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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nogestol Tablet 21's is used for contraception and treating dysmenorrhea (irregular and painful periods). It contains Ethinylestradiol and Levonorgestrel, which maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Also, it prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). It may also change the lining of the uterus to prevent the development of a pregnancy. It may cause side effects such as stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Nogestol Tablet:
Coadministration of Acitretin with Nogestol Tablet can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Nogestol Tablet together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use acitretin if you are pregnant. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet with Tranexamic acid may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Tranexamic acid with Nogestol Tablet may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LevonorgestrelEtretinate
Critical
How does the drug interact with Nogestol Tablet:
Using etretinate and Nogestol Tablet can cause severe birth defects.

How to manage the interaction:
Taking Etretinate with Nogestol Tablet can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Nogestol Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet with rifabutin it may lower Nogestol Tablet blood levels and effects.

How to manage the interaction:
Although taking Nogestol Tablet and rifabutin together can result in an interaction, it can be taken if a doctor has prescribed it. If you use hormone replacement treatment(Nogestol Tablet) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet and felbamate together can reduce the effects of Nogestol Tablet which may result in a higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking Nogestol Tablet and felbamate together can result in an interaction, it can be taken if a doctor has prescribed it. If you use hormone replacement treatment (Nogestol Tablet) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet and Oxcarbazepine may lower Nogestol Tablet blood levels and effects.

How to manage the interaction:
Although taking Nogestol Tablet and oxcarbazepine together can result in an interaction, it can be taken if a doctor has prescribed it. If you use hormone replacement treatment (Nogestol Tablet) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
A combined use of Nogestol Tablet with mycophenolic acid may reduce the blood levels and effects of Nogestol Tablet, which may make it less reliable as a form of birth control, mycophenolic acid may cause pregnancy loss in the first trimester and also birth defects in the unborn child.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Nogestol Tablet, but they can be taken together if a doctor has prescribed them. However, if you take hormone replacement (Nogestol Tablet) for menopause, and if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
LevonorgestrelRifapentine
Severe
How does the drug interact with Nogestol Tablet:
Taking Nogestol Tablet and Rifapentine may lower Nogestol Tablet blood levels and effects.

How to manage the interaction:
Although taking Nogestol Tablet and rifapentine together can result in an interaction, they can be taken if a doctor has prescribed it. If you use hormone replacement treatment(Nogestol Tablet) for menopause, consult the doctor if your symptoms do not improve or if you begin to bleed abnormally. Do not stop using any medications without talking to a doctor.
How does the drug interact with Nogestol Tablet:
Carfilzomib can occasionally cause dangerous blood clots and using it together with Nogestol Tablet may increase the risk.

How to manage the interaction:
Co-administration of Carfilzomib with Nogestol Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: blood clots that can be harmful, high blood pressure or cholesterol, heart problems like heart attack or blockage in the lung, stroke, complications, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of your body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ETHINYLESTRADIOL-0.03MG+LEVONORGESTREL-0.15MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETHINYLESTRADIOL-0.03MG+LEVONORGESTREL-0.15MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

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