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About SUMATRIPTAN+NAPROXEN SODIUM

NAPROXEN SODIUM+SUMATRIPTAN belongs to the group of medicines called antimigraine agents used to prevent migraine symptoms such as headache, nausea, and vomiting. Migraine is a neurological condition characterised by an intense pulsating, throbbing, pounding, debilitating headache that usually occurs on one side of the head; however, it can occur on both sides or shift. Hormonal changes, stress, bright lights, loud sounds, and certain foods and drinks can trigger migraine headaches.

NAPROXEN SODIUM+SUMATRIPTAN is a combination of two drugs, namely: Sumatriptan and Naproxen sodium. Sumatriptan acts on the serotonin (5-HT) receptors in the brain, thereby causing the narrowing of the brain's blood vessels, affecting the blood flow patterns associated with headaches. Naproxen sodium is a painkiller that works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) and prostaglandins (PG) responsible for pain/inflammation. Thus, NAPROXEN SODIUM+SUMATRIPTAN prevents symptoms of migraine.

Take NAPROXEN SODIUM+SUMATRIPTAN as prescribed. You are advised to take NAPROXEN SODIUM+SUMATRIPTAN for as long as your doctor has recommended it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, sleepiness, nausea, chest discomfort, dry mouth, irregular heartbeats, and heartburn. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently. 

NAPROXEN SODIUM+SUMATRIPTAN can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Consult your doctor before taking NAPROXEN SODIUM+SUMATRIPTAN if you are pregnant or breastfeeding. NAPROXEN SODIUM+SUMATRIPTAN should not be taken during the third trimester of pregnancy. NAPROXEN SODIUM+SUMATRIPTAN may cause drowsiness and dizziness, so drive with caution. NAPROXEN SODIUM+SUMATRIPTAN is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with NAPROXEN SODIUM+SUMATRIPTAN as it could lead to increased drowsiness and dizziness.

Uses of SUMATRIPTAN+NAPROXEN SODIUM

Migraine

Medicinal Benefits

NAPROXEN SODIUM+SUMATRIPTAN is a combination of two drugs, namely: Sumatriptan and Naproxen sodium. NAPROXEN SODIUM+SUMATRIPTAN is indicated for the acute treatment of migraine with or without aura. Sumatriptan is a serotonin receptor agonist that acts on the serotonin (5-HT) receptors located in the brain which causes narrowing of the brain's blood vessels, thereby affecting the blood flow patterns with a headache. Naproxen sodium is a pain killer which works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins (PG). By blocking the effect of COX enzymes, lesser PGs are produced, thereby reducing pain in migraine.

Directions for Use

Take NAPROXEN SODIUM+SUMATRIPTAN with or without food as advised by the doctor. Swallow it as a whole with a glass of water; do not chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of SUMATRIPTAN+NAPROXEN SODIUM

  • Dizziness
  • Sleepiness
  • Nausea
  • Chest discomfort
  • Dry mouth
  • Irregular heartbeats
  • Heartburn

In-Depth Precautions and Warning

Drug Warnings

Do not take NAPROXEN SODIUM+SUMATRIPTAN if you are allergic to any of its contents; if you have had any recent heart surgery or stroke, blood circulation problems, heart problems, narrowing of blood vessels to the stomach, legs, arms or kidneys, or uncontrolled high blood pressure; if you are taking MAO inhibitors/antidepressants or have taken them in the last 14 days; or if you have taken 5-HT agonists called triptan or ergotamine in the last 24 hours. Be cautious as NAPROXEN SODIUM+SUMATRIPTAN can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, stomach and intestine perforation. Inform your doctor before taking NAPROXEN SODIUM+SUMATRIPTAN if you have high blood pressure, asthma, diabetes, epilepsy, overweight, heart, kidney or liver problems. Consult your doctor before taking NAPROXEN SODIUM+SUMATRIPTAN if you are pregnant or breastfeeding. NAPROXEN SODIUM+SUMATRIPTAN should not be taken during the third trimester of pregnancy. NAPROXEN SODIUM+SUMATRIPTAN may cause drowsiness and dizziness, so drive only if you are alert. NAPROXEN SODIUM+SUMATRIPTAN should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with NAPROXEN SODIUM+SUMATRIPTAN as it could lead to increased drowsiness. Stop taking NAPROXEN SODIUM+SUMATRIPTAN and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools.

Drug Interactions

Drug-Drug Interactions: NAPROXEN SODIUM+SUMATRIPTAN may have interaction with blood thinners (warfarin, aspirin), cardiac glycoside (digoxin), anti-psychotic (lithium), anti-rheumatoid (methotrexate), anti-depressant (citalopram, duloxetine, desvenlafaxine, fluoxetine), anti-hypertensive (metoprolol), an antacid (omeprazole). 

Drug-Food Interactions: Avoid the consumption of alcohol, smoking, and caffeinated products. Do not consume grapefruit while taking NAPROXEN SODIUM+SUMATRIPTAN.

Drug-Disease Interactions: Inform your doctor if you have asthma, fluid retention, gastrointestinal toxicity, renal toxicity, cardiovascular disease, anaemia, heart failure, liver toxicity, high blood pressure, seizure, hyperkalemia (high levels of potassium), and platelet aggregation inhibition.

Safety Advice

  • Safety Warning

    Alcohol

    Consult Your Doctor

    Avoid consumption of alcohol while taking NAPROXEN SODIUM+SUMATRIPTAN as it may cause increased drowsiness.

  • Safety Warning

    Pregnancy

    NAPROXEN SODIUM+SUMATRIPTAN should be used during the first and second trimester of pregnancy only if the benefits outweigh the risks. NAPROXEN SODIUM+SUMATRIPTAN should not be taken during the third trimester of pregnancy.

  • Safety Warning

    Breast Feeding

    NAPROXEN SODIUM+SUMATRIPTAN may pass into breastmilk and harm the baby. Please consult your doctor before taking NAPROXEN SODIUM+SUMATRIPTAN if you are breastfeeding; your doctor will decide whether NAPROXEN SODIUM+SUMATRIPTAN can be taken by breastfeeding mothers or not.

  • Safety Warning

    Driving

    NAPROXEN SODIUM+SUMATRIPTAN may cause dizziness, weakness and drowsiness. Do not drive or operate machinery unless you are alert.

  • Safety Warning

    Liver

    Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

  • Safety Warning

    Kidney

    Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

Habit Forming

No

Diet & Lifestyle Advise

  • Maintaining a healthy diet and exercising regularly helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noise, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, darkroom.
  • Place a cold cloth over your forehead or neck.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills as they help in reducing stress.

Patients Concern

Disease/Condition Glossary

Migraine: Migraine is a neurological condition that is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Warning symptoms precede migraine headache one or two days before the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one particular area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, sensitivity to sound and light.

FAQs

How does NAPROXEN SODIUM+SUMATRIPTAN work?

NAPROXEN SODIUM+SUMATRIPTAN contains Sumatriptan and Naproxen sodium. Sumatriptan acts on the serotonin (5-HT) receptors located in the brain; this causes narrowing of the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Naproxen sodium works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins (PG). By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain.

How to cope with dry mouth?

Dry mouth could be a side-effect of NAPROXEN SODIUM+SUMATRIPTAN. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Is NAPROXEN SODIUM+SUMATRIPTAN used to prevent migraine attacks?

NAPROXEN SODIUM+SUMATRIPTAN treats a headache that has already begun but does not prevent or reduce the attacks. NAPROXEN SODIUM+SUMATRIPTAN should not be used to treat cluster headache or other types of headache, which may cause loss of movement on one side of the body.

Can I take pain killers along with NAPROXEN SODIUM+SUMATRIPTAN?

NAPROXEN SODIUM+SUMATRIPTAN contains Naproxen sodium, an NSAID. Therefore, consult your doctor before taking any pain killer medicines, fever-reducing medicines, medicines for cold or sleeping problems along with NAPROXEN SODIUM+SUMATRIPTAN as they may also contain NSAID.

Can I take antihypertensives with NAPROXEN SODIUM+SUMATRIPTAN?

Talk to your doctor before taking NAPROXEN SODIUM+SUMATRIPTAN with anti-hypertensive medicines as they may cause impaired response when taken with painkiller. Regular monitoring of blood pressure levels is advised while taking NAPROXEN SODIUM+SUMATRIPTAN if you have high blood pressure. NAPROXEN SODIUM+SUMATRIPTAN should not be taken if you have uncontrolled high blood pressure.

I have stomach ulcers. Can I take NAPROXEN SODIUM+SUMATRIPTAN?

NAPROXEN SODIUM+SUMATRIPTAN contains a pain killer, which might increase the risk of gastrointestinal adverse effects such as ulceration, bleeding, and perforation of intestines or stomach. Therefore, avoid taking NAPROXEN SODIUM+SUMATRIPTAN if you have stomach ulcers unless prescribed by the doctor.

Available Medicines for

NAPROXEN SODIUM+SUMATRIPTAN