must seek immediate medical attention if you notice serious signs like a fever, severe chills, unusual bruising, or sudden swelling in your legs. Talk to your doctor or pharmacist if you experience any persistent discomfort.

Before you begin therapy, tell your doctor if you have a history of heart disease, liver damage, kidney issues, or low blood cell counts. Do not take this if you have severe bone marrow suppression, have recently suffered a severe heart attack, or have significant pre-existing heart failure.

This medicine can interact with other drugs that impact your immune system or heart health, and you should avoid alcohol and smoking to prevent extra stress on your liver and lungs. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, talk to your doctor or pharmacist to discuss the specific risks and benefits for your situation.

Uses of Daunorubicin

Daunorubicin is used to treat certain types of blood cancers. The detailed uses of Daunorubicin are as follows: • Treats acute myeloid leukaemia (AML): Daunorubicin is used in combination with other chemotherapy drugs to manage AML, a cancer of the white blood cells. • Used for acute lymphocytic leukaemia (ALL): Daunorubicin is given with other chemotherapy agents to treat ALL, another type of white blood cell cancer. • Helps slow cancer growth: Daunorubicin works by inhibiting the growth and spread of cancer cells in the body.

Medicinal Benefits

When taken consistently as directed, this medicine may provide the following physiological benefits:

  • Targets cancer cells: This medicine works by targeting and destroying rapidly growing leukaemia cells in the blood and bone marrow. By reducing these abnormal cells, it helps the body restore the production of healthy blood cells, including red blood cells, white blood cells, and platelets.
  • Supports recovery: By helping control leukaemia and improve blood cell counts, this medicine may reduce symptoms such as fatigue, frequent infections, easy bruising, and bone pain, helping patients regain strength and return to daily activities.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Daunorubicin will be administered by a trained healthcare professional.
  • Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Daunorubicin

Common Side Effects (Usually mild):

  • Nausea and vomiting
  • Temporary hair loss (hair usually grows back after treatment is complete)
  • Red-colored urine (this is harmless and is simply the colour of the medicine passing through your body)
  • Mild mouth sores or a sore throat
     

Serious Side Effects (Consult your doctor right away):

  • High fever, chills, sweating, or severe sore throat (signs of infection)
  • Shortness of breath, a rapid or irregular heartbeat, or swelling in your ankles and feet (signs of heart trouble)
  • Severe pain, burning, redness, or swelling at the injection site (which may indicate the medicine has leaked into the surrounding skin)
  • Unusual bleeding, easy bruising, or dark, tarry stools

Drug Warnings

  • Alert your nurse immediately to injection pain: If you feel any burning, stinging, coldness, or pain around your vein during your infusion, tell your healthcare provider right away, as the injection must be stopped immediately to avoid skin damage.
  • Heart monitoring: Daunorubicin can affect the heart, especially with higher total lifetime doses. Your doctor will track your cumulative dose (total amount received over time) and may perform heart tests such as an echocardiogram before and during treatment to check how well your heart is pumping.
  • Avoid live vaccines: Do not receive live vaccines (like the shingles or yellow fever vaccines) while using this medicine, as your weakened immune system cannot safely process them.
  • Check your temperature daily: Call your doctor immediately if your temperature rises above 100.4°F (38°C), as a fever can be a medical emergency when your white blood cell count is low.

Drug Interactions

  • Other chemotherapy medications: May increase the risk of heart damage or severely lower your blood cell counts.
  • Live vaccines: Can cause serious, potentially life-threatening infections when given while your immune system is weakened by medicine.
  • Medicines that affect the heart: Taking other medications that put stress on your heart muscle can increase your risk of heart damage.

Drug-Drug Interactions Checker List:

  • MESALAZINE
  • OLSALAZINE
  • SULFASALAZINE
  • GENTAMICIN
  • NEOMYCIN
  • AMIKACIN
  • CHOLERA VACCINE
  • TYPHOID VACCINE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consumption of alcohol with Daunorubicin as it may increase the risk of liver damage.

    • Safety Warning

      Pregnancy

      unsafe

      It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving Daunorubicin.

    • Safety Warning

      Breast Feeding

      unsafe

      It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Daunorubicin. Your doctor may suggest you stop feeding while on treatment with this medicine.

    • Safety Warning

      Driving

      unsafe

      Daunorubicin causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Daunorubicin.

    • Safety Warning

      Liver

      caution

      If you have a pre-existing or a history of liver disease, inform your doctor before receiving Daunorubicin. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

    • Safety Warning

      Kidney

      caution

      If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Daunorubicin. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

    • Safety Warning

      Children

      safe if prescribed

      Daunorubicin can be recommended for acute lymphocytic leukemia in children. Please consult your doctor. Your child's doctor may prescribe a suitable dose based on the condition and age of your child. If this medicine is given, the child should be observed carefully for any unwanted effects.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Follow a low-infection diet: Since your white blood cell count will be lower during treatment, eat only well-cooked meats, wash all fresh produce thoroughly, and avoid dairy products that have not been heat-treated to remove harmful bacteria, such as raw milk or certain artisan cheeses, to protect yourself from infections.
    • Stay well-hydrated: Drink plenty of water and caffeine-free fluids to help your kidneys efficiently process and flush out the waste products from destroyed cancer cells.
    • Eat small, frequent meals: If you experience nausea or mouth sores, eating small portions of soft, bland foods can help maintain your strength without irritating your stomach or mouth.
    • Avoid crowds and sick contacts: Stay away from public crowds and individuals with colds, flu, or other infections, and practice frequent handwashing.
    • Fertility: Daunorubicin may affect fertility in some patients. If you are concerned about future fertility, discuss available fertility preservation options with your oncologist before starting treatment.

    Special Advise

    • Regular blood tests are recommended while taking Daunorubicin to monitor the number and type of cells in the blood and liver functioning.

    Patients Concern

    Disease/Condition Glossary

    Acute lymphocytic leukemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

    FAQs

    Daunorubicin is used to treat lymphocytic leukemia, and Acute non-lymphocytic leukemia.

    Daunorubicin contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

    Daunorubicin may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Daunorubicin if you are planning to become a parent.

    If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Daunorubicin as it may cause infections.

    Yes, Daunorubicin is a vesicant (irritant) which means, it can cause severe tissue damage if it leaks into the surrounding tissues during injection (extravasation).

    Daunorubicin should be administered by the doctor or nurse through an intravenous route (into a vein). Do not self-administer.

    The frequency and duration of treatment may vary depending on your medical condition being treated. Always follow the doctor's instructions regarding the dosing schedule to get full benefits.

    The side effects of Daunorubicin include mouth ulcers, diarrhoea, vomiting, nausea, loss of appetite, dizziness, weakness, fever, chills, and pain at the site of injection. Consult the doctor if any of these symptoms persist or worsen.

    Medicine is given as a slow injection or infusion directly into a vein by a trained healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about your treatment schedule.

    The red colour is harmless and occurs because the medicine naturally passes through your kidneys and out of your body. This usually lasts for a day or two after your injection. Talk to your doctor if the redness persists or if you experience pain.

    No, you should avoid becoming pregnant during treatment because this medicine can cause severe harm to an unborn baby. Both men and women should use effective, highly reliable birth control during therapy. Talk to your doctor for specific advice.

    Yes, temporary hair loss is a common side effect of this medicine. Your hair will typically begin to grow back once your complete treatment cycle is finished. Talk to your doctor or pharmacist if you need advice on hair care during treatment.

    This medicine can sometimes stress or weaken the heart muscle, especially after receiving higher doses over time. Your doctor will monitor your heart function closely with tests before and during treatment. Talk to your doctor if you notice any shortness of breath or swelling in your feet.

    Tell your nurse or doctor immediately if you feel any burning, stinging, or pain around your vein during the infusion. This can mean the medicine is leaking into the skin, which requires immediate medical attention. Talk to your doctor.

    It is highly recommended to avoid alcohol during your treatment, as alcohol can place extra strain on your liver and worsen dehydration, nausea, or mouth sores. Talk to your doctor or pharmacist for guidance.

    Author Details

    Doctor image
    We provide you with authentic, trustworthy and relevant information.
    Apollo 247 Floating Button
    DAUNORUBICIN | View uses, side-effects, medicines | Apollo Pharmacy