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compositionComposition:ACETAMINOPHEN-325MG+TRAMADOL-37.5MG
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Prescription Medicine
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TRAMADIN PLUS TABLET is used to treat moderate to severe pain. It contains Tramadol and Acetaminophen which work by inhibiting the transmission of pain signals from nerves to the brain and blocking the chemical messengers that cause pain. In some cases, this medicine may cause side effects such as drowsiness, nausea, dizziness, headache, vomiting, dry mouth, constipation, excessive sweating, shaking, confusion or mood changes. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ACETAMINOPHEN-325MG+TRAMADOL-37.5MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TRAMADIN PLUS TABLET

TRAMADIN PLUS TABLET is a combination prescription medicine used to manage moderate to moderately severe pain in adults. It is formulated to help relieve acute pain, such as pain following surgical procedures or dental work, when other treatments are not sufficient. This medicine helps restore physical comfort by targeting pain signals in the body.

Your doctor will determine how often you should take TRAMADIN PLUS TABLET, and it is crucial to use it consistently exactly as directed. You can take this medication with or without food, though taking it with a meal can help if you experience stomach upset. To get the best results, incorporate supportive lifestyle adjustments such as staying well-hydrated, resting properly, and eating fibre-rich foods to prevent bowel sluggishness.

While taking TRAMADIN PLUS TABLET, some people may experience common side effects such as mild dizziness, sleepiness, or nausea. However, you must contact your doctor immediately if you experience serious side effects, including severe breathing difficulties, extreme drowsiness, or signs of liver damage such as yellowing of your skin or eyes.

Before you begin taking TRAMADIN PLUS TABLET, tell your doctor about your complete medical history, especially if you have a history of head injuries, seizures, or kidney problems. Do not take this if you have severe lung disease, asthma, severe breathing problems, or a history of drug or alcohol dependency.

This medication can interact with other substances; for instance, taking it with sleeping pills or alcohol can lead to dangerous breathing issues, while taking it with certain antidepressants can cause a rare but serious nervous system reaction. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist before starting this medicine to ensure it is safe for you.

Uses of TRAMADIN PLUS TABLET

TRAMADIN PLUS TABLET is used for the short-term management of moderate to moderately severe pain when adequate pain relief is needed. Its uses include:

  • Moderate to moderately severe acute pain: TRAMADIN PLUS TABLET helps reduce severe pain from surgeries, dental procedures, or sudden injuries, allowing you to recover more comfortably.
  • Short-term pain management: This medicine helps control temporary, intense pain flare-ups when non-opioid pain relievers alone do not provide enough relief.
     

Key Benefits

TRAMADIN PLUS TABLET combines two pain-relieving medicines that work in different ways to manage moderate to severe pain. This dual-action approach provides effective pain relief, improving comfort and supporting recovery.

  • Provides Effective Pain Relief: Helps relieve moderate to severe pain associated with injuries, surgical procedures, and other painful conditions.
  • Offers Dual-Action Relief: Combines complementary pain-relieving mechanisms to provide better pain control than either medicine may provide alone in some patients.
  • Improves Daily Comfort: By reducing pain intensity, it can make everyday movements and activities more manageable.
  • Supports Rest and Recovery: Better pain control may improve sleep and rest, which are important during recovery from injury or surgery.
  • Supports Physical Rehabilitation: Reduced pain may help you participate more comfortably in prescribed physiotherapy, rehabilitation exercises, and gentle daily movement.

Directions for Use

  • TRAMADIN PLUS TABLET can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow TRAMADIN PLUS TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

How TRAMADIN PLUS TABLET Works

TRAMADIN PLUS TABLET contains tramadol and acetaminophen, which work together to relieve pain. The first ingredient, tramadol, is a central analgesic that acts on specific opioid receptors in the brain to change how your nervous system feels and responds to pain. It also helps keep natural chemical messengers like serotonin and norepinephrine active in the brain, which helps block pain signals from travelling up the spinal cord. The second ingredient, acetaminophen, works centrally to raise your body's overall pain threshold, making you less sensitive to discomfort. It also helps lower fevers. Together, these two ingredients provide a stronger, more comprehensive pain-relief effect than when used individually, allowing for effective pain control.
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Alcohol

Unsafe

Avoid consumption of alcohol with TRAMADIN PLUS TABLET as it may cause drowsiness.

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Pregnancy

Unsafe

TRAMADIN PLUS TABLET is not recommended for pregnant women as it may cause withdrawal symptoms in the newborn baby. However, please consult your doctor if you are pregnant.

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Breast Feeding

Caution

TRAMADIN PLUS TABLET may be excreted in breast milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

TRAMADIN PLUS TABLET may cause dizziness or drowsiness in some people. It is an offence to drive if TRAMADIN PLUS TABLET affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking TRAMADIN PLUS TABLET.

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Liver

Caution

Take TRAMADIN PLUS TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking TRAMADIN PLUS TABLET if you have severe liver insufficiency.

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Kidney

Caution

Take TRAMADIN PLUS TABLET with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking TRAMADIN PLUS TABLET if you have severe kidney insufficiency.

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Children

Unsafe

TRAMADIN PLUS TABLET is not recommended for children below 12 years of age, as the safety and effectiveness were not established.

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Heart

Caution

TRAMADIN PLUS TABLET can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

TRAMADIN PLUS TABLET should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of TRAMADIN PLUS TABLET

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre right away. An overdose of this medication can lead to life-threatening breathing difficulties and severe, irreversible liver damage. Look for symptoms such as extreme drowsiness, pinpoint pupils, slow breathing, cold and clammy skin, or severe nausea and vomiting.

Diet & Lifestyle Advise

  • Prevent constipation: Because one of the active ingredients can slow down digestion, drink plenty of fluids throughout the day and eat high-fibre foods such as vegetables, fruits, and whole grains.
  • Avoid alcohol completely: Do not drink beer, wine, or spirits while taking this medicine, as alcohol combined with these active ingredients significantly increases the risk of liver damage and dangerous drowsiness.
  • Stand up slowly: To prevent dizziness or fainting caused by sudden blood pressure changes, rise slowly from a sitting or lying position.
  • Incorporate gentle movement: If recovering from surgery or injury, engage in light stretching or short walks as approved by your doctor to promote blood circulation and muscle recovery.
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Have a query?

How Soon It Starts Working

The time required for TRAMADIN PLUS TABLET to start to work: TRAMADIN PLUS TABLET ideally shows its action within 30 to 60 minutes of administration. The time for which the effects of TRAMADIN PLUS TABLET last: TRAMADIN PLUS TABLET effect lasts for 6 to 8 hours..

What if you forget to take TRAMADIN PLUS TABLET

If you take TRAMADIN PLUS TABLET on a regular schedule and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular routine. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store TRAMADIN PLUS TABLET tablets at a controlled room temperature between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from light and moisture.

Drug Warnings

  • Check Other Medicine Labels: Avoid taking other medicines containing acetaminophen or paracetamol unless advised by your doctor, as excessive total doses can cause serious liver damage.
  • Use Caution During Activities: Do not drive, operate machinery, or perform tasks requiring full alertness until you know how TRAMADIN PLUS TABLET affects you, as it may cause dizziness, drowsiness, or impaired coordination.
  • Take Only as Prescribed: Tramadol can cause dependence and misuse. Do not take larger doses or use the medicine for longer than prescribed.
  • Do Not Stop Suddenly After Long-Term Use: If you have been taking this medicine regularly for a prolonged period, your doctor may gradually reduce the dose to lower the risk of withdrawal symptoms.
  • Inform Healthcare Providers: Tell your doctor, dentist, surgeon, or other healthcare professional that you are taking TRAMADIN PLUS TABLET before undergoing any procedure or starting new treatment.

verifiedApollotooltip

Certain medicines may interact with TRAMADIN PLUS TABLET and increase the risk of serious side effects, including excessive sedation, breathing problems, serotonin syndrome, or liver damage. Important interactions include:

  • Other acetaminophen-containing products: Taking these together increases the risk of severe liver damage.
  • MAO Inhibitors (MAOIs): Do not take this medicine within 14 days of using an MAO inhibitor, as this can cause a dangerous, life-threatening reaction.
  • Antidepressants (SSRIs, SNRIs, tricyclics): Combining these can increase the risk of a serious, high-fever condition called serotonin syndrome.
  • Sedatives, sleeping pills, or muscle relaxants: Taking these with TRAMADIN PLUS TABLET can cause extreme drowsiness, shallow breathing, coma, or death.
     

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verifiedApollotooltip

Certain foods and drinks may interact with TRAMADIN PLUS TABLET or increase the risk of adverse effects. Important interactions include:

  • Alcohol: Significantly increases the risk of liver damage, extreme sleepiness, and dangerously slow breathing.
  • Grapefruit or grapefruit juice: May interfere with how your body processes tramadol, increasing the risk of adverse side effects.
     

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANALGESICS]

FAQs

TRAMADIN PLUS TABLET is used to treat moderate to severe pain.
TRAMADIN PLUS TABLET contains Tramadol and Acetaminophen. Tramadol is an opioid analgesic that works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby, inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever.
TRAMADIN PLUS TABLET may cause dry mouth as a common side effect. It is not necessary for everyone taking TRAMADIN PLUS TABLET to experience this side effect. However, drink plenty of water, suck on sugar candy or chew sugar-free gum to prevent such side effects while taking TRAMADIN PLUS TABLET. If the condition worsens or persist, please consult a doctor.
TRAMADIN PLUS TABLET should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, it is recommended to inform your doctor if you ever had fits before taking TRAMADIN PLUS TABLET.
No, you are not recommended to take TRAMADIN PLUS TABLET with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with TRAMADIN PLUS TABLET may increase the risk of fits. However, please consult a doctor before taking TRAMADIN PLUS TABLET with other medicines.
TRAMADIN PLUS TABLET may cause addiction, especially if taken for a prolonged time. Therefore, TRAMADIN PLUS TABLET should be given only for a short duration under strict medical supervision, particularly to patients who are susceptible to drug abuse. Take TRAMADIN PLUS TABLET only as a doctor advised as overuse or misuse of TRAMADIN PLUS TABLET can lead to overdose and cause severe adverse effects.
You are not recommended to take TRAMADIN PLUS TABLET with warfarin as co-administration of these two medicines may increase bleeding risk more easily. However, if you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
TRAMADIN PLUS TABLET may cause withdrawal symptoms such as difficulty sleeping, anxiety, nervousness, shaking, stomach or bowel disorders, or making you overactive when you stop taking TRAMADIN PLUS TABLET suddenly. Therefore, if you experience any difficulty while taking TRAMADIN PLUS TABLET, do not stop taking suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Yes, you can take TRAMADIN PLUS TABLET with or without food. If you experience mild nausea, taking the tablet with food may help settle your stomach. Talk to your doctor or pharmacist if nausea persists.
Taking TRAMADIN PLUS TABLET during pregnancy is generally not recommended, as the active ingredients can pass to the unborn baby and cause severe breathing problems or withdrawal symptoms after birth. Talk to your doctor or pharmacist about safer pain-relief options.
You must check the labels of all over-the-counter products carefully. Many contain acetaminophen, which can cause severe liver damage if combined with TRAMADIN PLUS TABLET. Talk to your doctor or pharmacist before taking any additional medicines.
If you are taking it on a regular schedule, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your regular routine. Do not double the dose. Talk to your doctor or pharmacist for guidance.
Alcohol significantly increases the risk of severe liver damage, extreme drowsiness, and life-threatening breathing difficulties when combined with TRAMADIN PLUS TABLET. Talk to your doctor or pharmacist if you have concerns about avoiding alcohol.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - TRA0229

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