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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Xylocaine 10% Spray is used to reduce/relieve pain and discomfort associated with skin irritation, burns, scratches, insect bites, skin abrasions, or sunburn. It is also used to treat post-herpetic neuralgia (lasting pain after a shingles infection). It may also be used to treat premature ejaculation. It is also indicated for the prevention and control of pain in urethritis (inflammation of the urethra). It may also be used as an adjunct for endotracheal intubation. It contains Lidocaine, which blocks the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. It produces local numbness by blocking the nerve signal in the affected area. Hence, it produces an anaesthetic effect and helps decrease the sensation of pain. In some cases, it may cause application site reactions such as burning sensation, itching, redness, and irritation.

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Drug-Drug Interactions

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LidocaineSaquinavir
Critical
LidocaineArbutamine
Critical

Drug-Drug Interactions

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LidocaineSaquinavir
Critical
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Saquinavir can increase the blood levels of Xylocaine 10% Spray 50 ml and cause an irregular heart rhythm.

How to manage the interaction:
Taking Xylocaine 10% Spray 50 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
LidocaineArbutamine
Critical
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Xylocaine 10% Spray 50 ml with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
LidocaineNitroprusside
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Co-administration of Xylocaine 10% Spray 50 ml with Nitroprusside may rarely cause methemoglobinemia (a blood disorder in which little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Xylocaine 10% Spray 50 ml and Nitroprusside can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like discoloration of the skin, headache, dizziness, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting your doctor.
LidocaineIopamidol
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml and Iopamidol may increase the risk of causing seizures(fits).

How to manage the interaction:
Although taking Xylocaine 10% Spray 50 ml and Iopamidol together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Rasburicase with Xylocaine 10% Spray 50 ml can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasburicase with Xylocaine 10% Spray 50 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Flutamide with Xylocaine 10% Spray 50 ml can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Xylocaine 10% Spray 50 ml and Flutamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking isosorbide dinitrate with Xylocaine 10% Spray 50 ml may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking isosorbide dinitrate and Xylocaine 10% Spray 50 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
LidocaineDofetilide
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml together with Dofetilide can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
There may be a possibility of interaction between Xylocaine 10% Spray 50 ml and Dofetilide, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without first consulting your doctor.
LidocaineMetrizamide
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml and Metrizamide may increase the risk of causing seizures(fits).

How to manage the interaction:
Although taking Xylocaine 10% Spray 50 ml and Metrizamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
LidocaineAmprenavir
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Amprenavir may increase the blood levels of Xylocaine 10% Spray 50 ml, which increases severe side effects.

How to manage the interaction:
There may be a possibility of interaction between Xylocaine 10% Spray 50 ml and Amprenavir, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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