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compositionComposition:CLADRIBINE-10MG
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CLADRIM 10MG INJECTION is used to treat hairy cell leukaemia (cancer of a specific type of white blood cell). It contains Cladribine, a class of medications known as purine analogues. It works by stopping or slowing the growth of cancer cells. Common side effects of this medication include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLADRIBINE-10MG

Manufacturer/Marketer :

Dabur India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION is an injectable prescription medicine primarily used to treat hairy cell leukaemia, a rare type of blood cancer. It works by targeting abnormal white blood cells to help restore a healthy balance of blood cells in your body. This treatment is prescribed by a specialist to manage specific, serious blood disorders.

Because this medicine is given as an infusion into a vein, it is administered in a hospital or specialised clinic. It is typically given as a continuous infusion over a set number of days as a single treatment course. Since it is injected directly into your bloodstream, food intake does not affect how well it works. Eating light, nutritious meals and resting during your treatment cycle can help your body recover.

While this medication is highly effective, it can cause side effects. Common issues include fever, fatigue, and mild nausea. However, because it temporarily lowers your body's ability to fight infections, you must contact your healthcare team immediately if you develop a sudden fever, severe shivering, or unusual bruising.

Do not receive this medicine if you have had a severe allergic reaction to it in the past. Before starting, talk to your doctor if you have kidney disease, liver damage, or an active infection. It is crucial to address these conditions beforehand to ensure the treatment can be given safely.

This medicine can interact with other treatments that suppress your immune system, increasing your risk of serious infections. It is also important to talk to your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as specific precautions must be taken to ensure your safety.

Uses of CLADRIM 10MG INJECTION

Your doctor may prescribe CLADRIM 10MG INJECTION to help manage the following conditions:

  • Hairy Cell Leukaemia: CLADRIM 10MG INJECTION helps by destroying abnormal 'hairy' white blood cells in the bone marrow, allowing normal, healthy blood cells to grow and function properly.
  • Chronic Lymphocytic Leukaemia (CLL): In certain clinical situations, this medicine is used to manage other white blood cell cancers when standard treatments have not provided sufficient relief.

Key Benefits

CLADRIM 10MG INJECTION provides critical therapeutic relief by targeting the root cause of specific blood cancers. The primary benefits of this treatment include:

  • Promotes Long-Term Remission: A single, short course of treatment is often highly effective at putting hairy cell leukaemia into complete remission for many years.
  • Restores Normal Blood Counts: By clearing out abnormal cancer cells, your bone marrow can resume producing healthy red blood cells, platelets, and white blood cells, which relieves chronic fatigue and reduces bleeding risks.
  • Reduces Daily Pill Burden: Because it is typically given as a single short-term infusion course, patients do not need to take daily anticancer medications for extended periods.
Side effects of Cladrim 10mg Injection
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Receive vaccinations to guard against bacterial infections.
  • Maintain good hygiene by washing hands often and covering your mouth/nose when coughing or sneezing.
  • Make sure to store, cook, and handle food properly, to prevent food-borne infections.
  • Regularly clean surfaces that are touched often with disinfectants.
  • Protect yourself from insect bites by using repellents and wearing appropriate clothing, especially in high-risk areas.
  • Use latex or polyurethane condoms during sex to minimize the risk of infections.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • CLADRIM 10MG INJECTION is administered by the doctor or nurse in a clinical setting.
  • Do not self-administer.

How CLADRIM 10MG INJECTION Works

CLADRIM 10MG INJECTION contains cladribine. It works by mimicking a natural chemical building block that cells need to repair and copy their DNA. Cancer cells, particularly abnormal white blood cells, absorb this medicine rapidly as they try to multiply. Once inside, the medicine incorporates itself into the cell's genetic material, permanently disrupting its ability to repair itself. This genetic disruption triggers a natural self-destruct mechanism within the cancer cells. Because cancer cells in hairy cell leukaemia divide slowly but accumulate in large numbers, this targeted cellular destruction clears them from the blood and bone marrow. This process helps healthy blood-producing tissues recover and function normally again.
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Alcohol

Caution

It is not known if alcohol interacts with CLADRIM 10MG INJECTION. Please consult the doctor.

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Pregnancy

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving CLADRIM 10MG INJECTION. You should not become pregnant while on treatment with CLADRIM 10MG INJECTION.

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Breast Feeding

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

CLADRIM 10MG INJECTION will be administered to hospitalized patients. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

CLADRIM 10MG INJECTION is not recommended for use in children as safety and effectiveness have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving CLADRIM 10MG INJECTION if you have pre-existing heart problems. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering CLADRIM 10MG INJECTION to geriatric patients. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.

What if I have taken an overdose of CLADRIM 10MG INJECTION

Because your dose is carefully calculated and prepared by trained healthcare providers, an overdose is extremely rare. However, if you suspect an error or experience sudden, severe symptoms during your infusion, tell your doctor or nurse right away.

Diet & Lifestyle Advise

  • Follow a clean-food diet: Since your immune system will be temporarily weakened, avoid eating raw or undercooked meats, unpasteurised dairy, and unwashed raw fruits and vegetables to lower your risk of foodborne infections.
  • Stay well-hydrated: Drink plenty of fluids (especially water) during and after your treatment days to help your kidneys flush out cellular waste products.
  • Practice strict hygiene: Wash your hands frequently with soap and water, and avoid crowded places or close contact with anyone who is currently sick.
  • Protect your gums and skin: Use a soft-bristled toothbrush to prevent gum bleeding, and avoid activities that carry a high risk of cuts or bruising.
     

Health Queries

What are the Ayurvedic treatment options for leukemia, and can Ayurveda help in managing or curing it?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Hello, Leukemia is often treatable with modern medical care, and many patients respond well to therapies such as chemotherapy, targeted therapy, or stem cell transplant. Ayurveda may help support general well-being, appetite, stress management, or recovery, but it should not replace standard cancer treatment. Some herbal or alternative medicines may interact with cancer medicines, so always discuss them with your oncologist before use. Early and appropriate treatment is very important in leukemia, so regular follow-up with a hematologist or oncologist is strongly recommended for safe and effective care.
health query

Have a query?

How Soon It Starts Working

The time required for CLADRIM 10MG INJECTION to start to work: CLADRIM 10MG INJECTION ideally shows its action within 30 minutes after administration. The time for which the effects of CLADRIM 10MG INJECTION last: The effect of CLADRIM 10MG INJECTION lasts for 10 hours.

What if you forget to take CLADRIM 10MG INJECTION

Since this medicine is given by medical professionals in a clinic or hospital, it is highly unlikely that you will miss a dose. If you miss or must reschedule an appointment for your infusion, contact your clinic immediately to set up a new time.

Storage

• Unopened vials of CLADRIM 10MG INJECTION must be stored in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze this medication.

Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the liquid: Before your infusion starts, ensure the solution is clear and colourless. Do not allow it to be used if it is discoloured or contains floating particles.
  • Monitor the injection site: Tell your nurse immediately if you feel burning, pain, or notice swelling where the needle is inserted, as the medicine must not leak into surrounding tissues.
  • Avoid live vaccines: Do not receive any live vaccines (such as the shingles or yellow fever vaccine) during or immediately after your treatment, as your weakened immune system cannot safely process them.
  • Use effective birth control: Both men and women must use highly effective birth control during treatment and for at least six months afterward to prevent pregnancy, as this medicine can harm an unborn baby.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Immune-suppressing medications: Combining this medicine with other cancer treatments or immune-suppressing drugs can severely increase your risk of dangerous infections.
  • Antiviral drugs: Certain antivirals may increase the risk of bone marrow suppression when taken during your treatment.
     
CladribineCertolizumab
Severe
CladribineRotavirus vaccine
Severe

Drug-Drug Interactions

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CladribineCertolizumab
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined Cladrim 10mg Injection with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladrim 10mg Injection and Certolizumab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineRotavirus vaccine
Severe
How does the drug interact with Cladrim 10mg Injection:
When Rotavirus vaccine is used together with Cladrim 10mg Injection, its effectiveness may be reduced.

How to manage the interaction:
Although there is a possible interaction between Cladrim 10mg Injection and Rotavirus vaccine, you can take these medicines together if prescribed by your doctor. If you notice any signs of infection, it's important to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
CladribineClozapine
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined Cladrim 10mg Injection with clozapine can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Cladrim 10mg Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribinePhenylbutazone
Severe
How does the drug interact with Cladrim 10mg Injection:
Using Cladrim 10mg Injection together with phenylbutazone may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Cladrim 10mg Injection with Phenylbutazone can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
CladribineAzathioprine
Severe
How does the drug interact with Cladrim 10mg Injection:
The use of Cladrim 10mg Injection with azathioprine can increase the risk of serious infections.

How to manage the interaction:
Although taking Azathioprine and Cladrim 10mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CladribinePrednisolone
Severe
How does the drug interact with Cladrim 10mg Injection:
Co-administration of Cladrim 10mg Injection with Prednisolone may increase the risk of serious infections.

How to manage the interaction:
Although taking Cladrim 10mg Injection with Prednisolone together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning while urinating. Do not stop using any medications without a doctor's advice.
CladribineDeflazacort
Severe
How does the drug interact with Cladrim 10mg Injection:
Co-administration of Deflazacort with Cladrim 10mg Injection may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Deflazacort and Cladrim 10mg Injection, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CladribineDasatinib
Severe
How does the drug interact with Cladrim 10mg Injection:
Using Cladrim 10mg Injection together with Dasatinib may increase the risk of infections.

How to manage the interaction:
There may be a possibility of interaction between Dasatinib and Cladrim 10mg Injection, but it can be taken if prescribed by a doctor. If you notice any symptoms such as fever, sore throat, or muscle aches, difficulty breathing, and pain or discomfort while urinating contact a doctor right away. Do not stop using any medications without a doctor's advice.
CladribineAltretamine
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined use of adalimumab with Cladrim 10mg Injection can increase the risk of side effects.

How to manage the interaction:
Co-administration of Cladrim 10mg Injection with Altretamine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.
CladribineFludarabine
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Cladrim 10mg Injection with Fludarabine can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Fludarabine with Cladrim 10mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with CLADRIM 10MG INJECTION when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

CLADRIM 10MG INJECTION is used to treat Hairy cell Leukemia.
CLADRIM 10MG INJECTION contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.
No, CLADRIM 10MG INJECTION is not a vesicant. CLADRIM 10MG INJECTION belongs to a group of anticancer medications called purine analogues used in the treatment of hairy cell leukaemia (a rare type of blood and bone marrow cancer).
CLADRIM 10MG INJECTION may cause hair loss in some cases. However, it is an uncommon side effect of CLADRIM 10MG INJECTION. Consult the doctor if you notice hair loss during treatment with CLADRIM 10MG INJECTION.
The common side effects of CLADRIM 10MG INJECTION may include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult the doctor.
It is given as an intravenous infusion (into a vein) by a healthcare professional in a clinic or hospital setting. Talk to your doctor for details about your specific schedule.
You must avoid live vaccines during and shortly after treatment because your immune system will be weakened. Talk to your doctor or pharmacist before getting any vaccine.
Complete hair loss is not a common side effect of CLADRIM 10MG INJECTION, though some mild thinning can sometimes occur. Talk to your doctor if you have concerns about hair changes.
It is best to avoid alcohol during your treatment course, as alcohol can strain your liver and worsen side effects like nausea and fatigue. Talk to your doctor about your lifestyle habits.
No, this medicine can cause severe birth defects. Both men and women should use reliable birth control during and for several months after treatment. Talk to your doctor if you are planning a family.
The medicine temporarily slows down the bone marrow's ability to make new cells while it clears out abnormal cancer cells. Talk to your doctor about how your blood counts will be monitored.
A fever can be a sign of a serious infection when your white blood cell count is low. You must contact your healthcare team or seek emergency medical care immediately. Talk to your doctor about what signs to watch for.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Mayo Clinic Staff. Drg 20062966 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A693015 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. DailyMed Database. Fdadrugxsl.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Cladribine Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. U.S. Food and Drug Administration (FDA). 020229S034Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 27 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

8/3, Asaf Ali Road, New Delhi-110002
Other Info - CLA0132
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