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Opsutan Tablet is an anti-hypertensive medicine used in the treatment of pulmonary arterial hypertension (PAH). This medicine contains macitentan which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure, thus increasing blood supply and lowering blood pressure. Common side effects include headache, inflammation of the airways, and oedema.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Side effects of Opsutan Tablet
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increase fibre intake to alleviate constipation.
  • Track your food intake to identify trigger foods.
  • Limit caffeine, fatty foods, and gas-producing foods.
  • Explore probiotics or a low fermented sugar diet for relief.
  • Regular exercise and stress management through therapy can help.
  • Stay hydrated by drinking plenty of water.
  • Your doctor may recommend medications to dissolve the small gallstones (like ursodiol) or use shock waves to break up the stones.
  • Try to eat regular meals because skipping meals can increase the risk of gallstones by making your gallbladder work less efficiently.
  • Eat breakfast soon after you wake up, as cholesterol in bile is highest in the morning.
  • If you are overweight, losing weight gradually can help lower the chance of developing gallstones.
  • Include plenty of fresh vegetables and fruits in your diet.
  • Base your meals around starchy foods like bread, pasta, rice, and potatoes, especially whole grain or high-fibre varieties.
  • If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
  • Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
  • Drink lots of water to thin mucus and help with coughing.
  • Get enough sleep to allow the body to heal.
  • Suck on lozenges to soothe sore throat.
  • Quit smoking and alcohol consumption.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with itraconazole may increase the blood levels of Opsutan Tablet that increases risk of side effects.

How to manage the interaction:
Itraconazole and Opsutan Tablet may interact, but if a doctor prescribes them, you can still take them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, seek medical attention. Never discontinue taking a medication without consulting a doctor.
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Ketoconazole may increase the blood levels of Opsutan Tablet, which increases severe side effects.

How to manage the interaction:
Although taking Ketoconazole and Opsutan Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MacitentanNelfinavir
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Nelfinavir may increase the blood levels of Opsutan Tablet, which increases severe side effects.

How to manage the interaction:
Although taking Opsutan Tablet and Nelfinavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanSaquinavir
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Saquinavir may increase the blood levels of Opsutan Tablet, which increases severe side effects.

How to manage the interaction:
Co-administration of Opsutan Tablet with Saquinavir can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanLomitapide
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Lomitapide affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Opsutan Tablet and Lomitapide, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Opsutan Tablet:
Using Opsutan Tablet together with Voriconazole can significantly increase the risk of liver problems.

How to manage the interaction:
Although taking Voriconazole and Opsutan Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, joint pain or swelling, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
MacitentanConivaptan
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Amprenavir may increase the blood levels of Opsutan Tablet, which increases severe side effects.

How to manage the interaction:
Although there is a possible interaction between Opsutan Tablet and Conivaptan, but can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanMipomersen
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Mipomersen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Opsutan Tablet and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
MacitentanAmprenavir
Severe
How does the drug interact with Opsutan Tablet:
Taking Opsutan Tablet with Amprenavir may increase the blood levels of Opsutan Tablet, which increases severe side effects.

How to manage the interaction:
There is a interaction between Opsutan Tablet and Amprenavir, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Opsutan Tablet:
Taking leflunomide with Opsutan Tablet affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Leflunomide and Opsutan Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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