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compositionComposition:BUPROPION-300MG
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Prescription Medicine
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Bupron XL 300 Tablet is used in the treatment of depression. It helps improve mood, increase vitality, and enhance focus, thereby supporting emotional well-being and daily functioning. This medicine may also assist in reducing the urge to smoke, making it beneficial for individuals trying to quit smoking. Compared to other antidepressants, Bupron XL 300 Tablet is associated with a lower risk of sexual side effects and weight gain, which can improve treatment adherence and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPROPION-300MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bupron XL 300 Tablet

Bupron XL 300 Tablet is an oral prescription medication primarily used to treat major depressive disorder and to help prevent seasonal affective disorder. It is also commonly prescribed to help adults quit smoking by reducing cravings and withdrawal effects. By regulating natural chemicals in the brain, it helps stabilise your mood and emotional well-being.

To get the best results, you should take this medication consistently at the same time every day. It can be taken with or without food, though taking it with food may help if it upsets your stomach. Combining this treatment with regular physical activity, a balanced diet, and healthy sleep habits can further support your mental health and overall well-being.

While taking Bupron XL 300 Tablet , you may experience mild side effects like dry mouth, trouble sleeping, or mild headaches. These are often temporary as your body adjusts. However, if you experience any severe side effects, such as a sudden change in mood, panic attacks, or seizures, you must contact your doctor immediately.

Talk to your doctor before starting this medicine if you have a history of seizures, eating disorders like anorexia or bulimia, or if you are undergoing sudden alcohol or sedative withdrawal. Do not take this if you are currently taking monoamine oxidase inhibitors (MAOIs) or have stopped taking them within the last 14 days, as this can cause dangerous reactions.

This medicine can interact with certain other drugs, alcohol, and nicotine, which can increase your risk of seizures or other serious side effects. If you are pregnant, planning to breastfeed, or an older adult, consult your doctor or pharmacist to discuss if this medication is safe for you.

Uses of Bupron XL 300 Tablet

Bupron XL 300 Tablet is used to treat major depressive disorder and to help prevent seasonal affective disorder. The detailed uses of Bupron XL 300 Tablet are as follows:

  • Major Depressive Disorder: Bupron XL 300 Tablet helps relieve symptoms of ongoing depression, such as persistent sadness, loss of interest in activities, and low energy, by balancing certain natural chemicals in the brain.
  • Seasonal Affective Disorder (SAD): Bupron XL 300 Tablet helps prevent depressive episodes that occur during specific seasons, typically starting in autumn and continuing through the winter months.
  • Smoking Cessation Support: Bupron XL 300 Tablet helps adults quit smoking by easing nicotine withdrawal symptoms and reducing the intense urge to smoke.

Key Benefits

Bupron XL 300 Tablet helps improve mood and emotional wellbeing by restoring the balance of certain brain chemicals. It is also used to support smoking cessation and, in appropriate patients, to help prevent seasonal depressive episodes.

  • Helps Relieve Symptoms of Depression: By balancing key brain chemicals, Bupron XL 300 Tablet helps improve mood, increase energy levels, restore interest in daily activities, and reduce the physical and emotional symptoms of depression.
  • Supports Smoking Cessation: Bupron XL 300 Tablet helps reduce nicotine cravings and withdrawal symptoms such as irritability, anxiety, and restlessness, making it easier to quit smoking and remain smoke-free as part of a comprehensive smoking-cessation programme.
  • Helps Prevent Seasonal Depressive Episodes: When started before the onset of seasonal symptoms, Bupron XL 300 Tablet can help reduce the risk of recurrent depression associated with seasonal changes, supporting emotional stability during the winter months.

Directions for Use

  • Bupron XL 300 Tablet should be taken with food to avoid stomach upset.
  • It is usually taken 3-4 times a day. However, your doctor may adjust the dose and duration of Bupron XL 300 Tablet based on your medical condition.
  • Swallow Bupron XL 300 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Bupron XL 300 Tablet Works

Bupron XL 300 Tablet contains bupropion, which works by affecting natural chemicals in your brain called neurotransmitters, specifically norepinephrine and dopamine. These chemicals play a vital role in regulating your mood, motivation, and feelings of pleasure. Normally, after these chemicals send messages between brain cells, they are reabsorbed. This medicine works by stopping this reabsorption process, keeping more norepinephrine and dopamine active in your brain for longer periods. This helps improve your overall mood and can also block the pathways in the brain that trigger nicotine cravings.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Bupron XL 300 Tablet as it may cause serious side effects.

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Pregnancy

Caution

Bupron XL 300 Tablet is a pregnancy category B drug. Consult your doctor if you are pregnant or suspect pregnancy. Your doctor might prescribe this medicine during pregnancy if the benefits outweigh the risks.

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Breast Feeding

Caution

In very small quantities, Bupron XL 300 Tablet enters the breast milk and may have negative effects on breastfed babies. Therefore, consult your doctor if you are breastfeeding.

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Driving

Unsafe

Do not drive after taking Bupron XL 300 Tablet as it may cause drowsiness and interfere with your driving ability.

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Liver

Caution

Bupron XL 300 Tablet to be taken with caution, especially if you have a history of liver diseases. Your doctor may adjust the dose if required based on your condition.

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Kidney

Caution

Bupron XL 300 Tablet to be taken with caution, especially if you have a history of kidney disease. Your doctor may adjust the dose if required based on your condition.

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Children

Unsafe

Bupron XL 300 Tablet is not recommended for use in children below 18 years. Its safety and efficacy are not established in children.

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Heart

Consult your doctor

It is unknown whether Bupron XL 300 Tablet is safe for use in cardiac patients. Please consult your physician.

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Geriatrics

Caution

Bupron XL 300 Tablet should be taken with caution in geriatric patients. Please consult your doctor before using Bupron XL 300 Tablet .

What if I have taken an overdose of Bupron XL 300 Tablet

If you take too much of this medicine, seek emergency medical care immediately. An overdose can lead to serious complications, including severe seizures, hallucinations, loss of consciousness, or rapid heart rate.

Diet & Lifestyle Advise

  • Avoid Alcohol: Drinking alcohol while taking this medicine can increase your risk of severe side effects, including seizures and mental health changes. If you drink alcohol regularly, talk to your doctor before stopping suddenly, as abrupt withdrawal can also trigger seizures.
  • Limit Caffeine: Since this medication can have a mild stimulating effect, cutting back on coffee, tea, and energy drinks can help prevent jitteriness, anxiety, and sleep problems.
  • Create a Sleep Routine: To counter potential insomnia, keep a consistent sleep schedule and avoid taking your evening dose too close to bedtime.
  • Stay Hydrated: Drink plenty of water throughout the day to help manage dry mouth, which is a common early side effect of bupropion.
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How Soon It Starts Working

The time required for Bupron XL 300 Tablet to start working: The time required for Bupron XL 300 Tablet to take effect is unknown.

The time for which the effects of Bupron XL 300 Tablet last: The duration of action for Bupron XL 300 Tablet is unknown.

What if you forget to take Bupron XL 300 Tablet

If you miss a dose, skip the missed dose and take your next dose at your regular scheduled time. Do not take a double dose to make up for the one you missed, as this can increase your risk of a seizure.

Storage

•Store Bupron XL 300 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the bottle tightly closed to protect the medication from moisture and light.

Drug Warnings

  • Check the tablet carefully before swallowing; do not use it if the tablet is broken, chipped, or crushed.
  • Be aware that this medication may cause a false-positive result on certain urine drug screens; inform the laboratory staff that you are taking this medicine.
  • Monitor your mood closely, especially when first starting this medication or when your dose is adjusted, and ask a family member or close friend to help watch for any unusual emotional changes.
  • If you are taking this medicine to quit smoking, you can continue to smoke for the first week, but you should set a target quit date within the second week of treatment.
  • Do not take any other medications that contain the same active ingredient, as this increases your risk of an overdose and seizures.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine oxidase inhibitors (MAOIs): Do not take Bupron XL 300 Tablet together with MAOIs or within 14 days of stopping an MAOI, as this combination may cause a dangerous rise in blood pressure. Your doctor will advise you on the appropriate washout period before starting treatment
  • Certain antidepressants, antipsychotics, and corticosteroids: These medicines may lower the seizure threshold when taken with Bupron XL 300 Tablet , increasing the risk of seizures. Your doctor may recommend closer monitoring or alternative treatment if these medicines are required.

Drug-Drug Interactions

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How does the drug interact with Bupron XL 300 Tablet:
Taking tranylcypromine with Bupron XL 300 Tablet can increase the risk of severe high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Bupron XL 300 Tablet can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Taking Safinamide with Bupron XL 300 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Safinamide with Bupron XL 300 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Taking Rasagiline with Bupron XL 300 Tablet can cause increased blood pressure.

How to manage the interaction:
Taking rasagiline with Bupron XL 300 Tablet is not recommended as it can result in an interaction but can be taken if a doctor has advised it. However, if you experience headache, sleep disturbances, tremor (shaking of hands & legs), restlessness, nervousness, anxiety, and rapid heartbeat contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Co-administration of Metoclopramide with Bupron XL 300 Tablet can increase the levels of Metoclopramide and increase the risk or severity of developing seizures (fits).

How to manage the interaction:
Taking Metoclopramide with Bupron XL 300 Tablet is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
BupropionIsocarboxazid
Critical
How does the drug interact with Bupron XL 300 Tablet:
Using Bupron XL 300 Tablet together with isocarboxazid can cause blood pressure to get dangerously high.

How to manage the interaction:
Taking Isocarboxazid with Bupron XL 300 Tablet can cause an interaction, consult a doctor before taking it. Consult a doctor if you experience headache, sleep disturbances, tremor, restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Talking Bupron XL 300 Tablet and Rivastigmine together can increase risk of having seizures (fits).

How to manage the interaction:
Co-administration of Bupron XL 300 Tablet along with rivastigmine can lead to an interaction, it can be taken if recommended by a doctor. In case you experience any symptoms like muscle spasms or movements, lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking of hands and legs, jitteriness, restlessness, pacing, and foot tapping, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Taking Bupron XL 300 Tablet with lithium can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of Bupron XL 300 Tablet along with lithium can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties or cessation, lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Leflunomide can cause liver issues, and combining it with Bupron XL 300 Tablet, can enhance the risk.

How to manage the interaction:
Co-administration of Bupron XL 300 Tablet along with leflunomide can lead to interaction, it can be taken if recommended by a doctor. If you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bupron XL 300 Tablet:
Co-administration of Bupron XL 300 Tablet with mexiletine can increase the risk or severity of seizures (fits).

How to manage the interaction:
Although taking Bupron XL 300 Tablet and mexiletine together can result in an interaction, it can be taken if a doctor has advised it. Refrain from engaging in tasks which require mental alertness. Do not discontinue any medications without consulting a doctor.
BupropionEphedrine
Severe
How does the drug interact with Bupron XL 300 Tablet:
Co-administration of Bupron XL 300 Tablet is capable of causing seizures, and combining it with Ephedrine, may enhance the risk.

How to manage the interaction:
Co-administration of Bupron XL 300 Tablet along with Ephedrine can lead to an interaction, it can be taken if recommended by a doctor. While taking these medications, you should avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Avoid drinking alcohol while taking Bupron XL 300 Tablet , as it may worsen mental health-related side effects and significantly increase the risk of seizures.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

Bupron XL 300 Tablet is used in the treatment of depression. It is also used to help people stop smoking.
Bupron XL 300 Tablet contains Bupropion, which works by increasing serotonin levels. Serotonin is a chemical messenger in the brain responsible for improving mood and physical symptoms of depression.
Certain side effects of Bupron XL 300 Tablet can be dealt with simple tips, such as if you experience dry mouth, you can chew sugar-free gum or take sugar-free sweets. If you are sweating a lot while taking Bupron XL 300 Tablet , wear loose clothing and use a strong antiperspirant. If you cannot sleep after taking Bupron XL 300 Tablet , prefer to take it in the morning to avoid sleep disturbances. If you feel sleepy after taking Bupron XL 300 Tablet , avoid taking it in the evening and limit your alcohol intake. If you feel tired or weak after taking Bupron XL 300 Tablet , sit or lie down until you feel better. If you feel that the side effects are worsening, please consult your doctor.
Yes, it is safe to use Bupron XL 300 Tablet if prescribed by your doctor. However, there may be an increased risk of experiencing suicidal tendencies in children, adolescents and young adults.
Taking Bupron XL 300 Tablet in more than the recommended dose can cause unpleasant side effects such as dizziness, tremor, agitation, convulsion, coma, nausea, vomiting, changes in heart rhythm, decreased blood pressure and changes in body fluid/salt balance.
In elderly patients, the risk of side effects is higher when taking Bupron XL 300 Tablet . For elderly patients, dose adjustment may be required, or your doctor may prescribe an alternative medication safe for the elderly.
No, Bupron XL 300 Tablet does not help with anxiety and sleeplessness. It is used to treat depression.
Though Bupropion may have a low risk of addiction, Bupron XL 300 Tablet does not cause addiction if taken in the dose and duration prescribed by the doctor.
Factors that can increase the chances of seizures with Bupron XL 300 Tablet are sudden and large increments in dose, bulimia or anorexia nervosa (eating disorder), history of head trauma or prior seizure, central nervous system (CNS) tumour, the presence of severe hepatic cirrhosis, and concomitant medications that lower the seizure threshold.
It is very rare to develop eye problems like redness, pain, and blurred vision with Bupron XL 300 Tablet . Please consult the doctor if you experience any eye problems during treatment with Bupron XL 300 Tablet .
Avoid exceeding the prescribed dose and use Bupron XL 300 Tablet cautiously with medicines that might lower the seizure threshold, such as antipsychotics, antidepressants, theophylline, and systemic steroids.
Bupron XL 300 Tablet may cause high blood pressure; therefore, let the doctor know if you have hypertension or if you are taking medicines used to treat high blood pressure.
Unlike many other antidepressants, Bupron XL 300 Tablet is more likely to cause mild weight loss or have a neutral effect on weight rather than causing weight gain. However, weight changes can vary from person to person. Talk to your doctor if you have concerns about weight changes.
No, you should avoid drinking alcohol while taking this medicine. Combining alcohol with this drug can increase your risk of seizures and worsen neurological or psychiatric side effects like dizziness and anxiety. Talk to your doctor if you drink alcohol regularly.
No, you should never stop taking this medication abruptly without consulting your healthcare provider. Stopping suddenly can cause withdrawal symptoms or cause your original condition to return. Your doctor will help you gradually decrease your dose safely. Talk to your doctor before making any changes.
This medication can cause dizziness, sleepiness, or blurred vision in some people, especially when first starting or changing doses. Do not drive, ride a bicycle, or operate machinery until you know how this medicine affects you. Talk to your doctor if you experience these symptoms.
There is limited information on the safety of using this medicine during pregnancy. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - BUP0005
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