Avibactam+ceftazidime
About Avibactam+ceftazidime
Avibactam+ceftazidime is a prescription antibiotic injection used to treat severe bacterial infections caused by certain bacteria, including some that are resistant to many commonly used antibiotics. It is commonly prescribed for complicated infections of the urinary tract, abdomen, and lungs. This medicine helps clear the infection by stopping the growth of harmful bacteria.
Because this antibiotic is often reserved for difficult-to-treat or multidrug-resistant (MDR) bacterial infections, it should only be used when prescribed by a healthcare professional. Using antibiotics only when needed helps reduce antibiotic resistance and keeps them effective for future infections.
This medicine is injected directly into a vein, usually on a regular schedule determined by your doctor to maintain a constant level of the drug in your body. Because it is given as an injection, food does not affect how it works. Drinking plenty of fluids, eating a balanced diet, and getting adequate rest can support your body's recovery during treatment.
While using Avibactam+ceftazidime, you may experience mild side effects such as nausea, diarrhea, headache, or redness at the injection site. However, contact your doctor immediately if you develop severe watery or bloody diarrhea, skin rashes, swelling of the face or throat, difficulty breathing, seizures, or yellowing of the skin or eyes.
If you have a severe infection, it is normal to feel tired or worried about your recovery. Taking your medicine exactly as prescribed and keeping in touch with your healthcare team can help ensure the best possible outcome.
Talk to your doctor before starting this medicine if you have kidney problems, a history of seizures, liver disease, or allergies to cephalosporin, penicillin, or other beta-lactam antibiotics. Tell your doctor about all medicines you take, especially water pills (diuretics) or other medicines that may affect kidney function. Inform your healthcare provider if you are pregnant, breastfeeding, caring for a child receiving this medicine, or if the patient is elderly, as closer monitoring may be needed.
Uses of Avibactam+ceftazidime
Medicinal Benefits
Avibactam+ceftazidime provides reliable treatment for severe bacterial infections, including many infections caused by bacteria that have become resistant to commonly used antibiotics. By delivering the antibiotic directly into the bloodstream, it quickly reaches the site of infection, helping control bacterial growth, reduce complications, and support recovery when used exactly as prescribed.
- Treats severe bacterial infections: Helps control serious bacterial infections that may not respond to standard antibiotics.
- Works quickly: Delivers the antibiotic directly into the bloodstream, allowing it to reach the infection site rapidly.
- Prevents the spread of infection: Helps stop bacteria from spreading to other parts of the body, reducing the risk of complications.
- Overcomes bacterial resistance: Avibactam blocks certain bacterial enzymes (beta-lactamases) that can break down ceftazidime, helping the antibiotic remain effective against many resistant bacteria.
- Supports faster recovery: By effectively controlling the infection, it helps relieve symptoms and promotes recovery when used as prescribed.
Directions for Use
- Follow your doctor's instructions regarding dosage and timing of Avibactam+ceftazidime.
- Avibactam+ceftazidime will be administered by a healthcare professional.
- Do not self-administer.
Storage
Side Effects of Avibactam+ceftazidime
Common Side Effects (Usually mild)
- Nausea or vomiting
- Mild diarrhea or stomach upset
- Headache
- Pain, redness, or swelling at the injection site
Serious Side Effects (Call a doctor right away)
- Severe allergic reactions, including hives, swelling of the face, lips, tongue, or throat, and difficulty breathing
- Severe, watery, or bloody diarrhea, which may be a sign of Clostridioides difficile (C. difficile) infection
- Seizures or fits, especially in people with kidney problems or seizure disorders
- Yellowing of the skin or eyes, dark urine, or persistent nausea, which may indicate liver problems
- Unusual bruising or bleeding or signs of a new infection that do not improve
Medicines Containing this Salt
View AllDrug Warnings
- Always check the injection solution for discoloration or visible particles before use. Do not use it if it appears cloudy or contains particles.
- Complete the full prescribed course, even if you feel better, unless your doctor tells you to stop.
- This antibiotic is usually reserved for serious infections caused by resistant bacteria. Do not use it for viral illnesses such as colds or flu.
- Inform your healthcare provider if you have ever had an allergic reaction to ceftazidime, avibactam, cephalosporins, penicillins, or other beta-lactam antibiotics.
- Your doctor may perform blood tests during treatment to monitor kidney function and, during prolonged therapy, liver function and blood cell counts.
- Seek medical attention immediately if you develop severe diarrhea during treatment or even several weeks after completing the antibiotic, as this may be caused by Clostridioides difficile (C. difficile) infection.
- Do not use Avibactam+ceftazidime if you have had a severe allergic reaction (such as anaphylaxis) to ceftazidime, avibactam, or any other cephalosporin antibiotic or you have experienced a serious allergic reaction to other beta-lactam antibiotics, such as penicillins or carbapenems, unless your doctor determines that the benefits outweigh the risks.
Drug Interactions
- Chloramphenicol: Taking this antibiotic alongside Avibactam+ceftazidime may reduce the overall effectiveness of your treatment.
- Strong water pills (diuretics like furosemide): Combining these medications with Avibactam+ceftazidime can increase the risk of kidney strain.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionThe interaction of Avibactam+ceftazidime with alcohol is unknown. Please consult a doctor before consuming alcohol while using Avibactam+ceftazidime.
Pregnancy
cautionPlease consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionAvibactam+ceftazidime may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.
Driving
cautionAvibactam+ceftazidime may cause dizziness. Therefore, avoid driving if you feel dizzy after taking Avibactam+ceftazidime.
Liver
cautionTake Avibactam+ceftazidime with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Avibactam+ceftazidime with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
cautionAvibactam+ceftazidime should be used in children only in doses as prescribed by a doctor. Avibactam+ceftazidime is not recommended for use in children below 3months.
Habit Forming
Diet & Lifestyle Advise
- Stay well-hydrated: Drink plenty of water to help your kidneys process the medication and flush out toxins.
- Support your gut health: Antibiotics can temporarily disrupt your gut bacteria. Consider eating fermented foods like yogurt or taking a probiotic supplement after completing your course, but talk to your doctor first.
- Get plenty of rest: Allow your body to direct its energy toward fighting the infection by getting adequate sleep.
- Eat easy-to-digest foods: If you experience nausea or mild stomach upset, stick to plain foods like rice, toast, or clear broths.
- Practice good hand hygiene and complete the full course of antibiotics to help prevent the spread of infection and reduce antibiotic resistance.
Special Advise
Regular kidney function tests are recommended, especially in patients with kidney problems while taking Avibactam+ceftazidime so that the dose may be adjusted accordingly.
If you are about to undergo any blood or urine tests, inform your doctor that you are taking Avibactam+ceftazidime as it may interfere with these tests.
Avibactam+ceftazidime may interact with certain tests such as glucose (sugar) in urine and coomb’s test (blood test), resulting in unusual results. Therefore, inform the lab technician that you are taking Avibactam+ceftazidime before undergoing any tests.
Patients Concern
Disease/Condition Glossary
Bacterial Infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue.
FAQs
Avibactam+ceftazidime belongs to a class of medicines called antibiotics used in the treatment of bacterial infections of the urinary tract, respiratory tract and abdomen.
Avibactam+ceftazidime works by damaging the bacterial cell wall (protective covering) that is necessary for their survival and by increasing bacterial sensitivity.
Exercise caution while taking Avibactam+ceftazidime with diuretics/water tablets. You are not advised to take Avibactam+ceftazidime with a diuretic called furosemide as co-administration of these two medicines may increase the risk of kidney problems, especially in patients with kidney impairment and also when Avibactam+ceftazidime is given in high doses. However, please consult your doctor before taking Avibactam+ceftazidime with other medicines.
Before receiving Avibactam+ceftazidime, you must inform your doctor if you are allergic to foods or medicines. You should also inform your doctor if you have kidney problems or diabetes or if you are pregnant or breastfeeding. If you are on a controlled sodium diet, let your doctor know before starting the medication. Also, inform your doctor if you are receiving or scheduled to receive any vaccinations.
The common side effects of Avibactam+ceftazidime include nausea, diarrhoea, and redness and swelling at the site of injection. These side effects are usually temporary, and not everyone will experience them. In most cases, they resolve on their own without the need for medical treatment. However, if the side effects persist or worsen, please consult your doctor for further advice and management.
If a bacterial infection is not treated, the bacteria can continue to grow and spread throughout the body. This may lead to serious health complications, such as damage to vital organs or tissues. In severe cases, it can result in sepsis (a life-threatening, body-wide infection). Additionally, the infection may become harder to treat over time, as the bacteria can develop resistance to antibiotics. It is important to seek medical treatment to prevent these risks and help your body recover.
Avibactam+ceftazidime is given as an injection directly into a vein (intravenous infusion) by a doctor or nurse, usually in a hospital or clinic setting. Talk to your doctor if you have questions about your administration schedule.
In some cases, you may be allowed to inject this medicine at home after receiving proper training from a healthcare professional. Always follow the exact instructions provided by your medical team and talk to your doctor if you face any difficulties.
Mild diarrhea can happen during antibiotic treatment, but if you experience severe, watery, or bloody diarrhea with stomach cramps, contact your healthcare provider immediately as this could be a sign of a serious gut infection. Talk to your doctor before taking any over-the-counter anti-diarrheal medicines.
There is limited information about the use of Avibactam+ceftazidime during pregnancy. Your doctor will prescribe it only if the expected benefit outweighs any possible risk to the baby. Small amounts of ceftazidime may pass into breast milk, so breastfeeding mothers should discuss the benefits and potential risks with their doctor before treatment.
There is no known direct interaction between alcohol and Avibactam+ceftazidime. However, alcohol may worsen side effects such as dizziness, nausea, or dehydration and may slow your recovery from a serious infection. It is generally best to avoid or limit alcohol until you have recovered. Talk to your doctor if you have questions.
If you are receiving this medicine in a hospital, your medical team will manage your doses. If you are taking it at home and miss a dose, contact your healthcare provider immediately to schedule your next dose. Talk to your doctor or pharmacist if you have questions.
No, Avibactam+ceftazidime is an antibiotic and only works against infections caused by bacteria. It will not work against viral infections like the common cold, flu, or COVID-19. Talk to your doctor to ensure you receive the correct diagnosis.
This medicine starts fighting bacteria as soon as it enters your bloodstream. However, you may not notice an improvement in your symptoms for a couple of days. Always finish the full course of treatment as prescribed. Talk to your doctor if you do not feel better after a few days.
Yes. This medicine may be prescribed for children when appropriate. However, the dose is carefully calculated based on the child's age, body weight, kidney function, and the type of infection. It should only be given under the supervision of a healthcare professional. Talk to your child's doctor if you have any questions.
Author Details
