EPALRESTAT belongs to a group of medicines called aldose reductase inhibitors used to manage diabetic neuropathy. Diabetic neuropathy is a chronic progressive nerve disease which causes nerve pain due to nerve damage in diabetic patients. It mostly affects the legs and feet.
EPALRESTAT contains ‘Epalrestat’ that works by inhibiting aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients who have diabetes which leads to nerve pain. EPALRESTAT prevents the accumulation of sorbitol, thereby helps in treating diabetic neuropathy.
You are advised to take EPALRESTAT for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor before taking EPALRESTAT if you are pregnant or breastfeeding. EPALRESTAT may cause drowsiness and dizziness, so drive only if you are alert. EPALRESTAT is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with EPALRESTAT as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Diabetic neuropathy (diabetic nerve pain)
EPALRESTAT belongs to a group of medicines called aldose reductase inhibitors. EPALRESTAT is used for the management of diabetic neuropathy. EPALRESTAT works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients who have diabetes which leads to nerve pain. EPALRESTAT prevents sorbitol accumulation, thereby treating diabetic neuropathy (pain due to nerve damage).
Do not take EPALRESTAT if you are allergic to any of its contents. Inform your doctor if you have liver or kidney problems. Consult your doctor before taking EPALRESTAT if you are pregnant or breastfeeding. EPALRESTAT may cause drowsiness and dizziness, so drive only if you are alert. EPALRESTAT is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with EPALRESTAT as it could lead to increased drowsiness and sleepiness.
Drug-Drug Interactions: No interactions found/established.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: No interactions found/established.
Avoid consumption of alcohol while taking EPALRESTAT as it may cause increased dizziness.
Limited information is available regarding the use of EPALRESTAT in pregnant women. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Limited information is available regarding the use of EPALRESTAT in breastfeeding women. Consult your doctor before taking EPALRESTAT; your doctor will decide whether EPALRESTAT can be taken by breastfeeding mothers or not.
EPALRESTAT may cause dizziness. Do not drive or operate machinery unless you are alert.
EPALRESTAT should not be used in patients with severe liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.
EPALRESTAT should be used with caution in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
EPALRESTAT should not be given to children as safety and efficacy have not been established.
Diabetic neuropathy: Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type1 and type2 diabetes, which usually develops slowly. If you have diabetes and experience numbness, pain, tingling sensation, or weakness in the hands or legs, you must consult a doctor. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty with coordination when walking, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).