Empagliflozin+metformin+sitagliptin
About Empagliflozin+metformin+sitagliptin
Empagliflozin+metformin+sitagliptin is used to manage type 2 diabetes, a condition in which blood sugar levels become too high. Type 2 diabetes is a long-term condition that can affect daily life, but with proper management, including a healthy diet, regular exercise, medication, and routine check-ups, blood sugar can be effectively controlled and the risk of complications reduced.
Empagliflozin+metformin+sitagliptin contains three active ingredients: Empagliflozin, Metformin, and Sitagliptin. Together, they help lower blood sugar through complementary actions. Empagliflozin works on the kidneys to remove excess sugar through urine. Metformin reduces sugar production in the liver and improves the body’s use of insulin. Sitagliptin boosts natural hormones (incretins) that stimulate insulin release after meals and limit excess sugar release from the liver. By combining these effects, Empagliflozin+metformin+sitagliptin can provide more effective blood sugar control than a single medicine alone.
Empagliflozin+metformin+sitagliptin is taken by mouth with meals as advised by your doctor, usually once or twice daily. The dose depends on your medical condition and response to treatment. Taking it at the same time each day helps maintain steady blood sugar control. Some people may experience mild side effects, such as frequent urination, nausea, diarrhoea, stomach upset, or skin rash. These are generally temporary, but if they persist or worsen, consult your doctor.
Before starting Empagliflozin+metformin+sitagliptin, inform your doctor about all medical conditions, medications, and any known allergies, including if you are pregnant or breastfeeding. This medicine is not recommended for children, as safety and effectiveness have not been established. Alcohol should be avoided, and caution is advised when driving or operating machinery, as fluctuations in blood sugar may affect alertness.
Medicinal Benefits
- Empagliflozin+metformin+sitagliptin contains three active ingredients: Empagliflozin, Metformin, and Sitagliptin. Together, they help lower blood sugar in different ways.
- Empagliflozin works on the kidneys to remove excess sugar through urine, and Metformin reduces sugar production in the liver. It improves how the body uses insulin, and Sitagliptin increases natural hormones (incretins) that stimulate insulin release after meals and reduce excess sugar release from the liver.
- With these combined actions, Empagliflozin+metformin+sitagliptin effectively lowers elevated blood sugar, especially in adults whose diabetes is not controlled with Metformin alone.
- When used in conjunction with diet and exercise, it enhances overall blood sugar control and provides better management of type 2 diabetes compared to single medications alone.
Directions for Use
- Take exactly as prescribed by your doctor; do not change the dose or frequency on your own.
- Swallow the tablets whole with water, with or after meals, to reduce stomach upset. Do not crush, chew, or break the tablets.
- Take at the same time each day to maintain consistent blood sugar control.
- Do not skip doses or stop suddenly, as this may lead to uncontrolled blood sugar and increase the risk of complications.
Storage
Side Effects of Empagliflozin+metformin+sitagliptin
- Diarrhea
- Headache
- Increased urination or dehydration
- Mild dizziness
- Nausea
- Stomach upset
- Urinary tract infections or yeast infections
- Vomiting
Drug Warnings
- Before taking Empagliflozin+metformin+sitagliptin, tell your doctor or pharmacist if you are allergic to any medicines or foods.
- Do not stop taking Empagliflozin+metformin+sitagliptin on your own, even if you feel better, as your blood sugar may rise and increase the risk of eye, kidney, or nerve problems.
- Empagliflozin+metformin+sitagliptin should not be taken if you have type 1 diabetes, severe kidney problems, or liver disease.
- Talk to your doctor if you are pregnant, planning to get pregnant, or breastfeeding, as this medicine is generally not recommended in these situations.
- Your blood sugar may be harder to control during illness, stress, surgery, or if you are not eating well, and your doctor may need to adjust your treatment.
- Watch for symptoms of low blood sugar, such as sweating, dizziness, fast heartbeat, or intense thirst, and eat something sugary immediately if these occur.
- Always inform your doctor about all your medical conditions and any medicines, supplements, or herbal products you are taking to avoid potential interactions.
Drug Interactions
Drug-Drug Interactions: Empagliflozin+metformin+sitagliptin may interact with certain diuretic medications (e.g. acetazolamide), certain medications that inhibit stomach acid production (e.g. cimetidine), HIV medications (e.g. dolutegravir), anticancer medications (e.g. bexarotene, capivasertib) and antibiotics (e.g. gatifloxacin).
Drug-Food Interactions: Avoid alcohol intake since it increases the risk of lactic acidosis.
Drug-Disease Interactions: Empagliflozin+metformin+sitagliptin may interact with certain medical conditions such as lactic acidosis, liver disease, renal dysfunction, hypoglycemia, B12 deficiency, hypotension and infections.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.
Pregnancy
unsafeEmpagliflozin+metformin+sitagliptin is not recommended during pregnancy because it is not yet known whether it is safe or effective for pregnant women.
Breast Feeding
unsafeEmpagliflozin+metformin+sitagliptin is not recommended while breastfeeding, as it is not known whether the medicine passes into breast milk or if it could affect the baby.
Driving
cautionYour driving ability may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you experience blurred vision, dizziness, or drowsiness due to extreme fluctuations in blood sugar.
Liver
cautionInform your doctor before receiving Empagliflozin+metformin+sitagliptin if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionInform your doctor before receiving Empagliflozin+metformin+sitagliptin if you have a history of kidney impairment/disorder. Dose adjustment may be needed.
Children
unsafeEmpagliflozin+metformin+sitagliptin is not recommended for people younger than 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Follow a balanced diet with controlled carbohydrate intake to manage blood sugar.
- Include high-fibre foods, such as whole grains, vegetables, and fruits, in your meals.
- Limit sugar, sweets, and refined carbohydrates.
- Maintain a healthy body weight through portion control and mindful eating.
- Engage in regular physical activity, such as walking, swimming, or yoga, as advised by your doctor.
- Stay hydrated by drinking plenty of water throughout the day.
- Avoid alcohol or consume only under medical guidance, as it can affect blood sugar.
- Quit smoking and reduce stress, as both can worsen diabetes control.
Special Advise
- Monitor blood sugar levels regularly to ensure effective control.
- Inform your doctor about all medications, medical conditions, pregnancy, or breastfeeding.
- Do not drive or operate machinery if you feel dizzy, drowsy, or experience blurred vision due to blood sugar fluctuations.
- Regular kidney function tests may be required, and temporarily stopping Empagliflozin+metformin+sitagliptin may be advised before certain X-ray or CT scans with contrast dye.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes: Type 2 diabetes is a common condition that causes the level of glucose (sugar) in the blood to become too high. It can cause symptoms such as excessive thirst, frequent urination, and tiredness. It can also increase your risk of getting serious problems with your eyes, heart and nerves. It's a lifelong condition that can affect your everyday life. You may need to change your diet, take medicines and have regular check-ups. It's caused by problems with a chemical in the body (hormone) called insulin. It's often linked to being overweight or inactive, or having a family history of type 2 diabetes.
FAQs
Empagliflozin+metformin+sitagliptin is indicated for adults with type 2 diabetes mellitus inadequately controlled on Metformin monotherapy. This combination therapy improves glycaemic control by enhancing insulin action and promoting renal glucose excretion. When used in conjunction with a balanced diet and regular exercise, it provides effective blood sugar management and may help reduce the risk of long-term diabetes-related complications.
Empagliflozin+metformin+sitagliptin works through three complementary actions: Empagliflozin removes excess sugar from the body through the kidneys, Metformin reduces sugar production in the liver and improves the body's use of insulin, and Sitagliptin increases natural hormones that stimulate insulin release after meals and decrease sugar release from the liver. Together, these actions help control blood sugar more effectively than any single medicine alone.
Common side effects include frequent urination and thirst, yeast or urinary infections, nausea, vomiting, diarrhoea, stomach upset, headache, and mild dizziness. Most are mild, but tell your doctor if they persist or worsen.
Serious side effects are rare but require immediate attention. These include severe stomach pain, tiredness or muscle pain (possible lactic acidosis), severe allergic reactions, signs of pancreatitis, or very low blood sugar, especially if taken with other diabetes medicines.
Empagliflozin+metformin+sitagliptin is not recommended during pregnancy or breastfeeding. Talk to your doctor if you are pregnant, planning pregnancy, or nursing so that they can suggest safer alternatives.
If you take too much, seek medical help immediately, as an overdose can cause low blood sugar and other serious complications.
Diabetes is usually treated for the rest of one's life. Do not discontinue taking Empagliflozin+metformin+sitagliptin pills without first consulting your doctor.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
There is no cure for diabetes as of now. Empagliflozin+metformin+sitagliptin only helps to control type 2 diabetes. However, it is advisable to maintain a proper diet and exercise regimen along with Empagliflozin+metformin+sitagliptin to control blood sugar levels.
For best results, follow a balanced, diabetes-friendly diet, exercise regularly, stay hydrated because of extra urination, maintain good hygiene to prevent infections, avoid smoking, and limit alcohol intake.
Your doctor will check your blood sugar, kidney function, blood pressure, and weight regularly to ensure Empagliflozin+metformin+sitagliptin is working safely. They may also test your electrolytes if needed. Be sure to tell your doctor about any new or unusual symptoms.
