ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN does not work against infections caused by the virus, including cold and flu.
ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN is a combination of four anti-tuberculosis drugs, namely: Rifampicin, isoniazid, pyrazinamide and ethambutol. Isoniazid prevents the formation of the bacterial cell wall, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria (Mycobacterium tuberculosis) to make essential proteins and to reproduce. Ethambutol and pyrazinamide work by slowing the growth of bacteria. Altogether, they kill the bacteria and treat the infection.
The dose and duration of ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN can vary depending upon your condition and severity of the infection. In some cases, you may experience certain common side-effects such as weakness, nausea, vomiting, malaise (feeling of discomfort), fatigue and vision problems. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as they might cause interaction. Maintain a gap of one hour between ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN and antacid medicines. Consult your doctor before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN if you are pregnant. Avoid breastfeeding while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it passes into breast milk. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN is not recommended for use in children. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN may cause dizziness and vision problems, so drive only if you are alert. Avoid consuming alcohol along with ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it might lead to liver problems and increased dizziness.
Tuberculosis (TB)
ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN is a combination of four anti-tuberculosis drugs, namely: Rifampicin, isoniazid, pyrazinamide and ethambutol. Isoniazid prevents the formation of the bacterial cell wall, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria (Mycobacterium tuberculosis) to make essential proteins and to reproduce. Ethambutol and pyrazinamide work by slowing the growth of bacteria. Altogether, they kill the bacteria and treat the infection.
Do not take ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN if you are allergic to any of its contents, if you have jaundice or if you are taking HIV medicines (saquinavir or ritonavir). Before starting ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN if you are pregnant. Avoid breastfeeding while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it passes into breast milk. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN is not recommended for use in children. ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN may cause dizziness and vision problems, so drive with caution. Avoid consuming alcohol along with ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it might lead to liver problems and increased dizziness.
Drug-Drug Interactions: ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN may interact with an antibiotic (erythromycin), pain killer (acetaminophen), anti-diabetic (insulin isophane), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), calcium channel blockers (diltiazem, verapamil), azole antifungals (itraconazole, ketoconazole), blood thinners (warfarin), Antiepileptics (phenytoin, carbamazepine), Immunosuppressive agents (ciclosporin, sirolimus, tacrolimus, leflunomide, azathioprine) and anti-HIV (saquinavir, ritonavir, atazanavir).
Drug-Food Interactions: Do not consume alcohol while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as they might cause interaction.
Drug-Disease Interaction: Inform your doctor if you have colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney and liver dysfunction.
Avoid alcohol consumption while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN as it could lead to increased dizziness and liver damage.
Please consult your doctor if you are pregnant, your doctor will prescribe ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN only if the benefits outweigh the risks.
ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN passes into breast milk. Do not breastfeed while taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN. Consult your doctor for further advice.
ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Dose adjustment may be needed. Please consult your doctor before taking ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN if you have liver impairment/liver disease.
Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.
ETHAMBUTOL+ISONIAZID+PYRAZINAMIDE+RIFAMPICIN is not recommended for use in children.
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, and people diagnosed with HIV and immune system problems are more likely at risk of developing active TB.