Daunomac-20 Injection 1's

Prescription drug

MRP ₹323

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₹48.5 Cashback (15%)

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Daunomac-20 Injection 1's is an antineoplastic medicine used in the treatment of cancer. It contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way, and causes cancer cell death.

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About Daunomac-20 Injection 1's

Daunomac-20 Injection 1's is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Daunomac-20 Injection 1's helps to induce remission of nonlymphocytic leukemia (myelogenous, monocytic, erythroid) and acute lymphocytic leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Daunomac-20 Injection 1's may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, fever, chills, and pain at the site of injection. Most of these side effects of Daunomac-20 Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Daunomac-20 Injection 1's is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

Daunomac-20 Injection 1's should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Daunomac-20 Injection 1's. Daunomac-20 Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Daunomac-20 Injection 1's as it may increase the risk of liver damage. This medicine may be recommended for use in children only if the benefits outweigh the risks.

Uses of Daunomac-20 Injection 1's

Daunomac-20 Injection 1's is used to treat certain types of blood cancers. The detailed uses of Daunomac-20 Injection 1's are as follows:

Treats acute myeloid leukaemia (AML) Daunomac-20 Injection 1's is used in combination with other chemotherapy drugs to manage AML, a cancer of the white blood cells.
Used for acute lymphocytic leukaemia (ALL): Daunomac-20 Injection 1's is given with other chemotherapy agents to treat ALL, another type of white blood cell cancer.
Helps slow cancer growth: Daunomac-20 Injection 1's works by inhibiting the growth and spread of cancer cells in the body.

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Directions for Use

Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
Daunomac-20 Injection 1's will be administered by a trained healthcare professional.
Do not self-administer.

Medicinal Benefits

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

How Daunomac-20 Injection 1's Works

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, Daunomac-20 Injection 1's stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Storage

• Store in a cool and dry place away from sunlight.• Keep Daunomac-20 Injection 1's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Daunomac-20 Injection

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Abnormal Heart Rhythm

Exercise regularly and maintain a healthy weight.
Manage cholesterol and blood pressure.
Limit intake of caffeine and alcohol.
Avoid vaping and tobacco smoke.
Get enough sleep.
Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.

Discolouration of urine

Hair Loss

Eat protein-rich foods like fish, poultry, eggs, and legumes.
Include foods with minerals and vitamins essential for hair health.
Join a support group to connect with others experiencing hair loss.
Openly discuss your feelings about hair loss.
Consider covering up with wigs, hats, or scarves.
Be patient and avoid seeking miracle cures.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Daunomac-20 Injection 1's

Daunomac-20 Injection 1's is administered in a hospital setting under the supervision of your doctor or medical personnel. Thus, an overdose is quite improbable. While in the hospital, you will be constantly monitored to ensure that any unpleasant side effects are handled.

Drug Warnings

Daunomac-20 Injection 1's should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Daunomac-20 Injection 1's. Daunomac-20 Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease. Avoid alcohol consumption with Daunomac-20 Injection 1's as it may increase the risk of liver damage. Avoid excessive exposure to sunlight as Daunomac-20 Injection 1's may cause sensitivity to sunlight. You are advised to use sunscreen and wear protective clothing while going out. If you are about to receive any vaccinations, inform your doctor that you are taking Daunomac-20 Injection 1's as it may cause infections.

Drug-Drug Interactions

DaunorubicinZiprasidone

Critical

DaunorubicinCladribine

Severe

Drug-Drug Interactions

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DaunorubicinZiprasidone

Critical

How does the drug interact with Daunomac-20 Injection:
Taking Daunomac-20 Injection with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Daunomac-20 Injection with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

DaunorubicinCladribine

Severe

How does the drug interact with Daunomac-20 Injection:
The combined use of cladribine with Daunomac-20 Injection can increase the risk of serious infections.

How to manage the interaction:
Taking Daunomac-20 Injection with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.

DaunorubicinClozapine

Severe

How does the drug interact with Daunomac-20 Injection:
When Clozapine is taken with Daunomac-20 Injection, may increase the risk of infection and irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Daunomac-20 Injection and Clozapine, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include problems with your immune system, heart rhythm, or signs of infection like fever, chills, or a sore throat. Other symptoms to watch out for are muscle aches, difficulty breathing, unexplained weight loss, pain, sudden dizziness, feeling lightheaded, fainting, or heart palpitations. Do not stop using any medications without first talking to your doctor.

DaunorubicinHaloperidol

Severe

How does the drug interact with Daunomac-20 Injection:
Co-administration of Daunomac-20 Injection with Haloperidol can increase the risk of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Daunomac-20 Injection with Haloperidol together can possibly result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting your doctor.

DaunorubicinTofacitinib

Severe

How does the drug interact with Daunomac-20 Injection:
When Tofacitinib is taken with Daunomac-20 Injection, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Daunomac-20 Injection, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

DaunorubicinAmiodarone

Severe

How does the drug interact with Daunomac-20 Injection:
Coadministration of Daunomac-20 Injection with amiodarone may increase the risk of abnormal cardiac rhythms.

How to manage the interaction:
Although taking Daunomac-20 Injection with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor . Do not stop taking any medications without visiting a doctor.

DaunorubicinMoxifloxacin

Severe

How does the drug interact with Daunomac-20 Injection:
Using Moxifloxacin together with Daunomac-20 Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Daunomac-20 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or heart palpitations, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

DaunorubicinCeritinib

Severe

How does the drug interact with Daunomac-20 Injection:
Taking Ceritinib with Daunomac-20 Injection may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Daunomac-20 Injection and Ceritinib, but it can be taken if prescribed by a doctor. If you have any symptoms like severe or long-lasting loose stools or vomiting, sudden dizziness or lightheadedness, fainting, difficulty breathing, or heart palpitations, consult a doctor. Don't hesitate to reach out to your doctor if you experience any of these symptoms. Do not discontinue any medications without first consulting your doctor.

DaunorubicinDisopyramide

Severe

How does the drug interact with Daunomac-20 Injection:
The combined use of Daunomac-20 Injection and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Daunomac-20 Injection and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

DaunorubicinEfavirenz

Severe

How does the drug interact with Daunomac-20 Injection:
Taking Efavirenz with Daunomac-20 Injection can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz with Daunomac-20 Injection together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
Drink plenty of water daily while taking Daunomac-20 Injection 1's as some cancer therapies may cause dehydration.
Exercise regularly and maintain a healthy body weight.
Regularly wash your hands and avoid contact with people having infections.
Quit smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Unsafe

Avoid consumption of alcohol with Daunomac-20 Injection 1's as it may increase the risk of liver damage.

Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving Daunomac-20 Injection 1's.

Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may suggest you stop feeding while on treatment with this medicine.

Driving

Unsafe

Daunomac-20 Injection 1's causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Daunomac-20 Injection 1's.

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Daunomac-20 Injection 1's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

Children

Safe if prescribed

Daunomac-20 Injection 1's can be recommended for acute lymphocytic leukemia in children. Please consult your doctor. Your child's doctor may prescribe a suitable dose based on the condition and age of your child. If this medicine is given, the child should be observed carefully for any unwanted effects.

Heart

Please consult your doctor if you have any pre-existing heart disease before using Daunomac-20 Injection 1's.

Geriatrics

Caution

Daunomac-20 Injection 1's can be used in the elderly when prescribed by a doctor. If you have any concerns about using Daunomac-20 Injection 1's, please consult a doctor.

FAQs

What is the use of Daunomac-20 Injection 1's?

Daunomac-20 Injection 1's is used to treat lymphocytic leukemia, and Acute non-lymphocytic leukemia.

How does Daunomac-20 Injection 1's work?

Daunomac-20 Injection 1's contains Daunorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Does Daunomac-20 Injection 1's affect fertility?

Daunomac-20 Injection 1's may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Daunomac-20 Injection 1's if you are planning to become a parent.

Can I take vaccinations with Daunomac-20 Injection 1's?

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Daunomac-20 Injection 1's as it may cause infections.

Is Daunomac-20 Injection 1's a vesicant?

Yes, Daunomac-20 Injection 1's is a vesicant (irritant) which means, it can cause severe tissue damage if it leaks into the surrounding tissues during injection (extravasation).

How is Daunomac-20 Injection 1's administered?

Daunomac-20 Injection 1's should be administered by the doctor or nurse through an intravenous route (into a vein). Do not self-administer.

How often is Daunomac-20 Injection 1's given?

The frequency and duration of treatment may vary depending on your medical condition being treated. Always follow the doctor's instructions regarding the dosing schedule to get full benefits.

What are the side effects of Daunomac-20 Injection 1's?

The side effects of Daunomac-20 Injection 1's include mouth ulcers, diarrhoea, vomiting, nausea, loss of appetite, dizziness, weakness, fever, chills, and pain at the site of injection. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.

Other Info - DAU0013

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 22, 2025 | 7:27 AM IST

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