SUMATRIPTAN+NAPROXEN SODIUM belongs to the group of medicines called antimigraine agents used to prevent migraine symptoms such as headache, nausea, and vomiting. Migraine is a neurological condition characterised by an intense pulsating, throbbing, pounding, debilitating headache that usually occurs on one side of the head; however, it can occur on both sides or shift. Hormonal changes, stress, bright lights, loud sounds, and certain foods and drinks can trigger migraine headaches.
SUMATRIPTAN+NAPROXEN SODIUM is a combination of two drugs, namely: Sumatriptan and Naproxen sodium. Sumatriptan acts on the serotonin (5-HT) receptors in the brain, thereby causing the narrowing of the brain's blood vessels, affecting the blood flow patterns associated with headaches. Naproxen sodium is a painkiller that works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) and prostaglandins (PG) responsible for pain/inflammation. Thus, SUMATRIPTAN+NAPROXEN SODIUM prevents symptoms of migraine.
Take SUMATRIPTAN+NAPROXEN SODIUM as prescribed. You are advised to take SUMATRIPTAN+NAPROXEN SODIUM for as long as your doctor has recommended it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, sleepiness, nausea, chest discomfort, dry mouth, irregular heartbeats, and heartburn. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
SUMATRIPTAN+NAPROXEN SODIUM can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Consult your doctor before taking SUMATRIPTAN+NAPROXEN SODIUM if you are pregnant or breastfeeding. SUMATRIPTAN+NAPROXEN SODIUM should not be taken during the third trimester of pregnancy. SUMATRIPTAN+NAPROXEN SODIUM may cause drowsiness and dizziness, so drive with caution. SUMATRIPTAN+NAPROXEN SODIUM is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with SUMATRIPTAN+NAPROXEN SODIUM as it could lead to increased drowsiness and dizziness.
Migraine
SUMATRIPTAN+NAPROXEN SODIUM is a combination of two drugs, namely: Sumatriptan and Naproxen sodium. SUMATRIPTAN+NAPROXEN SODIUM is indicated for the acute treatment of migraine with or without aura. Sumatriptan is a serotonin receptor agonist that acts on the serotonin (5-HT) receptors located in the brain which causes narrowing of the brain's blood vessels, thereby affecting the blood flow patterns with a headache. Naproxen sodium is a pain killer which works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins (PG). By blocking the effect of COX enzymes, lesser PGs are produced, thereby reducing pain in migraine.
Do not take SUMATRIPTAN+NAPROXEN SODIUM if you are allergic to any of its contents; if you have had any recent heart surgery or stroke, blood circulation problems, heart problems, narrowing of blood vessels to the stomach, legs, arms or kidneys, or uncontrolled high blood pressure; if you are taking MAO inhibitors/antidepressants or have taken them in the last 14 days; or if you have taken 5-HT agonists called triptan or ergotamine in the last 24 hours. Be cautious as SUMATRIPTAN+NAPROXEN SODIUM can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, stomach and intestine perforation. Inform your doctor before taking SUMATRIPTAN+NAPROXEN SODIUM if you have high blood pressure, asthma, diabetes, epilepsy, overweight, heart, kidney or liver problems. Consult your doctor before taking SUMATRIPTAN+NAPROXEN SODIUM if you are pregnant or breastfeeding. SUMATRIPTAN+NAPROXEN SODIUM should not be taken during the third trimester of pregnancy. SUMATRIPTAN+NAPROXEN SODIUM may cause drowsiness and dizziness, so drive only if you are alert. SUMATRIPTAN+NAPROXEN SODIUM should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with SUMATRIPTAN+NAPROXEN SODIUM as it could lead to increased drowsiness. Stop taking SUMATRIPTAN+NAPROXEN SODIUM and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools.
Drug-Drug Interactions: SUMATRIPTAN+NAPROXEN SODIUM may have interaction with blood thinners (warfarin, aspirin), cardiac glycoside (digoxin), anti-psychotic (lithium), anti-rheumatoid (methotrexate), anti-depressant (citalopram, duloxetine, desvenlafaxine, fluoxetine), anti-hypertensive (metoprolol), an antacid (omeprazole).
Drug-Food Interactions: Avoid the consumption of alcohol, smoking, and caffeinated products. Do not consume grapefruit while taking SUMATRIPTAN+NAPROXEN SODIUM.
Drug-Disease Interactions: Inform your doctor if you have asthma, fluid retention, gastrointestinal toxicity, renal toxicity, cardiovascular disease, anaemia, heart failure, liver toxicity, high blood pressure, seizure, hyperkalemia (high levels of potassium), and platelet aggregation inhibition.
Avoid consumption of alcohol while taking SUMATRIPTAN+NAPROXEN SODIUM as it may cause increased drowsiness.
SUMATRIPTAN+NAPROXEN SODIUM should be used during the first and second trimester of pregnancy only if the benefits outweigh the risks. SUMATRIPTAN+NAPROXEN SODIUM should not be taken during the third trimester of pregnancy.
SUMATRIPTAN+NAPROXEN SODIUM may pass into breastmilk and harm the baby. Please consult your doctor before taking SUMATRIPTAN+NAPROXEN SODIUM if you are breastfeeding; your doctor will decide whether SUMATRIPTAN+NAPROXEN SODIUM can be taken by breastfeeding mothers or not.
SUMATRIPTAN+NAPROXEN SODIUM may cause dizziness, weakness and drowsiness. Do not drive or operate machinery unless you are alert.
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
SUMATRIPTAN+NAPROXEN SODIUM is not recommended for children as the safety and effectiveness were not established.
Migraine: Migraine is a neurological condition that is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Warning symptoms precede migraine headache one or two days before the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one particular area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, sensitivity to sound and light.