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Enapil 5mg Tablet is used to treat hypertension and heart failure. It relaxes and widens blood vessels, helping the heart pump blood more easily. This helps reduce symptoms like swelling, shortness of breath, and tiredness, and lowers the risk of hospitalisation and complications such as heart attack, stroke, and kidney damage.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Enapil 5mg Tablet
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

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Drug-Drug Interactions

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Drug-Drug Interactions: Inform your doctor if you are taking any of the following medicines, as there may be an interaction.

  • Drugs used to treat high blood pressure (Aliskiren, Candesartan)
    Potential effect: May increase the risk of serious side effects such as kidney problems, low blood pressure, and high blood potassium levels.
  • Drugs used to treat oedema (Triamterene)
    Potential effect: May increase the risk of hyperkalaemia (high blood potassium levels).
  • Electrolyte supplements (Potassium chloride, Potassium citrate)
    Potential effect: May increase the risk of hyperkalaemia, potentially leading to muscular paralysis, kidney problems, and abnormal heart rhythms.
  • Iron preparations (Ferric carboxymaltose)
    Potential effect: May increase the risk of side effects of Enalapril.
  • Immunosuppressants (Leflunomide)
    Potential effect: May increase the risk of liver damage.
  • Antifungals (Ketoconazole)
    Potential effect: May increase the risk of liver problems.

Drug-Food Interactions: Avoid high-potassium and high-sodium foods, as they may raise your blood potassium level (hyperkalemia). Besides this, do not use salt substitutes or potassium supplements while taking Enapil 5mg Tablet.

Drug-Disease Interactions: Enapil 5mg Tablet should be avoided or used with caution in people with:

  • Angioedema (swelling)
  • Bone marrow suppression
  • Haemodialysis
  • Hyperkalaemia (high potassium level)
  • Hypotension (low blood pressure)
  • Diabetes (low blood sugar)
  • Kidney dysfunction
EnalaprilPotassium acetate
Severe

Drug-Drug Interactions

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How does the drug interact with Enapil 5mg Tablet:
Using aliskiren together with Enapil 5mg Tablet may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.

How to manage the interaction:
Taking Enapil 5mg Tablet with aliskiren is not recommended, but it can be taken together if your doctor advises. However, contact your doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or feelings of heaviness in the legs. Do not stop taking any medications without consulting a doctor.
EnalaprilPotassium acetate
Severe
How does the drug interact with Enapil 5mg Tablet:
Combining Enapil 5mg Tablet and Potassium acetate may result in significantly higher blood potassium levels. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscle paralysis, abnormal heart rhythm

How to manage the interaction:
Although taking Enapil 5mg Tablet and Potassium acetate together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, and feelings of heaviness in your legs. Do not stop using any medications without a doctor's advice.
How does the drug interact with Enapil 5mg Tablet:
Taking Azilsartan medoxomil with Enapil 5mg Tablet may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Azilsartan medoxomil with Enapil 5mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience symptoms like vomiting, weakness, confusion, tingling in your hands and feet, or palpitations. Do not stop using any medications without talking to a doctor.
How does the drug interact with Enapil 5mg Tablet:
Taking Enapil 5mg Tablet with Lithium increases the levels of lithium in your blood, which may cause lithium toxicity. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although using Enapil 5mg Tablet and Lithium together may cause an interaction, they can be taken together if your doctor prescribes it. However, if you experience diarrhoea, vomiting, sleepiness, dizziness, muscular weakness, blurred vision, increased thirst and urination, or ringing in the ears, you should seek medical attention. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Enapil 5mg Tablet:
Teriflunomide can cause liver damage, and taking it with medications like Enapil 5mg Tablet, which have a similar effect, increases the risk.

How to manage the interaction:
Although taking Enapil 5mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. However, contact your doctor if you experience fever, chills, joint discomfort, swelling, skin irritation, itching, tiredness, stomach ache, dark urine, or bleeding. Do not stop using any medications without a doctor's advice.
EnalaprilPotassium iodide
Severe
How does the drug interact with Enapil 5mg Tablet:
Taking Enapil 5mg Tablet with Potassium iodide increases the potassium levels in the blood, which may lead to hyperkalemia. In severe cases, hyperkalemia may lead to muscular paralysis, kidney damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Enapil 5mg Tablet together with Potassium iodide may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, coconut and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
EnalaprilLomitapide
Severe
How does the drug interact with Enapil 5mg Tablet:
Combining lipitapide with other drugs that can damage the liver, including Enapil 5mg Tablet, increases the risk of liver issues.

How to manage the interaction:
Although taking Enapil 5mg Tablet and Lomitapide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - joint pain, swelling, skin rash, itching, abdominal pain, or dark urine - immediately contact your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Enapil 5mg Tablet:
Due to additive or synergistic effects, coadministration of Enapil 5mg Tablet with Irbesartan may raise the risk of hyperkalemia, hypotension, syncope, and renal failure. In severe cases, hyperkalemia can lead to muscle paralysis,kidney damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Enapil 5mg Tablet together with Irbesartan may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
EnalaprilMipomersen
Severe
How does the drug interact with Enapil 5mg Tablet:
When mipomersen is used with other drugs that can potentially damage the liver, like Enapil 5mg Tablet, the risk of liver issues increases.

How to manage the interaction:
Although taking Enapil 5mg Tablet and Mipomersen together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - joint pain, swelling, skin rash, itching, fatigue, abdominal pain, or dark urine - immediately contact your doctor. Do not stop using any medications without a doctor's advice.
EnalaprilEprosartan
Severe
How does the drug interact with Enapil 5mg Tablet:
Coadministration of Enapil 5mg Tablet with Eprosartan may raise the risk of hyperkalemia, hypotension, syncope, and renal failure due to additive or synergistic effects. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Enapil 5mg Tablet together with Eprosartan may result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

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ENALAPRIL-5MGPotassium rich foods
Moderate

Drug-Food Interactions

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ENALAPRIL-5MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming a high-potassium diet while taking Enapil 5mg Tablet can cause hyperkalemia (elevated blood potassium levels). Hyperkalemia may lead to dizziness, lightheadedness, fainting, or a rapid heartbeat. Avoid the consumption of potassium-rich foods.

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